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Entry version 135 (17 Jun 2020)
Sequence version 1 (15 Dec 2003)
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Protein

Magnesium transporter NIPA1

Gene

NIPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a Mg2+ transporter. Can also transport other divalent cations such as Fe2+, Sr2+, Ba2+, Mn2+ and Co2+ but to a much less extent than Mg2+ (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport
LigandMagnesium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5223345 Miscellaneous transport and binding events

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.7.25.1 the drug/metabolite transporter (dmt) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Magnesium transporter NIPA1
Alternative name(s):
Non-imprinted in Prader-Willi/Angelman syndrome region protein 1
Spastic paraplegia 6 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NIPA1
Synonyms:SPG6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170113.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17043 NIPA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608145 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7RTP0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Topological domaini49 – 66CytoplasmicSequence analysisAdd BLAST18
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88ExtracellularSequence analysis1
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 117CytoplasmicSequence analysis8
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 159ExtracellularSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 183CytoplasmicSequence analysis3
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 224ExtracellularSequence analysisAdd BLAST20
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 259CytoplasmicSequence analysisAdd BLAST14
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 290ExtracellularSequence analysis10
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Topological domaini312 – 329CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spastic paraplegia 6, autosomal dominant (SPG6)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02344045T → R in SPG6. 1 PublicationCorresponds to variant dbSNP:rs104894496EnsemblClinVar.1
Natural variantiVAR_023441106G → R in SPG6. 1 PublicationCorresponds to variant dbSNP:rs104894490EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
123606

MalaCards human disease database

More...
MalaCardsi
NIPA1
MIMi600363 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000170113

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
100988 Autosomal dominant spastic paraplegia type 6

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134967361

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7RTP0 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NIPA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73921215

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001917411 – 329Magnesium transporter NIPA1Add BLAST329

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7RTP0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7RTP0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7RTP0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7RTP0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7RTP0

PeptideAtlas

More...
PeptideAtlasi
Q7RTP0

PRoteomics IDEntifications database

More...
PRIDEi
Q7RTP0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68877 [Q7RTP0-1]
68878 [Q7RTP0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7RTP0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7RTP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in neuronal tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170113 Expressed in brain and 193 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7RTP0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7RTP0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000170113 Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q7RTP0, 4 interactors

Molecular INTeraction database

More...
MINTi
Q7RTP0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337452

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7RTP0 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NIPA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2922 Eukaryota
ENOG410XNR8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159067

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012349_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7RTP0

KEGG Orthology (KO)

More...
KOi
K19364

Identification of Orthologs from Complete Genome Data

More...
OMAi
YLTDVVW

Database of Orthologous Groups

More...
OrthoDBi
754939at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7RTP0

TreeFam database of animal gene trees

More...
TreeFami
TF313214

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008521 Mg_trans_NIPA

The PANTHER Classification System

More...
PANTHERi
PTHR12570 PTHR12570, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05653 Mg_trans_NIPA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7RTP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTAAAAAAA AAAAAAGEGA RSPSPAAVSL GLGVAVVSSL VNGSTFVLQK
60 70 80 90 100
KGIVRAKRRG TSYLTDIVWW AGTIAMAVGQ IGNFLAYTAV PTVLVTPLGA
110 120 130 140 150
LGVPFGSILA SYLLKEKLNI LGKLGCLLSC AGSVVLIIHS PKSESVTTQA
160 170 180 190 200
ELEEKLTNPV FVGYLCIVLL MLLLLIFWIA PAHGPTNIMV YISICSLLGS
210 220 230 240 250
FTVPSTKGIG LAAQDILHNN PSSQRALCLC LVLLAVLGCS IIVQFRYINK
260 270 280 290 300
ALECFDSSVF GAIYYVVFTT LVLLASAILF REWSNVGLVD FLGMACGFTT
310 320
VSVGIVLIQV FKEFNFNLGE MNKSNMKTD
Length:329
Mass (Da):34,562
Last modified:December 15, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88B7506C93457A12
GO
Isoform 2 (identifier: Q7RTP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Show »
Length:254
Mass (Da):27,310
Checksum:iFCDF5586AAADACFE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMY7H0YMY7_HUMAN
Magnesium transporter NIPA1
NIPA1
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLP7H0YLP7_HUMAN
Magnesium transporter NIPA1
NIPA1
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC67707 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAC67707 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02344045T → R in SPG6. 1 PublicationCorresponds to variant dbSNP:rs104894496EnsemblClinVar.1
Natural variantiVAR_023441106G → R in SPG6. 1 PublicationCorresponds to variant dbSNP:rs104894490EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0171891 – 75Missing in isoform 2. 2 PublicationsAdd BLAST75

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BK001020 mRNA Translation: DAA01477.1
CR614719 mRNA No translation available.
AK314073 mRNA Translation: BAG36773.1
BX537997 mRNA Translation: CAD97953.1
BX648722 mRNA Translation: CAI45979.2
CH471258 Genomic DNA Translation: EAW65549.1
AB089319 mRNA Translation: BAC67707.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS73691.1 [Q7RTP0-1]
CCDS73692.1 [Q7RTP0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001135747.1, NM_001142275.1 [Q7RTP0-2]
NP_653200.2, NM_144599.4 [Q7RTP0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337435; ENSP00000337452; ENSG00000170113 [Q7RTP0-1]
ENST00000437912; ENSP00000393962; ENSG00000170113 [Q7RTP0-2]
ENST00000561183; ENSP00000453722; ENSG00000170113 [Q7RTP0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
123606

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:123606

UCSC genome browser

More...
UCSCi
uc001yvc.4 human [Q7RTP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001020 mRNA Translation: DAA01477.1
CR614719 mRNA No translation available.
AK314073 mRNA Translation: BAG36773.1
BX537997 mRNA Translation: CAD97953.1
BX648722 mRNA Translation: CAI45979.2
CH471258 Genomic DNA Translation: EAW65549.1
AB089319 mRNA Translation: BAC67707.1 Different initiation.
CCDSiCCDS73691.1 [Q7RTP0-1]
CCDS73692.1 [Q7RTP0-2]
RefSeqiNP_001135747.1, NM_001142275.1 [Q7RTP0-2]
NP_653200.2, NM_144599.4 [Q7RTP0-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ7RTP0, 4 interactors
MINTiQ7RTP0
STRINGi9606.ENSP00000337452

Protein family/group databases

TCDBi2.A.7.25.1 the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetiQ7RTP0
PhosphoSitePlusiQ7RTP0

Polymorphism and mutation databases

BioMutaiNIPA1
DMDMi73921215

Proteomic databases

EPDiQ7RTP0
jPOSTiQ7RTP0
MassIVEiQ7RTP0
MaxQBiQ7RTP0
PaxDbiQ7RTP0
PeptideAtlasiQ7RTP0
PRIDEiQ7RTP0
ProteomicsDBi68877 [Q7RTP0-1]
68878 [Q7RTP0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
8965 28 antibodies

The DNASU plasmid repository

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DNASUi
123606

Genome annotation databases

EnsembliENST00000337435; ENSP00000337452; ENSG00000170113 [Q7RTP0-1]
ENST00000437912; ENSP00000393962; ENSG00000170113 [Q7RTP0-2]
ENST00000561183; ENSP00000453722; ENSG00000170113 [Q7RTP0-2]
GeneIDi123606
KEGGihsa:123606
UCSCiuc001yvc.4 human [Q7RTP0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
123606
DisGeNETi123606
EuPathDBiHostDB:ENSG00000170113.15

GeneCards: human genes, protein and diseases

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GeneCardsi
NIPA1
HGNCiHGNC:17043 NIPA1
HPAiENSG00000170113 Tissue enhanced (brain)
MalaCardsiNIPA1
MIMi600363 phenotype
608145 gene
neXtProtiNX_Q7RTP0
OpenTargetsiENSG00000170113
Orphaneti100988 Autosomal dominant spastic paraplegia type 6
PharmGKBiPA134967361

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2922 Eukaryota
ENOG410XNR8 LUCA
GeneTreeiENSGT00940000159067
HOGENOMiCLU_012349_1_1_1
InParanoidiQ7RTP0
KOiK19364
OMAiYLTDVVW
OrthoDBi754939at2759
PhylomeDBiQ7RTP0
TreeFamiTF313214

Enzyme and pathway databases

ReactomeiR-HSA-5223345 Miscellaneous transport and binding events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
123606 3 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NIPA1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NIPA1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
123606
PharosiQ7RTP0 Tbio

Protein Ontology

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PROi
PR:Q7RTP0
RNActiQ7RTP0 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000170113 Expressed in brain and 193 other tissues
ExpressionAtlasiQ7RTP0 baseline and differential
GenevisibleiQ7RTP0 HS

Family and domain databases

InterProiView protein in InterPro
IPR008521 Mg_trans_NIPA
PANTHERiPTHR12570 PTHR12570, 1 hit
PfamiView protein in Pfam
PF05653 Mg_trans_NIPA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNIPA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7RTP0
Secondary accession number(s): B2RA76
, Q5HYA9, Q7KZB0, Q86XW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 15, 2003
Last modified: June 17, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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