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Protein

Monocarboxylate transporter 9

Gene

SLC16A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.By similarity

GO - Molecular functioni

  • monocarboxylic acid transmembrane transporter activity Source: GO_Central
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • monocarboxylic acid transport Source: GO_Central
  • urate metabolic process Source: BHF-UCL

Keywordsi

Biological processSymport, Transport

Protein family/group databases

TCDBi2.A.1.13.16 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 9
Short name:
MCT 9
Alternative name(s):
Solute carrier family 16 member 9
Gene namesi
Name:SLC16A9
Synonyms:C10orf36, MCT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165449.11
HGNCiHGNC:23520 SLC16A9
neXtProtiNX_Q7RTY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 509CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi220963
OpenTargetsiENSG00000165449
PharmGKBiPA134991247

Polymorphism and mutation databases

BioMutaiSLC16A9
DMDMi74723223

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002893321 – 509Monocarboxylate transporter 9Add BLAST509

Proteomic databases

EPDiQ7RTY1
PaxDbiQ7RTY1
PeptideAtlasiQ7RTY1
PRIDEiQ7RTY1
ProteomicsDBi68931

PTM databases

iPTMnetiQ7RTY1
PhosphoSitePlusiQ7RTY1

Expressioni

Gene expression databases

BgeeiENSG00000165449 Expressed in 154 organ(s), highest expression level in kidney epithelium
CleanExiHS_SLC16A9
GenevisibleiQ7RTY1 HS

Organism-specific databases

HPAiHPA049286

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi128664, 5 interactors
IntActiQ7RTY1, 4 interactors
MINTiQ7RTY1
STRINGi9606.ENSP00000378756

Structurei

3D structure databases

ProteinModelPortaliQ7RTY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00910000144077
HOGENOMiHOG000113632
HOVERGENiHBG097515
InParanoidiQ7RTY1
KOiK08186
OMAiSACVDNF
OrthoDBiEOG091G04XL
PhylomeDBiQ7RTY1
TreeFamiTF313792

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR030767 MCT9
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF158 PTHR11360:SF158, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q7RTY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELKKSPDGG WGWVIVFVSF LTQFLCYGSP LAVGVLYIEW LDAFGEGKGK
60 70 80 90 100
TAWVGSLASG VGLLASPVCS LCVSSFGARP VTIFSGFMVA GGLMLSSFAP
110 120 130 140 150
NIYFLFFSYG IVVGLGCGLL YTATVTITCQ YFDDRRGLAL GLISTGSSVG
160 170 180 190 200
LFIYAALQRM LVEFYGLDGC LLIVGALALN ILACGSLMRP LQSSDCPLPK
210 220 230 240 250
KIAPEDLPDK YSIYNEKGKN LEENINILDK SYSSEEKCRI TLANGDWKQD
260 270 280 290 300
SLLHKNPTVT HTKEPETYKK KVAEQTYFCK QLAKRKWQLY KNYCGETVAL
310 320 330 340 350
FKNKVFSALF IAILLFDIGG FPPSLLMEDV ARSSNVKEEE FIMPLISIIG
360 370 380 390 400
IMTAVGKLLL GILADFKWIN TLYLYVATLI IMGLALCAIP FAKSYVTLAL
410 420 430 440 450
LSGILGFLTG NWSIFPYVTT KTVGIEKLAH AYGILMFFAG LGNSLGPPIV
460 470 480 490 500
GWFYDWTQTY DIAFYFSGFC VLLGGFILLL AALPSWDTCN KQLPKPAPTT

FLYKVASNV
Length:509
Mass (Da):55,794
Last modified:December 15, 2003 - v1
Checksum:i716D56D969B1B0A8
GO

Sequence cautioni

The sequence BAD18743 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062149203A → V. Corresponds to variant dbSNP:rs56370926Ensembl.1
Natural variantiVAR_032619258T → K. Corresponds to variant dbSNP:rs2242206Ensembl.1
Natural variantiVAR_032620461D → E. Corresponds to variant dbSNP:rs11006655Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125791 mRNA Translation: BAC86293.1
AK172758 mRNA Translation: BAD18743.1 Different initiation.
BC126238 mRNA Translation: AAI26239.1
BC130567 mRNA Translation: AAI30568.1
AL122071 mRNA Translation: CAB59247.1
BN000144 mRNA Translation: CAD80155.1
CCDSiCCDS7256.1
PIRiT34552
RefSeqiNP_001310910.1, NM_001323981.1
NP_919274.1, NM_194298.2
XP_016871373.1, XM_017015884.1
UniGeneiHs.499709

Genome annotation databases

EnsembliENST00000395347; ENSP00000378756; ENSG00000165449
ENST00000395348; ENSP00000378757; ENSG00000165449
GeneIDi220963
KEGGihsa:220963
UCSCiuc010qig.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125791 mRNA Translation: BAC86293.1
AK172758 mRNA Translation: BAD18743.1 Different initiation.
BC126238 mRNA Translation: AAI26239.1
BC130567 mRNA Translation: AAI30568.1
AL122071 mRNA Translation: CAB59247.1
BN000144 mRNA Translation: CAD80155.1
CCDSiCCDS7256.1
PIRiT34552
RefSeqiNP_001310910.1, NM_001323981.1
NP_919274.1, NM_194298.2
XP_016871373.1, XM_017015884.1
UniGeneiHs.499709

3D structure databases

ProteinModelPortaliQ7RTY1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128664, 5 interactors
IntActiQ7RTY1, 4 interactors
MINTiQ7RTY1
STRINGi9606.ENSP00000378756

Protein family/group databases

TCDBi2.A.1.13.16 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ7RTY1
PhosphoSitePlusiQ7RTY1

Polymorphism and mutation databases

BioMutaiSLC16A9
DMDMi74723223

Proteomic databases

EPDiQ7RTY1
PaxDbiQ7RTY1
PeptideAtlasiQ7RTY1
PRIDEiQ7RTY1
ProteomicsDBi68931

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395347; ENSP00000378756; ENSG00000165449
ENST00000395348; ENSP00000378757; ENSG00000165449
GeneIDi220963
KEGGihsa:220963
UCSCiuc010qig.2 human

Organism-specific databases

CTDi220963
DisGeNETi220963
EuPathDBiHostDB:ENSG00000165449.11
GeneCardsiSLC16A9
HGNCiHGNC:23520 SLC16A9
HPAiHPA049286
neXtProtiNX_Q7RTY1
OpenTargetsiENSG00000165449
PharmGKBiPA134991247
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00910000144077
HOGENOMiHOG000113632
HOVERGENiHBG097515
InParanoidiQ7RTY1
KOiK08186
OMAiSACVDNF
OrthoDBiEOG091G04XL
PhylomeDBiQ7RTY1
TreeFamiTF313792

Miscellaneous databases

ChiTaRSiSLC16A9 human
GeneWikiiSLC16A9
GenomeRNAii220963
PROiPR:Q7RTY1

Gene expression databases

BgeeiENSG00000165449 Expressed in 154 organ(s), highest expression level in kidney epithelium
CleanExiHS_SLC16A9
GenevisibleiQ7RTY1 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR030767 MCT9
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF158 PTHR11360:SF158, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOT9_HUMAN
AccessioniPrimary (citable) accession number: Q7RTY1
Secondary accession number(s): Q6ZMI2, Q9UFH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 15, 2003
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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