BHLHA15

Functionⁱ

Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).By similarity

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein homodimerization activity Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-mediated signaling Source: Ensembl
cell-cell signaling Source: Ensembl
cell maturation Source: Ensembl
cellular response to glucose starvation Source: UniProtKB
endoplasmic reticulum unfolded protein response Source: UniProtKB
glucose homeostasis Source: Ensembl
Golgi organization Source: Ensembl
G protein-coupled receptor signaling pathway Source: Ensembl
intracellular distribution of mitochondria Source: Ensembl
mitochondrial calcium ion transmembrane transport Source: Ensembl
negative regulation of myotube differentiation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Class A basic helix-loop-helix protein 15 Short name: bHLHa15 Alternative name(s): Class B basic helix-loop-helix protein 8 Short name: bHLHb8 Muscle, intestine and stomach expression 1 Short name: MIST-1
Gene namesⁱ	Name:BHLHA15 Synonyms:BHLHB8, MIST1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000180535.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:22265 BHLHA15
MIMⁱ	608606 gene
neXtProtⁱ	NX_Q7RTS1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	168620
Open Targets More...OpenTargetsⁱ	ENSG00000180535
PharmGKBⁱ	PA164716601

Polymorphism and mutation databases

BioMutaⁱ	BHLHA15
DMDMⁱ	50400944

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127150	1 – 189	Class A basic helix-loop-helix protein 15Add BLAST		189

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	25	PhosphothreonineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q7RTS1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7RTS1
PaxDbⁱ	Q7RTS1
PeptideAtlas More...PeptideAtlasⁱ	Q7RTS1
PRIDEⁱ	Q7RTS1
ProteomicsDBⁱ	68891

PTM databases

iPTMnetⁱ	Q7RTS1
PhosphoSitePlusⁱ	Q7RTS1

Expressionⁱ

Tissue specificityⁱ

Expressed in brain, liver, spleen and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000180535 Expressed in 71 organ(s), highest expression level in body of pancreas

Bgeeⁱ

ENSG00000180535 Expressed in 71 organ(s), highest expression level in body of pancreas

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB034083 HPA047834

HPAⁱ

CAB034083
HPA047834

Interactionⁱ

Subunit structureⁱ

Forms homodimers or heterodimers with TCF3 gene products E12 and E47. These dimers bind to the E-box site, however, heterodimer with MYOD1 does not bind target DNA (By similarity).By similarity

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	127970, 45 interactors
IntActⁱ	Q7RTS1, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q7RTS1
STRINGⁱ	9606.ENSP00000326391

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7RTS1
SMRⁱ	Q7RTS1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	75 – 127	bHLHPROSITE-ProRule annotationAdd BLAST		53

Domainⁱ

Lacks a classic transcription activation domain and instead possesses an N-terminal region capable of inhibiting heterologous activators.By similarity

Phylogenomic databases

eggNOGⁱ	ENOG410IQ4H Eukaryota ENOG4111ZMK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00680000099860
HOGENOMⁱ	HOG000095227
InParanoidⁱ	Q7RTS1
KEGG Orthology (KO) More...KOⁱ	K08040
OMAⁱ	HRYSTQI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G15AI
PhylomeDBⁱ	Q7RTS1
TreeFamⁱ	TF315153

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q7RTS1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKTKNRPPRR RAPVQDTEAT PGEGTPDGSL PNPGPEPAKG LRSRPARAAA 
        60         70         80         90        100
RAPGEGRRRR PGPSGPGGRR DSSIQRRLES NERERQRMHK LNNAFQALRE 
       110        120        130        140        150
VIPHVRADKK LSKIETLTLA KNYIKSLTAT ILTMSSSRLP GLEGPGPKLY 
       160        170        180 
QHYQQQQQVA GGALGATEAQ PQGHLQRYST QIHSFREGT

Length:189

Mass (Da):20,818

Last modified:December 15, 2003 - v1

Checksum:ⁱ38D7230D85F16D22

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC025605 Genomic DNA No translation available. CH236956 Genomic DNA Translation: EAL23893.1 BC113394 mRNA Translation: AAI13395.1 BC113396 mRNA Translation: AAI13397.1 BK000276 mRNA Translation: DAA01056.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5655.1
NCBI Reference Sequences More...RefSeqⁱ	NP_803238.1, NM_177455.3
UniGeneⁱ	Hs.511979 Hs.674510

Genome annotation databases

Ensemblⁱ	ENST00000314018; ENSP00000326391; ENSG00000180535 ENST00000609256; ENSP00000476312; ENSG00000180535
GeneIDⁱ	168620
KEGGⁱ	hsa:168620
UCSC genome browser More...UCSCⁱ	uc003upe.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7RTS1	Uncharacterized protein		COLAP		194	UniRef90_Q7RTS1
Uncharacterized protein		CHLSB		194
Uncharacterized protein		PAPAN		193
Uncharacterized protein		MACMU		191
Uncharacterized protein		MACNE		191
+14

Protein	Similar proteins		Species	Score	Length	Source
Q7RTS1	Uncharacterized protein		CHLSB		194	UniRef50_Q7RTS1
Uncharacterized protein		COLAP		194
Uncharacterized protein		PAPAN		193
Uncharacterized protein		MANLE		191
Uncharacterized protein		CERAT		191
+53

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC025605 Genomic DNA No translation available. CH236956 Genomic DNA Translation: EAL23893.1 BC113394 mRNA Translation: AAI13395.1 BC113396 mRNA Translation: AAI13397.1 BK000276 mRNA Translation: DAA01056.1
CCDSⁱ	CCDS5655.1
RefSeqⁱ	NP_803238.1, NM_177455.3
UniGeneⁱ	Hs.511979 Hs.674510

3D structure databases

ProteinModelPortalⁱ	Q7RTS1
SMRⁱ	Q7RTS1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127970, 45 interactors
IntActⁱ	Q7RTS1, 2 interactors
MINTⁱ	Q7RTS1
STRINGⁱ	9606.ENSP00000326391

PTM databases

iPTMnetⁱ	Q7RTS1
PhosphoSitePlusⁱ	Q7RTS1

Polymorphism and mutation databases

BioMutaⁱ	BHLHA15
DMDMⁱ	50400944

Proteomic databases

EPDⁱ	Q7RTS1
MaxQBⁱ	Q7RTS1
PaxDbⁱ	Q7RTS1
PeptideAtlasⁱ	Q7RTS1
PRIDEⁱ	Q7RTS1
ProteomicsDBⁱ	68891

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000314018; ENSP00000326391; ENSG00000180535 ENST00000609256; ENSP00000476312; ENSG00000180535
GeneIDⁱ	168620
KEGGⁱ	hsa:168620
UCSCⁱ	uc003upe.2 human

Organism-specific databases

CTDⁱ	168620
DisGeNETⁱ	168620
EuPathDBⁱ	HostDB:ENSG00000180535.3
GeneCardsⁱ	BHLHA15
HGNCⁱ	HGNC:22265 BHLHA15
HPAⁱ	CAB034083 HPA047834
MIMⁱ	608606 gene
neXtProtⁱ	NX_Q7RTS1
OpenTargetsⁱ	ENSG00000180535
PharmGKBⁱ	PA164716601
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IQ4H Eukaryota ENOG4111ZMK LUCA
GeneTreeⁱ	ENSGT00680000099860
HOGENOMⁱ	HOG000095227
InParanoidⁱ	Q7RTS1
KOⁱ	K08040
OMAⁱ	HRYSTQI
OrthoDBⁱ	EOG091G15AI
PhylomeDBⁱ	Q7RTS1
TreeFamⁱ	TF315153

Miscellaneous databases

GeneWikiⁱ	BHLHB8
GenomeRNAiⁱ	168620
Protein Ontology More...PROⁱ	PR:Q7RTS1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000180535 Expressed in 71 organ(s), highest expression level in body of pancreas

Bgeeⁱ

ENSG00000180535 Expressed in 71 organ(s), highest expression level in body of pancreas

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BHA15_HUMAN
Accessionⁱ	Q7RTS1Primary (citable) accession number: Q7RTS1 Secondary accession number(s): A4D271, Q14DE4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	December 15, 2003
	Last modified:	November 7, 2018
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

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UniProtKB - Q7RTS1 (BHA15_HUMAN)

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Class A basic helix-loop-helix protein 15

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ