OLIG3

Functionⁱ

May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein dimerization activity Source: InterPro
transcription corepressor activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II Source: Ensembl
spinal cord motor neuron cell fate specification Source: Ensembl
spinal cord motor neuron migration Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Oligodendrocyte transcription factor 3 Short name: Oligo3 Alternative name(s): Class B basic helix-loop-helix protein 7 Short name: bHLHb7 Class E basic helix-loop-helix protein 20 Short name: bHLHe20
Gene namesⁱ	Name:OLIG3 Synonyms:BHLHB7, BHLHE20
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000177468.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18003 OLIG3
MIMⁱ	609323 gene
neXtProtⁱ	NX_Q7RTU3

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	167826
Open Targets More...OpenTargetsⁱ	ENSG00000177468
PharmGKBⁱ	PA134945348

Polymorphism and mutation databases

BioMutaⁱ	OLIG3
DMDMⁱ	51701664

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127417	1 – 272	Oligodendrocyte transcription factor 3Add BLAST		272

Proteomic databases

PaxDbⁱ	Q7RTU3
PeptideAtlas More...PeptideAtlasⁱ	Q7RTU3
PRIDEⁱ	Q7RTU3
ProteomicsDBⁱ	68906

PTM databases

iPTMnetⁱ	Q7RTU3
PhosphoSitePlusⁱ	Q7RTU3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000177468 Expressed in 7 organ(s), highest expression level in placenta
CleanExⁱ	HS_OLIG3
Genevisibleⁱ	Q7RTU3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB024865 HPA018303

HPAⁱ

CAB024865
HPA018303

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AES	Q08117	3	EBI-10225049,EBI-717810
BYSL	Q13895	5	EBI-10225049,EBI-358049
MDFI	Q99750	5	EBI-10225049,EBI-724076
TRAF1	Q13077	5	EBI-10225049,EBI-359224

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	127951, 6 interactors
IntActⁱ	Q7RTU3, 27 interactors
STRINGⁱ	9606.ENSP00000356708

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7RTU3
SMRⁱ	Q7RTU3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	83 – 137	bHLHPROSITE-ProRule annotationAdd BLAST		55

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	68 – 89	Sequence analysisAdd BLAST		22

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	25 – 32	Poly-His		8
Compositional biasⁱ	247 – 250	Poly-Pro		4

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IQ4F Eukaryota ENOG410XTTW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063239
HOGENOMⁱ	HOG000015765
HOVERGENⁱ	HBG053370
InParanoidⁱ	Q7RTU3
KEGG Orthology (KO) More...KOⁱ	K09085
OMAⁱ	MVQKMPG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G129L
PhylomeDBⁱ	Q7RTU3
TreeFamⁱ	TF322733

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032659 Olig3
PANTHERⁱ	PTHR19290:SF96 PTHR19290:SF96, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q7RTU3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHQESRLNSV SSTQGDMMQK 
        60         70         80         90        100
MPGESLSRAG AKAAGESSKY KIKKQLSEQD LQQLRLKING RERKRMHDLN 
       110        120        130        140        150
LAMDGLREVM PYAHGPSVRK LSKIATLLLA RNYILMLTSS LEEMKRLVGE 
       160        170        180        190        200
IYGGHHSAFH CGTVGHSAGH PAHAANSVHP VHPILGGALS SGNASSPLSA 
       210        220        230        240        250
ASLPAIGTIR PPHSLLKAPS TPPALQLGSG FQHWAGLPCP CTICQMPPPP 
       260        270 
HLSALSTANM ARLSAESKDL LK

Length:272

Mass (Da):29,358

Last modified:August 31, 2004 - v2

Checksum:ⁱ9ED98EF52F34D9A5

GO

Sequence cautionⁱ

The sequence DAA00303 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096362 mRNA Translation: BAC04768.1 AL023580 Genomic DNA No translation available. BC051352 mRNA Translation: AAH51352.1 BK000141 Genomic DNA Translation: DAA00303.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5186.1
NCBI Reference Sequences More...RefSeqⁱ	NP_786923.1, NM_175747.2
UniGeneⁱ	Hs.195398

Genome annotation databases

Ensemblⁱ	ENST00000367734; ENSP00000356708; ENSG00000177468
GeneIDⁱ	167826
KEGGⁱ	hsa:167826
UCSC genome browser More...UCSCⁱ	uc003qhp.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7RTU3	Oligodendrocyte transcription factor 3		MOUSE		273	UniRef90_Q6PFG8
oligodendrocyte transcription factor 3		TARSY		313
Uncharacterized protein		RHIBE		274
Oligodendrocyte transcription factor 3		MACMU		273
Uncharacterized protein		CERAT		273
+92

Protein	Similar proteins		Species	Score	Length	Source
Q7RTU3	Oligodendrocyte transcription factor 3		MOUSE		273	UniRef50_Q6PFG8
Oligodendrocyte transcription factor 2		CHICK		298
oligodendrocyte transcription factor 3		TARSY		313
Uncharacterized protein		RHIBE		274
oligodendrocyte transcription factor 3		DIPOR		273
+133

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096362 mRNA Translation: BAC04768.1 AL023580 Genomic DNA No translation available. BC051352 mRNA Translation: AAH51352.1 BK000141 Genomic DNA Translation: DAA00303.1 Different initiation.
CCDSⁱ	CCDS5186.1
RefSeqⁱ	NP_786923.1, NM_175747.2
UniGeneⁱ	Hs.195398

3D structure databases

ProteinModelPortalⁱ	Q7RTU3
SMRⁱ	Q7RTU3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127951, 6 interactors
IntActⁱ	Q7RTU3, 27 interactors
STRINGⁱ	9606.ENSP00000356708

PTM databases

iPTMnetⁱ	Q7RTU3
PhosphoSitePlusⁱ	Q7RTU3

Polymorphism and mutation databases

BioMutaⁱ	OLIG3
DMDMⁱ	51701664

Proteomic databases

PaxDbⁱ	Q7RTU3
PeptideAtlasⁱ	Q7RTU3
PRIDEⁱ	Q7RTU3
ProteomicsDBⁱ	68906

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	167826
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367734; ENSP00000356708; ENSG00000177468
GeneIDⁱ	167826
KEGGⁱ	hsa:167826
UCSCⁱ	uc003qhp.2 human

Organism-specific databases

CTDⁱ	167826
DisGeNETⁱ	167826
EuPathDBⁱ	HostDB:ENSG00000177468.6
GeneCardsⁱ	OLIG3
HGNCⁱ	HGNC:18003 OLIG3
HPAⁱ	CAB024865 HPA018303
MIMⁱ	609323 gene
neXtProtⁱ	NX_Q7RTU3
OpenTargetsⁱ	ENSG00000177468
PharmGKBⁱ	PA134945348
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IQ4F Eukaryota ENOG410XTTW LUCA
GeneTreeⁱ	ENSGT00530000063239
HOGENOMⁱ	HOG000015765
HOVERGENⁱ	HBG053370
InParanoidⁱ	Q7RTU3
KOⁱ	K09085
OMAⁱ	MVQKMPG
OrthoDBⁱ	EOG091G129L
PhylomeDBⁱ	Q7RTU3
TreeFamⁱ	TF322733

Miscellaneous databases

GenomeRNAiⁱ	167826
Protein Ontology More...PROⁱ	PR:Q7RTU3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177468 Expressed in 7 organ(s), highest expression level in placenta
CleanExⁱ	HS_OLIG3
Genevisibleⁱ	Q7RTU3 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032659 Olig3
PANTHERⁱ	PTHR19290:SF96 PTHR19290:SF96, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OLIG3_HUMAN
Accessionⁱ	Q7RTU3Primary (citable) accession number: Q7RTU3 Secondary accession number(s): Q8N8Q0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	August 31, 2004
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniProtKB - Q7RTU3 (OLIG3_HUMAN)

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Oligodendrocyte transcription factor 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ