UniProtKB - Q7RTX0 (TS1R3_HUMAN)
Protein
Taste receptor type 1 member 3
Gene
TAS1R3
Organism
Homo sapiens (Human)
Status
Functioni
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.By similarity2 Publications
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- signaling receptor activity Source: GO_Central
- taste receptor activity Source: UniProtKB
GO - Biological processi
- detection of chemical stimulus involved in sensory perception of sweet taste Source: HGNC-UCL
- G protein-coupled receptor signaling pathway Source: Reactome
- sensory perception of sweet taste Source: UniProtKB
- sensory perception of umami taste Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Sensory transduction, Taste |
Enzyme and pathway databases
PathwayCommonsi | Q7RTX0 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Names & Taxonomyi
Protein namesi | Recommended name: Taste receptor type 1 member 3Alternative name(s): Sweet taste receptor T1R3 |
Gene namesi | Name:TAS1R3 Synonyms:T1R3, TR3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000169962.4 |
HGNCi | HGNC:15661, TAS1R3 |
MIMi | 605865, gene |
neXtProti | NX_Q7RTX0 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB
- sweet taste receptor complex Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 570 | ExtracellularSequence analysisAdd BLAST | 550 | |
Transmembranei | 571 – 591 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 592 – 603 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 604 – 624 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 625 – 639 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 640 – 660 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 661 – 682 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 683 – 703 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 704 – 729 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 730 – 750 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 751 – 762 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 763 – 783 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 784 – 789 | ExtracellularSequence analysis | 6 | |
Transmembranei | 790 – 810 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 811 – 852 | CytoplasmicSequence analysisAdd BLAST | 42 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 537 | A → G: Retains partial activity toward brazzein; however response to other sweeteners tested is suppressed. 1 Publication | 1 | |
Mutagenesisi | 537 | A → P: Receptor unresponsive to all sweeteners tested. 1 Publication | 1 | |
Mutagenesisi | 537 | A → T, S, E or V: Abolished the response to brazzein. 1 Publication | 1 | |
Mutagenesisi | 540 | F → A or H: Reduces the response to brazzein and monellin. 1 Publication | 1 | |
Mutagenesisi | 540 | F → L: Reduces the response to monellin. 1 Publication | 1 | |
Mutagenesisi | 540 | F → Y or P: Reduces the response to brazzein; P-540 also enhances responses to the small molecule sweeteners. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 83756 |
OpenTargetsi | ENSG00000169962 |
PharmGKBi | PA38012 |
Miscellaneous databases
Pharosi | Q7RTX0, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1613742 |
DrugBanki | DB00168, Aspartame |
Polymorphism and mutation databases
BioMutai | TAS1R3 |
DMDMi | 62299063 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000012961 | 21 – 852 | Taste receptor type 1 member 3Add BLAST | 832 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 85 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 130 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 264 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 285 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 380 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 411 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 432 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 475 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q7RTX0 |
MassIVEi | Q7RTX0 |
PaxDbi | Q7RTX0 |
PeptideAtlasi | Q7RTX0 |
PRIDEi | Q7RTX0 |
ProteomicsDBi | 68920 |
PTM databases
GlyGeni | Q7RTX0, 9 sites |
Expressioni
Gene expression databases
Bgeei | ENSG00000169962, Expressed in saliva-secreting gland and 100 other tissues |
Organism-specific databases
HPAi | ENSG00000169962, Group enriched (epididymis, salivary gland) |
Interactioni
Subunit structurei
Forms homodimers or heterodimers with TAS1R1 and TAS1R2.
Protein-protein interaction databases
BioGRIDi | 123757, 5 interactors |
STRINGi | 9606.ENSP00000344411 |
Chemistry databases
BindingDBi | Q7RTX0 |
Miscellaneous databases
RNActi | Q7RTX0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 536 – 545 | Required for brazzein responsiveness | 10 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT00940000160679 |
HOGENOMi | CLU_005389_1_0_1 |
InParanoidi | Q7RTX0 |
OMAi | MEYDLKL |
OrthoDBi | 342693at2759 |
PhylomeDBi | Q7RTX0 |
TreeFami | TF331269 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR000068, GPCR_3_Ca_sens_rcpt-rel IPR017979, GPCR_3_CS IPR028082, Peripla_BP_I |
PANTHERi | PTHR24061, PTHR24061, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q7RTX0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGPAVLGLS LWALLHPGTG APLCLSQQLR MKGDYVLGGL FPLGEAEEAG
60 70 80 90 100
LRSRTRPSSP VCTRFSSNGL LWALAMKMAV EEINNKSDLL PGLRLGYDLF
110 120 130 140 150
DTCSEPVVAM KPSLMFLAKA GSRDIAAYCN YTQYQPRVLA VIGPHSSELA
160 170 180 190 200
MVTGKFFSFF LMPQVSYGAS MELLSARETF PSFFRTVPSD RVQLTAAAEL
210 220 230 240 250
LQEFGWNWVA ALGSDDEYGR QGLSIFSALA AARGICIAHE GLVPLPRADD
260 270 280 290 300
SRLGKVQDVL HQVNQSSVQV VLLFASVHAA HALFNYSISS RLSPKVWVAS
310 320 330 340 350
EAWLTSDLVM GLPGMAQMGT VLGFLQRGAQ LHEFPQYVKT HLALATDPAF
360 370 380 390 400
CSALGEREQG LEEDVVGQRC PQCDCITLQN VSAGLNHHQT FSVYAAVYSV
410 420 430 440 450
AQALHNTLQC NASGCPAQDP VKPWQLLENM YNLTFHVGGL PLRFDSSGNV
460 470 480 490 500
DMEYDLKLWV WQGSVPRLHD VGRFNGSLRT ERLKIRWHTS DNQKPVSRCS
510 520 530 540 550
RQCQEGQVRR VKGFHSCCYD CVDCEAGSYR QNPDDIACTF CGQDEWSPER
560 570 580 590 600
STRCFRRRSR FLAWGEPAVL LLLLLLSLAL GLVLAALGLF VHHRDSPLVQ
610 620 630 640 650
ASGGPLACFG LVCLGLVCLS VLLFPGQPSP ARCLAQQPLS HLPLTGCLST
660 670 680 690 700
LFLQAAEIFV ESELPLSWAD RLSGCLRGPW AWLVVLLAML VEVALCTWYL
710 720 730 740 750
VAFPPEVVTD WHMLPTEALV HCRTRSWVSF GLAHATNATL AFLCFLGTFL
760 770 780 790 800
VRSQPGCYNR ARGLTFAMLA YFITWVSFVP LLANVQVVLR PAVQMGALLL
810 820 830 840 850
CVLGILAAFH LPRCYLLMRQ PGLNTPEFFL GGGPGDAQGQ NDGNTGNQGK
HE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 852 | E → EAPILHPARHHSSGRPGGGT QAYAQGRARRGRGGTQLPTL PFAQWVDSIMTVTSTRDRAQ DLTPARRQAHTGSPVRVPGS APSRA in BAC05873 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020788 | 757 | C → R. Corresponds to variant dbSNP:rs307377Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065647 Genomic DNA Translation: BAC05873.1 AL139287 Genomic DNA No translation available. BK000152 mRNA Translation: DAA00013.1 |
CCDSi | CCDS30556.1 |
RefSeqi | NP_689414.1, NM_152228.2 |
Genome annotation databases
Ensembli | ENST00000339381; ENSP00000344411; ENSG00000169962 |
GeneIDi | 83756 |
KEGGi | hsa:83756 |
UCSCi | uc010nyk.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight The taste experience - Issue 55 of February 2005 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065647 Genomic DNA Translation: BAC05873.1 AL139287 Genomic DNA No translation available. BK000152 mRNA Translation: DAA00013.1 |
CCDSi | CCDS30556.1 |
RefSeqi | NP_689414.1, NM_152228.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123757, 5 interactors |
STRINGi | 9606.ENSP00000344411 |
Chemistry databases
BindingDBi | Q7RTX0 |
ChEMBLi | CHEMBL1613742 |
DrugBanki | DB00168, Aspartame |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q7RTX0, 9 sites |
Polymorphism and mutation databases
BioMutai | TAS1R3 |
DMDMi | 62299063 |
Proteomic databases
jPOSTi | Q7RTX0 |
MassIVEi | Q7RTX0 |
PaxDbi | Q7RTX0 |
PeptideAtlasi | Q7RTX0 |
PRIDEi | Q7RTX0 |
ProteomicsDBi | 68920 |
Protocols and materials databases
Antibodypediai | 26289, 318 antibodies |
DNASUi | 83756 |
Genome annotation databases
Ensembli | ENST00000339381; ENSP00000344411; ENSG00000169962 |
GeneIDi | 83756 |
KEGGi | hsa:83756 |
UCSCi | uc010nyk.3, human |
Organism-specific databases
CTDi | 83756 |
DisGeNETi | 83756 |
EuPathDBi | HostDB:ENSG00000169962.4 |
GeneCardsi | TAS1R3 |
HGNCi | HGNC:15661, TAS1R3 |
HPAi | ENSG00000169962, Group enriched (epididymis, salivary gland) |
MIMi | 605865, gene |
neXtProti | NX_Q7RTX0 |
OpenTargetsi | ENSG00000169962 |
PharmGKBi | PA38012 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT00940000160679 |
HOGENOMi | CLU_005389_1_0_1 |
InParanoidi | Q7RTX0 |
OMAi | MEYDLKL |
OrthoDBi | 342693at2759 |
PhylomeDBi | Q7RTX0 |
TreeFami | TF331269 |
Enzyme and pathway databases
PathwayCommonsi | Q7RTX0 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Miscellaneous databases
BioGRID-ORCSi | 83756, 8 hits in 839 CRISPR screens |
GeneWikii | TAS1R3 |
GenomeRNAii | 83756 |
Pharosi | Q7RTX0, Tbio |
PROi | PR:Q7RTX0 |
RNActi | Q7RTX0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169962, Expressed in saliva-secreting gland and 100 other tissues |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR000068, GPCR_3_Ca_sens_rcpt-rel IPR017979, GPCR_3_CS IPR028082, Peripla_BP_I |
PANTHERi | PTHR24061, PTHR24061, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TS1R3_HUMAN | |
Accessioni | Q7RTX0Primary (citable) accession number: Q7RTX0 Secondary accession number(s): Q5TA49, Q8NGW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | March 29, 2005 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries