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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per tetramer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi454MagnesiumUniRule annotation1
Metal bindingi460Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi463MagnesiumUniRule annotation1
Metal bindingi464MagnesiumUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • phenylalanyl-tRNA aminoacylation Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GVIO251221:G1G3K-2962-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunitUniRule annotation
Short name:
PheRSUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pheTUniRule annotation
Ordered Locus Names:gll2926
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGloeobacter violaceus (strain PCC 7421)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri251221 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacteraceaeGloeobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000557 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001268901 – 785Phenylalanine--tRNA ligase beta subunitAdd BLAST785

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer of two alpha and two beta subunits.UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
251221.gvip406

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q7NCQ2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 150tRNA-bindingUniRule annotationAdd BLAST112
Domaini400 – 476B5UniRule annotationAdd BLAST77
Domaini692 – 784FDX-ACBUniRule annotationAdd BLAST93

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C6A Bacteria
COG0072 LUCA
COG0073 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7NCQ2

KEGG Orthology (KO)

More...
KOi
K01890

Identification of Orthologs from Complete Genome Data

More...
OMAi
LTPNRSD

Database of Orthologous Groups

More...
OrthoDBi
POG091H01YS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7NCQ2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02796 tRNA_bind_bactPheRS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.380, 1 hit
3.50.40.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00283 Phe_tRNA_synth_beta1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005146 B3/B4_tRNA-bd
IPR009061 DNA-bd_dom_put_sf
IPR005121 Fdx_antiC-bd
IPR036690 Fdx_antiC-bd_sf
IPR012340 NA-bd_OB-fold
IPR004532 Phe-tRNA-ligase_IIc_bsu
IPR020825 Phe-tRNA_synthase_B3/B4
IPR002547 tRNA-bd_dom
IPR033714 tRNA_bind_bactPheRS
IPR005147 tRNA_synthase_B5-dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03483 B3_4, 1 hit
PF03484 B5, 1 hit
PF03147 FDX-ACB, 1 hit
PF01588 tRNA_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00873 B3_4, 1 hit
SM00874 B5, 1 hit
SM00896 FDX-ACB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46955 SSF46955, 1 hit
SSF50249 SSF50249, 1 hit
SSF54991 SSF54991, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00472 pheT_bact, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51483 B5, 1 hit
PS51447 FDX_ACB, 1 hit
PS50886 TRBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7NCQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVSFNWLQE YVEFDFTPSE LAEKLTMAGF EVEHVEDRRT WAAGVVVGRV
60 70 80 90 100
LECAPHPQAD RLHVCRVDIG TGRLLNIVCG APNARAGIYA PVAPVGTYLP
110 120 130 140 150
IKDLKLRAAS IRGMPSEGML CSLEELGLEK ASEGIHIFPE ASLPLGLDVG
160 170 180 190 200
PLLGLDDAIL EVASTANRAD ALSMVGIARE VAALTGGILR LPLVDAPLVP
210 220 230 240 250
RGDLAARIAE PEACPVYTAT LLEEVAVGPA PDWLRERLEK AGMRPINNVV
260 270 280 290 300
DVTNYVLLEW GQPLHAFDAD RLAAGTLGVR FAHKGEQLVT LDGTERPLTP
310 320 330 340 350
ANLLITAGER PVALAGVMGG EATEVGGQTR RIVLEAAIFD PPAIRRSARV
360 370 380 390 400
FALRTEASAR YERGVDASAL EHALGRALQL LADCAGARAV VQATDDYRRR
410 420 430 440 450
ENRVVSLRPE RLAQILGEDI PDAEIARVLK NLGFDVQTGP QEFAVTVPGH
460 470 480 490 500
RLRDIEREID LIEEVARVVG YDRFAPTLPP PADGGYLPFE DFIERRVRSL
510 520 530 540 550
CQGAGLTEVV TYSLAPDRDQ QPVVLSNPLS AELNSLRTNL IDGLLEILRF
560 570 580 590 600
NRSQGNMPFH AFEVGVVFLR SDEGIFESGR LGAVMCGEPA VGDWQKLTPP
610 620 630 640 650
FDWFAAKGVL AAILQPWQIE VEYQADRRDE RLHPGRTASL WVSGERLGTL
660 670 680 690 700
GQLHPRLASR LDLPEQTFVF EIDLDFLIDL VRERPVEFRS FSPFPPAARD
710 720 730 740 750
LSFYAREALT VFEFERLIRE QGEPLLESVA LLDEFKGQGV PEGCRSLAFR
760 770 780
MVYRSDHTLT EEEITAVHQR VRQALAERYS VDLRS
Length:785
Mass (Da):86,447
Last modified:December 15, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i263B819B44EF465D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BA000045 Genomic DNA Translation: BAC90867.1

NCBI Reference Sequences

More...
RefSeqi
NP_925872.1, NC_005125.1
WP_011142920.1, NC_005125.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAC90867; BAC90867; BAC90867

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2601327

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gvi:gvip406

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|251221.4.peg.2955

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA Translation: BAC90867.1
RefSeqiNP_925872.1, NC_005125.1
WP_011142920.1, NC_005125.1

3D structure databases

ProteinModelPortaliQ7NCQ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi251221.gvip406

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC90867; BAC90867; BAC90867
GeneIDi2601327
KEGGigvi:gvip406
PATRICifig|251221.4.peg.2955

Phylogenomic databases

eggNOGiENOG4105C6A Bacteria
COG0072 LUCA
COG0073 LUCA
InParanoidiQ7NCQ2
KOiK01890
OMAiLTPNRSD
OrthoDBiPOG091H01YS
PhylomeDBiQ7NCQ2

Enzyme and pathway databases

BioCyciGVIO251221:G1G3K-2962-MONOMER

Family and domain databases

CDDicd02796 tRNA_bind_bactPheRS, 1 hit
Gene3Di3.30.70.380, 1 hit
3.50.40.10, 1 hit
HAMAPiMF_00283 Phe_tRNA_synth_beta1, 1 hit
InterProiView protein in InterPro
IPR005146 B3/B4_tRNA-bd
IPR009061 DNA-bd_dom_put_sf
IPR005121 Fdx_antiC-bd
IPR036690 Fdx_antiC-bd_sf
IPR012340 NA-bd_OB-fold
IPR004532 Phe-tRNA-ligase_IIc_bsu
IPR020825 Phe-tRNA_synthase_B3/B4
IPR002547 tRNA-bd_dom
IPR033714 tRNA_bind_bactPheRS
IPR005147 tRNA_synthase_B5-dom
PfamiView protein in Pfam
PF03483 B3_4, 1 hit
PF03484 B5, 1 hit
PF03147 FDX-ACB, 1 hit
PF01588 tRNA_bind, 1 hit
SMARTiView protein in SMART
SM00873 B3_4, 1 hit
SM00874 B5, 1 hit
SM00896 FDX-ACB, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF50249 SSF50249, 1 hit
SSF54991 SSF54991, 1 hit
TIGRFAMsiTIGR00472 pheT_bact, 1 hit
PROSITEiView protein in PROSITE
PS51483 B5, 1 hit
PS51447 FDX_ACB, 1 hit
PS50886 TRBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYFB_GLOVI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7NCQ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 15, 2003
Last modified: December 5, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
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