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Protein

Receptor protein serine/threonine kinase

Gene

1269509

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:1269509Imported
ORF Names:AgaP_AGAP007729Imported
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componenti: Chromosome 2L

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei171 – 196HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501458860320 – 569Receptor protein serine/threonine kinaseSequence analysisAdd BLAST550

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP007729-PA

Structurei

3D structure databases

ProteinModelPortaliQ7QJY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 261GSInterPro annotationAdd BLAST30
Domaini262 – 550Protein kinaseInterPro annotationAdd BLAST289

Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
HOGENOMiHOG000230587
InParanoidiQ7QJY6
KOiK04675
OMAiLSHNDMI
OrthoDBiEOG091G0BIU
PhylomeDBiQ7QJY6

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF00069 Pkinase, 1 hit
PF08515 TGF_beta_GS, 1 hit
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q7QJY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLARGLVFF VLTLNICKGD LDGKLLDEMD DNDMEIESVQ ENRNLPIHAN
60 70 80 90 100
GILAHPRYKC YSCEPPDCAD TAIHAHYCQN AIQCWKSRTR DPEGNENVQR
110 120 130 140 150
GCTTEHEQLP LYCSQNQKPN TGDSGGPKKR HVSSTGMYNI ECCTGDYCNN
160 170 180 190 200
GSFPELPPMR VSNTEQDADP FALKMAAAIL IPFGTVVLLA VTVIYWMRRA
210 220 230 240 250
HKKRMSACRT KYDAETYYTN DDVLRATSAG DSTLREYLQH SVTSGSGSGL
260 270 280 290 300
PLLIQRTLAK QVSLCECIGR GRYGEVWRGI WHGESVAVKI FFSRDEDSWK
310 320 330 340 350
RETEIYGTVL LRHENILGYV GSDMTSRNSC TQLWLITHYY PQGSLFDYLN
360 370 380 390 400
RTAISTHQMI TICLSIANGM VHLHTEIFGT EGKPAIAHRD LKTKNILIRA
410 420 430 440 450
NGTCVIADFG LAVMHSQTTN KIDIGNTARV GTKRYMAPEV LDESISMECF
460 470 480 490 500
DALRKADIYA IGLIFWEVCR RTISCGIAEE YKVPYFDYVS SDPSFEEMRK
510 520 530 540 550
VVCVDNYRPS VQNRWTSDPF LASMSKLMRE CWHMNPNVRL PALRIKKTLL
560
KLASSDETIK ITPDGEVVV
Length:569
Mass (Da):64,163
Last modified:October 23, 2007 - v4
Checksum:i42268D7BA39243D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008807 Genomic DNA Translation: EAA04704.4
RefSeqiXP_308147.4, XM_308147.4

Genome annotation databases

EnsemblMetazoaiAGAP007729-RA; AGAP007729-PA; AGAP007729
GeneIDi1269509
KEGGiaga:AgaP_AGAP007729
VectorBaseiAGAP007729-RA; AGAP007729-PA; AGAP007729

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008807 Genomic DNA Translation: EAA04704.4
RefSeqiXP_308147.4, XM_308147.4

3D structure databases

ProteinModelPortaliQ7QJY6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7165.AGAP007729-PA

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP007729-RA; AGAP007729-PA; AGAP007729
GeneIDi1269509
KEGGiaga:AgaP_AGAP007729
VectorBaseiAGAP007729-RA; AGAP007729-PA; AGAP007729

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
HOGENOMiHOG000230587
InParanoidiQ7QJY6
KOiK04675
OMAiLSHNDMI
OrthoDBiEOG091G0BIU
PhylomeDBiQ7QJY6

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF00069 Pkinase, 1 hit
PF08515 TGF_beta_GS, 1 hit
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ7QJY6_ANOGA
AccessioniPrimary (citable) accession number: Q7QJY6
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: October 23, 2007
Last modified: June 20, 2018
This is version 132 of the entry and version 4 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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