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Entry version 135 (07 Apr 2021)
Sequence version 1 (15 Dec 2003)
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Protein

Stereocilin

Gene

STRC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential to the formation of horizontal top connectors between outer hair cell stereocilia.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHearing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7RTU9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stereocilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STRC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16035, STRC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606440, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7RTU9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000242866.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal recessive, 16 (DFNB16)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIM
Deafness-infertility syndrome (DIS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionCharacterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes.
Related information in OMIM

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
161497

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
STRC

MalaCards human disease database

More...
MalaCardsi
STRC
MIMi603720, phenotype
611102, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000242866

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB
94064, Deafness-infertility syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38082

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7RTU9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STRC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47606114

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002242623 – 1775StereocilinAdd BLAST1753

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi565N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi656N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi824N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi916N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi964N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1274N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7RTU9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7RTU9

PeptideAtlas

More...
PeptideAtlasi
Q7RTU9

PRoteomics IDEntifications database

More...
PRIDEi
Q7RTU9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68910

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q7RTU9, 14 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7RTU9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7RTU9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000242866, Expressed in right hemisphere of cerebellum and 131 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7RTU9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7RTU9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000242866, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127793, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000401513

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7RTU9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7RTU9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the stereocilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTHC, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182957

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001286_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7RTU9

Identification of Orthologs from Complete Genome Data

More...
OMAi
FSIYLLC

Database of Orthologous Groups

More...
OrthoDBi
86428at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7RTU9

TreeFam database of animal gene trees

More...
TreeFami
TF330914

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026061, Stereocilin
IPR026664, Stereocilin-rel

The PANTHER Classification System

More...
PANTHERi
PTHR23412, PTHR23412, 1 hit
PTHR23412:SF14, PTHR23412:SF14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q7RTU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSLWPLLL LLLLLLLLSF AVTLAPTGPH SLDPGLSFLK SLLSTLDQAP
60 70 80 90 100
QGSLSRSRFF TFLANISSSF EPGRMGEGPV GEPPPLQPPA LRLHDFLVTL
110 120 130 140 150
RGSPDWEPML GLLGDMLALL GQEQTPRDFL VHQAGVLGGL VEVLLGALVP
160 170 180 190 200
GGPPTPTRPP CTRDGPSDCV LAADWLPSLL LLLEGTRWQA LVQVQPSVDP
210 220 230 240 250
TNATGLDGRE AAPHFLQGLL GLLTPTGELG SKEALWGGLL RTVGAPLYAA
260 270 280 290 300
FQEGLLRVTH SLQDEVFSIL GQPEPDTNGQ CQGGNLQQLL LWGVRHNLSW
310 320 330 340 350
DVQALGFLSG SPPPPPALLH CLSTGVPLPR ASQPSAHISP RQRRAITVEA
360 370 380 390 400
LCENHLGPAP PYSISNFSIH LLCQHTKPAT PQPHPSTTAI CQTAVWYAVS
410 420 430 440 450
WAPGAQGWLQ ACHDQFPDEF LDAICSNLSF SALSGSNRRL VKRLCAGLLP
460 470 480 490 500
PPTSCPEGLP PVPLTPDIFW GCFLENETLW AERLCGEASL QAVPPSNQAW
510 520 530 540 550
VQHVCQGPTP DVTASPPCHI GPCGERCPDG GSFLVMVCAN DTMYEVLVPF
560 570 580 590 600
WPWLAGQCRI SRGGNDTCFL EGLLGPLLPS LPPLGPSPLC LTPGPFLLGM
610 620 630 640 650
LSQLPRCQSS VPALAHPTRL HYLLRLLTFL LGPGAGGAEA QGMLGRALLL
660 670 680 690 700
SSLPDNCSFW DAFRPEGRRS VLRTIGEYLE QDEEQPTPSG FEPTVNPSSG
710 720 730 740 750
ISKMELLACF SPVLWDLLQR EKSVWALQIL VQAYLHMPPE NLQQLVLSAE
760 770 780 790 800
REAAQGFLTL MLQGKLQGKL QVPPSEEQAL GRLTALLLQR YPRLTSQLFI
810 820 830 840 850
DLSPLIPFLA VSDLMRFPPS LLANDSVLAA IRDYSPGMRP EQKEALAKRL
860 870 880 890 900
LAPELFGEVP AWPQELLWAV LPLLPHLPLE NFLQLSPHQI QALEDSWPAA
910 920 930 940 950
GLGPGHARHV LRSLVNQSVQ DGEEQVRRLG PLACFLSPEE LQSLVPLSDP
960 970 980 990 1000
TGPVERGLLE CAANGTLSPE GRVAYELLGV LRSSGGAVLS PRELRVWAPL
1010 1020 1030 1040 1050
FSQLGLRFLQ ELSEPQLRAM LPVLQGTSVT PAQAVLLLGR LLPRHDLSLE
1060 1070 1080 1090 1100
ELCSLHLLLP GLSPQTLQAI PRRVLVGACS CLAPELSRLS ACQTAALLQT
1110 1120 1130 1140 1150
FRVKDGVKNM GTTGAGPAVC IPGQPIPTTW PDCLLPLLPL KLLQLDSLAL
1160 1170 1180 1190 1200
LANRRRYWEL PWSEQQAQFL WKKMQVPTNL TLRNLQALGT LAGGMSCEFL
1210 1220 1230 1240 1250
QQINSMVDFL EVVHMIYQLP TRVRGSLRAC IWAELQRRMA MPEPEWTTVG
1260 1270 1280 1290 1300
PELNGLDSKL LLDLPIQLMD RLSNESIMLV VELVQRAPEQ LLALTPLHQA
1310 1320 1330 1340 1350
ALAERALQNL APKETPVSGE VLETLGPLVG FLGTESTRQI PLQILLSHLS
1360 1370 1380 1390 1400
QLQGFCLGET FATELGWLLL QESVLGKPEL WSQDEVEQAG RLVFTLSTEA
1410 1420 1430 1440 1450
ISLIPREALG PETLERLLEK QQSWEQSRVG QLCREPQLAA KKAALVAGVV
1460 1470 1480 1490 1500
RPAAEDLPEP VPNCADVRGT FPAAWSATQI AEMELSDFED CLTLFAGDPG
1510 1520 1530 1540 1550
LGPEELRAAM GKAKQLWGPP RGFRPEQILQ LGRLLIGLGD RELQELILVD
1560 1570 1580 1590 1600
WGVLSTLGQI DGWSTTQLRI VVSSFLRQSG RHVSHLDFVH LTALGYTLCG
1610 1620 1630 1640 1650
LRPEELQHIS SWEFSQAALF LGTLHLQCSE EQLEVLAHLL VLPGGFGPIS
1660 1670 1680 1690 1700
NWGPEIFTEI GTIAAGIPDL ALSALLRGQI QGVTPLAISV IPPPKFAVVF
1710 1720 1730 1740 1750
SPIQLSSLTS AQAVAVTPEQ MAFLSPEQRR AVAWAQHEGK ESPEQQGRST
1760 1770
AWGLQDWSRP SWSLVLTISF LGHLL
Length:1,775
Mass (Da):192,967
Last modified:December 15, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C13E9A6015F22A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PBT5E9PBT5_HUMAN
Stereocilin
STRC
969Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPM8E7EPM8_HUMAN
Stereocilin
STRC
351Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXA4F5GXA4_HUMAN
Stereocilin
STRC
1,002Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2Q6H7C2Q6_HUMAN
Stereocilin
STRC
663Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0F7H7C0F7_HUMAN
Stereocilin
STRC
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0513891640L → F. Corresponds to variant dbSNP:rs2920791EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC011330 Genomic DNA No translation available.
BK000138 mRNA Translation: DAA00085.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10098.1

NCBI Reference Sequences

More...
RefSeqi
NP_714544.1, NM_153700.2
XP_016877448.1, XM_017021959.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000450892; ENSP00000401513; ENSG00000242866

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
161497

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:161497

UCSC genome browser

More...
UCSCi
uc001zsf.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011330 Genomic DNA No translation available.
BK000138 mRNA Translation: DAA00085.1
CCDSiCCDS10098.1
RefSeqiNP_714544.1, NM_153700.2
XP_016877448.1, XM_017021959.1

3D structure databases

SMRiQ7RTU9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127793, 1 interactor
STRINGi9606.ENSP00000401513

PTM databases

GlyGeniQ7RTU9, 14 sites
iPTMnetiQ7RTU9
PhosphoSitePlusiQ7RTU9

Genetic variation databases

BioMutaiSTRC
DMDMi47606114

Proteomic databases

MassIVEiQ7RTU9
PaxDbiQ7RTU9
PeptideAtlasiQ7RTU9
PRIDEiQ7RTU9
ProteomicsDBi68910

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
56334, 18 antibodies

Genome annotation databases

EnsembliENST00000450892; ENSP00000401513; ENSG00000242866
GeneIDi161497
KEGGihsa:161497
UCSCiuc001zsf.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
161497
DisGeNETi161497

GeneCards: human genes, protein and diseases

More...
GeneCardsi
STRC
GeneReviewsiSTRC
HGNCiHGNC:16035, STRC
HPAiENSG00000242866, Tissue enriched (brain)
MalaCardsiSTRC
MIMi603720, phenotype
606440, gene
611102, phenotype
neXtProtiNX_Q7RTU9
OpenTargetsiENSG00000242866
Orphaneti90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB
94064, Deafness-infertility syndrome
PharmGKBiPA38082
VEuPathDBiHostDB:ENSG00000242866.9

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QTHC, Eukaryota
GeneTreeiENSGT00950000182957
HOGENOMiCLU_001286_0_0_1
InParanoidiQ7RTU9
OMAiFSIYLLC
OrthoDBi86428at2759
PhylomeDBiQ7RTU9
TreeFamiTF330914

Enzyme and pathway databases

PathwayCommonsiQ7RTU9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
161497, 7 hits in 940 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
STRC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
161497
PharosiQ7RTU9, Tbio

Protein Ontology

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PROi
PR:Q7RTU9
RNActiQ7RTU9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000242866, Expressed in right hemisphere of cerebellum and 131 other tissues
ExpressionAtlasiQ7RTU9, baseline and differential
GenevisibleiQ7RTU9, HS

Family and domain databases

InterProiView protein in InterPro
IPR026061, Stereocilin
IPR026664, Stereocilin-rel
PANTHERiPTHR23412, PTHR23412, 1 hit
PTHR23412:SF14, PTHR23412:SF14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTRC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7RTU9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 15, 2003
Last modified: April 7, 2021
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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