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Entry version 110 (22 Apr 2020)
Sequence version 1 (15 Dec 2003)
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Protein

Proton-gated ion channel

Gene

glvI

Organism
Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cationic channel with similar permeabilities for Na+ and K+, that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.1 Publication

Miscellaneous

The homologous nature of GLIC to eukaryotic nicotinic acetylcholine receptors and other eukaryotic pentameric ligand-gated ion channels, and its sensitivity to general anesthetics, define GLIC as a structural and functional model of signal transduction in the nervous system, also relevant for exploring the molecular basis of anesthetic action.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Tetraethylammonium (TEA) and tetrabutylammonium (TBA) inhibit the proton-activated currents in a dose- and voltage-dependent manner in vitro, whereas the blocker of acid sensing ion channels, amiloride, has no effect. Channel current of GLIC can be inhibited by inhaled and intravenous general anesthetics at and below concentrations used clinically. Ion conduction is also inhibited by lidocaine and by divalent transition metal ions such as cadmium ions.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Potassium channel, Receptor, Sodium channel
Biological processIon transport, Potassium transport, Sodium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GVIO251221:G1G3K-4249-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.9.8.1 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proton-gated ion channel
Alternative name(s):
GLIC
Ligand-gated ion channel
Short name:
LGIC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:glvI
Ordered Locus Names:glr4197
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGloeobacter violaceus (strain ATCC 29082 / PCC 7421)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri251221 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacteraceaeGloeobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000557 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini44 – 235PeriplasmicSequence analysisAdd BLAST192
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei236 – 258HelicalAdd BLAST23
Topological domaini259 – 261CytoplasmicSequence analysis3
Transmembranei262 – 286HelicalAdd BLAST25
Topological domaini287 – 294PeriplasmicSequence analysis8
Transmembranei295 – 323HelicalAdd BLAST29
Topological domaini324 – 326CytoplasmicSequence analysis3
Transmembranei327 – 359HelicalAdd BLAST33

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi244I → Y: Marked gain of function, with a ten-fold shift of the proton dose-response curve towards lower concentrations. 1 Publication1
Mutagenesisi264E → A: Decreases cation selectivity. Decreases the binding affinity of TEA and TBA. Nearly abolishes block by Cd(2+). 2 Publications1
Mutagenesisi264E → Q or D: Decreases binding affinity of TBA. 2 Publications1
Mutagenesisi268T → A: Increases the binding affinity of TBA. Weakens block by Cd(2+). 1 Publication1
Mutagenesisi272S → A: Increases the binding affinity of TBA. 1 Publication1
Mutagenesisi284V → M: Displays an increased sensitivity to propofol but not to desflurane. 1 Publication1
Mutagenesisi297T → A: Marked gain of function, with a ten-fold shift of the proton dose-response curve towards lower concentrations. Shows also slower apparent rate constants for activation and deactivation. Displays an increased sensitivity to propofol but a decreased sensitivity to desflurane. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 43Sequence analysisAdd BLAST43
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000041272244 – 359Proton-gated ion channelAdd BLAST316

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homopentamer.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q7NDN8
With#Exp.IntAct
itself26EBI-8423601,EBI-8423601

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-59040N

Molecular INTeraction database

More...
MINTi
Q7NDN8

STRING: functional protein association networks

More...
STRINGi
251221.35214771

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7NDN8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7NDN8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists of an N-terminal ligand-binding domain that encloses a wide aqueous vestibule and a transmembrane domain that forms a narrow channel.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105TA1 Bacteria
ENOG4111U8M LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010920_3_0_3

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7NDN8

Identification of Orthologs from Complete Genome Data

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OMAi
TMNDLMF

Database of Orthologous Groups

More...
OrthoDBi
1795552at2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7NDN8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.70.170.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf

The PANTHER Classification System

More...
PANTHERi
PTHR18945 PTHR18945, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02931 Neur_chan_LBD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00253 GABAARECEPTR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q7NDN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPTGWRPKL SESIAASRML WQPMAAVAVV QIGLLWFSPP VWGQDMVSPP
60 70 80 90 100
PPIADEPLTV NTGIYLIECY SLDDKAETFK VNAFLSLSWK DRRLAFDPVR
110 120 130 140 150
SGVRVKTYEP EAIWIPEIRF VNVENARDAD VVDISVSPDG TVQYLERFSA
160 170 180 190 200
RVLSPLDFRR YPFDSQTLHI YLIVRSVDTR NIVLAVDLEK VGKNDDVFLT
210 220 230 240 250
GWDIESFTAV VKPANFALED RLESKLDYQL RISRQYFSYI PNIILPMLFI
260 270 280 290 300
LFISWTAFWS TSYEANVTLV VSTLIAHIAF NILVETNLPK TPYMTYTGAI
310 320 330 340 350
IFMIYLFYFV AVIEVTVQHY LKVESQPARA ASITRASRIA FPVVFLLANI

ILAFLFFGF
Length:359
Mass (Da):40,986
Last modified:December 15, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F9009F96172C025
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BA000045 Genomic DNA Translation: BAC92138.1

NCBI Reference Sequences

More...
RefSeqi
NP_927143.1, NC_005125.1
WP_011144181.1, NC_005125.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAC92138; BAC92138; BAC92138

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2602600

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gvi:glr4197

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA Translation: BAC92138.1
RefSeqiNP_927143.1, NC_005125.1
WP_011144181.1, NC_005125.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XQ3X-ray3.50A/B/C/D/E43-359[»]
2XQ4X-ray3.60A/B/C/D/E43-359[»]
2XQ5X-ray3.50A/B/C/D/E43-359[»]
2XQ6X-ray3.70A/B/C/D/E43-359[»]
2XQ7X-ray3.40A/B/C/D/E43-359[»]
2XQ8X-ray3.60A/B/C/D/E43-359[»]
2XQ9X-ray3.20A/B/C/D/E43-359[»]
2XQAX-ray3.70A/B/C/D/E43-359[»]
3EAMX-ray2.90A/B/C/D/E44-359[»]
3EHZX-ray3.10A/B/C/D/E50-359[»]
3EI0X-ray3.50A/B/C/D/E50-359[»]
3IGQX-ray2.30A/B/C/D/E/F44-235[»]
3LSVX-ray3.15A/B/C/D/E44-359[»]
3P4WX-ray3.20A/B/C/D/E44-359[»]
3P50X-ray3.30A/B/C/D/E44-359[»]
3TLSX-ray3.20A/B/C/D/E44-359[»]
3TLTX-ray3.30A/B/C/D/E44-359[»]
3TLUX-ray2.85A/B/C/D/E44-359[»]
3TLVX-ray2.90A/B/C/D/E44-359[»]
3TLWX-ray2.60A/B/C/D/E44-359[»]
3UU3X-ray3.15A/B/C/D/E44-359[»]
3UU4X-ray3.05A/B/C/D/E44-359[»]
3UU5X-ray2.90A/B/C/D/E44-359[»]
3UU6X-ray2.98A/B/C/D/E44-359[»]
3UU8X-ray3.25A/B/C/D/E44-359[»]
3UUBX-ray2.90A/B/C/D/E/F/G/H/I/J44-359[»]
4F8HX-ray2.99A/B/C/D/E43-359[»]
4HFBX-ray2.75A/B/C/D/E44-359[»]
4HFCX-ray3.05A/B/C/D/E44-359[»]
4HFDX-ray3.10A/B/C/D/E44-359[»]
4HFEX-ray2.80A/B/C/D/E44-359[»]
4HFHX-ray2.65A/B/C/D/E44-359[»]
4HFIX-ray2.40A/B/C/D/E44-359[»]
4IL4X-ray3.30A/B/C/D/E44-359[»]
4IL9X-ray2.83A/B/C/D/E44-358[»]
4ILAX-ray3.50A/B/C/D/E44-358[»]
4ILBX-ray3.15A/B/C/D/E44-358[»]
4ILCX-ray2.99A/B/C/D/E44-358[»]
4IREX-ray3.19A/B/C/D/E43-359[»]
4LMJX-ray3.44A/B/C/D/E44-359[»]
4LMKX-ray3.22A/B/C/D/E44-359[»]
4LMLX-ray3.80A/B/C/D/E44-359[»]
4NPPX-ray3.35A/B/C/D/E44-359[»]
4NPQX-ray4.35A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T44-359[»]
4QH1X-ray3.40A/B/C/D/E44-359[»]
4QH4X-ray3.20A/B/C/D/E44-359[»]
4QH5X-ray3.00A/B/C/D/E44-359[»]
4X5TX-ray3.50A/B/C/D/E44-235[»]
4YEUX-ray4.60A/B/C/D/E236-357[»]
4ZZBX-ray3.40A/B/C/D/E44-359[»]
4ZZCX-ray3.10A/B/C/D/E43-359[»]
5HCJX-ray2.95A/B/C/D/E44-359[»]
5HCMX-ray3.15A/B/C/D/E44-359[»]
5HEGX-ray3.21A/B/C/D/E44-359[»]
5HEHX-ray3.30A/B/C/D/E44-359[»]
5IUXX-ray2.60A/B/C/D/E43-359[»]
5J0ZX-ray3.25A/B/C/D/E47-357[»]
5L47X-ray3.30A/B/C/D/E43-359[»]
5L4EX-ray3.50A/B/C/D/E43-359[»]
5L4HX-ray3.30A/B/C/D/E43-359[»]
5MUOX-ray3.19A/B/C/D/E44-359[»]
5MURX-ray3.10A/B/C/D/E43-359[»]
5MVMX-ray3.10A/B/C/D/E43-359[»]
5MVNX-ray3.49A/B/C/D/E43-359[»]
5MZQX-ray2.80A/B/C/D/E43-359[»]
5MZRX-ray2.65A/B/C/D/E43-359[»]
5MZTX-ray2.65A/B/C/D/E43-359[»]
5NJYX-ray2.95A/B/C/D/E43-359[»]
5NKJX-ray3.74A/B/C/D/E43-359[»]
5OSAX-ray2.75A/B/C/D/E44-236[»]
5OSBX-ray3.80A/B/C/D/E44-236[»]
5OSCX-ray3.10A/B/C/D/E44-236[»]
5V6NX-ray3.35A/B/C/D/E50-359[»]
5V6OX-ray3.12A/B/C/D/E50-359[»]
6EMXX-ray3.20A/B/C/D/E43-359[»]
6F0IX-ray3.00A/B/C/D/E43-359[»]
6F0JX-ray3.15A/B/C/D/E43-359[»]
6F0MX-ray2.65A/B/C/D/E43-359[»]
6F0NX-ray3.20A/B/C/D/E43-359[»]
6F0RX-ray2.50A/B/C/D/E43-359[»]
6F0UX-ray2.35A/B/C/D/E43-359[»]
6F0VX-ray2.85A/B/C/D/E43-359[»]
6F0ZX-ray2.50A/B/C/D/E43-359[»]
6F10X-ray2.85A/B/C/D/E43-359[»]
6F11X-ray2.95A/B/C/D/E43-359[»]
6F12X-ray3.20A/B/C/D/E43-359[»]
6F13X-ray2.70A/B/C/D/E43-359[»]
6F15X-ray2.85A/B/C/D/E43-359[»]
6F16X-ray2.60A/B/C/D/E43-359[»]
6F7AX-ray6.00A/B/C/D/E47-357[»]
6HJ3X-ray2.70A/B/C/D/E43-359[»]
6HJAX-ray2.70A/B/C/D/E1-359[»]
6HJBX-ray3.00A/B/C/D/E1-359[»]
6HJIX-ray2.80A/B/C/D/E43-359[»]
6HJZX-ray2.50A/B/C/D/E/F/G/H/I/J43-359[»]
6HPPX-ray3.20A/B/C/D/E43-359[»]
6HY5X-ray2.58A/B/C/D/E47-357[»]
6HY9X-ray2.95A/B/C/D/E44-359[»]
6HYAX-ray3.39A/B/C/D/E43-359[»]
6HYRX-ray3.50A/B/C/D/E47-357[»]
6HYVX-ray2.80A/B/C/D/E43-359[»]
6HYWX-ray2.80A/B/C/D/E43-359[»]
6HYXX-ray3.00A/B/C/D/E43-359[»]
6HYZX-ray3.05A/B/C/D/E43-359[»]
6HZ0X-ray2.75A/B/C/D/E43-359[»]
6HZ1X-ray2.50A/B/C/D/E44-359[»]
6HZ3X-ray3.15A/B/C/D/E43-359[»]
6HZWX-ray2.22A/B/C/D/E43-359[»]
6I08X-ray3.00A/B/C/D/E43-359[»]
SMRiQ7NDN8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-59040N
MINTiQ7NDN8
STRINGi251221.35214771

Protein family/group databases

TCDBi1.A.9.8.1 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

Genome annotation databases

EnsemblBacteriaiBAC92138; BAC92138; BAC92138
GeneIDi2602600
KEGGigvi:glr4197

Phylogenomic databases

eggNOGiENOG4105TA1 Bacteria
ENOG4111U8M LUCA
HOGENOMiCLU_010920_3_0_3
InParanoidiQ7NDN8
OMAiTMNDLMF
OrthoDBi1795552at2
PhylomeDBiQ7NDN8

Enzyme and pathway databases

BioCyciGVIO251221:G1G3K-4249-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ7NDN8

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PRINTSiPR00253 GABAARECEPTR
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLIC_GLOVI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7NDN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: December 15, 2003
Last modified: April 22, 2020
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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