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Protein

Pyrrolidone-carboxylate peptidase 2

Gene

pcp2

Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83UniRule annotation1
Active sitei146UniRule annotation1
Active sitei170UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciPLUM243265:PLU_RS21850-MONOMER

Protein family/group databases

MEROPSiC15.001

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidase 2UniRule annotation (EC:3.4.19.3UniRule annotation)
Alternative name(s):
5-oxoprolyl-peptidase 2UniRule annotation
Pyroglutamyl-peptidase I 2UniRule annotation
Short name:
PGP-I 2UniRule annotation
Short name:
Pyrase 2UniRule annotation
Gene namesi
Name:pcp2UniRule annotation
Ordered Locus Names:plu4418
OrganismiPhotorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaePhotorhabdus
Proteomesi
  • UP000002514 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001847271 – 218Pyrrolidone-carboxylate peptidase 2Add BLAST218

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi243265.plu4418

Structurei

3D structure databases

ProteinModelPortaliQ7MZ76
SMRiQ7MZ76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108KN7 Bacteria
COG2039 LUCA
HOGENOMiHOG000242641
KOiK01304
OMAiHHIATRA
OrthoDBiPOG091H07B8

Family and domain databases

CDDicd00501 Peptidase_C15, 1 hit
Gene3Di3.40.630.20, 1 hit
HAMAPiMF_00417 Pyrrolid_peptidase, 1 hit
InterProiView protein in InterPro
IPR000816 Peptidase_C15
IPR016125 Peptidase_C15-like
IPR036440 Peptidase_C15-like_sf
IPR029762 PGP-I_bact-type
IPR033694 PGPEP1_Cys_AS
IPR033693 PGPEP1_Glu_AS
PANTHERiPTHR23402 PTHR23402, 1 hit
PfamiView protein in Pfam
PF01470 Peptidase_C15, 1 hit
PIRSFiPIRSF015592 Prld-crbxl_pptds, 1 hit
PRINTSiPR00706 PYROGLUPTASE
SUPFAMiSSF53182 SSF53182, 1 hit
TIGRFAMsiTIGR00504 pyro_pdase, 1 hit
PROSITEiView protein in PROSITE
PS01334 PYRASE_CYS, 1 hit
PS01333 PYRASE_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Q7MZ76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQKTVLIT GFEPFGKETI NPSWEAAKQL QGRELCGARV EARQLPCVFD
60 70 80 90 100
VSLACLYAAI DDVQPDLVIA VGQAGGRPNI TVERVAININ DASIPDNQGN
110 120 130 140 150
QPINTPIVAT GPAAYFATLP INAIVKGLRD AGVPASISQT AGTFVCNHVM
160 170 180 190 200
YGLLHHLACI YPEIRGGVLH IPYLPEQAAR YSGTPSMALE TVITALEIAI
210
DEALKNSEDI ANNGDTAH
Length:218
Mass (Da):23,158
Last modified:December 15, 2003 - v1
Checksum:i6519209111AB823C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571873 Genomic DNA Translation: CAE16790.1
RefSeqiWP_011148508.1, NC_005126.1

Genome annotation databases

EnsemblBacteriaiCAE16790; CAE16790; plu4418
KEGGiplu:plu4418

Similar proteinsi

Entry informationi

Entry nameiPCP2_PHOLL
AccessioniPrimary (citable) accession number: Q7MZ76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: December 15, 2003
Last modified: June 20, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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