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Protein

Transcription factor 24

Gene

TCF24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Putative transcription factor.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 24
Short name:
TCF-24
Gene namesi
Name:TCF24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000261787.1
HGNCiHGNC:32275 TCF24
neXtProtiNX_Q7RTU0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000261787

Polymorphism and mutation databases

DMDMi408360247

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004053151 – 167Transcription factor 24Add BLAST167

Proteomic databases

PaxDbiQ7RTU0
PRIDEiQ7RTU0
ProteomicsDBi68904

PTM databases

iPTMnetiQ7RTU0
PhosphoSitePlusiQ7RTU0

Expressioni

Gene expression databases

BgeeiENSG00000261787
GenevisibleiQ7RTU0 HS

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi934215, 2 interactors
IntActiQ7RTU0, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ7RTU0
SMRiQ7RTU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 101bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00710000106684
HOGENOMiHOG000206610
InParanoidiQ7RTU0
OMAiHDNTPTD
OrthoDBiEOG091G1AQF
TreeFamiTF350742

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q7RTU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRGRPAGSP LSASAEPAPL AAAIRDSRPG RTGPGPAGPG GGSRSGSGRP
60 70 80 90 100
AAANAARERS RVQTLRHAFL ELQRTLPSVP PDTKLSKLDV LLLATTYIAH
110 120 130 140 150
LTRSLQDDAE APADAGLGAL RGDGYLHPVK KWPMRSRLYI GATGQFLKHS
160
VSGEKTNHDN TPTDSQP
Length:167
Mass (Da):17,516
Last modified:October 3, 2012 - v3
Checksum:iB1637A24221E6A59
GO

Sequence cautioni

The sequence DAA00306 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110998 Genomic DNA No translation available.
BK000144 Genomic DNA Translation: DAA00306.1 Sequence problems.
CCDSiCCDS59103.1
RefSeqiNP_001180431.1, NM_001193502.1
XP_016868429.1, XM_017012940.1
UniGeneiHs.120040

Genome annotation databases

EnsembliENST00000563496; ENSP00000455444; ENSG00000261787
GeneIDi100129654
KEGGihsa:100129654
UCSCiuc022avl.1 human

Similar proteinsi

Entry informationi

Entry nameiTCF24_HUMAN
AccessioniPrimary (citable) accession number: Q7RTU0
Secondary accession number(s): H3BPR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: October 3, 2012
Last modified: July 18, 2018
This is version 83 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM

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