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Entry version 105 (02 Jun 2021)
Sequence version 4 (23 Oct 2007)
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Protein
Submitted name:

AGAP010715-PA

Gene

AgaP_AGAP010715

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AGAP010715-PAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AgaP_AGAP010715Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnopheles gambiae (African malaria mosquito)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7165 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:AGAP010715

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7165.AGAP010715-PA

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1213 – 1337PHInterPro annotationAdd BLAST125

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni36 – 97DisorderedSequence analysisAdd BLAST62
Regioni177 – 202DisorderedSequence analysisAdd BLAST26
Regioni216 – 438DisorderedSequence analysisAdd BLAST223
Regioni472 – 540DisorderedSequence analysisAdd BLAST69
Regioni593 – 632DisorderedSequence analysisAdd BLAST40
Regioni668 – 734DisorderedSequence analysisAdd BLAST67
Regioni754 – 790DisorderedSequence analysisAdd BLAST37
Regioni803 – 888DisorderedSequence analysisAdd BLAST86
Regioni905 – 944DisorderedSequence analysisAdd BLAST40
Regioni1144 – 1163DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi79 – 97Polar residuesSequence analysisAdd BLAST19
Compositional biasi181 – 199Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi218 – 237Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi239 – 257Polar residuesSequence analysisAdd BLAST19
Compositional biasi285 – 301Polar residuesSequence analysisAdd BLAST17
Compositional biasi339 – 354Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi355 – 399Polar residuesSequence analysisAdd BLAST45
Compositional biasi472 – 515Polar residuesSequence analysisAdd BLAST44
Compositional biasi613 – 631Polar residuesSequence analysisAdd BLAST19
Compositional biasi706 – 721Acidic residuesSequence analysisAdd BLAST16
Compositional biasi765 – 780Polar residuesSequence analysisAdd BLAST16
Compositional biasi818 – 836Polar residuesSequence analysisAdd BLAST19
Compositional biasi837 – 857Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi860 – 881Polar residuesSequence analysisAdd BLAST22

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3640, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008475_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7PRK2

Identification of Orthologs from Complete Genome Data

More...
OMAi
EIQRTSW

Database of Orthologous Groups

More...
OrthoDBi
200480at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7PRK2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01263, PH_anillin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012966, AHD
IPR011993, PH-like_dom_sf
IPR037840, PH_Anillin
IPR001849, PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08174, Anillin, 1 hit
PF00169, PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q7PRK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
FGDFFQNILE RAEKRAAALG ITNTSKFPLS EFNYEADQQG SAAGASPKKK
60 70 80 90 100
SGGAAGASPK KKSVTKKHSA PKPPPPTTTV STRTATDGER TTTVDIGGQD
110 120 130 140 150
NCDLALEINI TTSANLQVDL GVKELENDGS VKKQWEHNIV RALEGEKENS
160 170 180 190 200
AEAKSVIRDQ SRNQLQRLGT LYSETQDLSS PVHRTEGRFH EDVKQSSNKP
210 220 230 240 250
KPKLAKLAML ADSINNWEDD TSHPDITHHR ETIVPGRERK SPISSSSTRQ
260 270 280 290 300
QSPKRAGEAR TGASGSSAPG TGATPKKYPA PNPPKSILTA TQKTGSNGGG
310 320 330 340 350
EPSSGAAGKP VQTKSLKWDQ KVMDTLESQG FQRRESTTSK LVYDYKEDKN
360 370 380 390 400
GQKTDTYRAP VTASAVSSTS RERNTTQADQ ADAVKKSAPV SSSSSQPKKV
410 420 430 440 450
AVGAPKPAGG LVSGRAAMFE KSSGRRQSIL KPGQKDPAEM SLKERMAIFE
460 470 480 490 500
KNKGAALVPK AAFGISPSIR QITGQKEGGK SGSSGSGPMS CAAIQGSGFG
510 520 530 540 550
SITQQAASSK GVAPASPQSK PKVDHDKAAP KVETKATGSA IRNTVEALMS
560 570 580 590 600
DTSTISQSEI SEEIRRMRQQ EMEMLLNRFT KPADMSSDTI EYETQPIPSA
610 620 630 640 650
PPMPPEGYLT GSGRKQSKHS AEGNNVHDGT NDSADVMAAL DDVKRIRVGP
660 670 680 690 700
AAKDGRMYPA LSDIETTATE SGDEGAVGDD YTTATVSGSE GSERAYRTCY
710 720 730 740 750
GEAEDGEREL GDEEEDYDEE EDNERRHFMY SDDDEEANIA NVSLGREILQ
760 770 780 790 800
AVKLNDRRTS RGRRQSQEWN GVSFSLDRSG ASDGTDPLED SDLIDACLEE
810 820 830 840 850
ALVDEEEEEE DSEAFDTPRK SSVSSNSFSY QKHSGRDRCA TINEEESAKD
860 870 880 890 900
PKSGANKRKS GTPRKSQVGT VDYSSPVRSE LQVKPSKDDD DMVTLVHTVS
910 920 930 940 950
FYRRQQQQNS MTPRKVPRTP VSTKMAATNS SPRAGTSTST GTEEGEFLVQ
960 970 980 990 1000
EKVKKLLDEV CKQQTIIAQA SQALNLCAAT IEFSGSTESA EGERHLLVAT
1010 1020 1030 1040 1050
HRRQAILDEV QRLRVEGCLR PPGAPTEKGR LTVKEITLPL KQEYMRKLAT
1060 1070 1080 1090 1100
DQISGHNLVC LLKYNETVLA TQTAPTLPGL LSVRFPDVLQ LSNVFADFKI
1110 1120 1130 1140 1150
TMEIYGMPAS REVLPHEIKY HIALGKKKTG SGSSKLLHTP KGLKSNSRLI
1160 1170 1180 1190 1200
MPPVQSPAGP QAVRSPSLTQ YGFIIFSLKE IQRTSWTLNP ISGCASPLDG
1210 1220 1230 1240 1250
TVNMRVNCEL AVTVDYHGFL TMYEDVSGLG AWHRRWCRLQ RHTINYWKYP
1260 1270 1280 1290 1300
DDEKRKAPIG SIDLQGCSTQ RVGVAPRDIC SRLNTLLLEF PRPARDDDVE
1310 1320 1330 1340 1350
SLKIVRHGKT TIERYLLSAD SKEERDEWCA HLNKTLALLK AWGASHVTSC
Length:1,350
Mass (Da):146,946
Last modified:October 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD6EB50E6D293AD0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAAB01008848 Genomic DNA Translation: EAA07071.5

NCBI Reference Sequences

More...
RefSeqi
XP_311427.4, XM_311427.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1272514

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
aga:AgaP_AGAP010715

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008848 Genomic DNA Translation: EAA07071.5
RefSeqiXP_311427.4, XM_311427.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7165.AGAP010715-PA

Genome annotation databases

GeneIDi1272514
KEGGiaga:AgaP_AGAP010715

Organism-specific databases

VEuPathDBiVectorBase:AGAP010715

Phylogenomic databases

eggNOGiKOG3640, Eukaryota
HOGENOMiCLU_008475_0_0_1
InParanoidiQ7PRK2
OMAiEIQRTSW
OrthoDBi200480at2759
PhylomeDBiQ7PRK2

Family and domain databases

CDDicd01263, PH_anillin, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR012966, AHD
IPR011993, PH-like_dom_sf
IPR037840, PH_Anillin
IPR001849, PH_domain
PfamiView protein in Pfam
PF08174, Anillin, 1 hit
PF00169, PH, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7PRK2_ANOGA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7PRK2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: October 23, 2007
Last modified: June 2, 2021
This is version 105 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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