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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-methyl-5'-thioadenosine phosphorylase (mtnP)
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route), the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14PhosphateUniRule annotation1
Sitei173Important for substrate specificityUniRule annotation1
Binding sitei191Substrate; via amide nitrogenUniRule annotation1
Binding sitei192PhosphateUniRule annotation1
Sitei228Important for substrate specificityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

BioCyciGVIO251221:G1G3K-2453-MONOMER
UniPathwayiUPA00904; UER00873

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Gene namesi
Name:mtnPUniRule annotation
Ordered Locus Names:gll2424
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacteraceaeGloeobacter
Proteomesi
  • UP000000557 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004150931 – 299S-methyl-5'-thioadenosine phosphorylaseAdd BLAST299

Proteomic databases

PRIDEiQ7NHW1

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi251221.gll2424

Structurei

3D structure databases

ProteinModelPortaliQ7NHW1
SMRiQ7NHW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 57Phosphate bindingUniRule annotation2
Regioni89 – 90Phosphate bindingUniRule annotation2
Regioni215 – 217Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RHB Bacteria
COG0005 LUCA
HOGENOMiHOG000228986
InParanoidiQ7NHW1
KOiK00772
OMAiNLYRSWG
OrthoDBiPOG091H0228
PhylomeDBiQ7NHW1

Family and domain databases

HAMAPiMF_01963 MTAP, 1 hit
InterProiView protein in InterPro
IPR010044 MTAP
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR018099 Purine_phosphorylase-2_CS
PANTHERiPTHR42679 PTHR42679, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01694 MTAP, 1 hit
PROSITEiView protein in PROSITE
PS01240 PNP_MTAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NHW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPQARIGV IGGSGLYQMA DLADTVEVQF NTPFGPPSDA LVIGTLAGER
60 70 80 90 100
VAFLPRHGRG HRLLPAELPF QANIYAMKML GVEYLLSASA VGSLREEYRP
110 120 130 140 150
RDIVFPDQFF DRTKDRPSTF FGGGLVAHIG FDQPICTELA HLAAEAARGV
160 170 180 190 200
ELIGETRIHT GGTYVCMEGP AFSTLAESRL YRSWGMDIIG MTNLQEAKLA
210 220 230 240 250
REAEICYATM ALVTDYDCWH PDHGAVTVEL IIDNLHKNAE NAQRIVRAVV
260 270 280 290
ERLHAAAPPC ASHSALKYAL LTQPEDVPQA TKQKLAAILA KYPAYRPEV
Length:299
Mass (Da):32,753
Last modified:December 15, 2003 - v1
Checksum:i0A134C2398AFD025
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA Translation: BAC90365.1
RefSeqiNP_925370.1, NC_005125.1
WP_011142419.1, NC_005125.1

Genome annotation databases

EnsemblBacteriaiBAC90365; BAC90365; BAC90365
GeneIDi2600825
KEGGigvi:gll2424
PATRICifig|251221.4.peg.2461

Similar proteinsi

Entry informationi

Entry nameiMTAP_GLOVI
AccessioniPrimary (citable) accession number: Q7NHW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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