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Protein

Eukaryotic translation initiation factor 3 subunit E

Gene

eIF3-S6

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit EUniRule annotation
Short name:
eIF3eUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6UniRule annotation
Gene namesi
Name:eIF3-S6
ORF Names:AGAP006944
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componentsi: Chromosome 2L, Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003659601 – 433Eukaryotic translation initiation factor 3 subunit EAdd BLAST433

Proteomic databases

PaxDbiQ7QIL8

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

STRINGi7165.AGAP006944-PA

Structurei

3D structure databases

ProteinModelPortaliQ7QIL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 390PCIPROSITE-ProRule annotationAdd BLAST174

Sequence similaritiesi

Belongs to the eIF-3 subunit E family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2758 Eukaryota
ENOG410XQK5 LUCA
HOGENOMiHOG000036697
InParanoidiQ7QIL8
KOiK03250
OMAiGFFRTQV
OrthoDBiEOG091G075K
PhylomeDBiQ7QIL8

Family and domain databases

HAMAPiMF_03004 eIF3e, 1 hit
InterProiView protein in InterPro
IPR016650 eIF3e
IPR019010 eIF3e_N
IPR000717 PCI_dom
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10317 PTHR10317, 1 hit
PfamiView protein in Pfam
PF09440 eIF3_N, 1 hit
PF01399 PCI, 1 hit
PIRSFiPIRSF016255 eIF3e_su6, 1 hit
SMARTiView protein in SMART
SM01186 eIF3_N, 1 hit
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

Q7QIL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKFDLTAKN CQYLDRHLTF PLLEFLLQKK VFDQTSLLKF ILETVSKTNM
60 70 80 90 100
VDYKHDIRER LAMDKVHPDE LAQGRANVLA TLKELQAEVA PLMKCMEELK
110 120 130 140 150
NPDSTKDSKS VIHALQQTLD YDIILSAQKL AKYLYECGNY NDSLSYLYVC
160 170 180 190 200
MLVMEPNDKN YLGVLWGKLA VEILTLNWQT ALEDLTRLRD FIENYNFSPI
210 220 230 240 250
QVLQQRAWLI HWSVLVFFNH GKGRDLIIDM FLYKPQYLNA IQTMCPHILR
260 270 280 290 300
YLATAVIINR GRRNALKDLI KVIQQESYTY RDPITEFLEH LYVNFDFEGA
310 320 330 340 350
RKKLHECQTV IVNDFFIIGC LTEFVENARL MIFETFCRIH QCITIGMLAD
360 370 380 390 400
KLNMKPDEAE CWIVNLIRNA RLDAKIDSKL GHVVMGTQPL SPYQQLVEKI
410 420 430
DSLSVRSEAL TLLVERKHKA KTQEAGEGHW KYY
Length:433
Mass (Da):50,489
Last modified:December 7, 2004 - v2
Checksum:i675D52209410A7F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008807 Genomic DNA Translation: EAA04727.2
RefSeqiXP_308812.2, XM_308812.4

Genome annotation databases

EnsemblMetazoaiAGAP006944-RA; AGAP006944-PA; AGAP006944
GeneIDi1270140
KEGGiaga:AgaP_AGAP006944
VectorBaseiAGAP006944-RA; AGAP006944-PA; AGAP006944

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008807 Genomic DNA Translation: EAA04727.2
RefSeqiXP_308812.2, XM_308812.4

3D structure databases

ProteinModelPortaliQ7QIL8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7165.AGAP006944-PA

Proteomic databases

PaxDbiQ7QIL8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP006944-RA; AGAP006944-PA; AGAP006944
GeneIDi1270140
KEGGiaga:AgaP_AGAP006944
VectorBaseiAGAP006944-RA; AGAP006944-PA; AGAP006944

Organism-specific databases

CTDi1270140

Phylogenomic databases

eggNOGiKOG2758 Eukaryota
ENOG410XQK5 LUCA
HOGENOMiHOG000036697
InParanoidiQ7QIL8
KOiK03250
OMAiGFFRTQV
OrthoDBiEOG091G075K
PhylomeDBiQ7QIL8

Family and domain databases

HAMAPiMF_03004 eIF3e, 1 hit
InterProiView protein in InterPro
IPR016650 eIF3e
IPR019010 eIF3e_N
IPR000717 PCI_dom
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10317 PTHR10317, 1 hit
PfamiView protein in Pfam
PF09440 eIF3_N, 1 hit
PF01399 PCI, 1 hit
PIRSFiPIRSF016255 eIF3e_su6, 1 hit
SMARTiView protein in SMART
SM01186 eIF3_N, 1 hit
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEIF3E_ANOGA
AccessioniPrimary (citable) accession number: Q7QIL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: December 7, 2004
Last modified: October 10, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families
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