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Protein

General transcription factor IIH subunit 4

Gene

1270972

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4UniRule annotation
Gene namesi
Name:1270972Imported
ORF Names:AgaP_AGAP010984Imported
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componenti: Chromosome 3L

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP010984-PA

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3471 Eukaryota
COG5144 LUCA
HOGENOMiHOG000170529
InParanoidiQ7QH12
KOiK03144
OMAiYLEQYAH
OrthoDBiEOG091G06YE
PhylomeDBiQ7QH12

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7QH12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEAKSSQGN SGTTSKGSSS SGSSLITKPA NLECKDLEEY LKSRPPEVLE
60 70 80 90 100
KLYNYPAICL AVYRELPEIA RQFVIRILFV EQPIPQAVVS SWATQVYAKE
110 120 130 140 150
NTSVSQVLTE LGVWRSAAYP GGLAAWELCP TFKKNLKIAL LGGGRPWSMS
160 170 180 190 200
NALDPDQKSR DIDFLDTYAM SRWRCVLHYM VGAGSSKGME GEGISPDAVR
210 220 230 240 250
ILLHANLMKR DESDGSPVIT RQGFQFLLLD TQAQVWHFML QYLDTCEARG
260 270 280 290 300
LNLPECLSML FQLSFSTLGR DYSSEGLSPG LLTFLQHLRE FGLVYQRKRK
310 320 330 340 350
EGRFYPTRLA HNITSKNATH ATTLAQDQES NATKDKGYII VETNYRVYAY
360 370 380 390 400
TDSNLQVALL GLFTELLYRF PNLVVGVLSR DSVRQAFRGG ITAEQIISYL
410 420 430 440 450
EQHAHPTMLT VEQAINSKSS LPPTVVDQIK LWENERNRFT YTEGVVYNQF
460 470 480 490 500
LSQADFITLR DYAQSIGVMI WQNERIRTMV VTKNGHDDVK KFWKRYSKGG

S
Length:501
Mass (Da):56,520
Last modified:December 15, 2003 - v1
Checksum:i94AA4F976D5C3E2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008823 Genomic DNA Translation: EAA05440.1
RefSeqiXP_309710.1, XM_309710.3

Genome annotation databases

EnsemblMetazoaiAGAP010984-RA; AGAP010984-PA; AGAP010984
GeneIDi1270972
KEGGiaga:AgaP_AGAP010984
VectorBaseiAGAP010984-RA; AGAP010984-PA; AGAP010984

Similar proteinsi

Entry informationi

Entry nameiQ7QH12_ANOGA
AccessioniPrimary (citable) accession number: Q7QH12
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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