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UniProtKB - Q7Q408 (Q7Q408_ANOGA)

Entry version 123 (02 Dec 2020)
Sequence version 4 (23 Oct 2007)
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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

AgaP_AGAP008136

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, RNA-bindingPROSITE-ProRule annotationARBA annotation, RotamaseUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
PPIaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AgaP_AGAP008136Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnopheles gambiae (African malaria mosquito)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7165 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicoidea › Culicidae › Anophelinae › Anopheles ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007062 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7165.AGAP008136-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 161PPIase cyclophilin-typeInterPro annotationAdd BLAST156
Domaini240 – 318RRMInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni165 – 189DisorderedSequence analysisAdd BLAST25
Regioni342 – 676DisorderedSequence analysisAdd BLAST335

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi352 – 399BasicSequence analysisAdd BLAST48
Compositional biasi400 – 416PolyampholyteSequence analysisAdd BLAST17
Compositional biasi417 – 436PolarSequence analysisAdd BLAST20
Compositional biasi498 – 515BasicSequence analysisAdd BLAST18
Compositional biasi516 – 546PolyampholyteSequence analysisAdd BLAST31
Compositional biasi555 – 582PolyampholyteSequence analysisAdd BLAST28
Compositional biasi595 – 610PolyampholyteSequence analysisAdd BLAST16
Compositional biasi611 – 625PolarSequence analysisAdd BLAST15
Compositional biasi632 – 648BasicSequence analysisAdd BLAST17
Compositional biasi649 – 663PolyampholyteSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0415, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018791_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Q408

Database of Orthologous Groups

More...OrthoDBi		1392223at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Q408

Family and domain databases

Conserved Domains Database

More...CDDi		cd01921, cyclophilin_RRM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.100.10, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035542, CRIP
IPR029000, Cyclophilin-like_dom_sf
IPR002130, Cyclophilin-type_PPIase_dom
IPR035538, Cyclophilin_PPIL4
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom

The PANTHER Classification System

More...PANTHERi		PTHR45843, PTHR45843, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00160, Pro_isomerase, 1 hit
PF00076, RRM_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00153, CSAPPISMRASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50891, SSF50891, 1 hit
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50072, CSA_PPIASE_2, 1 hit
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7Q408-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVVIETTIG DITVDLFLKE RPRAALNFLK LCKLKYYNYN LFHTIQSDFI 
        60         70         80         90        100
AQTGDPTGAG DGGSSVWGIL EGAEKRYFEG ESVPKIKHSE PGLLSMVNAG 
       110        120        130        140        150
EHLIGSQFFF TLGPDLTSLD GRHTVIGEVT EGHEVLRKLN EVICDDRHRP 
       160        170        180        190        200
YKDVRITHTV VLDDPFEDPR GFREPSRSPS PSAERLQGGR IAADEEIDDL 
       210        220        230        240        250
GGKTEQEIAE MIAEREAKAR ATILEIVGDI PDADIAPPEN VLFVCKLNPV 
       260        270        280        290        300
TTDDDLQIIF SRFGKIVGCE VIRDKLTGDS LQYAFIEFEN QKSCEDAYFK 
       310        320        330        340        350
MDNVLIDDRR IHVDFSQSVS KIKWRGKGRG IEFKDGADKR SFKDYDRSRS 
       360        370        380        390        400
RSRSRSRSKS RSKSRSQSRS RSRSRSRSRS RSRSGSRSRA RKVDRRQRSR 
       410        420        430        440        450
SRDHMRDRDR NRPPGRNAQE SNRGRKPNLT ERNSAYMEQR NGRDIRINQG 
       460        470        480        490        500
MVDYKNRPYP NSFVQRNGPR DKNAPRGGGR SSRGALHWSD PLPPRRRSRS 
       510        520        530        540        550
RDRRTRRSRS RSRSRDRRHS PPDRHAGSQR MHSREDRDRR QHYGERSARS 
       560        570        580        590        600
PSYSRQSRAD KEYGRGEPAK QDRSRPEAKP VKRRSSSSGS SRSGSSEPKE 
       610        620        630        640        650
KRKRRSPSPD SVDSDSSSTS SSSSASDERA KKRKKKASKK KSKSSSKSSK 
       660        670 
KRKDSVSSDE GKHRKKSKGK KKKKKH
Length:676
Mass (Da):77,177
Last modified:October 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i420705A7DAF51C36
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAAB01008964 Genomic DNA Translation: EAA12690.4

NCBI Reference Sequences

More...RefSeqi		XP_317325.4, XM_317325.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1277821

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		aga:AgaP_AGAP008136

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...VectorBasei		AGAP008136-RA; AGAP008136-PA; AGAP008136

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008964 Genomic DNA Translation: EAA12690.4
RefSeqiXP_317325.4, XM_317325.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7165.AGAP008136-PA

Genome annotation databases

GeneIDi1277821
KEGGiaga:AgaP_AGAP008136
VectorBaseiAGAP008136-RA; AGAP008136-PA; AGAP008136

Phylogenomic databases

eggNOGiKOG0415, Eukaryota
HOGENOMiCLU_018791_3_1_1
InParanoidiQ7Q408
OrthoDBi1392223at2759
PhylomeDBiQ7Q408

Family and domain databases

CDDicd01921, cyclophilin_RRM, 1 hit
Gene3Di2.40.100.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR035542, CRIP
IPR029000, Cyclophilin-like_dom_sf
IPR002130, Cyclophilin-type_PPIase_dom
IPR035538, Cyclophilin_PPIL4
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
PANTHERiPTHR45843, PTHR45843, 1 hit
PfamiView protein in Pfam
PF00160, Pro_isomerase, 1 hit
PF00076, RRM_1, 1 hit
PRINTSiPR00153, CSAPPISMRASE
SMARTiView protein in SMART
SM00360, RRM, 1 hit
SUPFAMiSSF50891, SSF50891, 1 hit
SSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50072, CSA_PPIASE_2, 1 hit
PS50102, RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7Q408_ANOGA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Q408
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: October 23, 2007
Last modified: December 2, 2020
This is version 123 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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