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Entry version 113 (05 Jun 2019)
Sequence version 5 (27 Jul 2011)
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Protein

AP complex subunit beta

Gene

1281911

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transportUniRule annotationSAAS annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP complex subunit betaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:1281911Imported
ORF Names:AgaP_AGAP001267Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnopheles gambiae (African malaria mosquito)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7165 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007062 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

MembraneUniRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7165.AGAP001267-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini699 – 808Alpha_adaptinC2InterPro annotationAdd BLAST110
Domaini817 – 927B2-adapt-app_CInterPro annotationAdd BLAST111

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adaptor complexes large subunit family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1061 Eukaryota
COG5096 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000163270

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7PX81

KEGG Orthology (KO)

More...
KOi
K12392

Database of Orthologous Groups

More...
OrthoDBi
323029at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7PX81

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit
2.60.40.1150, 1 hit
3.30.310.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026739 AP_beta
IPR016342 AP_complex_bsu_1_2_4
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR015151 B-adaptin_app_sub_C
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR013037 Clathrin_b-adaptin_app_Ig-like
IPR009028 Coatomer/calthrin_app_sub_C
IPR012295 TBP_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11134 PTHR11134, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PF09066 B2-adapt-app_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002291 AP_complex_beta, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SM01020 B2-adapt-app_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7PX81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDSKYFTTT KKGEIFELKS ELNNDKKEKK KEAVKKVIAS MTVGKDVSAL
60 70 80 90 100
FPDVVNCMQT DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDTNP
110 120 130 140 150
LIRALAVRTM GCIRVDKITE YLCEPLRKCL KDEDPYVRKT AAVCVAKLYD
160 170 180 190 200
ISSSMVEDQG FLDQLKDLLS DSNPMVVANA VAALSEINEA SASGQPLVEM
210 220 230 240 250
NSVTINKLLT ALNECTEWGQ VFILDSLANY TPKDEREAQS ICERITPRLA
260 270 280 290 300
HANAAVVLSA IKVLMKLLEI LAGDNDFCSM LTKKLAPPLV TLLSSEPEVQ
310 320 330 340 350
YVALRNINLI VQKRPDILKH EMKVFFVKYN DPIYVKLEKL DIMIRLANQS
360 370 380 390 400
NIAQVLSELK EYATEVDVDF VRKAVRAIGR CAIKVEPSAE RCVSTLLDLI
410 420 430 440 450
QTKVNYVVQE AIVVIKDIFR KYPNKYESII STLCENLDTL DEPEARASMV
460 470 480 490 500
WIIGEYAERI DNADELLDGF LEGFQDENAQ VQLQLLTAVV KLFLKRPADT
510 520 530 540 550
QELVQHILSL ATQDSDNPDL RDRGFIYWRL LSTDPAAAKE VVLADKPLIS
560 570 580 590 600
EETDLLEPTL LDELICHISS LASVYHKPPT AFVEGRGAGV RKSLPNRSAS
610 620 630 640 650
AAGEDSSSVQ EATVIPNQES LIGDLLSMDI GAPAAPAAPA PASSNVDLLG
660 670 680 690 700
GGLDILLGGG PVASNDAAPA APAPAGGSAA GGLLGDIFGI GPVSSSNMIQ
710 720 730 740 750
IPKITWLPAD KGKGLEIQGT FSRRAGQVYM DMTFTNKAMQ AMTGFAIQLN
760 770 780 790 800
KNSFGLVPSA PLQVAPLQPS QSVDTSLALG TTGPVQRMEP LNNLQVAIKN
810 820 830 840 850
NVDIFYFACL VHGNVLFVED GQLDKRVFLT TWKEIPAANE IQYNLHGIVG
860 870 880 890 900
TADTVAAKMT ANSIFTIAKR NVEGQDMLYQ SLKLTNNIWV LLELKLSPGS
910 920
SDATLSLKTR SVEVGAIIFA AYEQIIRSP
Length:929
Mass (Da):101,559
Last modified:July 27, 2011 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i436932861D0D9DD8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAAB01008987 Genomic DNA Translation: EAA01744.5

NCBI Reference Sequences

More...
RefSeqi
XP_321886.5, XM_321886.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
AGAP001267-RA; AGAP001267-PA; AGAP001267

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1281911

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
aga:AgaP_AGAP001267

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...
VectorBasei
AGAP001267-RA; AGAP001267-PA; AGAP001267

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008987 Genomic DNA Translation: EAA01744.5
RefSeqiXP_321886.5, XM_321886.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7165.AGAP001267-PA

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP001267-RA; AGAP001267-PA; AGAP001267
GeneIDi1281911
KEGGiaga:AgaP_AGAP001267
VectorBaseiAGAP001267-RA; AGAP001267-PA; AGAP001267

Phylogenomic databases

eggNOGiKOG1061 Eukaryota
COG5096 LUCA
HOGENOMiHOG000163270
InParanoidiQ7PX81
KOiK12392
OrthoDBi323029at2759
PhylomeDBiQ7PX81

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.60.40.1150, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR026739 AP_beta
IPR016342 AP_complex_bsu_1_2_4
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR015151 B-adaptin_app_sub_C
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR013037 Clathrin_b-adaptin_app_Ig-like
IPR009028 Coatomer/calthrin_app_sub_C
IPR012295 TBP_dom_sf
PANTHERiPTHR11134 PTHR11134, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PF09066 B2-adapt-app_C, 1 hit
PIRSFiPIRSF002291 AP_complex_beta, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SM01020 B2-adapt-app_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7PX81_ANOGA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7PX81
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: July 27, 2011
Last modified: June 5, 2019
This is version 113 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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