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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62SubstrateUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Binding sitei159SubstrateUniRule annotation1
Binding sitei189SubstrateUniRule annotation1
Binding sitei193SubstrateUniRule annotation1
Binding sitei194NADUniRule annotation1
Binding sitei246NADUniRule annotation1
Binding sitei281NADUniRule annotation1
Binding sitei349NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi160 – 162NADUniRule annotation3
Nucleotide bindingi223 – 228NADUniRule annotation6
Nucleotide bindingi302 – 304NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

BioCyciGVIO251221:G1G3K-3222-MONOMER
UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:glr3183
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacteraceaeGloeobacter
Proteomesi
  • UP000000557 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169641 – 428AdenosylhomocysteinaseAdd BLAST428

Proteomic databases

PRIDEiQ7NGI6

Interactioni

Protein-protein interaction databases

STRINGi251221.glr3183

Structurei

3D structure databases

ProteinModelPortaliQ7NGI6
SMRiQ7NGI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E Bacteria
COG0499 LUCA
HOGENOMiHOG000227987
InParanoidiQ7NGI6
KOiK01251
OMAiTGNRDII
OrthoDBiPOG091H00W2
PhylomeDBiQ7NGI6

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 2 hits
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NGI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVKTPIQV RYEVRNLELA AEGRQRIEWA AREMPVLKQL RQRFSQERPL
60 70 80 90 100
AGIRISACCH VTTETANLAV ALKAAGADAL LIASNPLSTQ DDVAASLVVD
110 120 130 140 150
HGIPVFALKG EDTATYLRHV RVALDHRPQI IIDDGSDVVA TMIKDRPDLI
160 170 180 190 200
AGVIGTTEET TTGIVRLKAM LAAGVLTFPA MAVNDAETKH FFDNRYGTGQ
210 220 230 240 250
STLDGIIRAT NILLAGKTIV VAGYGWCGKG VALRARGMGA NVVVTEINPV
260 270 280 290 300
RAIEAAMDGL QVMPMAEAAC LGDLFITVTG NKHVIRREHF AMMKDGAIVC
310 320 330 340 350
NSGHFDIEID LVALGELSSE RRMVRPFTEE YTLEGGKSVI VLGEGRLINL
360 370 380 390 400
AAAEGHPASV MDMSFANQAL AVEYLIKNQG KLSPGIYNIP EELDRQIAAL
410 420
KLAAMGIAID TLTPDQLHYI SSWDEGTE
Length:428
Mass (Da):46,150
Last modified:December 15, 2003 - v1
Checksum:i55B8B09585998B9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA Translation: BAC91124.1
RefSeqiNP_926129.1, NC_005125.1
WP_011143175.1, NC_005125.1

Genome annotation databases

EnsemblBacteriaiBAC91124; BAC91124; BAC91124
GeneIDi2601584
KEGGigvi:glr3183
PATRICifig|251221.4.peg.3213

Similar proteinsi

Entry informationi

Entry nameiSAHH_GLOVI
AccessioniPrimary (citable) accession number: Q7NGI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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