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UniProtKB - Q7RTU3 (OLIG3_HUMAN)
Protein
Oligodendrocyte transcription factor 3
Gene
OLIG3
Organism
Homo sapiens (Human)
Status
Functioni
May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neuron differentiation Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- spinal cord motor neuron cell fate specification Source: Ensembl
- spinal cord motor neuron migration Source: Ensembl
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q7RTU3 |
SignaLinki | Q7RTU3 |
Names & Taxonomyi
Protein namesi | Recommended name: Oligodendrocyte transcription factor 3Short name: Oligo3 Alternative name(s): Class B basic helix-loop-helix protein 7 Short name: bHLHb7 Class E basic helix-loop-helix protein 20 Short name: bHLHe20 |
Gene namesi | Name:OLIG3 Synonyms:BHLHB7, BHLHE20 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18003, OLIG3 |
MIMi | 609323, gene |
neXtProti | NX_Q7RTU3 |
VEuPathDBi | HostDB:ENSG00000177468 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 167826 |
OpenTargetsi | ENSG00000177468 |
PharmGKBi | PA134945348 |
Miscellaneous databases
Pharosi | Q7RTU3, Tbio |
Genetic variation databases
BioMutai | OLIG3 |
DMDMi | 51701664 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127417 | 1 – 272 | Oligodendrocyte transcription factor 3Add BLAST | 272 |
Proteomic databases
PaxDbi | Q7RTU3 |
PeptideAtlasi | Q7RTU3 |
PRIDEi | Q7RTU3 |
ProteomicsDBi | 68906 |
PTM databases
GlyGeni | Q7RTU3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q7RTU3 |
PhosphoSitePlusi | Q7RTU3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177468, Expressed in islet of Langerhans and 15 other tissues |
Genevisiblei | Q7RTU3, HS |
Organism-specific databases
HPAi | ENSG00000177468, Not detected |
Interactioni
Binary interactionsi
Q7RTU3
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 127951, 30 interactors |
IntActi | Q7RTU3, 29 interactors |
STRINGi | 9606.ENSP00000356708 |
Miscellaneous databases
RNActi | Q7RTU3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 83 – 137 | bHLHPROSITE-ProRule annotationAdd BLAST | 55 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 71 | DisorderedSequence analysisAdd BLAST | 71 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 68 – 89 | Sequence analysisAdd BLAST | 22 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000160850 |
HOGENOMi | CLU_065376_1_0_1 |
InParanoidi | Q7RTU3 |
OMAi | SNMARIS |
OrthoDBi | 1290623at2759 |
PhylomeDBi | Q7RTU3 |
TreeFami | TF322733 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032659, Olig3 |
PANTHERi | PTHR19290:SF96, PTHR19290:SF96, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7RTU3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHQESRLNSV SSTQGDMMQK
60 70 80 90 100
MPGESLSRAG AKAAGESSKY KIKKQLSEQD LQQLRLKING RERKRMHDLN
110 120 130 140 150
LAMDGLREVM PYAHGPSVRK LSKIATLLLA RNYILMLTSS LEEMKRLVGE
160 170 180 190 200
IYGGHHSAFH CGTVGHSAGH PAHAANSVHP VHPILGGALS SGNASSPLSA
210 220 230 240 250
ASLPAIGTIR PPHSLLKAPS TPPALQLGSG FQHWAGLPCP CTICQMPPPP
260 270
HLSALSTANM ARLSAESKDL LK
Sequence cautioni
The sequence DAA00303 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096362 mRNA Translation: BAC04768.1 AL023580 Genomic DNA No translation available. BC051352 mRNA Translation: AAH51352.1 BK000141 Genomic DNA Translation: DAA00303.1 Different initiation. |
CCDSi | CCDS5186.1 |
RefSeqi | NP_786923.1, NM_175747.2 |
Genome annotation databases
Ensembli | ENST00000367734; ENSP00000356708; ENSG00000177468 |
GeneIDi | 167826 |
KEGGi | hsa:167826 |
MANE-Selecti | ENST00000367734.4; ENSP00000356708.2; NM_175747.2; NP_786923.1 |
UCSCi | uc003qhp.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096362 mRNA Translation: BAC04768.1 AL023580 Genomic DNA No translation available. BC051352 mRNA Translation: AAH51352.1 BK000141 Genomic DNA Translation: DAA00303.1 Different initiation. |
CCDSi | CCDS5186.1 |
RefSeqi | NP_786923.1, NM_175747.2 |
3D structure databases
SMRi | Q7RTU3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127951, 30 interactors |
IntActi | Q7RTU3, 29 interactors |
STRINGi | 9606.ENSP00000356708 |
PTM databases
GlyGeni | Q7RTU3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q7RTU3 |
PhosphoSitePlusi | Q7RTU3 |
Genetic variation databases
BioMutai | OLIG3 |
DMDMi | 51701664 |
Proteomic databases
PaxDbi | Q7RTU3 |
PeptideAtlasi | Q7RTU3 |
PRIDEi | Q7RTU3 |
ProteomicsDBi | 68906 |
Protocols and materials databases
Antibodypediai | 19782, 194 antibodies from 29 providers |
DNASUi | 167826 |
Genome annotation databases
Ensembli | ENST00000367734; ENSP00000356708; ENSG00000177468 |
GeneIDi | 167826 |
KEGGi | hsa:167826 |
MANE-Selecti | ENST00000367734.4; ENSP00000356708.2; NM_175747.2; NP_786923.1 |
UCSCi | uc003qhp.2, human |
Organism-specific databases
CTDi | 167826 |
DisGeNETi | 167826 |
GeneCardsi | OLIG3 |
HGNCi | HGNC:18003, OLIG3 |
HPAi | ENSG00000177468, Not detected |
MIMi | 609323, gene |
neXtProti | NX_Q7RTU3 |
OpenTargetsi | ENSG00000177468 |
PharmGKBi | PA134945348 |
VEuPathDBi | HostDB:ENSG00000177468 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000160850 |
HOGENOMi | CLU_065376_1_0_1 |
InParanoidi | Q7RTU3 |
OMAi | SNMARIS |
OrthoDBi | 1290623at2759 |
PhylomeDBi | Q7RTU3 |
TreeFami | TF322733 |
Enzyme and pathway databases
PathwayCommonsi | Q7RTU3 |
SignaLinki | Q7RTU3 |
Miscellaneous databases
BioGRID-ORCSi | 167826, 6 hits in 1051 CRISPR screens |
ChiTaRSi | OLIG3, human |
GenomeRNAii | 167826 |
Pharosi | Q7RTU3, Tbio |
PROi | PR:Q7RTU3 |
RNActi | Q7RTU3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177468, Expressed in islet of Langerhans and 15 other tissues |
Genevisiblei | Q7RTU3, HS |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032659, Olig3 |
PANTHERi | PTHR19290:SF96, PTHR19290:SF96, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OLIG3_HUMAN | |
Accessioni | Q7RTU3Primary (citable) accession number: Q7RTU3 Secondary accession number(s): Q8N8Q0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | August 31, 2004 | |
Last modified: | February 23, 2022 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot