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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

[Biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Biotin carboxylase (accC)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPLUM243265:PLU_RS03405-MONOMER
UniPathwayi
UPA00655;UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotation (EC:2.1.3.15UniRule annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
Ordered Locus Names:plu0688
OrganismiPhotorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaePhotorhabdus
Proteomesi
  • UP000002514 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002238001 – 319Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaAdd BLAST319

Proteomic databases

PRIDEiQ7N8N1

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotation

Protein-protein interaction databases

STRINGi243265.plu0688

Structurei

3D structure databases

ProteinModelPortaliQ7N8N1
SMRiQ7N8N1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 296CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST262

Sequence similaritiesi

Belongs to the AccA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QM9 Bacteria
COG0825 LUCA
HOGENOMiHOG000273832
KOiK01962
OMAiCSSILWR
OrthoDBiPOG091H0647

Family and domain databases

HAMAPiMF_00823 AcetylCoA_CT_alpha, 1 hit
InterProiView protein in InterPro
IPR001095 Acetyl_CoA_COase_a_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
PANTHERiPTHR42853 PTHR42853, 1 hit
PfamiView protein in Pfam
PF03255 ACCA, 1 hit
PRINTSiPR01069 ACCCTRFRASEA
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00513 accA, 1 hit
PROSITEiView protein in PROSITE
PS50989 COA_CT_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q7N8N1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLNFLEFEQ PIAELEAKID SLTAVSRQGE KLDINLDEEV QRLREKSLEL
60 70 80 90 100
TRKIFSDLGA WQIAQLARHP RRPYTLDYIQ HIFTDFEELA GDRAYADDKA
110 120 130 140 150
IVGGLARIDG RPVMVIGHQK GRETKEKIRR NFGMPAPEGY RKALRLMEMA
160 170 180 190 200
ERFKLPIITF IDTPGAYPGV GAEERGQSEA IARNLREMSR LSVPVICTVI
210 220 230 240 250
GEGGSGGALA IGVGDKVNML QYSTYSVISP EGCASILWKS AEKAPLAAEA
260 270 280 290 300
MGITAPRLKE LELVDTVISE PLGGAHRDYE AISTSLKAQL LIDLAELDHL
310
TSEELVNRRY QRLMQYGYC
Length:319
Mass (Da):35,524
Last modified:December 15, 2003 - v1
Checksum:iE1F08BF0F450FCE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571861 Genomic DNA Translation: CAE12983.1
RefSeqiWP_011145064.1, NC_005126.1

Genome annotation databases

EnsemblBacteriaiCAE12983; CAE12983; plu0688
KEGGiplu:plu0688

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571861 Genomic DNA Translation: CAE12983.1
RefSeqiWP_011145064.1, NC_005126.1

3D structure databases

ProteinModelPortaliQ7N8N1
SMRiQ7N8N1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243265.plu0688

Proteomic databases

PRIDEiQ7N8N1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE12983; CAE12983; plu0688
KEGGiplu:plu0688

Phylogenomic databases

eggNOGiENOG4107QM9 Bacteria
COG0825 LUCA
HOGENOMiHOG000273832
KOiK01962
OMAiCSSILWR
OrthoDBiPOG091H0647

Enzyme and pathway databases

UniPathwayi
UPA00655;UER00711

BioCyciPLUM243265:PLU_RS03405-MONOMER

Family and domain databases

HAMAPiMF_00823 AcetylCoA_CT_alpha, 1 hit
InterProiView protein in InterPro
IPR001095 Acetyl_CoA_COase_a_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
PANTHERiPTHR42853 PTHR42853, 1 hit
PfamiView protein in Pfam
PF03255 ACCA, 1 hit
PRINTSiPR01069 ACCCTRFRASEA
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00513 accA, 1 hit
PROSITEiView protein in PROSITE
PS50989 COA_CT_CTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACCA_PHOLL
AccessioniPrimary (citable) accession number: Q7N8N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 15, 2003
Last modified: October 10, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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