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Protein
Submitted name:

AGAP011336-PA

Gene

AgaP_AGAP011336

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AGAP011336-PAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AgaP_AGAP011336Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnopheles gambiae (African malaria mosquito)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7165 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007062 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei367 – 383HelicalSequence analysisAdd BLAST17
Transmembranei395 – 424HelicalSequence analysisAdd BLAST30
Transmembranei430 – 451HelicalSequence analysisAdd BLAST22
Transmembranei478 – 496HelicalSequence analysisAdd BLAST19
Transmembranei815 – 837HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7QHS6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7165.AGAP011336-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini366 – 524SSDInterPro annotationAdd BLAST159
Domaini875 – 914WD_REPEATS_REGIONInterPro annotationAdd BLAST40
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati875 – 914WDPROSITE-ProRule annotationAdd BLAST40
Domaini1069 – 1230WD_REPEATS_REGIONInterPro annotationAdd BLAST162
Repeati1109 – 1151WDPROSITE-ProRule annotationAdd BLAST43
Repeati1152 – 1191WDPROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis, WD repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1933 Eukaryota
ENOG410XR54 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230538

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7QHS6

Identification of Orthologs from Complete Genome Data

More...
OMAi
PIVADKC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G04AA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7QHS6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030225 SCAP
IPR000731 SSD
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10796:SF127 PTHR10796:SF127, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12349 Sterol-sensing, 1 hit
PF00400 WD40, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156 SSD, 1 hit
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q7QHS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AASGFTQHPS LGPATMKPPP RPTATTAGAR GPPKPPSDRS KGAGGSTGGT
60 70 80 90 100
TLPSRVSQIY YKHGLFLSSY PTTATSFALA IIIFCCYPLL NIPLPGTIPT
110 120 130 140 150
KVIFPYTESI SENLHLSNAN LTSEFYNPFS FSGGNMFNIY NISVETPFPW
160 170 180 190 200
ARIDPLLYVQ QIIMRTSVVP WEEDLLLTDA FRAPLYEVFK LLEIIRNHED
210 220 230 240 250
QSKTMLSHLC LHVENVKRSS QQTLFPEYNC LLLSPANLWQ QNMQNFNKDS
260 270 280 290 300
NLLNTVYVNH NLQKSKVSTA EMLFGIPLRD TGVKRYPMRV RPRIIQYAVT
310 320 330 340 350
LILRENNPAF IESLKQKLTR AYPLHQKEPS TDASGGVPAQ PEAPSAPKQQ
360 370 380 390 400
QSIMYIFYPG EFNWKEVLPQ CIAFCVLFIY VYFSVRKIEA IRSRIMLASC
410 420 430 440 450
AVLTVLGSLL MSLGLCFFFG LTISFQSKGV YPYLVILVGL ENVLVITKSV
460 470 480 490 500
LTTDNNLDVK IRVAQGLSRE GWSITKNLLT EITILTGGLA TFVPVIQEFC
510 520 530 540 550
IFAMVGLVSD FLLQMLFFAT VLALDIKRVE YSAEVRRLPK MLYFNNELRR
560 570 580 590 600
GTGTAAGQTN GPAREVRNGG GSINRSRSHP KLTGLEQAAS HPKTGPGSGK
610 620 630 640 650
DVKIPKRLRI VNFWARTRFF QRGFMIWMVL WISNIIYNAG LIEELFVIDK
660 670 680 690 700
NLTGHERLPT EATLEMDRLN YHKNLPDAGM LRGGGGGGGV ASDKAGTVEH
710 720 730 740 750
RALNVSEQLQ RLKHPDYETV YQLSNFHWSS ILKQYNVSLS GRYVTVLPAI
760 770 780 790 800
KLSHAVSPAT AIQLRNADEK APHHFQWKAL AVALDPLDFS DADTGDGSHV
810 820 830 840 850
PIGNAPFYPK TPMEILLTCM LLVVSTFVVT YTMIVLYRCV CTRNYAEWRA
860 870 880 890 900
SWQESDSETE PKPEQCLLEG VPVQVDGHVH RIECLVTDGN MVASSCLQGQ
910 920 930 940 950
VKVWDVSNGE LLAEIDRLHY FELQQHRGSS APKQQQHHVS PIWCLDFLDN
960 970 980 990 1000
LIVIGCADGR LEFWEGSSGS FKCIHDAEHS HNNGVTNIKL TGDRVIAARL
1010 1020 1030 1040 1050
SGRIDFFRLE TYNQGRQIDW GFTSAYRRTH MRTGSAGSLG SLQAAMAASS
1060 1070 1080 1090 1100
GPGSHSASEE LRCLLEFQQQ GHQQPVTCLE VAGNTVMTGS QDHTLKVYRA
1110 1120 1130 1140 1150
DSHVMLYTLH GHCGPITCLF IDQWQSGMAG SGSQDGLLCV WDLTTGACMY
1160 1170 1180 1190 1200
KIQAHDDSIV ALVGSPSYVI SLGLDERIRV WDRFQGHPLN TITVSHAYSA
1210 1220 1230 1240 1250
LVMLTPSLLV TGKPGALVVW DARSGEVARE VKLDCSNMQL CPKIMLPACG
1260 1270
SVICDYGNQM RIVRFPLVAA DKCD
Length:1,274
Mass (Da):141,448
Last modified:October 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F7AE31269EEE7A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAAB01008816 Genomic DNA Translation: EAA05048.4

NCBI Reference Sequences

More...
RefSeqi
XP_309314.4, XM_309314.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1270602

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
aga:AgaP_AGAP011336

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008816 Genomic DNA Translation: EAA05048.4
RefSeqiXP_309314.4, XM_309314.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7165.AGAP011336-PA

Proteomic databases

PaxDbiQ7QHS6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1270602
KEGGiaga:AgaP_AGAP011336

Phylogenomic databases

eggNOGiKOG1933 Eukaryota
ENOG410XR54 LUCA
HOGENOMiHOG000230538
InParanoidiQ7QHS6
OMAiPIVADKC
OrthoDBiEOG091G04AA
PhylomeDBiQ7QHS6

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR030225 SCAP
IPR000731 SSD
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10796:SF127 PTHR10796:SF127, 1 hit
PfamiView protein in Pfam
PF12349 Sterol-sensing, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7QHS6_ANOGA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7QHS6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: October 23, 2007
Last modified: November 7, 2018
This is version 114 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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