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Entry version 139 (02 Jun 2021)
Sequence version 3 (09 Jan 2007)
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Protein
Submitted name:

AGAP010750-PA

Gene

1278919

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Ion channel, Ligand-gated ion channelARBA annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.3.1.3, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AGAP010750-PAImported
Submitted name:
Ryanodine receptor 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:1278919Imported
ORF Names:AgaP_AGAP010750Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnopheles gambiae (African malaria mosquito)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7165 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007062 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:AGAP010750

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4437 – 4457HelicalSequence analysisAdd BLAST21
Transmembranei4623 – 4644HelicalSequence analysisAdd BLAST22
Transmembranei4714 – 4736HelicalSequence analysisAdd BLAST23
Transmembranei4904 – 4926HelicalSequence analysisAdd BLAST23
Transmembranei4982 – 5005HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulumARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7165.AGAP010750-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini94 – 148MIRInterPro annotationAdd BLAST55
Domaini155 – 200MIRInterPro annotationAdd BLAST46
Domaini210 – 264MIRInterPro annotationAdd BLAST55
Domaini270 – 328MIRInterPro annotationAdd BLAST59
Domaini336 – 394MIRInterPro annotationAdd BLAST59
Domaini577 – 803B30.2/SPRYInterPro annotationAdd BLAST227
Domaini1016 – 1218B30.2/SPRYInterPro annotationAdd BLAST203
Domaini1437 – 1651B30.2/SPRYInterPro annotationAdd BLAST215

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1366 – 1491DisorderedSequence analysisAdd BLAST126
Regioni2269 – 2289DisorderedSequence analysisAdd BLAST21
Regioni2797 – 2818DisorderedSequence analysisAdd BLAST22
Regioni3571 – 3600DisorderedSequence analysisAdd BLAST30
Regioni3844 – 3864DisorderedSequence analysisAdd BLAST21
Regioni4471 – 4490DisorderedSequence analysisAdd BLAST20
Regioni4514 – 4553DisorderedSequence analysisAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili460 – 480Sequence analysisAdd BLAST21
Coiled coili3782 – 3802Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1413 – 1456Basic and acidic residuesSequence analysisAdd BLAST44
Compositional biasi1457 – 1476Polar residuesSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2243, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000040_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7PMK5

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDINDMA

Database of Orthologous Groups

More...
OrthoDBi
5161at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7PMK5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795, RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7PMK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI
60 70 80 90 100
ADKNIPPDLS QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG
110 120 130 140 150
NAILLRHNNS DMYLACLSTS SSNDKLSFDV GLQEHSQGEA CWWTVHPASK
160 170 180 190 200
QRSEGEKVRV GDDLILVSVA TERYLHTTKE NDLSIVNASF HVTHWSVQPY
210 220 230 240 250
GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWSLDSG QNIVVYEGGS
260 270 280 290 300
VMSQARSLWR LELARTKWAG GFINWSHPMR IRHLTTGRYL GVNENNELIL
310 320 330 340 350
MSRDQATTSQ TAFVLRLEKD DQKVVLEDKD LEIIGAPIIK YGDSTVIMQH
360 370 380 390 400
YESGLWVSYK SYETKKKGVG KVEEKQAILH EEGKMDDGLD FSRSQEEESR
410 420 430 440 450
TARVIRKCSS LFTKFISGLE TLQENRRHSI FLQTVNLGEM VMCLEDLINY
460 470 480 490 500
FAQPEDDMEH EEKQNRLRAL RNRQDLFQEE GVLNLILEAI DKINVISSQG
510 520 530 540 550
FLASFLASDE SGQSWDMISG YLYQLLAAII KGNHTNCAQF ANSNRLNWLF
560 570 580 590 600
SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD
610 620 630 640 650
PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTG LVDHVASIRP
660 670 680 690 700
NIFVGRVEGS AIYQKWYFEV TMDHIEQMTH MTPHLRIGWA NTAGYVPYPG
710 720 730 740 750
GGEKWGGNGV GDDLFSYGFD GVYFWSAGRR TCVVPREVTE PFIKKGDVIG
760 770 780 790 800
CTLDLSVPVI RFTFNGEPVQ GCFTDFNLDG MFFPVMSCSS KLSCRFLFGG
810 820 830 840 850
DNGRLKFNPP PGFSPLVQCL MPHQNLSLDP CFYFGNLNKN VLAGPWLVED
860 870 880 890 900
DSAFVPKPVD TSIVTLPSSV ETIKDKLAEN IHEMWALNKI EAGWTWGERR
910 920 930 940 950
DDVYRIHPCL TSFEKLPAAE KRYDCQLAVQ TLKTILALGY YISMDKPPAR
960 970 980 990 1000
IRPIRLPNDP YMQGNGYKPA PLDLSAAVLT PKMEELVDQL AENTHNLWAK
1010 1020 1030 1040 1050
ERIQQGWTYG LNEDSENLRS PHLVPYSKVD EAIKKANRDT ASETVRTLLI
1060 1070 1080 1090 1100
YGYNLDPPTG EANEALAAEA LRQKFAAYRT YRVERTYAVT SGKWYFEFEV
1110 1120 1130 1140 1150
LTAGPMRVGW ARADCNPGTM LGSDDASWAF DGYNEEKVSG GATESFGKQW
1160 1170 1180 1190 1200
VPGDIVGVFL DLVDHTISFS LNGELLMDAL GGETTFADVN APDGVGFVPA
1210 1220 1230 1240 1250
CTIGIGQKAR VVYGQDVDSL KWFTTCGLQE GYEPFCVNMK RPVTHWYTKD
1260 1270 1280 1290 1300
QPIFENTDEI PECKIDVTRI PGGADTPPCM KISHNTFETM EKANWEFLRL
1310 1320 1330 1340 1350
SLPVTCANTF ITEQEKMRRW EEIRIRQHRL MTEVDHSAPA HFDHIMRSGF
1360 1370 1380 1390 1400
TMNDIKGLHR NYSEDAAEAD EMMRNGPRRP SRHQGRGGLS PPGIEINGEA
1410 1420 1430 1440 1450
TSDGELNAYS DNELEGGDDR KKRGRSPFRL FGKKRDQSKD KLKDRRTPEP
1460 1470 1480 1490 1500
EPRKSNLKVT QRGQATRMSN SDLRAQAPLT PERKGMGSPQ VESFGNEVYD
1510 1520 1530 1540 1550
ADCLRLINEY FYGVRIFPGQ DPTHVYVGWV TTQYHVHSKE FSQNKVRHAA
1560 1570 1580 1590 1600
IYVEDENEKT IEIVNRQSCY MVRADELFNE VTQDSSGKGA SQGMFVGCFV
1610 1620 1630 1640 1650
DTATGTIRFT CEGKETSHVF LMEPDTKLFP AIFVEATSKE ILQIELGRTP
1660 1670 1680 1690 1700
TTLPLSAAVL PTSDKHINPQ FPPRLKVQCL KPHQWARVPN TALQVHALKL
1710 1720 1730 1740 1750
SDIRGWSMLC EDPVSMLALH IPEEDRCIDI LELIEIDRLL QFHAHTLTLY
1760 1770 1780 1790 1800
SALCYQSNYR AAHALCSHVD QKQLLYAIQS EYMSGPLRLG FYDLLISLHL
1810 1820 1830 1840 1850
ESHATTMEVC KNEYIIPLGS ELRELYIDPE MCHSLRSLQT LSVRPEMNMT
1860 1870 1880 1890 1900
EIAPTPSQSN MPTIVAPDSS SEPIPAIDSL YSPRFPLEVV REFVMSALQE
1910 1920 1930 1940 1950
AVQINQVHNR DPIGGSNENL FLPLIKLIDR LLLVGVITNE DVEKLLIMID
1960 1970 1980 1990 2000
PETWDPSFEK EGRDEHRKGL LTMKMAEGAK LQMCYLLHHL YDVQLRHRVE
2010 2020 2030 2040 2050
SIIAFAHNYV GDLQQDQLRR YIEIKQSDLP SAVAAKKTRE FRCPPREQMN
2060 2070 2080 2090 2100
AILGYKNLEE DDLENASCGP ELRNRLIEFH EKLMGKVSLN ALQEPEEPEA
2110 2120 2130 2140 2150
DKLEEGRPGA MKKLYNFINA VKELEEDPKE PVEEEKKTPE EVFRKVLIKQ
2160 2170 2180 2190 2200
LVSWAEESQI ENPKLVREMF GLLVRQYDTI GELIKALNKT YVINSKTKGD
2210 2220 2230 2240 2250
VANMWIGLSQ IRALLPVQMS QEEEELMRKR LWKLVNNHTF FQHPDLIRIL
2260 2270 2280 2290 2300
RVHENVMAVM MNTLGRRAQA QSDAPVQTAD GEESAPKEKD TSHQMVVACC
2310 2320 2330 2340 2350
RFLCYFCRTG RMNQKAMFDH FDFLLENSNI LLSRPSLRGS TPLDVAYSSL
2360 2370 2380 2390 2400
MENTELALAL REHYLEKIAI YLSRCGLQSN SELIERGYPD LGWDPVEGER
2410 2420 2430 2440 2450
YLDFLRFCVW VNGESVEENA NLVIRLLIRR PECLGPALRG EGEGLLKAIV
2460 2470 2480 2490 2500
DANKMSERIS ERRKMQDEAE GTITGLNFSH PLPEGDDDED YIDTGAAILC
2510 2520 2530 2540 2550
FYCTLVDLLG RCAPDAAVIE QGKNESLRAR AILRSLVPLE DLQGVLSLKF
2560 2570 2580 2590 2600
TLTNPALGED RPKSDMPSGL VPGHKQSIVL FLERVYGIET QELFYRLLED
2610 2620 2630 2640 2650
AFLPDLRAAT MLDRSDGSES DMALSMNRYI GNSILPLLIK HSKFYNEAEN
2660 2670 2680 2690 2700
YASLLDATLH TVYRMSKNRM LTKGQREAVS DFLVALTSAM HPAMLLKLLR
2710 2720 2730 2740 2750
KLTIDVSKLS EYTTVALRLL TLHYERCAKY YGTTGGGQAS QFGASSDEEK
2760 2770 2780 2790 2800
RLTMLLFSNI FDSLSNMDYD PELFGKALPC LIAIGCALPP DYSLSKNSDD
2810 2820 2830 2840 2850
DLYGKPTGGG PDQPHYNPQP IDTTAVQLTN DLNQIVQKFS EHYHDAWASR
2860 2870 2880 2890 2900
KLENGWTYGD QWSDANKTHP RLKPYNTLSE YERERYREPV RESLKALLAL
2910 2920 2930 2940 2950
HWRIEHSEGD VPLSNRGSMR RQSKPNLELQ GDTGSPFNYN PHPVDMTNLT
2960 2970 2980 2990 3000
LSREMQNMAE RLAENSHDIW AKKKNEELDQ CGGAIHAQLV PYDLLTDKEK
3010 3020 3030 3040 3050
RKDRERSQEF LKYLQYQGLK LHKPSRGQTE EPGMSTAAIE LRFAYSLLEK
3060 3070 3080 3090 3100
LISYSDRATI NMKLLKPSST FSRRSSFKTC SRDIKFFSKV VLPLMEKYFS
3110 3120 3130 3140 3150
SNRNYFIAIA TATNNVGAAS LKEKEMVAGL FCKLASLLRH RLAAFGADVR
3160 3170 3180 3190 3200
ITVRCLQVLV KSIDAKSLVK NCPEFIRTSM LTFFNNTADD LGQTIVNLTD
3210 3220 3230 3240 3250
GKYDRLRGTH LKTSTSLAYV NQVILPVLTS LFDHLAACDY GSDLLLDEIQ
3260 3270 3280 3290 3300
VASYKILSAL YTLGTDTSLT RDRKYLKTEL ERHKPALGSC LGAFSSCFPV
3310 3320 3330 3340 3350
AFLEPHANKH NPFSLLNRIA DTSLEAQDIM SKMESCMPTL ESILSEVDQF
3360 3370 3380 3390 3400
VESEKTYQEA QHIIDVILPL LCSYLPFWWN QGPDNVSPQS GNHVTMVTAD
3410 3420 3430 3440 3450
HMNHLLKNVL KMIRKNIANE NAPWMTRIAT YTQQIIINSS EELLKDVFLP
3460 3470 3480 3490 3500
LAERVKKRCD SMFHKEESLR GFLKSSTDDT SQIEAQIQED WQLLVRDIYS
3510 3520 3530 3540 3550
FYPLLIKYVD LQRNHWLKDN VAEAEELYNY VAEIFNVWSK SQYFLKEEQN
3560 3570 3580 3590 3600
FISANEIDNM TLIMPTATRR SAAVSGDMPA SGGKVKKKKR SRDKKRDKDK
3610 3620 3630 3640 3650
EIQSSLMVAC LKRLLPVGLN LFAGKEQELV QHCKDRYLKK MPEYEVIEFA
3660 3670 3680 3690 3700
RTQLTLPDKL DPADEMSWQH YLYSKLGKKE QIVQDTLEKS DKKPENKIED
3710 3720 3730 3740 3750
TVERIVAMAK VLYGLHMIDH PQQQSKNVYR SCVSIQRKRA VIACFRQVSL
3760 3770 3780 3790 3800
HSLPRHRACN IFARSYSELW LEDENTGQEV MIEDLTQTFE DAEKKKKDEE
3810 3820 3830 3840 3850
EEEGKPDPLT QLVTTFCRGA MTERSGALQE DPLYMSYASI VARSCGEEEE
3860 3870 3880 3890 3900
EGGDEEEGAG EDEGGASIHE QEMEKQKLLF HQARLANRGV AEMVLLHISA
3910 3920 3930 3940 3950
SKGVPSEMVM RTLELGIAVL RGGNIDIQMG MLNHLKEKKD VGFFTSIAGL
3960 3970 3980 3990 4000
MNSCSVLDLD AFERNTKAEG LGVGSDGAAG EKNMHDAEFT CALFRFIQLT
4010 4020 4030 4040 4050
CEGHNLDWQN YLRTQAGNTT TVNVVICTVD YLLRLQESIM DFYWHYSSKE
4060 4070 4080 4090 4100
LIDPAGKANF FKAIGVASQV FNTLTEVIQG PCTQNQQALA HSRLWDAVGG
4110 4120 4130 4140 4150
FLFLFSHMQD KLSKHSSQVD LLKELLNLQK DMITMMLSML EGNVVNGTIG
4160 4170 4180 4190 4200
KQMVDTLVES ASNVELILKY FDMFLKLKDL TSTPSFMEID SNGDGWIMPK
4210 4220 4230 4240 4250
DFREKMEQQK SYTPEEIDFL LACCETNHDG KIDYIGFVDR FHEPAKEIGF
4260 4270 4280 4290 4300
NLAVLLTNLS EHMPNEPRLA RFLETAGSVL NYFESFLGRI EIMGSSKRIE
4310 4320 4330 4340 4350
RVYFEIKEAN IEQWEKPQIK ESKRAFFYSI VTEGGDKEKL EAFVNFCEDA
4360 4370 4380 4390 4400
IFEMTHASGL MASDDDGGTV RRDQAFTYIS EEEEERAARD PIKRTIQAVK
4410 4420 4430 4440 4450
DGLSYSMYMI SPSNIKHQIT VLQSKSFPEI IVGFFKMIFY AFYYSGFGVS
4460 4470 4480 4490 4500
VVIKYLVNIL MSLMRGPAQE EEEPIPEAEP SLRALPPLPL EEPPGTVQAF
4510 4520 4530 4540 4550
GLDISKEENG QYRMAPHESP ALSPSSSIEE TGESSPEDGA AELTGEGVPP
4560 4570 4580 4590 4600
GEQMTLVDLL GGEAAKRAAQ ERTEAQKAQE ATLASIEAES KKASTETKEP
4610 4620 4630 4640 4650
AAVHQIDFSK YTKKCVSYLA RNFYNLKYVA LVLAFCINFM LLFYKVTTLG
4660 4670 4680 4690 4700
DDEDGEGGSG ESLMGLGSGL GSGLGILETG SGGGEGGSGD GEGEEEDPPE
4710 4720 4730 4740 4750
KVHVDEDFFY MEHVLRIAAI LHSLVSLCML IAYYHLKVPL AIFKREKEIA
4760 4770 4780 4790 4800
RRLEFDGLFI AEQPEDDDIK SHWDKLVISA KTFPVNYWDK FVKKKVRQKY
4810 4820 4830 4840 4850
SETYDFDSIS NLLGMEKTAF AAQEANEGGG FFHFITNIDW RYQIWKAGVT
4860 4870 4880 4890 4900
ITDNSFLYSL WYFSFSVMGN FNQFFFAAHL LDVAVGFKTL RTILQSVTHN
4910 4920 4930 4940 4950
GKQLVLTVML LTIIVYIYTV IAFNFFRKFY VQEDDDGEEG DRKCHDMATC
4960 4970 4980 4990 5000
FVFHLYKGVR AGGGIGDEIG DPDGDEYEVY RILFDITFFF FVIVILLAII
5010 5020 5030 5040 5050
QGLIIDAFGE LRDQLESVKE DMESNCFICG IGKDYFDKVP HGFDTHVAQE
5060 5070 5080 5090 5100
HNLANYMFFL MHLINKPDTE YTGQETYVWN MYQQRCWDFF PVGDCFRKQY

EDELGGGGS
Length:5,109
Mass (Da):577,541
Last modified:January 9, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6129F1A05493258B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AAAB01008979 Genomic DNA Translation: EAA13701.4

NCBI Reference Sequences

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RefSeqi
XP_318561.3, XM_318561.3

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
AGAP010750-RA; AGAP010750-PA; AGAP010750

Database of genes from NCBI RefSeq genomes

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GeneIDi
1278919

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
aga:AgaP_AGAP010750

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008979 Genomic DNA Translation: EAA13701.4
RefSeqiXP_318561.3, XM_318561.3

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7165.AGAP010750-PA

Protein family/group databases

TCDBi1.A.3.1.3, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

Genome annotation databases

EnsemblMetazoaiAGAP010750-RA; AGAP010750-PA; AGAP010750
GeneIDi1278919
KEGGiaga:AgaP_AGAP010750

Organism-specific databases

VEuPathDBiVectorBase:AGAP010750

Phylogenomic databases

eggNOGiKOG2243, Eukaryota
HOGENOMiCLU_000040_2_0_1
InParanoidiQ7PMK5
OMAiKDINDMA
OrthoDBi5161at2759
PhylomeDBiQ7PMK5

Family and domain databases

CDDicd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits
PRINTSiPR00795, RYANODINER
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits
SUPFAMiSSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7PMK5_ANOGA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7PMK5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: January 9, 2007
Last modified: June 2, 2021
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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