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Protein

Achaete-scute homolog 5

Gene

ASCL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Achaete-scute homolog 5
Short name:
ASH-5
Short name:
hASH5
Alternative name(s):
Class A basic helix-loop-helix protein 47
Short name:
bHLHa47
Gene namesi
Name:ASCL5
Synonyms:BHLHA47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000232237.3
HGNCiHGNC:33169 ASCL5
neXtProtiNX_Q7RTU5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi166988402

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172981 – 278Achaete-scute homolog 5Add BLAST278

Proteomic databases

PaxDbiQ7RTU5
PRIDEiQ7RTU5
ProteomicsDBi68908

Expressioni

Gene expression databases

BgeeiENSG00000232237 Expressed in 41 organ(s), highest expression level in body of pancreas
ExpressionAtlasiQ7RTU5 baseline and differential
GenevisibleiQ7RTU5 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000469019

Structurei

3D structure databases

ProteinModelPortaliQ7RTU5
SMRiQ7RTU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 207bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
InParanoidiQ7RTU5
OrthoDBiEOG091G0RR2

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR015660 MASH1/Ascl1a-like
PANTHERiPTHR13935 PTHR13935, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7RTU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMGAAERGA GPQSSAAPWA GSEKAAKRGP SKSWYPRAAA SDVTCPTGGD
60 70 80 90 100
GADPKPGPFG GGLALGPAPR GTMNNNFCRA LVDRRPLGPP SCMQLGVMPP
110 120 130 140 150
PRQAPLPPAE PLGNVPFLLY PGPAEPPYYD AYAGVFPYVP FPGAFGVYEY
160 170 180 190 200
PFEPAFIQKR NERERQRVKC VNEGYARLRG HLPGALAEKR LSKVETLRAA
210 220 230 240 250
IRYIKYLQEL LSSAPDGSTP PASRGLPGTG PCPAPPATPR PDRPGDGEAR
260 270
APSSLVPESS ESSCFSPSPF LESEESWH
Length:278
Mass (Da):29,462
Last modified:February 5, 2008 - v2
Checksum:i96DC775BDA61C176
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R2M9M0R2M9_HUMAN
Achaete-scute homolog 5
ASCL5
206Annotation score:

Sequence cautioni

The sequence DAA00301 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139159 Genomic DNA No translation available.
BK000139 Genomic DNA Translation: DAA00301.1 Different initiation.
UniGeneiHs.143949
Hs.721460

Genome annotation databases

EnsembliENST00000458416; ENSP00000469019; ENSG00000232237
UCSCiuc031prl.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139159 Genomic DNA No translation available.
BK000139 Genomic DNA Translation: DAA00301.1 Different initiation.
UniGeneiHs.143949
Hs.721460

3D structure databases

ProteinModelPortaliQ7RTU5
SMRiQ7RTU5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000469019

Polymorphism and mutation databases

DMDMi166988402

Proteomic databases

PaxDbiQ7RTU5
PRIDEiQ7RTU5
ProteomicsDBi68908

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000458416; ENSP00000469019; ENSG00000232237
UCSCiuc031prl.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000232237.3
GeneCardsiASCL5
HGNCiHGNC:33169 ASCL5
neXtProtiNX_Q7RTU5
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
InParanoidiQ7RTU5
OrthoDBiEOG091G0RR2

Miscellaneous databases

PROiPR:Q7RTU5

Gene expression databases

BgeeiENSG00000232237 Expressed in 41 organ(s), highest expression level in body of pancreas
ExpressionAtlasiQ7RTU5 baseline and differential
GenevisibleiQ7RTU5 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR015660 MASH1/Ascl1a-like
PANTHERiPTHR13935 PTHR13935, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASCL5_HUMAN
AccessioniPrimary (citable) accession number: Q7RTU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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