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Protein

Malate dehydrogenase

Gene

mdh

Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92SubstrateUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Binding sitei105NADUniRule annotation1
Binding sitei112NADUniRule annotation1
Binding sitei131SubstrateUniRule annotation1
Binding sitei162SubstrateUniRule annotation1
Active sitei187Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 17NADUniRule annotation7
Nucleotide bindingi129 – 131NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:CV_1062
OrganismiChromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Taxonomic identifieri243365 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesChromobacteriaceaeChromobacterium
Proteomesi
  • UP000001424 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001133601 – 326Malate dehydrogenaseAdd BLAST326

Interactioni

Protein-protein interaction databases

STRINGi243365.CV_1062

Structurei

3D structure databases

ProteinModelPortaliQ7NZ60
SMRiQ7NZ60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z Bacteria
COG0039 LUCA
HOGENOMiHOG000220953
KOiK00024
OMAiDPMTAFK
OrthoDBiPOG091H03R4

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NZ60-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAPVRVAVT GAAGQIGYSL LFRIASGEML GKDQPVILHL LDLPQAQTAL
60 70 80 90 100
KGVMMELEDC AFPLLAGMVA TDDPNVAFKD VKVALLVGAR PRSKGMERKD
110 120 130 140 150
LLEANGAIFT VQGKALNDHA ARDVKVLVVG NPANTNAWIA MKSAPDLDPK
160 170 180 190 200
NFTAMLRLDH NRALSQIAAK TGKPVASIEK LAVWGNHSPT MYADYRFATI
210 220 230 240 250
DGQSVKAMIN DDVWNRDVFL PTVGKRGAAI IEARGLSSAA SAANAAIDHI
260 270 280 290 300
RDWVLGTNGK WVTMGVPSDG SYGIPEGVMY GVPVVCENGE YKRVEGLEID
310 320
AFSRERMDLT LAELEEERAA IAHLFG
Length:326
Mass (Da):35,037
Last modified:December 15, 2003 - v1
Checksum:i083A6B066431488A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA Translation: AAQ58737.1
RefSeqiWP_011134617.1, NC_005085.1

Genome annotation databases

EnsemblBacteriaiAAQ58737; AAQ58737; CV_1062
GeneIDi24946943
KEGGicvi:CV_1062

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016825 Genomic DNA Translation: AAQ58737.1
RefSeqiWP_011134617.1, NC_005085.1

3D structure databases

ProteinModelPortaliQ7NZ60
SMRiQ7NZ60
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243365.CV_1062

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAQ58737; AAQ58737; CV_1062
GeneIDi24946943
KEGGicvi:CV_1062

Phylogenomic databases

eggNOGiENOG4105D9Z Bacteria
COG0039 LUCA
HOGENOMiHOG000220953
KOiK00024
OMAiDPMTAFK
OrthoDBiPOG091H03R4

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_CHRVO
AccessioniPrimary (citable) accession number: Q7NZ60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 15, 2003
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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