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Entry version 122 (05 Jun 2019)
Sequence version 4 (23 Oct 2007)
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Protein
Submitted name:

AGAP006055-PA

Gene

AgaP_AGAP006055

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AGAP006055-PAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AgaP_AGAP006055Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnopheles gambiae (African malaria mosquito)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7165 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007062 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7165.AGAP006055-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni701 – 795DisorderedSequence analysisAdd BLAST95
Regioni811 – 834DisorderedSequence analysisAdd BLAST24
Regioni869 – 965DisorderedSequence analysisAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi709 – 754PolarSequence analysisAdd BLAST46
Compositional biasi759 – 791PolyampholyteSequence analysisAdd BLAST33
Compositional biasi869 – 885PolarSequence analysisAdd BLAST17
Compositional biasi925 – 965PolarSequence analysisAdd BLAST41

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
COG0666 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043818

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Q642

KEGG Orthology (KO)

More...
KOi
K09257

Identification of Orthologs from Complete Genome Data

More...
OMAi
TWLNIAD

Database of Orthologous Groups

More...
OrthoDBi
56880at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Q642

Family and domain databases

Conserved Domains Database

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CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits
1.25.40.20, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF13516 LRR_6, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits
SM00367 LRR_CC, 2 hits
SM00028 TPR, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF48452 SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7Q642-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEYREQKLLK KKVKYANEDN YGALAETCLL LGELYKDREE HQRALNEYKL
60 70 80 90 100
AAKAYEKLHK PMDRGLAFRM VGEMHCTLGQ FKEALTNVHA YMRAAQREGN
110 120 130 140 150
TKALQEAHTT VGRVYLARAE SNQRLGKPAE SETDLAEAEK SFRTALSICD
160 170 180 190 200
ELKRVLSKTE LINMQARAHL NLGLTFDYQN KPDRAKEQMD RAIRLAKEAD
210 220 230 240 250
LFELLYTCYN AMALCSSRCE INPAPGDGGE HCGQTLRLLN LSLEVASRLP
260 270 280 290 300
SRAAKMCQTL ALMATFFLRM DDFQSARQAL KRAYRLKTPV AGDAKRIARK
310 320 330 340 350
LKVLVAMCRM EDELITTDAT NYARRKELYE RMGDGACKLR NFTKAIDYYK
360 370 380 390 400
RMLECAEANG EADRQLLPCY VSLYQTYIDN RQYEQALEYL WKEHSIIAHE
410 420 430 440 450
PQEAYHTLMK IAKLYERQKQ SFFTIQTVYL QAKDEGKKLN SIELQREAIA
460 470 480 490 500
EGIELSSTVE PDSEELPDAN QSLDLADYDV DEEEEEAADA EHDTPDVGDE
510 520 530 540 550
IDLEVDLSDE SDGDPALTIG EDLNNASAAD TSLKGRKRGK RFTVRRNKKG
560 570 580 590 600
ETQLHQAAIS GNKTLAEQLL QLGHPVNERD YAGWLPLHEA CIHGHAEIVA
610 620 630 640 650
LLLDRGAHIN DKGGTSCEGI TPLHDACRNG HLSVITVLLD RGANATLRND
660 670 680 690 700
YGETALSMLD GWYEKLKAPL MSAETKQYND VRERLVAQFN AAAITVSPPA
710 720 730 740 750
ALKPTSTVGR GTRRHTSNGD LEASIPPSAI SPSRSSRLTP ATSTNSSGYV
760 770 780 790 800
SEVGGSSRHR NVIYDDENDH YSSAEDSPSE EDREHRAVIK RKSTSAGVSE
810 820 830 840 850
YLSVMKAMRK NHLADEPKAP TASAQKKRPA CRYYDEEDEK DDWLIDDMKQ
860 870 880 890 900
SAKKSRVIRD LQRTALVGGS LERSKSSSSL PATSRTVELG GDPTARLNSL
910 920 930 940 950
LDSDDDDPFE VEPDSHDKRS QQENGKEGSA FNVLMNNSAK SFRRTQSRRN
960 970 980 990 1000
SNESRSLYGR RSSTHQTSLL EAGFQRVASP SLEEKENLLP KAAGTTCSPA
1010 1020 1030 1040 1050
RTPIKQTGEC RTQPSLRDAT QKCTIQVRLD NGEVYRVSYD EKLIFTTQTV
1060 1070 1080 1090 1100
GWLRKAVAKQ YAMNHGKRPI IDLKPAEGCI VNSFFDSDTL NVVLQSASTD
1110 1120 1130 1140 1150
GVLQMHGQIT GWEHIDLEEY YEEYCEQHKL ETDKDLRKRL ITMNRNKIIT
1160 1170 1180 1190 1200
IEPDFAQTVP ATPVPPKHVL SMVLTVAFFQ QDWMNHLDLS MNGITDDDVG
1210 1220 1230 1240 1250
TLVLYLPACR QLRVLRLRMN LLTSRSVEML CFGCKSPSDG TSAAATATAP
1260 1270 1280 1290 1300
LGGGQLTELD LSHNPLQDAA LVPLARLCSN LPLLRVLRIR STDVTHFSTT
1310 1320 1330 1340 1350
DAPCIDVSRL ETFDISENKL TERSVACLLQ QLGDGVLREA YFRSLPVHCD
1360 1370 1380 1390 1400
NFKPKLWQTL TERQRLDGMR VLSLTNCRLS DDELEGSLFP ALGPNCPALT
1410 1420 1430 1440 1450
QLDLSYNVAL TKRSFVALLR CCAGAVFRLE EVRFDHDVQL WVDLETDESI
1460 1470 1480 1490 1500
RSMEHSPTGR YPQQIHAILP VHGYDEQRYA KLLAVIEQLW RSLWPAGQSY
1510
TRRHEGNGLQ VTLSTDPVG
Length:1,519
Mass (Da):170,386
Last modified:October 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC54DCE1D0E0FB2C5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAAB01008960 Genomic DNA Translation: EAA11011.4

NCBI Reference Sequences

More...
RefSeqi
XP_316104.4, XM_316104.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
AGAP006055-RA; AGAP006055-PA; AGAP006055

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1276726

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
aga:AgaP_AGAP006055

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008960 Genomic DNA Translation: EAA11011.4
RefSeqiXP_316104.4, XM_316104.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7165.AGAP006055-PA

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP006055-RA; AGAP006055-PA; AGAP006055
GeneIDi1276726
KEGGiaga:AgaP_AGAP006055

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
HOGENOMiHOG000043818
InParanoidiQ7Q642
KOiK09257
OMAiTWLNIAD
OrthoDBi56880at2759
PhylomeDBiQ7Q642

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.10, 3 hits
1.25.40.20, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF13516 LRR_6, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00367 LRR_CC, 2 hits
SM00028 TPR, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7Q642_ANOGA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Q642
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: October 23, 2007
Last modified: June 5, 2019
This is version 122 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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