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Protein

Monocarboxylate transporter 14

Gene

SLC16A14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Protein family/group databases

TCDBi2.A.1.13.12 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 14
Short name:
MCT 14
Alternative name(s):
Solute carrier family 16 member 14
Gene namesi
Name:SLC16A14
Synonyms:MCT14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163053.10
HGNCiHGNC:26417 SLC16A14
neXtProtiNX_Q7RTX9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei191 – 209HelicalSequence analysisAdd BLAST19
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 510CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163053
PharmGKBiPA134983567

Polymorphism and mutation databases

BioMutaiSLC16A14
DMDMi74738645

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889231 – 510Monocarboxylate transporter 14Add BLAST510

Proteomic databases

PaxDbiQ7RTX9
PeptideAtlasiQ7RTX9
PRIDEiQ7RTX9
ProteomicsDBi68928
68929 [Q7RTX9-2]

PTM databases

iPTMnetiQ7RTX9
PhosphoSitePlusiQ7RTX9

Expressioni

Gene expression databases

BgeeiENSG00000163053 Expressed in 194 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLC16A14
ExpressionAtlasiQ7RTX9 baseline and differential
GenevisibleiQ7RTX9 HS

Organism-specific databases

HPAiHPA040518

Interactioni

Protein-protein interaction databases

BioGridi127380, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliQ7RTX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
ENOG411000Y LUCA
GeneTreeiENSGT00910000144077
HOGENOMiHOG000013205
HOVERGENiHBG094888
InParanoidiQ7RTX9
KOiK08190
OMAiCGLLYMI
OrthoDBiEOG091G04XL
PhylomeDBiQ7RTX9
TreeFamiTF313792

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR030767 MCT9
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF158 PTHR11360:SF158, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7RTX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYTSHEDIGY DFEDGPKDKK TLKPHPNIDG GWAWMMVLSS FFVHILIMGS
60 70 80 90 100
QMALGVLNVE WLEEFHQSRG LTAWVSSLSM GITLIVGPFI GLFINTCGCR
110 120 130 140 150
QTAIIGGLVN SLGWVLSAYA ANVHYLFITF GVAAGLGSGM AYLPAVVMVG
160 170 180 190 200
RYFQKRRALA QGLSTTGTGF GTFLMTVLLK YLCAEYGWRN AMLIQGAVSL
210 220 230 240 250
NLCVCGALMR PLSPGKNPND PGEKDVRGLP AHSTESVKST GQQGRTEEKD
260 270 280 290 300
GGLGNEETLC DLQAQECPDQ AGHRKNMCAL RILKTVSWLT MRVRKGFEDW
310 320 330 340 350
YSGYFGTASL FTNRMFVAFI FWALFAYSSF VIPFIHLPEI VNLYNLSEQN
360 370 380 390 400
DVFPLTSIIA IVHIFGKVIL GVIADLPCIS VWNVFLLANF TLVLSIFILP
410 420 430 440 450
LMHTYAGLAV ICALIGFSSG YFSLMPVVTE DLVGIEHLAN AYGIIICANG
460 470 480 490 500
ISALLGPPFA GWIYDITQKY DFSFYICGLL YMIGILFLLI QPCIRIIEQS
510
RRKYMDGAHV
Length:510
Mass (Da):56,254
Last modified:December 15, 2003 - v1
Checksum:i5510E3E9ED63C280
GO
Isoform 2 (identifier: Q7RTX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-174: Missing.

Note: No experimental confirmation available.
Show »
Length:336
Mass (Da):37,367
Checksum:i09DCD3205470CD02
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6ZWE5Q6ZWE5_HUMAN
Monocarboxylate transporter 14
SLC16A14
485Annotation score:
E7EMG7E7EMG7_HUMAN
Monocarboxylate transporter 14
SLC16A14
489Annotation score:
C9JME4C9JME4_HUMAN
Monocarboxylate transporter 14
SLC16A14
42Annotation score:
C9JIV1C9JIV1_HUMAN
Monocarboxylate transporter 14
SLC16A14
18Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209M → T in BAB70909 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0258261 – 174Missing in isoform 2. 1 PublicationAdd BLAST174

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055356 mRNA Translation: BAB70909.1
AK292873 mRNA Translation: BAF85562.1
AC093171 Genomic DNA Translation: AAY24109.1
CH471063 Genomic DNA Translation: EAW70913.1
BC065524 mRNA Translation: AAH65524.1
BN000146 mRNA Translation: CAD80157.1
CCDSiCCDS2473.1 [Q7RTX9-1]
RefSeqiNP_689740.2, NM_152527.4 [Q7RTX9-1]
XP_011509053.1, XM_011510751.2 [Q7RTX9-1]
XP_016858969.1, XM_017003480.1 [Q7RTX9-1]
UniGeneiHs.504317

Genome annotation databases

EnsembliENST00000295190; ENSP00000295190; ENSG00000163053 [Q7RTX9-1]
GeneIDi151473
KEGGihsa:151473
UCSCiuc002vqd.2 human [Q7RTX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055356 mRNA Translation: BAB70909.1
AK292873 mRNA Translation: BAF85562.1
AC093171 Genomic DNA Translation: AAY24109.1
CH471063 Genomic DNA Translation: EAW70913.1
BC065524 mRNA Translation: AAH65524.1
BN000146 mRNA Translation: CAD80157.1
CCDSiCCDS2473.1 [Q7RTX9-1]
RefSeqiNP_689740.2, NM_152527.4 [Q7RTX9-1]
XP_011509053.1, XM_011510751.2 [Q7RTX9-1]
XP_016858969.1, XM_017003480.1 [Q7RTX9-1]
UniGeneiHs.504317

3D structure databases

ProteinModelPortaliQ7RTX9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127380, 4 interactors

Protein family/group databases

TCDBi2.A.1.13.12 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ7RTX9
PhosphoSitePlusiQ7RTX9

Polymorphism and mutation databases

BioMutaiSLC16A14
DMDMi74738645

Proteomic databases

PaxDbiQ7RTX9
PeptideAtlasiQ7RTX9
PRIDEiQ7RTX9
ProteomicsDBi68928
68929 [Q7RTX9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295190; ENSP00000295190; ENSG00000163053 [Q7RTX9-1]
GeneIDi151473
KEGGihsa:151473
UCSCiuc002vqd.2 human [Q7RTX9-1]

Organism-specific databases

CTDi151473
EuPathDBiHostDB:ENSG00000163053.10
GeneCardsiSLC16A14
HGNCiHGNC:26417 SLC16A14
HPAiHPA040518
neXtProtiNX_Q7RTX9
OpenTargetsiENSG00000163053
PharmGKBiPA134983567
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
ENOG411000Y LUCA
GeneTreeiENSGT00910000144077
HOGENOMiHOG000013205
HOVERGENiHBG094888
InParanoidiQ7RTX9
KOiK08190
OMAiCGLLYMI
OrthoDBiEOG091G04XL
PhylomeDBiQ7RTX9
TreeFamiTF313792

Miscellaneous databases

ChiTaRSiSLC16A14 human
GenomeRNAii151473
PROiPR:Q7RTX9

Gene expression databases

BgeeiENSG00000163053 Expressed in 194 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLC16A14
ExpressionAtlasiQ7RTX9 baseline and differential
GenevisibleiQ7RTX9 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR030767 MCT9
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF158 PTHR11360:SF158, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOT14_HUMAN
AccessioniPrimary (citable) accession number: Q7RTX9
Secondary accession number(s): A8KA08, Q53R92, Q96NI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 15, 2003
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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