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Entry version 156 (02 Jun 2021)
Sequence version 3 (05 Apr 2011)
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Protein

Transmembrane protease serine 7

Gene

TMPRSS7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei646Charge relay systemBy similarity1
Active sitei694Charge relay systemBy similarity1
Active sitei790Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7RTY8

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.072

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protease serine 7 (EC:3.4.21.-)
Alternative name(s):
Matriptase-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMPRSS7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30846, TMPRSS7

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7RTY8

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000176040.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei77 – 97Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini98 – 843ExtracellularSequence analysisAdd BLAST746

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
344805

Open Targets

More...
OpenTargetsi
ENSG00000176040

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134928796

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7RTY8, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMPRSS7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478556

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000278591 – 843Transmembrane protease serine 7Add BLAST843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi247 ↔ 273By similarity
Disulfide bondi299 ↔ 322By similarity
Disulfide bondi365 ↔ 396By similarity
Disulfide bondi484 ↔ 496By similarity
Disulfide bondi491 ↔ 509By similarity
Disulfide bondi503 ↔ 518By similarity
Disulfide bondi525 ↔ 544By similarity
Disulfide bondi538 ↔ 553By similarity
Disulfide bondi559 ↔ 571By similarity
Disulfide bondi566 ↔ 585By similarity
Disulfide bondi579 ↔ 594By similarity
Disulfide bondi631 ↔ 647By similarity
Disulfide bondi730 ↔ 796By similarity
Disulfide bondi762 ↔ 775By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7RTY8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7RTY8

PeptideAtlas

More...
PeptideAtlasi
Q7RTY8

PRoteomics IDEntifications database

More...
PRIDEi
Q7RTY8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68937 [Q7RTY8-1]
68938 [Q7RTY8-2]
68939 [Q7RTY8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7RTY8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7RTY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, ovary, testis, salivary gland, trachea and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176040, Expressed in testis and 33 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7RTY8, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000176040, Tissue enhanced (blood, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with SERPINA5.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131324, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000478830

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7RTY8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7RTY8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini106 – 234SEAPROSITE-ProRule annotationAdd BLAST129
Domaini247 – 360CUB 1PROSITE-ProRule annotationAdd BLAST114
Domaini365 – 481CUB 2PROSITE-ProRule annotationAdd BLAST117
Domaini483 – 519LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
Domaini517 – 554LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST38
Domaini558 – 595LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST38
Domaini606 – 840Peptidase S1PROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 67DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi37 – 53Pro residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3627, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160085

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006842_19_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7RTY8

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHGWWEI

Database of Orthologous Groups

More...
OrthoDBi
1314811at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7RTY8

TreeFam database of animal gene trees

More...
TreeFami
TF330647

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 1 hit
cd00112, LDLa, 2 hits
cd00190, Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
2.60.120.290, 2 hits
3.30.70.960, 1 hit
4.10.400.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR000082, SEA_dom
IPR036364, SEA_dom_sf
IPR035914, Sperma_CUB_dom_sf
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 2 hits
PF00057, Ldl_recept_a, 2 hits
PF01390, SEA, 1 hit
PF00089, Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00722, CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 1 hit
SM00192, LDLa, 3 hits
SM00020, Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 2 hits
SSF50494, SSF50494, 1 hit
SSF57424, SSF57424, 3 hits
SSF82671, SSF82671, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 2 hits
PS50024, SEA, 1 hit
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7RTY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKENSDVSA APADLKISNI SVQVVSAQKK LPVRRPPLPG RRLPLPGRRP
60 70 80 90 100
PQRPIGKAKP KKQSKKKVPF WNVQNKIILF TVFLFILAVI AWTLLWLYIS
110 120 130 140 150
KTESKDAFYF AGMFRITNIE FLPEYRQKES REFLSVSRTV QQVINLVYTT
160 170 180 190 200
SAFSKFYEQS VVADVSSNNK GGLLVHFWIV FVMPRAKGHI FCEDCVAAIL
210 220 230 240 250
KDSIQTSIIN RTSVGSLQGL AVDMDSVVLN AGLRSDYSST IGSDKGCSQY
260 270 280 290 300
FYAEHLSLHY PLEISAASGR LMCHFKLVAI VGYLIRLSIK SIQIEADNCV
310 320 330 340 350
TDSLTIYDSL LPIRSSILYR ICEPTRTLMS FVSTNNLMLV TFKSPHIRRL
360 370 380 390 400
SGIRAYFEVI PEQKCENTVL VKDITGFEGK ISSPYYPSYY PPKCKCTWKF
410 420 430 440 450
QTSLSTLGIA LKFYNYSITK KSMKGCEHGW WEINEHMYCG SYMDHQTIFR
460 470 480 490 500
VPSPLVHIQL QCSSRLSDKP LLAEYGSYNI SQPCPVGSFR CSSGLCVPQA
510 520 530 540 550
QRCDGVNDCF DESDELFCVS PQPACNTSSF RQHGPLICDG FRDCENGRDE
560 570 580 590 600
QNCTQSIPCN NRTFKCGNDI CFRKQNAKCD GTVDCPDGSD EEGCTCSRSS
610 620 630 640 650
SALHRIIGGT DTLEGGWPWQ VSLHFVGSAY CGASVISREW LLSAAHCFHG
660 670 680 690 700
NRLSDPTPWT AHLGMYVQGN AKFVSPVRRI VVHEYYNSQT FDYDIALLQL
710 720 730 740 750
SIAWPETLKQ LIQPICIPPT GQRVRSGEKC WVTGWGRRHE ADNKGSLVLQ
760 770 780 790 800
QAEVELIDQT LCVSTYGIIT SRMLCAGIMS GKRDACKGDS GGPLSCRRKS
810 820 830 840
DGKWILTGIV SWGHGSGRPN FPGVYTRVSN FVPWIHKYVP SLL
Length:843
Mass (Da):94,415
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D97E984FD87934C
GO
Isoform 2 (identifier: Q7RTY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     166-166: Missing.
     231-243: Missing.

Show »
Length:717
Mass (Da):80,354
Checksum:i95151028202683C8
GO
Isoform 3 (identifier: Q7RTY8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-271: Missing.

Show »
Length:572
Mass (Da):64,025
Checksum:i0458CBFB987EA285
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1W5G3V1W5_HUMAN
HCG2045367
TMPRSS7 hCG_2045367
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCZ2F8WCZ2_HUMAN
Transmembrane protease serine 7
TMPRSS7
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti816S → C in BAD18401 (PubMed:14702039).Curated1
Sequence conflicti816S → C in AAI17323 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0407711 – 271Missing in isoform 3. 1 PublicationAdd BLAST271
Alternative sequenceiVSP_0407721 – 112Missing in isoform 2. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_040773166Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_040774231 – 243Missing in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC015778 Genomic DNA No translation available.
AC024887 Genomic DNA No translation available.
AK131211 mRNA Translation: BAD18401.1
BC117322 mRNA Translation: AAI17323.1
BN000125 mRNA Translation: CAD67577.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43129.2 [Q7RTY8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001036040.2, NM_001042575.2 [Q7RTY8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000419127; ENSP00000411645; ENSG00000176040 [Q7RTY8-2]
ENST00000452346; ENSP00000398236; ENSG00000176040 [Q7RTY8-1]
ENST00000617607; ENSP00000478830; ENSG00000176040 [Q7RTY8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
344805

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:344805

UCSC genome browser

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UCSCi
uc010hqb.3, human [Q7RTY8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015778 Genomic DNA No translation available.
AC024887 Genomic DNA No translation available.
AK131211 mRNA Translation: BAD18401.1
BC117322 mRNA Translation: AAI17323.1
BN000125 mRNA Translation: CAD67577.1
CCDSiCCDS43129.2 [Q7RTY8-2]
RefSeqiNP_001036040.2, NM_001042575.2 [Q7RTY8-2]

3D structure databases

SMRiQ7RTY8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131324, 1 interactor
STRINGi9606.ENSP00000478830

Protein family/group databases

MEROPSiS01.072

PTM databases

iPTMnetiQ7RTY8
PhosphoSitePlusiQ7RTY8

Genetic variation databases

BioMutaiTMPRSS7
DMDMi327478556

Proteomic databases

MassIVEiQ7RTY8
PaxDbiQ7RTY8
PeptideAtlasiQ7RTY8
PRIDEiQ7RTY8
ProteomicsDBi68937 [Q7RTY8-1]
68938 [Q7RTY8-2]
68939 [Q7RTY8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
52124, 114 antibodies

The DNASU plasmid repository

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DNASUi
344805

Genome annotation databases

EnsembliENST00000419127; ENSP00000411645; ENSG00000176040 [Q7RTY8-2]
ENST00000452346; ENSP00000398236; ENSG00000176040 [Q7RTY8-1]
ENST00000617607; ENSP00000478830; ENSG00000176040 [Q7RTY8-2]
GeneIDi344805
KEGGihsa:344805
UCSCiuc010hqb.3, human [Q7RTY8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
344805
DisGeNETi344805

GeneCards: human genes, protein and diseases

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GeneCardsi
TMPRSS7
HGNCiHGNC:30846, TMPRSS7
HPAiENSG00000176040, Tissue enhanced (blood, testis)
neXtProtiNX_Q7RTY8
OpenTargetsiENSG00000176040
PharmGKBiPA134928796
VEuPathDBiHostDB:ENSG00000176040.13

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3627, Eukaryota
GeneTreeiENSGT00940000160085
HOGENOMiCLU_006842_19_3_1
InParanoidiQ7RTY8
OMAiDHGWWEI
OrthoDBi1314811at2759
PhylomeDBiQ7RTY8
TreeFamiTF330647

Enzyme and pathway databases

PathwayCommonsiQ7RTY8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
344805, 6 hits in 983 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
344805
PharosiQ7RTY8, Tdark

Protein Ontology

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PROi
PR:Q7RTY8
RNActiQ7RTY8, protein

Gene expression databases

BgeeiENSG00000176040, Expressed in testis and 33 other tissues
ExpressionAtlasiQ7RTY8, baseline and differential

Family and domain databases

CDDicd00041, CUB, 1 hit
cd00112, LDLa, 2 hits
cd00190, Tryp_SPc, 1 hit
Gene3Di2.40.10.10, 2 hits
2.60.120.290, 2 hits
3.30.70.960, 1 hit
4.10.400.10, 2 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR000082, SEA_dom
IPR036364, SEA_dom_sf
IPR035914, Sperma_CUB_dom_sf
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER
PfamiView protein in Pfam
PF00431, CUB, 2 hits
PF00057, Ldl_recept_a, 2 hits
PF01390, SEA, 1 hit
PF00089, Trypsin, 1 hit
PRINTSiPR00722, CHYMOTRYPSIN
SMARTiView protein in SMART
SM00042, CUB, 1 hit
SM00192, LDLa, 3 hits
SM00020, Tryp_SPc, 1 hit
SUPFAMiSSF49854, SSF49854, 2 hits
SSF50494, SSF50494, 1 hit
SSF57424, SSF57424, 3 hits
SSF82671, SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 2 hits
PS50024, SEA, 1 hit
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMPS7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7RTY8
Secondary accession number(s): C9J8P7, E9PAS3, Q17RH4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: April 5, 2011
Last modified: June 2, 2021
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families
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