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Entry version 126 (16 Oct 2019)
Sequence version 2 (07 Dec 2004)
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Protein
Submitted name:

AGAP002836-PA

Gene

AgaP_AGAP002836

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AGAP002836-PAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AgaP_AGAP002836Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnopheles gambiae (African malaria mosquito)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7165 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007062 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni97 – 116DisorderedSequence analysisAdd BLAST20
Regioni276 – 308DisorderedSequence analysisAdd BLAST33
Regioni1220 – 1386DisorderedSequence analysisAdd BLAST167
Regioni1810 – 1850DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1233 – 1256PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1263 – 1281PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1317 – 1333PolarSequence analysisAdd BLAST17
Compositional biasi1359 – 1386PolarSequence analysisAdd BLAST28
Compositional biasi1821 – 1842AcidicSequence analysisAdd BLAST22

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0701 Eukaryota
COG0571 LUCA

Database of Orthologous Groups

More...
OrthoDBi
1337630at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00048 DSRM, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 1 hit
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00358 DSRM, 1 hit
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7QCW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLFHWTDGN IHTTALTPRD YQTELLATAR EENLIVCIAH NSAKEFLAVK
60 70 80 90 100
LIQSMRTNRW SSHPEAPGKA IYLTRMDRSL LSSMVSNLTD LQVANVDDVE
110 120 130 140 150
DSEGSHEPDG ASNTPVTDVA SADVLFFGSE TTLLQYIEQG TVRVQDISLL
160 170 180 190 200
IVDECHKNYG RQELWEICAR LTHQAPSSDR PAQRTRILGL AGPLHGAGCT
210 220 230 240 250
PERLCWELHY LERCLRARIE TASDITSVLR FSTKPTELIL ECIPPKPSNL
260 270 280 290 300
TQLLRMLIQR QIAFLKQHRY EPLAVYGLDG NDSASDKPDT DGEPEKDEEN
310 320 330 340 350
DDLRRELKSI PDPTVGPLSY LKQYLELLDE FGPWGADRGA LELLTTIDQE
360 370 380 390 400
KVKVPYDRHF LLFCMVYTTL LQARATVASV FAQHDTELER IKRYSTPKVR
410 420 430 440 450
RLLEVLAWFG EQRNRPKDRN QPATLHHHQQ VHNQQRILYC FCRNVECKEL
460 470 480 490 500
EKSYHTFGAQ IADVDERIKQ LDGLLASVRK RTERLNLKHK VVDNAAAEGG
510 520 530 540 550
GTLGVQSPRH GHESRANNFR RKRFAGGGHS HHRSNDTTDA LCGLIFCNNR
560 570 580 590 600
AMARILYVLL YEVSRSQREF EFISPQYTVD KVATNPQNCL KQTTIEHRKQ
610 620 630 640 650
EEVLKRFRMH ECNLLIGTSV LEEGIELPKC NLVIRWNSPA NYRSYAQCKG
660 670 680 690 700
RAKAPGAYHV LFVTPENAAS RNEQQEDMAS IEDVSLDGMI PEGPKDDNTR
710 720 730 740 750
ETIDDQDRRM IETATDAMIE QVAIYREVEK LLLAKCRNGE PPDWELKHAD
760 770 780 790 800
CFNHCLEVYR PSSGGAVALQ SNGTCASLWL GNAIQTLNKY CAKLPSDTFT
810 820 830 840 850
KLTPIWRCAT TVRKGRKLYQ YTIRLPINSP WKEDILIASV FNECRPDAET
860 870 880 890 900
VAYLYHIRME LICPIPEEQN TRGRKIYAPE ESAQGFGILT TKLIPKISSF
910 920 930 940 950
PIFTRSGEVK VSLDLCPQRV KLSAHQLEMV NCFVKYTFTK VLRLQKSLML
960 970 980 990 1000
YDANATENCF FIVPTVKQAV AGAAGKDEPP LQSDDVMVDW EFVEKIATNV
1010 1020 1030 1040 1050
HRSGPTFIPD EARKGYTFDV GKFRDAVVMP WYRNRDQPQY FYVAEICNHL
1060 1070 1080 1090 1100
SPKSTFPGSN YATFEEYYHR KYKIHIQNQR QPLLDVDHTS ARLNFLTPRY
1110 1120 1130 1140 1150
VNRKGVALPT SSEETKRAKR ENLEQKQILV PELCTIHPFP ASLWRAAVCL
1160 1170 1180 1190 1200
PCVLYRINAL LLADEIRRQV ARDLRLGWEN VDELQEGQFQ WPMLSFGWNL
1210 1220 1230 1240 1250
ADVLRKTKEQ KIAQAQEAID ASAPEVEDEV ELDKEAPNVR DAAEVDEEDG
1260 1270 1280 1290 1300
LKMENGVIAE VEKSQVDGED DTGDKKTDSD GTLLEIGTWS NEMAVGVGTD
1310 1320 1330 1340 1350
NDMGEEGRRG ASSPSFLRYD SDCSSNSSAN FYSSDEYDEE DDYYLYDGSE
1360 1370 1380 1390 1400
KPKNAIEPSQ EAVSGTDNAN DSGDKPGSRN RTITQSQDTV VNLGGRLKIE
1410 1420 1430 1440 1450
FKSETDAEAI DSECDLQRQR TQQSIIERSR QNDMLYQSSK NAVDGFCYSP
1460 1470 1480 1490 1500
SDRQCAEERE QAEQRFERQK NHTKDTIRQQ GSLVRWNEPL SVSHWRSKLD
1510 1520 1530 1540 1550
ESEAATLGAL MDDLGGQPFT ELVPYVEPEQ LFELLVRNGS SGERWLRLHD
1560 1570 1580 1590 1600
LYCLNRPFFP ERYTIFRGGS QFDNFLDESC QEGEGASSPP KVIELTICDP
1610 1620 1630 1640 1650
FPAIAAGQMA CNYKPKQHSM RSDEANKNGH DSAGVLSTTD EAGGVDYFSF
1660 1670 1680 1690 1700
DYQPDLSQHP GPSPAIILQA LTMSNANDGI NLERLETIGD SFLKYAITTY
1710 1720 1730 1740 1750
LYCRYDNVHE GKLSHLRSKQ VSNLNLYRLG RRKRLGDCMI AAKFEPHDNW
1760 1770 1780 1790 1800
LPPCYYVPKE LEQTLIDAKI PACHWNLADL PDIKRLSCAE ICQLVKERAR
1810 1820 1830 1840 1850
AKRREDVDRF DLQHADSNGG EDGNEDDDDD DDDDEDDTTT GEGNEHEADN
1860 1870 1880 1890 1900
GSCYIPYNLV TQHSIPDKSV ADCVEALIGA YLIECGPRGA LLFMAWLGIR
1910 1920 1930 1940 1950
VLPIREPPVK LNSNNETALT PYKATGQNDG PLSTGVTIAE YGHWVAPPSP
1960 1970 1980 1990 2000
MVRANITFGG IETGAAATSR ELARLLQGFE EFEQALGYRF RDRSYLLQAM
2010 2020 2030 2040 2050
THASYSPNRL TDCYQRLEFL GDAILDYLIT RHLYEDRRQH SPGALTDLRS
2060 2070 2080 2090 2100
ALVNNTIFAS LAVRHGFHKY FLHLSPGLQE VIDRFVRIQQ ENGHRITEEE
2110 2120 2130 2140 2150
YYLPDEDDEL GEYGAMGEDG PGEGRGVGEA EDVEVPKALG DVFESIAGAI
2160 2170 2180 2190 2200
FLDSDMSLDT VWKVYRKMMG PEIEKFSSSV PKSPIRELLE MEPETAKFGK
2210 2220 2230 2240 2250
PEKLTDGRRV RVTVEVFGKG TFRGIGRNYR IAKCTAAKCA LRQLKKLGYA

NHHKRR
Length:2,256
Mass (Da):255,312
Last modified:December 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDCDEB6E47419140A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5HKK5F5HKK5_ANOGA
AGAP002836-PB
1273124 AgaP_AGAP002836
2,336Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAAB01008859 Genomic DNA Translation: EAA07793.2

NCBI Reference Sequences

More...
RefSeqi
XP_312076.2, XM_312076.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
AGAP002836-RA; AGAP002836-PA; AGAP002836

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1273124

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008859 Genomic DNA Translation: EAA07793.2
RefSeqiXP_312076.2, XM_312076.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiAGAP002836-RA; AGAP002836-PA; AGAP002836
GeneIDi1273124

Phylogenomic databases

eggNOGiKOG0701 Eukaryota
COG0571 LUCA
OrthoDBi1337630at2759

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 1 hit
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7QCW7_ANOGA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7QCW7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 7, 2004
Last modified: October 16, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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