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Protein

Taste receptor type 1 member 1

Gene

TAS1R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.1 Publication

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • protein heterodimerization activity Source: UniProtKB
  • taste receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Protein family/group databases

TCDBi9.A.14.7.5 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 1
Alternative name(s):
G-protein coupled receptor 70
Gene namesi
Name:TAS1R1
Synonyms:GPR70, T1R1, TR1
ORF Names:GM148
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000173662.19
HGNCiHGNC:14448 TAS1R1
MIMi606225 gene
neXtProtiNX_Q7RTX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 567ExtracellularSequence analysisAdd BLAST547
Transmembranei568 – 588Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini589 – 603CytoplasmicSequence analysisAdd BLAST15
Transmembranei604 – 624Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini625 – 639ExtracellularSequence analysisAdd BLAST15
Transmembranei640 – 660Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini661 – 680CytoplasmicSequence analysisAdd BLAST20
Transmembranei681 – 701Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini702 – 725ExtracellularSequence analysisAdd BLAST24
Transmembranei726 – 746Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini747 – 761CytoplasmicSequence analysisAdd BLAST15
Transmembranei762 – 782Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini783 – 795ExtracellularSequence analysisAdd BLAST13
Transmembranei796 – 816Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini817 – 841CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80835
OpenTargetsiENSG00000173662
PharmGKBiPA37882

Chemistry databases

ChEMBLiCHEMBL3832641

Polymorphism and mutation databases

BioMutaiTAS1R1
DMDMi57013075

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001295421 – 841Taste receptor type 1 member 1Add BLAST821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi479N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi529N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7RTX1
PeptideAtlasiQ7RTX1
PRIDEiQ7RTX1
ProteomicsDBi68921
68922 [Q7RTX1-2]
68923 [Q7RTX1-3]
68924 [Q7RTX1-4]

PTM databases

iPTMnetiQ7RTX1
PhosphoSitePlusiQ7RTX1

Expressioni

Gene expression databases

BgeeiENSG00000173662 Expressed in 51 organ(s), highest expression level in left testis
ExpressionAtlasiQ7RTX1 baseline and differential
GenevisibleiQ7RTX1 HS

Organism-specific databases

HPAiHPA034579
HPA034580

Interactioni

Subunit structurei

Forms heterodimers with TAS1R3.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123328, 1 interactor
STRINGi9606.ENSP00000331867

Structurei

3D structure databases

ProteinModelPortaliQ7RTX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00760000118884
HOVERGENiHBG108601
InParanoidiQ7RTX1
KOiK04624
OMAiNQLCREC
OrthoDBiEOG091G02T4
PhylomeDBiQ7RTX1
TreeFamiTF331269

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR000068 GPCR_3_Ca_sens_rcpt-rel
IPR017979 GPCR_3_CS
IPR028082 Peripla_BP_I
PANTHERiPTHR24061 PTHR24061, 1 hit
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00592 CASENSINGR
PR00248 GPCRMGR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7RTX1-1) [UniParc]FASTAAdd to basket
Also known as: Gm148 form B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLCTARLVG LQLLISCCWA FACHSTESSP DFTLPGDYLL AGLFPLHSGC
60 70 80 90 100
LQVRHRPEVT LCDRSCSFNE HGYHLFQAMR LGVEEINNST ALLPNITLGY
110 120 130 140 150
QLYDVCSDSA NVYATLRVLS LPGQHHIELQ GDLLHYSPTV LAVIGPDSTN
160 170 180 190 200
RAATTAALLS PFLVPMISYA ASSETLSVKR QYPSFLRTIP NDKYQVETMV
210 220 230 240 250
LLLQKFGWTW ISLVGSSDDY GQLGVQALEN QATGQGICIA FKDIMPFSAQ
260 270 280 290 300
VGDERMQCLM RHLAQAGATV VVVFSSRQLA RVFFESVVLT NLTGKVWVAS
310 320 330 340 350
EAWALSRHIT GVPGIQRIGM VLGVAIQKRA VPGLKAFEEA YARADKKAPR
360 370 380 390 400
PCHKGSWCSS NQLCRECQAF MAHTMPKLKA FSMSSAYNAY RAVYAVAHGL
410 420 430 440 450
HQLLGCASGA CSRGRVYPWQ LLEQIHKVHF LLHKDTVAFN DNRDPLSSYN
460 470 480 490 500
IIAWDWNGPK WTFTVLGSST WSPVQLNINE TKIQWHGKDN QVPKSVCSSD
510 520 530 540 550
CLEGHQRVVT GFHHCCFECV PCGAGTFLNK SDLYRCQPCG KEEWAPEGSQ
560 570 580 590 600
TCFPRTVVFL ALREHTSWVL LAANTLLLLL LLGTAGLFAW HLDTPVVRSA
610 620 630 640 650
GGRLCFLMLG SLAAGSGSLY GFFGEPTRPA CLLRQALFAL GFTIFLSCLT
660 670 680 690 700
VRSFQLIIIF KFSTKVPTFY HAWVQNHGAG LFVMISSAAQ LLICLTWLVV
710 720 730 740 750
WTPLPAREYQ RFPHLVMLEC TETNSLGFIL AFLYNGLLSI SAFACSYLGK
760 770 780 790 800
DLPENYNEAK CVTFSLLFNF VSWIAFFTTA SVYDGKYLPA ANMMAGLSSL
810 820 830 840
SSGFGGYFLP KCYVILCRPD LNSTEHFQAS IQDYTRRCGS T
Length:841
Mass (Da):93,074
Last modified:December 15, 2003 - v1
Checksum:iE800772B267D0216
GO
Isoform 2 (identifier: Q7RTX1-2) [UniParc]FASTAAdd to basket
Also known as: Gm148 form C

The sequence of this isoform differs from the canonical sequence as follows:
     167-420: Missing.

Note: No experimental confirmation available.
Show »
Length:587
Mass (Da):65,130
Checksum:i236CCE778949C68F
GO
Isoform 3 (identifier: Q7RTX1-3) [UniParc]FASTAAdd to basket
Also known as: Gm148 form A

The sequence of this isoform differs from the canonical sequence as follows:
     167-420: Missing.
     421-841: LLEQIHKVHF...QDYTRRCGST → LSYAASSETL...LGLLACLPGT

Note: No experimental confirmation available.Curated
Show »
Length:480
Mass (Da):52,522
Checksum:i451E536935DD36D9
GO
Isoform 4 (identifier: Q7RTX1-4) [UniParc]FASTAAdd to basket
Also known as: Gm148 form D

The sequence of this isoform differs from the canonical sequence as follows:
     167-420: Missing.
     532-574: DLYRCQPCGK...HTSWVLLAAN → ATWVRTCQRT...RPASTTAXTC
     575-841: Missing.

Note: Incomplete sequence.
Show »
Length:320
Mass (Da):35,134
Checksum:i9A44A1B5A61BA88C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6X0H0Y6X0_HUMAN
Taste receptor type 1 member 1
TAS1R1
247Annotation score:
H7C3W7H7C3W7_HUMAN
Taste receptor type 1 member 1
TAS1R1
406Annotation score:

Sequence cautioni

Isoform 3 : The sequence AAL91358 differs from that shown. Reason: Frameshift at positions 340 and 548.Curated
The sequence AAL91359 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL91360 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL91361 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC05845 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167I → L in AAL91358 (PubMed:11891061).Curated1
Sequence conflicti550Q → R in CAI16076 (PubMed:16710414).Curated1
Sequence conflicti648C → W in AAL91360 (PubMed:11891061).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036707347K → E2 PublicationsCorresponds to variant dbSNP:rs10864628Ensembl.1
Natural variantiVAR_036708372A → T. Corresponds to variant dbSNP:rs34160967Ensembl.1
Natural variantiVAR_036709507R → Q. Corresponds to variant dbSNP:rs35118458Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012418167 – 420Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationAdd BLAST254
Alternative sequenceiVSP_012420421 – 841LLEQI…RCGST → LSYAASSETLSVKRQYPSFL RTIPNDKYQVETMVLLLQKF GWTWISLVGSSDDYGQLGVQ ALENQATGQGICIAFKDIMP FSAQVGDERMQCLMRHLAQA GATVVVVFSSRQLARVFFES VVLTNLTGKVWVASEAWALS RHITGVPGIQRIGMVLGVAI QKRAVPGLKAFEEAYARADK KAPRPCHKGSWCSSNQLCRE CQAFMAHTMPKLKAFSMSSA YNAYRAVYAVAHGLHQLLGC ASGACSRGRVYPWQTSTDAS LVGKKSGHLREARPASRALW CFWLCVSTPLGCCWQLTRCC CCCCLGLLACLPGT in isoform 3. 1 PublicationAdd BLAST421
Alternative sequenceiVSP_012421532 – 574DLYRC…LLAAN → ATWVRTCQRTTTRTNVSPSA CSSTSCPGSPSSPRPASTTA XTC in isoform 4. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_012422575 – 841Missing in isoform 4. 1 PublicationAdd BLAST267

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065618 Genomic DNA Translation: BAC05845.1 Sequence problems.
AL591866 Genomic DNA Translation: CAI16073.1
AL591866 Genomic DNA Translation: CAI16074.1
AL591866 Genomic DNA Translation: CAI16076.1
BC136515 mRNA Translation: AAI36516.1
BC136516 mRNA Translation: AAI36517.1
AF387617 mRNA Translation: AAL91358.1 Sequence problems.
AF387618 mRNA Translation: AAL91359.1 Different initiation.
AF387619 mRNA Translation: AAL91360.1 Different initiation.
AF387620 mRNA Translation: AAL91361.1 Different initiation.
BK000153 mRNA Translation: DAA00012.1
CCDSiCCDS81.1 [Q7RTX1-1]
CCDS82.1 [Q7RTX1-2]
RefSeqiNP_619642.2, NM_138697.3 [Q7RTX1-1]
NP_803884.1, NM_177540.2 [Q7RTX1-2]
UniGeneiHs.124574

Genome annotation databases

EnsembliENST00000333172; ENSP00000331867; ENSG00000173662 [Q7RTX1-1]
ENST00000351136; ENSP00000312558; ENSG00000173662 [Q7RTX1-2]
GeneIDi80835
KEGGihsa:80835
UCSCiuc001ant.4 human [Q7RTX1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

The taste experience - Issue 55 of February 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065618 Genomic DNA Translation: BAC05845.1 Sequence problems.
AL591866 Genomic DNA Translation: CAI16073.1
AL591866 Genomic DNA Translation: CAI16074.1
AL591866 Genomic DNA Translation: CAI16076.1
BC136515 mRNA Translation: AAI36516.1
BC136516 mRNA Translation: AAI36517.1
AF387617 mRNA Translation: AAL91358.1 Sequence problems.
AF387618 mRNA Translation: AAL91359.1 Different initiation.
AF387619 mRNA Translation: AAL91360.1 Different initiation.
AF387620 mRNA Translation: AAL91361.1 Different initiation.
BK000153 mRNA Translation: DAA00012.1
CCDSiCCDS81.1 [Q7RTX1-1]
CCDS82.1 [Q7RTX1-2]
RefSeqiNP_619642.2, NM_138697.3 [Q7RTX1-1]
NP_803884.1, NM_177540.2 [Q7RTX1-2]
UniGeneiHs.124574

3D structure databases

ProteinModelPortaliQ7RTX1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123328, 1 interactor
STRINGi9606.ENSP00000331867

Chemistry databases

ChEMBLiCHEMBL3832641

Protein family/group databases

TCDBi9.A.14.7.5 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiQ7RTX1
PhosphoSitePlusiQ7RTX1

Polymorphism and mutation databases

BioMutaiTAS1R1
DMDMi57013075

Proteomic databases

PaxDbiQ7RTX1
PeptideAtlasiQ7RTX1
PRIDEiQ7RTX1
ProteomicsDBi68921
68922 [Q7RTX1-2]
68923 [Q7RTX1-3]
68924 [Q7RTX1-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333172; ENSP00000331867; ENSG00000173662 [Q7RTX1-1]
ENST00000351136; ENSP00000312558; ENSG00000173662 [Q7RTX1-2]
GeneIDi80835
KEGGihsa:80835
UCSCiuc001ant.4 human [Q7RTX1-1]

Organism-specific databases

CTDi80835
DisGeNETi80835
EuPathDBiHostDB:ENSG00000173662.19
GeneCardsiTAS1R1
HGNCiHGNC:14448 TAS1R1
HPAiHPA034579
HPA034580
MIMi606225 gene
neXtProtiNX_Q7RTX1
OpenTargetsiENSG00000173662
PharmGKBiPA37882
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00760000118884
HOVERGENiHBG108601
InParanoidiQ7RTX1
KOiK04624
OMAiNQLCREC
OrthoDBiEOG091G02T4
PhylomeDBiQ7RTX1
TreeFamiTF331269

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

ChiTaRSiTAS1R1 human
GeneWikiiTAS1R1
GenomeRNAii80835
PROiPR:Q7RTX1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173662 Expressed in 51 organ(s), highest expression level in left testis
ExpressionAtlasiQ7RTX1 baseline and differential
GenevisibleiQ7RTX1 HS

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR000068 GPCR_3_Ca_sens_rcpt-rel
IPR017979 GPCR_3_CS
IPR028082 Peripla_BP_I
PANTHERiPTHR24061 PTHR24061, 1 hit
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00592 CASENSINGR
PR00248 GPCRMGR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTS1R1_HUMAN
AccessioniPrimary (citable) accession number: Q7RTX1
Secondary accession number(s): B2RMX0
, Q5SY22, Q5SY24, Q8NGZ7, Q8TDJ7, Q8TDJ8, Q8TDJ9, Q8TDK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 15, 2003
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  7. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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