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UniProtKB - Q7RTX0 (TS1R3_HUMAN)

Entry version 159 (12 Aug 2020)
Sequence version 2 (29 Mar 2005)
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Protein

Taste receptor type 1 member 3

Gene

TAS1R3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7RTX0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418594, G alpha (i) signalling events
R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Taste receptor type 1 member 3
Alternative name(s):
Sweet taste receptor T1R3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAS1R3
Synonyms:T1R3, TR3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000169962.4

Human Gene Nomenclature Database

More...HGNCi		HGNC:15661, TAS1R3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605865, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7RTX0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 570ExtracellularSequence analysisAdd BLAST550
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei571 – 591Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini592 – 603CytoplasmicSequence analysisAdd BLAST12
Transmembranei604 – 624Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini625 – 639ExtracellularSequence analysisAdd BLAST15
Transmembranei640 – 660Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini661 – 682CytoplasmicSequence analysisAdd BLAST22
Transmembranei683 – 703Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini704 – 729ExtracellularSequence analysisAdd BLAST26
Transmembranei730 – 750Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini751 – 762CytoplasmicSequence analysisAdd BLAST12
Transmembranei763 – 783Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini784 – 789ExtracellularSequence analysis6
Transmembranei790 – 810Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini811 – 852CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi537A → G: Retains partial activity toward brazzein; however response to other sweeteners tested is suppressed. 1 Publication1
Mutagenesisi537A → P: Receptor unresponsive to all sweeteners tested. 1 Publication1
Mutagenesisi537A → T, S, E or V: Abolished the response to brazzein. 1 Publication1
Mutagenesisi540F → A or H: Reduces the response to brazzein and monellin. 1 Publication1
Mutagenesisi540F → L: Reduces the response to monellin. 1 Publication1
Mutagenesisi540F → Y or P: Reduces the response to brazzein; P-540 also enhances responses to the small molecule sweeteners. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		83756

Open Targets

More...OpenTargetsi		ENSG00000169962

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38012

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7RTX0, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1613742

Drug and drug target database

More...DrugBanki		DB00168, Aspartame

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TAS1R3

Domain mapping of disease mutations (DMDM)

More...DMDMi		62299063

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001296121 – 852Taste receptor type 1 member 3Add BLAST832

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi380N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi432N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi475N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7RTX0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7RTX0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7RTX0

PeptideAtlas

More...PeptideAtlasi		Q7RTX0

PRoteomics IDEntifications database

More...PRIDEi		Q7RTX0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68920

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q7RTX0, 9 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000169962, Expressed in saliva-secreting gland and 100 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000169962, Group enriched (epididymis, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers or heterodimers with TAS1R1 and TAS1R2.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123757, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000344411

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q7RTX0

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7RTX0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni536 – 545Required for brazzein responsiveness10

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1056, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160679

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005389_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7RTX0

KEGG Orthology (KO)

More...KOi		K04626

Identification of Orthologs from Complete Genome Data

More...OMAi		MEYDLKL

Database of Orthologous Groups

More...OrthoDBi		342693at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7RTX0

TreeFam database of animal gene trees

More...TreeFami		TF331269

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.50.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR000337, GPCR_3
IPR011500, GPCR_3_9-Cys_dom
IPR038550, GPCR_3_9-Cys_sf
IPR017978, GPCR_3_C
IPR000068, GPCR_3_Ca_sens_rcpt-rel
IPR017979, GPCR_3_CS
IPR028082, Peripla_BP_I

The PANTHER Classification System

More...PANTHERi		PTHR24061, PTHR24061, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF07562, NCD3G, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00248, GPCRMGR

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53822, SSF53822, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00980, G_PROTEIN_RECEP_F3_2, 1 hit
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q7RTX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGPAVLGLS LWALLHPGTG APLCLSQQLR MKGDYVLGGL FPLGEAEEAG 
        60         70         80         90        100
LRSRTRPSSP VCTRFSSNGL LWALAMKMAV EEINNKSDLL PGLRLGYDLF 
       110        120        130        140        150
DTCSEPVVAM KPSLMFLAKA GSRDIAAYCN YTQYQPRVLA VIGPHSSELA 
       160        170        180        190        200
MVTGKFFSFF LMPQVSYGAS MELLSARETF PSFFRTVPSD RVQLTAAAEL 
       210        220        230        240        250
LQEFGWNWVA ALGSDDEYGR QGLSIFSALA AARGICIAHE GLVPLPRADD 
       260        270        280        290        300
SRLGKVQDVL HQVNQSSVQV VLLFASVHAA HALFNYSISS RLSPKVWVAS 
       310        320        330        340        350
EAWLTSDLVM GLPGMAQMGT VLGFLQRGAQ LHEFPQYVKT HLALATDPAF 
       360        370        380        390        400
CSALGEREQG LEEDVVGQRC PQCDCITLQN VSAGLNHHQT FSVYAAVYSV 
       410        420        430        440        450
AQALHNTLQC NASGCPAQDP VKPWQLLENM YNLTFHVGGL PLRFDSSGNV 
       460        470        480        490        500
DMEYDLKLWV WQGSVPRLHD VGRFNGSLRT ERLKIRWHTS DNQKPVSRCS 
       510        520        530        540        550
RQCQEGQVRR VKGFHSCCYD CVDCEAGSYR QNPDDIACTF CGQDEWSPER 
       560        570        580        590        600
STRCFRRRSR FLAWGEPAVL LLLLLLSLAL GLVLAALGLF VHHRDSPLVQ 
       610        620        630        640        650
ASGGPLACFG LVCLGLVCLS VLLFPGQPSP ARCLAQQPLS HLPLTGCLST 
       660        670        680        690        700
LFLQAAEIFV ESELPLSWAD RLSGCLRGPW AWLVVLLAML VEVALCTWYL 
       710        720        730        740        750
VAFPPEVVTD WHMLPTEALV HCRTRSWVSF GLAHATNATL AFLCFLGTFL 
       760        770        780        790        800
VRSQPGCYNR ARGLTFAMLA YFITWVSFVP LLANVQVVLR PAVQMGALLL 
       810        820        830        840        850
CVLGILAAFH LPRCYLLMRQ PGLNTPEFFL GGGPGDAQGQ NDGNTGNQGK 

HE
Length:852
Mass (Da):93,386
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9690DEC23E75EB3E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti852E → EAPILHPARHHSSGRPGGGT QAYAQGRARRGRGGTQLPTL PFAQWVDSIMTVTSTRDRAQ DLTPARRQAHTGSPVRVPGS APSRA in BAC05873 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020788757C → R. Corresponds to variant dbSNP:rs307377Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB065647 Genomic DNA Translation: BAC05873.1
AL139287 Genomic DNA No translation available.
BK000152 mRNA Translation: DAA00013.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30556.1

NCBI Reference Sequences

More...RefSeqi		NP_689414.1, NM_152228.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339381; ENSP00000344411; ENSG00000169962

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83756

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:83756

UCSC genome browser

More...UCSCi		uc010nyk.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

The taste experience - Issue 55 of February 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065647 Genomic DNA Translation: BAC05873.1
AL139287 Genomic DNA No translation available.
BK000152 mRNA Translation: DAA00013.1
CCDSiCCDS30556.1
RefSeqiNP_689414.1, NM_152228.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123757, 5 interactors
STRINGi9606.ENSP00000344411

Chemistry databases

BindingDBiQ7RTX0
ChEMBLiCHEMBL1613742
DrugBankiDB00168, Aspartame

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ7RTX0, 9 sites

Polymorphism and mutation databases

BioMutaiTAS1R3
DMDMi62299063

Proteomic databases

jPOSTiQ7RTX0
MassIVEiQ7RTX0
PaxDbiQ7RTX0
PeptideAtlasiQ7RTX0
PRIDEiQ7RTX0
ProteomicsDBi68920

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26289, 315 antibodies

The DNASU plasmid repository

More...DNASUi		83756

Genome annotation databases

EnsembliENST00000339381; ENSP00000344411; ENSG00000169962
GeneIDi83756
KEGGihsa:83756
UCSCiuc010nyk.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83756
DisGeNETi83756
EuPathDBiHostDB:ENSG00000169962.4

GeneCards: human genes, protein and diseases

More...GeneCardsi		TAS1R3
HGNCiHGNC:15661, TAS1R3
HPAiENSG00000169962, Group enriched (epididymis, salivary gland)
MIMi605865, gene
neXtProtiNX_Q7RTX0
OpenTargetsiENSG00000169962
PharmGKBiPA38012

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1056, Eukaryota
GeneTreeiENSGT00940000160679
HOGENOMiCLU_005389_1_0_1
InParanoidiQ7RTX0
KOiK04626
OMAiMEYDLKL
OrthoDBi342693at2759
PhylomeDBiQ7RTX0
TreeFamiTF331269

Enzyme and pathway databases

PathwayCommonsiQ7RTX0
ReactomeiR-HSA-418594, G alpha (i) signalling events
R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		83756, 8 hits in 865 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TAS1R3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		83756
PharosiQ7RTX0, Tbio

Protein Ontology

More...PROi		PR:Q7RTX0
RNActiQ7RTX0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000169962, Expressed in saliva-secreting gland and 100 other tissues

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR000337, GPCR_3
IPR011500, GPCR_3_9-Cys_dom
IPR038550, GPCR_3_9-Cys_sf
IPR017978, GPCR_3_C
IPR000068, GPCR_3_Ca_sens_rcpt-rel
IPR017979, GPCR_3_CS
IPR028082, Peripla_BP_I
PANTHERiPTHR24061, PTHR24061, 1 hit
PfamiView protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF07562, NCD3G, 1 hit
PRINTSiPR00248, GPCRMGR
SUPFAMiSSF53822, SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00980, G_PROTEIN_RECEP_F3_2, 1 hit
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTS1R3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7RTX0
Secondary accession number(s): Q5TA49, Q8NGW9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 29, 2005
Last modified: August 12, 2020
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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