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Entry version 120 (07 Oct 2020)
Sequence version 3 (03 Mar 2009)
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Protein

Protein argonaute-3

Gene

AGO3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates predominantly with sense piRNAs that contain adenine at nucleotide 10, but shows no preference for uridine at the 5' end. In testis, however, associates with Su(Ste) and AT-chX-1 piRNAs mostly produced from antisense precursors. Shows RNA cleavage activity. In the germline, acts to amplify pools of antisense piRNAs, among others Su(Ste), AT-chX-1 and roo, and to limit sense piRNA accumulation. Forms a complex with smg, twin, aub and specific piRNAs that targets nos mRNA (and probably other maternal mRNAS) for deadenylation promoting its decay during early embryogenesis. Involved in transposon silencing in the adult brain.6 Publications

Caution

Has been given the gene name AGO3 by FlyBase based on the literature but is more similar to members of the Piwi subfamily.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processRNA-mediated gene silencing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein argonaute-3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGO3
ORF Names:CG40300
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0250816, AGO3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Female sterility. Male semi-sterility accompanied by production of Ste protein crystals in primary spermatocytes. Mutant males fail to maintain germline stem cells.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi68 – 72RGRAR → KGKAK: Abolishes binding to papi. 1 Publication5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004229141 – 867Protein argonaute-3Add BLAST867

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4Symmetric dimethylarginine1 Publication1
Modified residuei68Symmetric dimethylarginine1 Publication1
Modified residuei70Symmetric dimethylarginine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Symmetrically dimethylated on Arg-4, Arg-68 and Arg-70, most likely by csul.1 Publication2 Publications

Keywords - PTMi

Methylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7PLK0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In ovary, expressed in germline stem cells, germline cyst cells, nurse cells and oocytes during early stages. Also found in the somatic cap cells of the germarium. In testis, expressed in germline stem cells, primary gonial cells and early spermatocytes. No expression detected in the somatic hub cells at the apical tip of the testis (at protein level). Expressed in neurons throughout the adult brain and in the mushroom body subdivision in the peduncle. In the mushroom body, expressed only in gamma and core alpha-beta neurons.5 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed maternally. Expression is high in early embryos but gradually decreases as development proceeds (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0250816, Expressed in embryo and 25 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7PLK0, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with aub (PubMed:19959991).

Interacts (when methylated on arginine residues) with tud (PubMed:19959991).

Forms a complex with smg, twin, aub, nos mRNA and piRNAs that target the nos 3'-untranslated region, in early embryos (PubMed:20953170).

Interacts (via the N-terminal region when symmetrically methylated on arginine residues) with papi (via C-terminus); this interaction is RNA-independent and may be required for AGO3 localization to the nuage (PubMed:21447556).

Interacts with TER94 and tral (PubMed:21447556).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
78275, 12 interactors

Protein interaction database and analysis system

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IntActi
Q7PLK0, 7 interactors

Molecular INTeraction database

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MINTi
Q7PLK0

STRING: functional protein association networks

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STRINGi
7227.FBpp0289159

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7PLK0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini286 – 402PAZPROSITE-ProRule annotationAdd BLAST117
Domaini566 – 853PiwiPROSITE-ProRule annotationAdd BLAST288

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 289Interaction with papi1 PublicationAdd BLAST289

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the argonaute family. Piwi subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1042, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000183200

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_008813_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7PLK0

KEGG Orthology (KO)

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KOi
K02156

Identification of Orthologs from Complete Genome Data

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OMAi
NYHPKMV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7PLK0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003100, PAZ_dom
IPR036085, PAZ_dom_sf
IPR003165, Piwi
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02170, PAZ, 1 hit
PF02171, Piwi, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00949, PAZ, 1 hit
SM00950, Piwi, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF101690, SSF101690, 1 hit
SSF53098, SSF53098, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50821, PAZ, 1 hit
PS50822, PIWI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform D2 Publications (identifier: Q7PLK0-1) [UniParc]FASTAAdd to basket
Also known as: E1 Publication, F1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGRGNLLSL FNKNAGNMGK SISSKDHEID SGLDFNNSES SGERLLSSHN
60 70 80 90 100
IETDLITTLQ HVNISVGRGR ARLIDTLKTD DHTSNQFITS ESKENITKKT
110 120 130 140 150
KGPESEAIAS ENGLFFPDLI YGSKGSSVNI YCNYLKLTTD ESKGVFNYEV
160 170 180 190 200
RFFPPIDSVH LRIKYLNDHK DKLGGTKTFD GNTLYLPILL PNKMTVFISK
210 220 230 240 250
AEDVELQIRI LYKKKEEMRN CTQLYNILFD RVMKVLNYVK FDRKQFDPSR
260 270 280 290 300
PKIIPLAKLE VWPGYVTAVD EYKGGLMLCC DVSHRILCQK TVLEMLVDLY
310 320 330 340 350
QQNVEHYQES ARKMLVGNIV LTRYNNRTYK INDICFDQNP TCQFEIKTGC
360 370 380 390 400
TSYVEYYKQY HNINIKDVNQ PLIYSIKKSR GIPAERENLQ FCLIPELCYL
410 420 430 440 450
TGLRDEVRSD NKLMREIATF TRVSPNQRQM ALNKFYENVS NTPAAQEILN
460 470 480 490 500
SWGLSLTNNS NKISGRQMDI EQIYFSKISV SAGRSAEFSK HAVTNEMLKV
510 520 530 540 550
VHLSKWIIIH LRNYRQAATS LLDNMKQACE SLGMNISNPT MISLDHDRID
560 570 580 590 600
AYIQALRRNI TMNTQMVVCI CHNRRDDRYA AIKKICCSEI PIPSQVINAK
610 620 630 640 650
TLQNDLKIRS VVQKIVLQMN CKLGGSLWTV KIPFKNVMIC GIDSYHDPSN
660 670 680 690 700
RGNSVAAFVA SINSSYSQWY SKAVVQTKRE EIVNGLSASF EIALKMYRKR
710 720 730 740 750
NGKLPTNIII YRDGIGDGQL YTCLNYEIPQ FEMVCGNRIK ISYIVVQKRI
760 770 780 790 800
NTRIFSGSGI HLENPLPGTV VDQHITKSNM YDFFLVSQLV RQGTVTPTHY
810 820 830 840 850
VVLRDDCNYG PDIIQKLSYK LCFLYYNWAG TVRIPACCMY AHKLAYLIGQ
860
SIQRDVAEAL SEKLFYL
Length:867
Mass (Da):99,129
Last modified:March 3, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE613D6C845F78BE
GO
Isoform G2 Publications (identifier: Q7PLK0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     840-867: YAHKLAYLIGQSIQRDVAEALSEKLFYL → VSHNYHLIFFKSTMITQDTINDFTRAL

Show »
Length:866
Mass (Da):99,102
Checksum:i15C5A61602A5702E
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ACJ13248 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence ACK77640 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti42G → R in ABO27430 (PubMed:17346786).Curated1
Sequence conflicti168D → G in AFX62827 (Ref. 6) Curated1
Sequence conflicti320V → L in AFX62828 (Ref. 6) Curated1
Sequence conflicti371P → L in AFX62828 (Ref. 6) Curated1
Sequence conflicti543S → L in AFX62828 (Ref. 6) Curated1
Sequence conflicti600K → R in AFX62828 (Ref. 6) Curated1
Sequence conflicti732E → A in AFX62827 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047355840 – 867YAHKL…KLFYL → VSHNYHLIFFKSTMITQDTI NDFTRAL in isoform G. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
EF211827 mRNA Translation: ABO27430.1
EF434174 mRNA Translation: ABO26294.1
AE014296 Genomic DNA Translation: ABI31274.2
AE014296 Genomic DNA Translation: ABI31275.2
AE014296 Genomic DNA Translation: ACZ94769.1
AE014296 Genomic DNA Translation: EAA45981.3
BT050541 mRNA Translation: ACJ13248.1 Different initiation.
BT053722 mRNA Translation: ACK77640.1 Sequence problems.
JX656887 mRNA Translation: AFX62827.1
JX656888 mRNA Translation: AFX62828.1
EF688531 mRNA Translation: ABU63676.1

NCBI Reference Sequences

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RefSeqi
NP_001036627.2, NM_001043162.3 [Q7PLK0-1]
NP_001036628.2, NM_001043163.3 [Q7PLK0-1]
NP_001036629.2, NM_001043164.3 [Q7PLK0-1]
NP_001163498.1, NM_001170027.2 [Q7PLK0-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0299880; FBpp0289158; FBgn0250816 [Q7PLK0-1]
FBtr0299881; FBpp0289159; FBgn0250816 [Q7PLK0-1]
FBtr0299882; FBpp0289160; FBgn0250816 [Q7PLK0-1]
FBtr0301725; FBpp0290939; FBgn0250816 [Q7PLK0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3355150

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG40300

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF211827 mRNA Translation: ABO27430.1
EF434174 mRNA Translation: ABO26294.1
AE014296 Genomic DNA Translation: ABI31274.2
AE014296 Genomic DNA Translation: ABI31275.2
AE014296 Genomic DNA Translation: ACZ94769.1
AE014296 Genomic DNA Translation: EAA45981.3
BT050541 mRNA Translation: ACJ13248.1 Different initiation.
BT053722 mRNA Translation: ACK77640.1 Sequence problems.
JX656887 mRNA Translation: AFX62827.1
JX656888 mRNA Translation: AFX62828.1
EF688531 mRNA Translation: ABU63676.1
RefSeqiNP_001036627.2, NM_001043162.3 [Q7PLK0-1]
NP_001036628.2, NM_001043163.3 [Q7PLK0-1]
NP_001036629.2, NM_001043164.3 [Q7PLK0-1]
NP_001163498.1, NM_001170027.2 [Q7PLK0-2]

3D structure databases

SMRiQ7PLK0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi78275, 12 interactors
IntActiQ7PLK0, 7 interactors
MINTiQ7PLK0
STRINGi7227.FBpp0289159

Proteomic databases

PaxDbiQ7PLK0

Genome annotation databases

EnsemblMetazoaiFBtr0299880; FBpp0289158; FBgn0250816 [Q7PLK0-1]
FBtr0299881; FBpp0289159; FBgn0250816 [Q7PLK0-1]
FBtr0299882; FBpp0289160; FBgn0250816 [Q7PLK0-1]
FBtr0301725; FBpp0290939; FBgn0250816 [Q7PLK0-2]
GeneIDi3355150
KEGGidme:Dmel_CG40300

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
192669
FlyBaseiFBgn0250816, AGO3

Phylogenomic databases

eggNOGiKOG1042, Eukaryota
GeneTreeiENSGT00950000183200
HOGENOMiCLU_008813_0_0_1
InParanoidiQ7PLK0
KOiK02156
OMAiNYHPKMV
PhylomeDBiQ7PLK0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3355150, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3355150

Protein Ontology

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PROi
PR:Q7PLK0

Gene expression databases

BgeeiFBgn0250816, Expressed in embryo and 25 other tissues
GenevisibleiQ7PLK0, DM

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR003100, PAZ_dom
IPR036085, PAZ_dom_sf
IPR003165, Piwi
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
PfamiView protein in Pfam
PF02170, PAZ, 1 hit
PF02171, Piwi, 1 hit
SMARTiView protein in SMART
SM00949, PAZ, 1 hit
SM00950, Piwi, 1 hit
SUPFAMiSSF101690, SSF101690, 1 hit
SSF53098, SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50821, PAZ, 1 hit
PS50822, PIWI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGO3_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7PLK0
Secondary accession number(s): A4GND8
, A4GUJ7, A7YFW6, B6IDV1, B7FNN2, K7WKR9, K7XHY4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: March 3, 2009
Last modified: October 7, 2020
This is version 120 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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