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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi252Magnesium or manganese 1UniRule annotation1
Metal bindingi265Magnesium or manganese 1UniRule annotation1
Metal bindingi265Magnesium or manganese 2UniRule annotation1
Metal bindingi267Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi128 – 183ATPUniRule annotationAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGVIO251221:G1G3K-300-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:gll0297
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacteraceaeGloeobacter
Proteomesi
  • UP000000557 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001778251 – 302D-alanine--D-alanine ligaseAdd BLAST302

Proteomic databases

PRIDEiQ7NNW1

Interactioni

Protein-protein interaction databases

STRINGi251221.gll0297

Structurei

3D structure databases

ProteinModelPortaliQ7NNW1
SMRiQ7NNW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 298ATP-graspUniRule annotationAdd BLAST200

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
HOGENOMiHOG000011592
InParanoidiQ7NNW1
KOiK01921
OMAiYETKYTE
OrthoDBiPOG091H00GT
PhylomeDBiQ7NNW1

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NNW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRITVLSGSD SPEREVSLVS GRAVQAALET LGHEVTMVDP GPDLPVRLLE
60 70 80 90 100
NPPDFVWIAL HGDKGENGKL QGLLDWLGLP YNGSGVTASA IAMDKVVSKR
110 120 130 140 150
LFVAEGIPTP AYRVAEAVPQ VSECQAWLAA LGSPVVVKPA DGGSTVGVTI
160 170 180 190 200
AREAGHLPEA VRLALQYSPQ VLIEQYIPGQ EITVALLDGL VLPAIEIVPQ
210 220 230 240 250
GRDFYDYEAK YAPGGSRHLI PPNLAADVLK ASVDAAYRAC RAVGSTGLVR
260 270 280 290 300
ADVRVDPEGR PWVLEVNTLP GMTATSLAPE AAQAAGIDFE QLIQRIIDRS

LD
Length:302
Mass (Da):32,020
Last modified:December 15, 2003 - v1
Checksum:iBF8B16064F5A733A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA Translation: BAC88238.1
RefSeqiNP_923243.1, NC_005125.1
WP_011140301.1, NC_005125.1

Genome annotation databases

EnsemblBacteriaiBAC88238; BAC88238; BAC88238
GeneIDi2599893
KEGGigvi:gll0297
PATRICifig|251221.4.peg.298

Similar proteinsi

Entry informationi

Entry nameiDDL_GLOVI
AccessioniPrimary (citable) accession number: Q7NNW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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