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Entry version 154 (12 Aug 2020)
Sequence version 1 (15 Dec 2003)
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Protein

Taste receptor type 1 member 1

Gene

TAS1R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7RTX1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418594, G alpha (i) signalling events
R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.7.5, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Taste receptor type 1 member 1
Alternative name(s):
G-protein coupled receptor 70
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAS1R1
Synonyms:GPR70, T1R1, TR1
ORF Names:GM148
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000173662.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14448, TAS1R1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606225, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7RTX1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 567ExtracellularSequence analysisAdd BLAST547
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei568 – 588Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini589 – 603CytoplasmicSequence analysisAdd BLAST15
Transmembranei604 – 624Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini625 – 639ExtracellularSequence analysisAdd BLAST15
Transmembranei640 – 660Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini661 – 680CytoplasmicSequence analysisAdd BLAST20
Transmembranei681 – 701Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini702 – 725ExtracellularSequence analysisAdd BLAST24
Transmembranei726 – 746Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini747 – 761CytoplasmicSequence analysisAdd BLAST15
Transmembranei762 – 782Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini783 – 795ExtracellularSequence analysisAdd BLAST13
Transmembranei796 – 816Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini817 – 841CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80835

Open Targets

More...
OpenTargetsi
ENSG00000173662

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37882

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7RTX1, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3832641

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAS1R1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
57013075

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001295421 – 841Taste receptor type 1 member 1Add BLAST821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi479N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi529N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7RTX1

PeptideAtlas

More...
PeptideAtlasi
Q7RTX1

PRoteomics IDEntifications database

More...
PRIDEi
Q7RTX1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68921 [Q7RTX1-1]
68922 [Q7RTX1-2]
68923 [Q7RTX1-3]
68924 [Q7RTX1-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q7RTX1, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7RTX1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7RTX1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173662, Expressed in left testis and 69 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7RTX1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7RTX1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000173662, Group enriched (salivary gland, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms heterodimers with TAS1R3.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123328, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000331867

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q7RTX1

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7RTX1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1056, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161264

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005389_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7RTX1

KEGG Orthology (KO)

More...
KOi
K04624

Identification of Orthologs from Complete Genome Data

More...
OMAi
QGICIAF

Database of Orthologous Groups

More...
OrthoDBi
136715at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7RTX1

TreeFam database of animal gene trees

More...
TreeFami
TF331269

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.50.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR000337, GPCR_3
IPR011500, GPCR_3_9-Cys_dom
IPR038550, GPCR_3_9-Cys_sf
IPR017978, GPCR_3_C
IPR000068, GPCR_3_Ca_sens_rcpt-rel
IPR017979, GPCR_3_CS
IPR028082, Peripla_BP_I

The PANTHER Classification System

More...
PANTHERi
PTHR24061, PTHR24061, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF07562, NCD3G, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00592, CASENSINGR
PR00248, GPCRMGR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822, SSF53822, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00980, G_PROTEIN_RECEP_F3_2, 1 hit
PS00981, G_PROTEIN_RECEP_F3_3, 1 hit
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7RTX1-1) [UniParc]FASTAAdd to basket
Also known as: Gm148 form B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLCTARLVG LQLLISCCWA FACHSTESSP DFTLPGDYLL AGLFPLHSGC
60 70 80 90 100
LQVRHRPEVT LCDRSCSFNE HGYHLFQAMR LGVEEINNST ALLPNITLGY
110 120 130 140 150
QLYDVCSDSA NVYATLRVLS LPGQHHIELQ GDLLHYSPTV LAVIGPDSTN
160 170 180 190 200
RAATTAALLS PFLVPMISYA ASSETLSVKR QYPSFLRTIP NDKYQVETMV
210 220 230 240 250
LLLQKFGWTW ISLVGSSDDY GQLGVQALEN QATGQGICIA FKDIMPFSAQ
260 270 280 290 300
VGDERMQCLM RHLAQAGATV VVVFSSRQLA RVFFESVVLT NLTGKVWVAS
310 320 330 340 350
EAWALSRHIT GVPGIQRIGM VLGVAIQKRA VPGLKAFEEA YARADKKAPR
360 370 380 390 400
PCHKGSWCSS NQLCRECQAF MAHTMPKLKA FSMSSAYNAY RAVYAVAHGL
410 420 430 440 450
HQLLGCASGA CSRGRVYPWQ LLEQIHKVHF LLHKDTVAFN DNRDPLSSYN
460 470 480 490 500
IIAWDWNGPK WTFTVLGSST WSPVQLNINE TKIQWHGKDN QVPKSVCSSD
510 520 530 540 550
CLEGHQRVVT GFHHCCFECV PCGAGTFLNK SDLYRCQPCG KEEWAPEGSQ
560 570 580 590 600
TCFPRTVVFL ALREHTSWVL LAANTLLLLL LLGTAGLFAW HLDTPVVRSA
610 620 630 640 650
GGRLCFLMLG SLAAGSGSLY GFFGEPTRPA CLLRQALFAL GFTIFLSCLT
660 670 680 690 700
VRSFQLIIIF KFSTKVPTFY HAWVQNHGAG LFVMISSAAQ LLICLTWLVV
710 720 730 740 750
WTPLPAREYQ RFPHLVMLEC TETNSLGFIL AFLYNGLLSI SAFACSYLGK
760 770 780 790 800
DLPENYNEAK CVTFSLLFNF VSWIAFFTTA SVYDGKYLPA ANMMAGLSSL
810 820 830 840
SSGFGGYFLP KCYVILCRPD LNSTEHFQAS IQDYTRRCGS T
Length:841
Mass (Da):93,074
Last modified:December 15, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE800772B267D0216
GO
Isoform 2 (identifier: Q7RTX1-2) [UniParc]FASTAAdd to basket
Also known as: Gm148 form C

The sequence of this isoform differs from the canonical sequence as follows:
     167-420: Missing.

Show »
Length:587
Mass (Da):65,130
Checksum:i236CCE778949C68F
GO
Isoform 3 (identifier: Q7RTX1-3) [UniParc]FASTAAdd to basket
Also known as: Gm148 form A

The sequence of this isoform differs from the canonical sequence as follows:
     167-420: Missing.
     421-841: LLEQIHKVHF...QDYTRRCGST → LSYAASSETL...LGLLACLPGT

Show »
Length:480
Mass (Da):52,522
Checksum:i451E536935DD36D9
GO
Isoform 4 (identifier: Q7RTX1-4) [UniParc]FASTAAdd to basket
Also known as: Gm148 form D

The sequence of this isoform differs from the canonical sequence as follows:
     167-420: Missing.
     532-574: DLYRCQPCGK...HTSWVLLAAN → ATWVRTCQRT...RPASTTAXTC
     575-841: Missing.

Note: Incomplete sequence.Curated
Show »
Length:320
Mass (Da):35,134
Checksum:i9A44A1B5A61BA88C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6X0H0Y6X0_HUMAN
Taste receptor type 1 member 1
TAS1R1
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3W7H7C3W7_HUMAN
Taste receptor type 1 member 1
TAS1R1
406Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL91358 differs from that shown. Reason: Frameshift.Curated
The sequence AAL91359 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL91360 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL91361 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC05845 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti167I → L in AAL91358 (PubMed:11891061).Curated1
Sequence conflicti648C → W in AAL91360 (PubMed:11891061).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036707347K → E2 PublicationsCorresponds to variant dbSNP:rs10864628Ensembl.1
Natural variantiVAR_036708372A → T. Corresponds to variant dbSNP:rs34160967Ensembl.1
Natural variantiVAR_036709507R → Q. Corresponds to variant dbSNP:rs35118458Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012418167 – 420Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationAdd BLAST254
Alternative sequenceiVSP_012420421 – 841LLEQI…RCGST → LSYAASSETLSVKRQYPSFL RTIPNDKYQVETMVLLLQKF GWTWISLVGSSDDYGQLGVQ ALENQATGQGICIAFKDIMP FSAQVGDERMQCLMRHLAQA GATVVVVFSSRQLARVFFES VVLTNLTGKVWVASEAWALS RHITGVPGIQRIGMVLGVAI QKRAVPGLKAFEEAYARADK KAPRPCHKGSWCSSNQLCRE CQAFMAHTMPKLKAFSMSSA YNAYRAVYAVAHGLHQLLGC ASGACSRGRVYPWQTSTDAS LVGKKSGHLREARPASRALW CFWLCVSTPLGCCWQLTRCC CCCCLGLLACLPGT in isoform 3. 1 PublicationAdd BLAST421
Alternative sequenceiVSP_012421532 – 574DLYRC…LLAAN → ATWVRTCQRTTTRTNVSPSA CSSTSCPGSPSSPRPASTTA XTC in isoform 4. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_012422575 – 841Missing in isoform 4. 1 PublicationAdd BLAST267

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB065618 Genomic DNA Translation: BAC05845.1 Sequence problems.
AL591866 Genomic DNA No translation available.
BC136515 mRNA Translation: AAI36516.1
BC136516 mRNA Translation: AAI36517.1
AF387617 mRNA Translation: AAL91358.1 Sequence problems.
AF387618 mRNA Translation: AAL91359.1 Different initiation.
AF387619 mRNA Translation: AAL91360.1 Different initiation.
AF387620 mRNA Translation: AAL91361.1 Different initiation.
BK000153 mRNA Translation: DAA00012.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS81.1 [Q7RTX1-1]
CCDS82.1 [Q7RTX1-2]

NCBI Reference Sequences

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RefSeqi
NP_619642.2, NM_138697.3 [Q7RTX1-1]
NP_803884.1, NM_177540.2 [Q7RTX1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333172; ENSP00000331867; ENSG00000173662 [Q7RTX1-1]
ENST00000351136; ENSP00000312558; ENSG00000173662 [Q7RTX1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80835

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80835

UCSC genome browser

More...
UCSCi
uc001ant.4, human [Q7RTX1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

The taste experience - Issue 55 of February 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065618 Genomic DNA Translation: BAC05845.1 Sequence problems.
AL591866 Genomic DNA No translation available.
BC136515 mRNA Translation: AAI36516.1
BC136516 mRNA Translation: AAI36517.1
AF387617 mRNA Translation: AAL91358.1 Sequence problems.
AF387618 mRNA Translation: AAL91359.1 Different initiation.
AF387619 mRNA Translation: AAL91360.1 Different initiation.
AF387620 mRNA Translation: AAL91361.1 Different initiation.
BK000153 mRNA Translation: DAA00012.1
CCDSiCCDS81.1 [Q7RTX1-1]
CCDS82.1 [Q7RTX1-2]
RefSeqiNP_619642.2, NM_138697.3 [Q7RTX1-1]
NP_803884.1, NM_177540.2 [Q7RTX1-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123328, 1 interactor
STRINGi9606.ENSP00000331867

Chemistry databases

BindingDBiQ7RTX1
ChEMBLiCHEMBL3832641

Protein family/group databases

TCDBi9.A.14.7.5, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyGeniQ7RTX1, 6 sites
iPTMnetiQ7RTX1
PhosphoSitePlusiQ7RTX1

Polymorphism and mutation databases

BioMutaiTAS1R1
DMDMi57013075

Proteomic databases

PaxDbiQ7RTX1
PeptideAtlasiQ7RTX1
PRIDEiQ7RTX1
ProteomicsDBi68921 [Q7RTX1-1]
68922 [Q7RTX1-2]
68923 [Q7RTX1-3]
68924 [Q7RTX1-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27421, 233 antibodies

Genome annotation databases

EnsembliENST00000333172; ENSP00000331867; ENSG00000173662 [Q7RTX1-1]
ENST00000351136; ENSP00000312558; ENSG00000173662 [Q7RTX1-2]
GeneIDi80835
KEGGihsa:80835
UCSCiuc001ant.4, human [Q7RTX1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80835
DisGeNETi80835
EuPathDBiHostDB:ENSG00000173662.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TAS1R1
HGNCiHGNC:14448, TAS1R1
HPAiENSG00000173662, Group enriched (salivary gland, testis)
MIMi606225, gene
neXtProtiNX_Q7RTX1
OpenTargetsiENSG00000173662
PharmGKBiPA37882

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1056, Eukaryota
GeneTreeiENSGT00940000161264
HOGENOMiCLU_005389_5_1_1
InParanoidiQ7RTX1
KOiK04624
OMAiQGICIAF
OrthoDBi136715at2759
PhylomeDBiQ7RTX1
TreeFamiTF331269

Enzyme and pathway databases

PathwayCommonsiQ7RTX1
ReactomeiR-HSA-418594, G alpha (i) signalling events
R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
80835, 3 hits in 867 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TAS1R1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TAS1R1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80835
PharosiQ7RTX1, Tbio

Protein Ontology

More...
PROi
PR:Q7RTX1
RNActiQ7RTX1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173662, Expressed in left testis and 69 other tissues
ExpressionAtlasiQ7RTX1, baseline and differential
GenevisibleiQ7RTX1, HS

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR000337, GPCR_3
IPR011500, GPCR_3_9-Cys_dom
IPR038550, GPCR_3_9-Cys_sf
IPR017978, GPCR_3_C
IPR000068, GPCR_3_Ca_sens_rcpt-rel
IPR017979, GPCR_3_CS
IPR028082, Peripla_BP_I
PANTHERiPTHR24061, PTHR24061, 1 hit
PfamiView protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF07562, NCD3G, 1 hit
PRINTSiPR00592, CASENSINGR
PR00248, GPCRMGR
SUPFAMiSSF53822, SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00980, G_PROTEIN_RECEP_F3_2, 1 hit
PS00981, G_PROTEIN_RECEP_F3_3, 1 hit
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTS1R1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7RTX1
Secondary accession number(s): B2RMX0
, Q5SY22, Q5SY24, Q8NGZ7, Q8TDJ7, Q8TDJ8, Q8TDJ9, Q8TDK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 15, 2003
Last modified: August 12, 2020
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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