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Entry version 139 (31 Jul 2019)
Sequence version 1 (15 Dec 2003)
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Protein

Otoancorin

Gene

OTOA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as an adhesion molecule.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHearing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Otoancorin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OTOA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:16378 OTOA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607038 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7RTW8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal recessive, 22 (DFNB22)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIM

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
146183

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
OTOA

MalaCards human disease database

More...
MalaCardsi
OTOA
MIMi607039 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000155719

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38403

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OTOA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56404568

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002197123 – 1130OtoancorinAdd BLAST1108
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000219721131 – 1153Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) (complex) asparagine1 Publication1
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi544N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi812N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi911N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi974N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1130GPI-anchor amidated alanineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7RTW8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7RTW8

PeptideAtlas

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PeptideAtlasi
Q7RTW8

PRoteomics IDEntifications database

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PRIDEi
Q7RTW8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
20029
68916 [Q7RTW8-1]
68917 [Q7RTW8-2]
68918 [Q7RTW8-3]
68919 [Q7RTW8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7RTW8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7RTW8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000155719 Expressed in 47 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7RTW8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7RTW8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041405

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373610

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the stereocilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIZ7 Eukaryota
ENOG4110T9H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182957

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065777

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7RTW8

Identification of Orthologs from Complete Genome Data

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OMAi
YQVNCLA

Database of Orthologous Groups

More...
OrthoDBi
86428at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7RTW8

TreeFam database of animal gene trees

More...
TreeFami
TF336607

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026663 Otoancorin
IPR026664 Stereocilin-rel

The PANTHER Classification System

More...
PANTHERi
PTHR23412 PTHR23412, 1 hit
PTHR23412:SF18 PTHR23412:SF18, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7RTW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQEPTTYSL FLFLFLSHGV SSYTVPNSRQ DLHPLLQNMA EEIIDGSYLN
60 70 80 90 100
ALLDLIQFQS SHVWTDDLSH RVLAYLNSRN VAFTIPSLQA AVENHLEQRL
110 120 130 140 150
HQPQKLLEDL RKTDAQQFRT AMKCLLEDKK DGLDLKDIII DLGEIRERAL
160 170 180 190 200
QSPGVNRSLF LITLERCFQM LNSLECVEIL GKVLRGSSGS FLQPDITERL
210 220 230 240 250
PRDLREDAFK NLSAVFKDLY DKTSAHSQRA LYSWMTGILQ TSSNATDDSA
260 270 280 290 300
SWVSAEHLWV LGRYMVHLSF EEITKISPIE IGLFISYDNA TKQLDMVYDI
310 320 330 340 350
TPELAQAFLE RISSSNFNMR NTSTIHRQAH ELWALEPFPK MLGLLVCFYN
360 370 380 390 400
DLELLDATVA QVLLYQMIKC SHLRGFQAGV QKLKAELLDI AMENQTLNET
410 420 430 440 450
LGSLSDAVVG LTYSQLESLS PEAVHGAIST LNQVSGWAKS QVIILSAKYL
460 470 480 490 500
AHEKVLSFYN VSQMGALLAG VSTQAFCSMK RKDISQVLRS AVSQYVSDLS
510 520 530 540 550
PAQQQGILSK MVQAEDTAPG IVEIQGAFFK EVSLFDLRRQ PGFNSTVLKD
560 570 580 590 600
KELGRSQALF LYELLLKTTR RPEELLSAGQ LVKGVTCSHI DAMSTDFFLA
610 620 630 640 650
HFQDFQNNFA LLSPYQVNCL AWKYWEVSRL SMPPFLLAAL PARYLASVPA
660 670 680 690 700
SQCVPFLISL GKSWLDSLVL DSHKKTSVLR KVQQCLDDSI ADEYTVDIMG
710 720 730 740 750
NLLCHLPAAI IDRGISPRAW ATALHGLRDC PDLNPEQKAA VRLKLLGQYG
760 770 780 790 800
LPQHWTAETT KDLGPFLVLF SGDELSSIAT KFPEILLQAA SKMARTLPTK
810 820 830 840 850
EFLWAVFQSV RNSSDKIPSY DPMPGCHGVV APSSDDIFKL AEANACWALE
860 870 880 890 900
DLRCMEEDTF IRTVELLGAV QGFSRPQLMT LKEKAIQVWD MPSYWREHHI
910 920 930 940 950
VSLGRIALAL NESELEQLDL SSIDTVASLS WQTEWTPGQA ESILQGYLDD
960 970 980 990 1000
SGYSIQDLKS FHLVGLGATL CAINITEIPL IKISEFRVVV ARIGTLLCST
1010 1020 1030 1040 1050
HVLAEFKRKA EVVFGDPTEW TSSVLQELGT IAAGLTKAEL RMLDKDLMPY
1060 1070 1080 1090 1100
FQPSAIKCLP DEIFKELSAE QIASLGPENA AAVTHAQRRR LSPLQLQSLQ
1110 1120 1130 1140 1150
QALDGAKTHS WQDAPASAGP TRTSSSRSPA GALQSWGLWL GCPLLVLMAK

LLW
Length:1,153
Mass (Da):128,533
Last modified:December 15, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD23E5767718021D7
GO
Isoform 2 (identifier: Q7RTW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-338: Missing.
     339-341: PKM → MFR

Show »
Length:815
Mass (Da):89,914
Checksum:iA8EFF6FA5850C894
GO
Isoform 3 (identifier: Q7RTW8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-728: Missing.
     729-750: DCPDLNPEQKAAVRLKLLGQYG → MNVCKDSPRNKVNQKSKVMEKK

Show »
Length:425
Mass (Da):46,980
Checksum:iA17635E55BA47451
GO
Isoform 4 (identifier: Q7RTW8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MSQEPTTYS → MGNSITYRD
     10-88: Missing.
     328-341: Missing.

Note: No experimental confirmation available.
Show »
Length:1,060
Mass (Da):117,880
Checksum:i816E440E9023D5D9
GO
Isoform 5 (identifier: Q7RTW8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-341: Missing.

Note: No experimental confirmation available.
Show »
Length:1,139
Mass (Da):126,854
Checksum:i3B8E705089670E8C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YG28A0A2R8YG28_HUMAN
Otoancorin
OTOA
353Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK057335 differs from that shown. Reason: Frameshift at position 1139.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1039E → A in AAI29994 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0122111 – 728Missing in isoform 3. 1 PublicationAdd BLAST728
Alternative sequenceiVSP_0122121 – 338Missing in isoform 2. 1 PublicationAdd BLAST338
Alternative sequenceiVSP_0433451 – 9MSQEPTTYS → MGNSITYRD in isoform 4. 1 Publication9
Alternative sequenceiVSP_04334610 – 88Missing in isoform 4. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_043347328 – 341Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_012213339 – 341PKM → MFR in isoform 2. 1 Publication3
Alternative sequenceiVSP_012214729 – 750DCPDL…LGQYG → MNVCKDSPRNKVNQKSKVME KK in isoform 3. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057335 mRNA No translation available.
AK093062 mRNA Translation: BAC04040.1
AK125840 mRNA Translation: BAG54255.1
AC092719 Genomic DNA No translation available.
BC129992 mRNA Translation: AAI29993.1
BC129993 mRNA Translation: AAI29994.1
BK000099 Genomic DNA Translation: DAA00022.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10600.2 [Q7RTW8-5]
CCDS32403.1 [Q7RTW8-2]
CCDS53994.1 [Q7RTW8-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001155155.1, NM_001161683.1 [Q7RTW8-4]
NP_733764.1, NM_170664.2 [Q7RTW8-2]
XP_011544049.1, XM_011545747.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000286149; ENSP00000286149; ENSG00000155719 [Q7RTW8-1]
ENST00000388956; ENSP00000373608; ENSG00000155719 [Q7RTW8-4]
ENST00000388957; ENSP00000373609; ENSG00000155719 [Q7RTW8-2]
ENST00000388958; ENSP00000373610; ENSG00000155719 [Q7RTW8-5]
ENST00000646100; ENSP00000496564; ENSG00000155719 [Q7RTW8-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
146183

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:146183

UCSC genome browser

More...
UCSCi
uc002djh.3 human [Q7RTW8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057335 mRNA No translation available.
AK093062 mRNA Translation: BAC04040.1
AK125840 mRNA Translation: BAG54255.1
AC092719 Genomic DNA No translation available.
BC129992 mRNA Translation: AAI29993.1
BC129993 mRNA Translation: AAI29994.1
BK000099 Genomic DNA Translation: DAA00022.1
CCDSiCCDS10600.2 [Q7RTW8-5]
CCDS32403.1 [Q7RTW8-2]
CCDS53994.1 [Q7RTW8-4]
RefSeqiNP_001155155.1, NM_001161683.1 [Q7RTW8-4]
NP_733764.1, NM_170664.2 [Q7RTW8-2]
XP_011544049.1, XM_011545747.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000373610

PTM databases

iPTMnetiQ7RTW8
PhosphoSitePlusiQ7RTW8

Polymorphism and mutation databases

BioMutaiOTOA
DMDMi56404568

Proteomic databases

jPOSTiQ7RTW8
PaxDbiQ7RTW8
PeptideAtlasiQ7RTW8
PRIDEiQ7RTW8
ProteomicsDBi20029
68916 [Q7RTW8-1]
68917 [Q7RTW8-2]
68918 [Q7RTW8-3]
68919 [Q7RTW8-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286149; ENSP00000286149; ENSG00000155719 [Q7RTW8-1]
ENST00000388956; ENSP00000373608; ENSG00000155719 [Q7RTW8-4]
ENST00000388957; ENSP00000373609; ENSG00000155719 [Q7RTW8-2]
ENST00000388958; ENSP00000373610; ENSG00000155719 [Q7RTW8-5]
ENST00000646100; ENSP00000496564; ENSG00000155719 [Q7RTW8-5]
GeneIDi146183
KEGGihsa:146183
UCSCiuc002djh.3 human [Q7RTW8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
146183
DisGeNETi146183

GeneCards: human genes, protein and diseases

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GeneCardsi
OTOA
GeneReviewsiOTOA
HGNCiHGNC:16378 OTOA
HPAiHPA041405
MalaCardsiOTOA
MIMi607038 gene
607039 phenotype
neXtProtiNX_Q7RTW8
OpenTargetsiENSG00000155719
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA38403

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIZ7 Eukaryota
ENOG4110T9H LUCA
GeneTreeiENSGT00950000182957
HOGENOMiHOG000065777
InParanoidiQ7RTW8
OMAiYQVNCLA
OrthoDBi86428at2759
PhylomeDBiQ7RTW8
TreeFamiTF336607

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
OTOA human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
146183

Protein Ontology

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PROi
PR:Q7RTW8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000155719 Expressed in 47 organ(s), highest expression level in right testis
ExpressionAtlasiQ7RTW8 baseline and differential
GenevisibleiQ7RTW8 HS

Family and domain databases

InterProiView protein in InterPro
IPR026663 Otoancorin
IPR026664 Stereocilin-rel
PANTHERiPTHR23412 PTHR23412, 1 hit
PTHR23412:SF18 PTHR23412:SF18, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOTOAN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7RTW8
Secondary accession number(s): A1L3A8
, A2VDI0, B3KWU3, E9PF51, Q8NA86, Q96M76
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 15, 2003
Last modified: July 31, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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