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Entry version 106 (16 Oct 2019)
Sequence version 5 (27 Jul 2011)
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Protein
Submitted name:

AGAP000178-PA

Gene

1272086

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AGAP000178-PAImported
Submitted name:
Splicing factor 3B subunit 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:1272086Imported
ORF Names:AgaP_AGAP000178Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnopheles gambiae (African malaria mosquito)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7165 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007062 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7165.AGAP000178-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini892 – 1132TOGInterPro annotationAdd BLAST241

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni116 – 153DisorderedSequence analysisAdd BLAST38
Regioni179 – 204DisorderedSequence analysisAdd BLAST26
Regioni220 – 365DisorderedSequence analysisAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 35Sequence analysisAdd BLAST35
Coiled coili870 – 890Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi116 – 135PolyampholyteSequence analysisAdd BLAST20
Compositional biasi230 – 244PolyampholyteSequence analysisAdd BLAST15
Compositional biasi278 – 304PolyampholyteSequence analysisAdd BLAST27
Compositional biasi335 – 365PolarSequence analysisAdd BLAST31

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0213 Eukaryota
COG5181 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000166737

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7QEW2

KEGG Orthology (KO)

More...
KOi
K12828

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSRWDAT

Database of Orthologous Groups

More...
OrthoDBi
245208at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7QEW2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR015016 SF3b_su1
IPR038737 SF3b_su1-like
IPR034085 TOG

The PANTHER Classification System

More...
PANTHERi
PTHR12097 PTHR12097, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08920 SF3b1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01349 TOG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7QEW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENIARTHED IESHIRDLQA KKKELNAEAA KDKGVGLADR GYFDIDLYDG
60 70 80 90 100
GDTNSKYEGY VTSIAPNDDI DDEEDEGLPI GRNNRPMGYT APAALLNEMG
110 120 130 140 150
QGEDYDPFAE RRKPTVAEKE DEYRQKRRRL VISPERVDPF ADGGKTPDVG
160 170 180 190 200
SRSYTEIMRE QMLKGEEAEL RKKIQEKAKD GSLKINSTAQ AAKPAPVEAK
210 220 230 240 250
KRGRWDQAVD EQFVAPKKLA VPATPSWDAE KTPADHRWDE TPGHKGSETP
260 270 280 290 300
GATPNVRIWD ATPAHVSGAA TTPGRETPAE KSTRRNRWDE TPKTERETPG
310 320 330 340 350
HSWAETPRAD RVSGDGVLLE GTTPASKRRS RWDETPSNAT PSAMTPSIAM
360 370 380 390 400
TPTPHGTTTP GHATPLLTPG GTTPIGHKAM AMATPTPGHL ASMTPEQLQA
410 420 430 440 450
YRWEKEIDER NRPFTDEELD VMFPPGYKIL PPPAGYIPIR TPARKLTATP
460 470 480 490 500
TPIAGTPAAF FIQTEDKSAK FVDNQPKGNL PFMKPEDAQY FDKLLVEVDE
510 520 530 540 550
DALSPEEQKE RKIMKLLLKI KNGTPPMRKA ALRQITDKSR EFGAGPLFNQ
560 570 580 590 600
ILPLLMSPTL EDQERHLLVK VIDRILYKLD DLVRPYVHKI LVVIEPLLID
610 620 630 640 650
EDYYARVEGR EIISNLAKAA GLATMISTMR PDIDNIDEYV RNTTARAFAV
660 670 680 690 700
VASALGIPSL LPFLKAVCKS KKSWQARHTG IKIVQQIAIL MGCAILPHLK
710 720 730 740 750
SLVEIIEHGL VDEQQKVRTI TALALAALAE AATPYGIESF DSVLKPLWKG
760 770 780 790 800
IRTHRGKGLA AFLKAIGYLI PLMDAEYANY YTREVMLILI REFQSPDEEM
810 820 830 840 850
KKIVLKVVKQ CCATDGVEAQ YIKEEILPHF FKHFWNHRMA LDRRNYRQLV
860 870 880 890 900
DTTVEIANKV GASEIVNRVV DDLKDENEQY RKMVMETIEK IMANLGAADI
910 920 930 940 950
DSRLEEQLID GILYAFQEQT TEDVVMLNGF GTIVNQLSKR VKPYLPQICG
960 970 980 990 1000
TILWRLNNKS AKVRQQAADL ISRIAVVMKT CQEEKLMGHL GVVLYEYLGE
1010 1020 1030 1040 1050
EYPEVLGSIL GALKAIVNVI GMTKMTPPIK DLLPRLTPIL KNRHEKVQEN
1060 1070 1080 1090 1100
CIDLVGRIAD RGPEYVSARE WMRICFELLE LLKAHKKAIR RATVNTFGYI
1110 1120 1130 1140 1150
AKAIGPHDVL ATLLNNLKVQ ERQNRVCTTV AIAIVAETCR PFTVLPALMN
1160 1170 1180 1190 1200
EYRVPELNVQ NGVLKSLSFL FEYIGEMGKD YIYAVCPLLE DALMDRDLVH
1210 1220 1230 1240 1250
RQTACAAIKH MALGVYGFGC EDALIHLLNY VWPNIFETSP HLVQAFMDAV
1260 1270 1280 1290 1300
EGLRVALGPI KILQYTLQGL FHPARKVRDV YWKIYNSLYI GAQDALIVGY
1310 1320
PRITNDPKNQ YIRYELEYNL
Length:1,320
Mass (Da):148,249
Last modified:July 27, 2011 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED3E1AE646247559
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAAB01008846 Genomic DNA Translation: EAA06480.5

NCBI Reference Sequences

More...
RefSeqi
XP_310958.5, XM_310958.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
AGAP000178-RA; AGAP000178-PA; AGAP000178

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1272086

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
aga:AgaP_AGAP000178

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...
VectorBasei
AGAP000178-RA; AGAP000178-PA; AGAP000178

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008846 Genomic DNA Translation: EAA06480.5
RefSeqiXP_310958.5, XM_310958.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7165.AGAP000178-PA

Genome annotation databases

EnsemblMetazoaiAGAP000178-RA; AGAP000178-PA; AGAP000178
GeneIDi1272086
KEGGiaga:AgaP_AGAP000178
VectorBaseiAGAP000178-RA; AGAP000178-PA; AGAP000178

Phylogenomic databases

eggNOGiKOG0213 Eukaryota
COG5181 LUCA
HOGENOMiHOG000166737
InParanoidiQ7QEW2
KOiK12828
OMAiRSRWDAT
OrthoDBi245208at2759
PhylomeDBiQ7QEW2

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR015016 SF3b_su1
IPR038737 SF3b_su1-like
IPR034085 TOG
PANTHERiPTHR12097 PTHR12097, 1 hit
PfamiView protein in Pfam
PF08920 SF3b1, 1 hit
SMARTiView protein in SMART
SM01349 TOG, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7QEW2_ANOGA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7QEW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 106 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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