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Protein

Transcription factor 23

Gene

TCF23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • decidualization Source: MGI
  • muscle organ development Source: UniProtKB-KW
  • positive regulation of gene expression Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 23
Short name:
TCF-23
Alternative name(s):
Class A basic helix-loop-helix protein 24
Short name:
bHLHa24
Gene namesi
Name:TCF23
Synonyms:BHLHA24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163792.6
HGNCiHGNC:18602 TCF23
MIMi609635 gene
neXtProtiNX_Q7RTU1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38359

Polymorphism and mutation databases

BioMutaiTCF23
DMDMi74749939

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158201 – 214Transcription factor 23Add BLAST214

Proteomic databases

PaxDbiQ7RTU1
PeptideAtlasiQ7RTU1
PRIDEiQ7RTU1
ProteomicsDBi68905

PTM databases

iPTMnetiQ7RTU1
PhosphoSitePlusiQ7RTU1

Expressioni

Tissue specificityi

Expressed in liver, kidney and spleen.1 Publication

Gene expression databases

BgeeiENSG00000163792
CleanExiHS_TCF23

Interactioni

Subunit structurei

Forms inactive heterodimeric complexes with TCF3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127330, 4 interactors
IntActiQ7RTU1, 5 interactors
STRINGi9606.ENSP00000296096

Structurei

3D structure databases

ProteinModelPortaliQ7RTU1
SMRiQ7RTU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 128bHLHPROSITE-ProRule annotationAdd BLAST53

Domaini

Both the bHLH region and the C-terminal portion are essential for inhibitory function.By similarity

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00710000106684
HOGENOMiHOG000154520
HOVERGENiHBG096612
InParanoidiQ7RTU1
OMAiRTRQDLW
OrthoDBiEOG091G0MGD
PhylomeDBiQ7RTU1
TreeFamiTF350742

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q7RTU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRKARGPP AMPGVGHSQT QAKARLLPGA DRKRSRLSRT RQDPWEERSW
60 70 80 90 100
SNQRWSRATP GPRGTRAGGL ALGRSEASPE NAARERSRVR TLRQAFLALQ
110 120 130 140 150
AALPAVPPDT KLSKLDVLVL AASYIAHLTR TLGHELPGPA WPPFLRGLRY
160 170 180 190 200
LHPLKKWPMR SRLYAGGLGY SDLDSTTAST PSQRTRDAEV GSQVPGEADA
210
LLSTTPLSPA LGDK
Length:214
Mass (Da):23,309
Last modified:December 15, 2003 - v1
Checksum:i5D1408A9BFFEE339
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03832525R → Q. Corresponds to variant dbSNP:rs11126879Ensembl.1
Natural variantiVAR_03832640T → S. Corresponds to variant dbSNP:rs4502371Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013403 Genomic DNA No translation available.
BC137191 mRNA Translation: AAI37192.1
BC137192 mRNA Translation: AAI37193.1
BK000143 Genomic DNA Translation: DAA00305.1
CCDSiCCDS33163.1
RefSeqiNP_786951.1, NM_175769.2
UniGeneiHs.591583

Genome annotation databases

EnsembliENST00000296096; ENSP00000296096; ENSG00000163792
GeneIDi150921
KEGGihsa:150921
UCSCiuc010ylg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCF23_HUMAN
AccessioniPrimary (citable) accession number: Q7RTU1
Secondary accession number(s): B2RNZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 15, 2003
Last modified: July 18, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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