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Entry version 106 (11 Dec 2019)
Sequence version 5 (27 Jul 2011)
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Protein
Submitted name:

AGAP001527-PA

Gene

1281652

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AGAP001527-PAImported
Submitted name:
Golgi-specific brefeldin a-resistance factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:1281652Imported
ORF Names:AgaP_AGAP001527Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnopheles gambiae (African malaria mosquito)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7165 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007062 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7165.AGAP001527-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini703 – 895SEC7InterPro annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni216 – 249DisorderedSequence analysisAdd BLAST34
Regioni1455 – 1509DisorderedSequence analysisAdd BLAST55
Regioni1746 – 1773DisorderedSequence analysisAdd BLAST28
Regioni1945 – 1979DisorderedSequence analysisAdd BLAST35
Regioni2043 – 2096DisorderedSequence analysisAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili326 – 346Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi220 – 235PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1463 – 1486PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1489 – 1508PolarSequence analysisAdd BLAST20
Compositional biasi2043 – 2080PolarSequence analysisAdd BLAST38

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0928 Eukaryota
COG5307 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230678

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7PXQ7

KEGG Orthology (KO)

More...
KOi
K18443

Identification of Orthologs from Complete Genome Data

More...
OMAi
DESVCEM

Database of Orthologous Groups

More...
OrthoDBi
815698at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7PXQ7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00171 Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1000.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032629 DCB_dom
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
IPR032691 Sec7_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16213 DCB, 1 hit
PF01369 Sec7, 1 hit
PF12783 Sec7_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00222 Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48425 SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50190 SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7PXQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPPGNGIFV VRGEMSTLTT AMRRGSRWSF NTYQDDDKDV LLKSFQELKE
60 70 80 90 100
VLLQVEDLRL VEPNVFLSPF LNVIRSEETT GPVTSLALSA VNKFLSYGLI
110 120 130 140 150
DPTHSTLAAT VENIADAVTH ARFVGTDQTS DGVVLMKIIQ VLRTLVLSPE
160 170 180 190 200
GSALSDESMC DIILSCFRLC FEPRLNELVR RTAENALKDI VLLLFMRLPQ
210 220 230 240 250
FVEGGSYNTL KTLKMRSSSM DQSGKRRKYS KTSMKEEQKP APTAVPSTNA
260 270 280 290 300
AAPVVPKIVT EDPTNVAGSG EEPVTPVMLT APNRLKPMPL STTPATPAGV
310 320 330 340 350
IVDLQGTISQ TPKAPLPSES AERQSIASAE DGISNAETEL ETVTAQGTEE
360 370 380 390 400
GTTAADPSFV NSVGVRFTSQ QAEEDVPQVA NGAATVTHLP YGLPCIRELF
410 420 430 440 450
RFLISLCNPM DKQNGDVMIH MGLTLLTVTF EVGADSIGRY DSLIAIVKDD
460 470 480 490 500
LCRNLFALLA TERISIFAAG LQLSFLLFES LRSQLKFQLE HYLTRVADMI
510 520 530 540 550
MNDSPRILYE ARELAMDNLL QLWRIPGFAA ELYINYDCDL YCSNLFEDLT
560 570 580 590 600
KLLSKNTLSA TQAIYSIHTL SMDALLTIVE SIERNCAQAK NGQKPKYMRH
610 620 630 640 650
SRNNSYATAK IVLDAGTPQA AREAGGQVAL ELEEGDSEEG AGNTEPAVLV
660 670 680 690 700
ENISKFLHSS QRDRISRVAA GIGTDASGGE DPSTAAEGAS LSEAVSQKLT
710 720 730 740 750
HEELAAIKRK KRLLTQGTDL FNQRPEKGIQ FLQENGLLNP VLDPQEVAQF
760 770 780 790 800
LRENSGLDKK MIGEYISKKK NVESRILEVY VKSFDFAGLT IDQALRLYLE
810 820 830 840 850
TFRLPGEAPL ISLVMEHFAD HWHECNNEPF ANTDAAFRLA YAVIMLNMDQ
860 870 880 890 900
HNHNAKRLNV PMTVEDFLRN LRGLNGNSDF DQEMLTKIYH AIRNEEIVMP
910 920 930 940 950
AEQTGQVREN YLWKVLLRRG ATKDGIFHHV FGPQHDRELY RVIQGSTLAA
960 970 980 990 1000
LSFVFDKSLD NASLYQKAIG GFMKSAAIAA HFQLHGDFDA LVLTLCKFTT
1010 1020 1030 1040 1050
LLTPPPNDAH EITASVMFGQ NVKAQLAMRT VFGLIHEHGD CMREGWRHTM
1060 1070 1080 1090 1100
DVLLQLFKLK LLPKALMEAE DFCEASGKVT LLREPNPLPK TEAGLFSSLY
1110 1120 1130 1140 1150
SYLANDGQRQ PSYEEQEVIK LSRKCVRDCQ IEQIVNESKF LQLESLEELI
1160 1170 1180 1190 1200
GCLLAMIVPP EAHKSTAPAY GECTVVFLLE LLVKVLIQNR DRLLPVWGRV
1210 1220 1230 1240 1250
QDKLYTLLVG ASAHEYTYLL QRTTVALLKL AIYLMRNEEI CSTILQSLRM
1260 1270 1280 1290 1300
LLALRPAVIL AISKPISIGM YELLKTSAQN IHTEADWVIV FTVLECVGAG
1310 1320 1330 1340 1350
AVPPECHAVE QVAAVSGAKS DGALSSEEDS GLPDRGYISD SELSSTATMP
1360 1370 1380 1390 1400
LVKTAAPTPP PAPLPSSPSA GDAWIMVNKD AIDLVSGGSG GHSPGTPVRH
1410 1420 1430 1440 1450
SIQYHCKLLE HSPFALVKCW ESLAFIVRNV AHITPYNFES CVRCIRTFVE
1460 1470 1480 1490 1500
ASMGQTHQHH QQQRDYQAAK KKPGSGKDRQ RKLRDGASHQ GSGLSSSSSS
1510 1520 1530 1540 1550
SLAMDSSDSE SEELPERYQS ISIQLLDLMH TLHTRTAQIF RWWAEEGGAV
1560 1570 1580 1590 1600
PQCSSLWSQG WCPLLQGIAR LATDQRRQVR TSAITCLQRA LLVQDLQTLT
1610 1620 1630 1640 1650
GLEWAGCFKQ VLFPLLQELL QEKATSPVEV SLLEESRIRT ATIMSKVFLH
1660 1670 1680 1690 1700
HLTPLIALPN FQELWIEILD YFERFMTAGS DMLYEAVLES LKNMLLVMHS
1710 1720 1730 1740 1750
VCVFHNTDGV THSMLWDVTW QRISGFLPNL KDELFKHEAV RSSVSISGGT
1760 1770 1780 1790 1800
GGNAGTGAAS PTVPPSHTTV PTAPPSLAGE QQHILEGGQI NNSSAVGESI
1810 1820 1830 1840 1850
NPRVVLHPIP ISTAATGSVL SASPPNSYIQ QLQQPQPMPI LPVSHSIPAV
1860 1870 1880 1890 1900
EVHRTPVHRA APSNNLLMSS TATSDFNTLP MVLPRVSTLP SPTGVAESSI
1910 1920 1930 1940 1950
TGLVEPANLL LSSPARDAVT QPQPAVSAPP SVAPAASNII ELPGIVGTSC
1960 1970 1980 1990 2000
PPPPAPPQQL PTERREEQGQ SETGSERAPV VTDVETGNVP MSHLLAGSQY
2010 2020 2030 2040 2050
PSLQHVPIGI AQSFAPIFVQ PNPAPAEASD IYSDYINDPY NLTLQIDNGA
2060 2070 2080 2090 2100
PGSAPSSSVT APEPAPPQSA TAQPDTLSRT LEDAKTGGPM LTGSTTVTAT
2110 2120 2130
PSAQLANVFQ SAQYFSFPAS GHIPPGSEML FGEP
Length:2,134
Mass (Da):233,062
Last modified:July 27, 2011 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i050D7929BB1BCF10
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAAB01008987 Genomic DNA Translation: EAA00837.5

NCBI Reference Sequences

More...
RefSeqi
XP_321598.5, XM_321598.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
AGAP001527-RA; AGAP001527-PA; AGAP001527

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1281652

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
aga:AgaP_AGAP001527

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...
VectorBasei
AGAP001527-RA; AGAP001527-PA; AGAP001527

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008987 Genomic DNA Translation: EAA00837.5
RefSeqiXP_321598.5, XM_321598.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7165.AGAP001527-PA

Genome annotation databases

EnsemblMetazoaiAGAP001527-RA; AGAP001527-PA; AGAP001527
GeneIDi1281652
KEGGiaga:AgaP_AGAP001527
VectorBaseiAGAP001527-RA; AGAP001527-PA; AGAP001527

Phylogenomic databases

eggNOGiKOG0928 Eukaryota
COG5307 LUCA
HOGENOMiHOG000230678
InParanoidiQ7PXQ7
KOiK18443
OMAiDESVCEM
OrthoDBi815698at2759
PhylomeDBiQ7PXQ7

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
InterProiView protein in InterPro
IPR032629 DCB_dom
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
IPR032691 Sec7_N
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF01369 Sec7, 1 hit
PF12783 Sec7_N, 1 hit
SMARTiView protein in SMART
SM00222 Sec7, 1 hit
SUPFAMiSSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50190 SEC7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7PXQ7_ANOGA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7PXQ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: July 27, 2011
Last modified: December 11, 2019
This is version 106 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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