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UniProtKB - Q7RTS5 (OTOP3_HUMAN)
Protein
Proton channel OTOP3
Gene
OTOP3
Organism
Homo sapiens (Human)
Status
Functioni
Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.
By similarityGO - Molecular functioni
- proton channel activity Source: UniProtKB
GO - Biological processi
- proton transmembrane transport Source: UniProtKB
Keywordsi
Molecular function | Ion channel |
Biological process | Hydrogen ion transport, Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q7RTS5 |
SignaLinki | Q7RTS5 |
Protein family/group databases
TCDBi | 1.A.110.1.4, the channel-forming otopetrin (otop) family |
Names & Taxonomyi
Protein namesi | Recommended name: Proton channel OTOP3CuratedAlternative name(s): Otopetrin-31 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19658, OTOP3 |
MIMi | 607828, gene |
neXtProti | NX_Q7RTS5 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 90 – 110 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 121 – 141 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 159 – 179 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 194 – 214 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 227 – 247 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 290 – 310 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 338 – 358 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 372 – 392 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 417 – 437 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 449 – 469 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 530 – 550 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 561 – 581 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA134888566 |
Miscellaneous databases
Pharosi | Q7RTS5, Tdark |
Genetic variation databases
BioMutai | OTOP3 |
DMDMi | 74713144 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000313822 | 1 – 596 | Proton channel OTOP3Add BLAST | 596 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 23 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q7RTS5 |
PaxDbi | Q7RTS5 |
PeptideAtlasi | Q7RTS5 |
PRIDEi | Q7RTS5 |
ProteomicsDBi | 68893 |
PTM databases
iPTMneti | Q7RTS5 |
PhosphoSitePlusi | Q7RTS5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182938, Expressed in duodenum and 30 other tissues |
ExpressionAtlasi | Q7RTS5, baseline and differential |
Interactioni
Binary interactionsi
Q7RTS5
Protein-protein interaction databases
BioGRIDi | 131488, 8 interactors |
IntActi | Q7RTS5, 7 interactors |
STRINGi | 9606.ENSP00000328090 |
Miscellaneous databases
RNActi | Q7RTS5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 59 | DisorderedSequence analysisAdd BLAST | 59 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 40 – 59 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the otopetrin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4740, Eukaryota |
HOGENOMi | CLU_032913_0_0_1 |
InParanoidi | Q7RTS5 |
OrthoDBi | 524642at2759 |
PhylomeDBi | Q7RTS5 |
TreeFami | TF313428 |
Family and domain databases
InterProi | View protein in InterPro IPR004878, Otopetrin IPR013087, Znf_C2H2_type |
PANTHERi | PTHR21522, PTHR21522, 1 hit |
Pfami | View protein in Pfam PF03189, Otopetrin, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7RTS5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRGARAAAA QSRWGRASRA SVSPGRTIRS APAVGEAQET EAAPEKENRV
60 70 80 90 100
DVGAEERAAA TRPRQKSWLV RHFSLLLRRD RQAQKAGQLF SGLLALNVVF
110 120 130 140 150
LGGAFICSMI FNKVAVTLGD VWILLATLKV LSLLWLLYYV ASTTRRPHAV
160 170 180 190 200
LYQDPHAGPL WVRGSLVLFG SCTFCLNIFR VGYDVSHIRC KSQLDLVFSV
210 220 230 240 250
IEMVFIGVQT WVLWKHCKDC VRVQTNFTRC GLMLTLATNL LLWVLAVTND
260 270 280 290 300
SMHREIEAEL GILMEKSTGN ETNTCLCLNA TACEAFRRGF LMLYPFSTEY
310 320 330 340 350
CLICCAVLFV MWKNVGRHVA PHMGAHPATA PFHLHGAIFG PLLGLLVLLA
360 370 380 390 400
GVCVFVLFQI EASGPAIACQ YFTLYYAFYV AVLPTMSLAC LAGTAIHGLE
410 420 430 440 450
ERELDTVKNP TRSLDVVLLM GAALGQMGIA YFSIVAIVAK RPHELLNRLI
460 470 480 490 500
LAYSLLLILQ HIAQNLFIIE GLHRRPLWET VPEGLAGKQE AEPPRRGSLL
510 520 530 540 550
ELGQGLQRAS LAYIHSYSHL NWKRRALKEI SLFLILCNIT LWMMPAFGIH
560 570 580 590
PEFENGLEKD FYGYQIWFAI VNFGLPLGVF YRMHSVGGLV EVYLGA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2U3TZI1 | A0A2U3TZI1_HUMAN | Proton channel OTOP3 | OTOP3 | 578 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037762 | 64 | R → Q. Corresponds to variant dbSNP:rs7210616Ensembl. | 1 | |
Natural variantiVAR_037763 | 146 | R → Q. Corresponds to variant dbSNP:rs9890664Ensembl. | 1 | |
Natural variantiVAR_037764 | 199 | S → P. Corresponds to variant dbSNP:rs1542752Ensembl. | 1 | |
Natural variantiVAR_062217 | 477 | L → V. Corresponds to variant dbSNP:rs35131040Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC087651 Genomic DNA No translation available. BK000568 mRNA Translation: DAA00896.1 |
CCDSi | CCDS11709.1 |
RefSeqi | NP_001258934.1, NM_001272005.1 NP_839947.1, NM_178233.2 |
Genome annotation databases
GeneIDi | 347741 |
KEGGi | hsa:347741 |
UCSCi | uc010wrr.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC087651 Genomic DNA No translation available. BK000568 mRNA Translation: DAA00896.1 |
CCDSi | CCDS11709.1 |
RefSeqi | NP_001258934.1, NM_001272005.1 NP_839947.1, NM_178233.2 |
3D structure databases
SMRi | Q7RTS5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131488, 8 interactors |
IntActi | Q7RTS5, 7 interactors |
STRINGi | 9606.ENSP00000328090 |
Protein family/group databases
TCDBi | 1.A.110.1.4, the channel-forming otopetrin (otop) family |
PTM databases
iPTMneti | Q7RTS5 |
PhosphoSitePlusi | Q7RTS5 |
Genetic variation databases
BioMutai | OTOP3 |
DMDMi | 74713144 |
Proteomic databases
jPOSTi | Q7RTS5 |
PaxDbi | Q7RTS5 |
PeptideAtlasi | Q7RTS5 |
PRIDEi | Q7RTS5 |
ProteomicsDBi | 68893 |
Protocols and materials databases
Antibodypediai | 19484, 80 antibodies from 20 providers |
DNASUi | 347741 |
Genome annotation databases
GeneIDi | 347741 |
KEGGi | hsa:347741 |
UCSCi | uc010wrr.4, human |
Organism-specific databases
CTDi | 347741 |
GeneCardsi | OTOP3 |
HGNCi | HGNC:19658, OTOP3 |
MIMi | 607828, gene |
neXtProti | NX_Q7RTS5 |
PharmGKBi | PA134888566 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4740, Eukaryota |
HOGENOMi | CLU_032913_0_0_1 |
InParanoidi | Q7RTS5 |
OrthoDBi | 524642at2759 |
PhylomeDBi | Q7RTS5 |
TreeFami | TF313428 |
Enzyme and pathway databases
PathwayCommonsi | Q7RTS5 |
SignaLinki | Q7RTS5 |
Miscellaneous databases
BioGRID-ORCSi | 347741, 7 hits in 1033 CRISPR screens |
GenomeRNAii | 347741 |
Pharosi | Q7RTS5, Tdark |
PROi | PR:Q7RTS5 |
RNActi | Q7RTS5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182938, Expressed in duodenum and 30 other tissues |
ExpressionAtlasi | Q7RTS5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR004878, Otopetrin IPR013087, Znf_C2H2_type |
PANTHERi | PTHR21522, PTHR21522, 1 hit |
Pfami | View protein in Pfam PF03189, Otopetrin, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | OTOP3_HUMAN | |
Accessioni | Q7RTS5Primary (citable) accession number: Q7RTS5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | December 15, 2003 | |
Last modified: | February 23, 2022 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families