UniProtKB - Q7Q408 (Q7Q408_ANOGA)
Protein
Peptidyl-prolyl cis-trans isomerase
Gene
AgaP_AGAP008136
Organism
Anopheles gambiae (African malaria mosquito)
Status
Functioni
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation
Caution
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported
Catalytic activityi
- [protein]-peptidylproline (ω=180) = [protein]-peptidylproline (ω=0)UniRule annotationARBA annotationEC:5.2.1.8UniRule annotationARBA annotation
GO - Molecular functioni
- peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-UniRule
- RNA binding Source: UniProtKB-UniRule
GO - Biological processi
- regulation of phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
Keywordsi
Molecular function | Isomerase, RNA-bindingPROSITE-ProRule annotationARBA annotation, RotamaseUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)Short name: PPIaseUniRule annotation |
Gene namesi | ORF Names:AgaP_AGAP008136Imported |
Organismi | Anopheles gambiae (African malaria mosquito)Imported |
Taxonomic identifieri | 7165 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicoidea › Culicidae › Anophelinae › Anopheles › |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
NucleusUniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 161 | PPIase cyclophilin-typeInterPro annotationAdd BLAST | 156 | |
Domaini | 240 – 318 | RRMInterPro annotationAdd BLAST | 79 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 165 – 189 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 342 – 676 | DisorderedSequence analysisAdd BLAST | 335 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 352 – 399 | BasicSequence analysisAdd BLAST | 48 | |
Compositional biasi | 400 – 416 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 417 – 436 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 498 – 515 | BasicSequence analysisAdd BLAST | 18 | |
Compositional biasi | 516 – 546 | PolyampholyteSequence analysisAdd BLAST | 31 | |
Compositional biasi | 555 – 582 | PolyampholyteSequence analysisAdd BLAST | 28 | |
Compositional biasi | 595 – 610 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 611 – 625 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 632 – 648 | BasicSequence analysisAdd BLAST | 17 | |
Compositional biasi | 649 – 663 | PolyampholyteSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0415, Eukaryota |
HOGENOMi | CLU_018791_3_1_1 |
InParanoidi | Q7Q408 |
OrthoDBi | 1392223at2759 |
PhylomeDBi | Q7Q408 |
Family and domain databases
CDDi | cd01921, cyclophilin_RRM, 1 hit |
Gene3Di | 2.40.100.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR035542, CRIP IPR029000, Cyclophilin-like_dom_sf IPR002130, Cyclophilin-type_PPIase_dom IPR035538, Cyclophilin_PPIL4 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR45843, PTHR45843, 1 hit |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit PF00076, RRM_1, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF50891, SSF50891, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50072, CSA_PPIASE_2, 1 hit PS50102, RRM, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7Q408-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVVIETTIG DITVDLFLKE RPRAALNFLK LCKLKYYNYN LFHTIQSDFI
60 70 80 90 100
AQTGDPTGAG DGGSSVWGIL EGAEKRYFEG ESVPKIKHSE PGLLSMVNAG
110 120 130 140 150
EHLIGSQFFF TLGPDLTSLD GRHTVIGEVT EGHEVLRKLN EVICDDRHRP
160 170 180 190 200
YKDVRITHTV VLDDPFEDPR GFREPSRSPS PSAERLQGGR IAADEEIDDL
210 220 230 240 250
GGKTEQEIAE MIAEREAKAR ATILEIVGDI PDADIAPPEN VLFVCKLNPV
260 270 280 290 300
TTDDDLQIIF SRFGKIVGCE VIRDKLTGDS LQYAFIEFEN QKSCEDAYFK
310 320 330 340 350
MDNVLIDDRR IHVDFSQSVS KIKWRGKGRG IEFKDGADKR SFKDYDRSRS
360 370 380 390 400
RSRSRSRSKS RSKSRSQSRS RSRSRSRSRS RSRSGSRSRA RKVDRRQRSR
410 420 430 440 450
SRDHMRDRDR NRPPGRNAQE SNRGRKPNLT ERNSAYMEQR NGRDIRINQG
460 470 480 490 500
MVDYKNRPYP NSFVQRNGPR DKNAPRGGGR SSRGALHWSD PLPPRRRSRS
510 520 530 540 550
RDRRTRRSRS RSRSRDRRHS PPDRHAGSQR MHSREDRDRR QHYGERSARS
560 570 580 590 600
PSYSRQSRAD KEYGRGEPAK QDRSRPEAKP VKRRSSSSGS SRSGSSEPKE
610 620 630 640 650
KRKRRSPSPD SVDSDSSSTS SSSSASDERA KKRKKKASKK KSKSSSKSSK
660 670
KRKDSVSSDE GKHRKKSKGK KKKKKH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAAB01008964 Genomic DNA Translation: EAA12690.4 |
RefSeqi | XP_317325.4, XM_317325.4 |
Genome annotation databases
GeneIDi | 1277821 |
KEGGi | aga:AgaP_AGAP008136 |
VectorBasei | AGAP008136-RA; AGAP008136-PA; AGAP008136 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAAB01008964 Genomic DNA Translation: EAA12690.4 |
RefSeqi | XP_317325.4, XM_317325.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7165.AGAP008136-PA |
Genome annotation databases
GeneIDi | 1277821 |
KEGGi | aga:AgaP_AGAP008136 |
VectorBasei | AGAP008136-RA; AGAP008136-PA; AGAP008136 |
Phylogenomic databases
eggNOGi | KOG0415, Eukaryota |
HOGENOMi | CLU_018791_3_1_1 |
InParanoidi | Q7Q408 |
OrthoDBi | 1392223at2759 |
PhylomeDBi | Q7Q408 |
Family and domain databases
CDDi | cd01921, cyclophilin_RRM, 1 hit |
Gene3Di | 2.40.100.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR035542, CRIP IPR029000, Cyclophilin-like_dom_sf IPR002130, Cyclophilin-type_PPIase_dom IPR035538, Cyclophilin_PPIL4 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR45843, PTHR45843, 1 hit |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit PF00076, RRM_1, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF50891, SSF50891, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50072, CSA_PPIASE_2, 1 hit PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7Q408_ANOGA | |
Accessioni | Q7Q408Primary (citable) accession number: Q7Q408 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 15, 2003 |
Last sequence update: | October 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |