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Protein

Prolyl tripeptidyl peptidase

Gene

ptpA

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position.1 Publication

Catalytic activityi

Hydrolysis of Xaa-Xaa-Pro-|-Yaa- releasing the N-terminal tripeptide of a peptide with Pro as the third residue (position P1) and where Yaa is not proline.1 Publication

Activity regulationi

Strongly inhibited by diisopropyl fluorophosphate and Pefabloc. Weakly inhibited by 3,4-dichloroisocumarin. Not inhibited by phenylmethylsulfonyl fluoride, leupeptin, antipain or prolinal. Activated by iodoacetamide.1 Publication

pH dependencei

Optimum pH is 6-8.1 Publication

Temperature dependencei

Stable for at least 12 hours at 25 or 37 degrees Celsius (at pH 7.6).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei603Charge relay systemBy similarity1
Active sitei678Charge relay systemBy similarity1
Active sitei710Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.14.12 756

Protein family/group databases

ESTHERiporgi-q7muw6 DPP4N_Peptidase_S9

Names & Taxonomyi

Protein namesi
Recommended name:
Prolyl tripeptidyl peptidase1 Publication (EC:3.4.14.12)
Short name:
PTP1 Publication
Alternative name(s):
Prolyl tripeptidyl peptidase 81.8 kDa form1 Publication
Prolyl tripeptidyl peptidase A1 Publication
Cleaved into the following chain:
Prolyl tripeptidyl peptidase 75.8 kDa form1 Publication
Gene namesi
Name:ptpA1 Publication
Ordered Locus Names:PG_1361
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000000588 Componenti: Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi205E → Q: Inactive. 1 Publication1
Mutagenesisi636E → A: Reduced activity. 1 Publication1

Chemistry databases

DrugBankiDB07813 GLYCYLALANYL-N-2-NAPHTHYL-L-PROLINEAMIDE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000039475725 – 732Prolyl tripeptidyl peptidaseSequence analysisAdd BLAST708
ChainiPRO_000039475881 – 732Prolyl tripeptidyl peptidase 75.8 kDa form1 PublicationAdd BLAST652

Post-translational modificationi

The N-terminus is blocked.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi242619.PG1361

Structurei

Secondary structure

1732
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ7MUW6
SMRiQ7MUW6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7MUW6

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C5Z Bacteria
COG1506 LUCA
KOiK18574
OMAiMYGERYM

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7MUW6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKTIFQQLF LSVCALTVAL PCSAQSPETS GKEFTLEQLM PGGKEFYNFY
60 70 80 90 100
PEYVVGLQWM GDNYVFIEGD DLVFNKANGK SAQTTRFSAA DLNALMPEGC
110 120 130 140 150
KFQTTDAFPS FRTLDAGRGL VVLFTQGGLV GFDMLARKVT YLFDTNEETA
160 170 180 190 200
SLDFSPVGDR VAYVRNHNLY IARGGKLGEG MSRAIAVTID GTETLVYGQA
210 220 230 240 250
VHQREFGIEK GTFWSPKGSC LAFYRMDQSM VKPTPIVDYH PLEAESKPLY
260 270 280 290 300
YPMAGTPSHH VTVGIYHLAT GKTVYLQTGE PKEKFLTNLS WSPDENILYV
310 320 330 340 350
AEVNRAQNEC KVNAYDAETG RFVRTLFVET DKHYVEPLHP LTFLPGSNNQ
360 370 380 390 400
FIWQSRRDGW NHLYLYDTTG RLIRQVTKGE WEVTNFAGFD PKGTRLYFES
410 420 430 440 450
TEASPLERHF YCIDIKGGKT KDLTPESGMH RTQLSPDGSA IIDIFQSPTV
460 470 480 490 500
PRKVTVTNIG KGSHTLLEAK NPDTGYAMPE IRTGTIMAAD GQTPLYYKLT
510 520 530 540 550
MPLHFDPAKK YPVIVYVYGG PHAQLVTKTW RSSVGGWDIY MAQKGYAVFT
560 570 580 590 600
VDSRGSANRG AAFEQVIHRR LGQTEMADQM CGVDFLKSQS WVDADRIGVH
610 620 630 640 650
GWSYGGFMTT NLMLTHGDVF KVGVAGGPVI DWNRYEIMYG ERYFDAPQEN
660 670 680 690 700
PEGYDAANLL KRAGDLKGRL MLIHGAIDPV VVWQHSLLFL DACVKARTYP
710 720 730
DYYVYPSHEH NVMGPDRVHL YETITRYFTD HL
Length:732
Mass (Da):82,266
Last modified:December 15, 2003 - v1
Checksum:iFE08469EB5562810
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015924 Genomic DNA Translation: AAQ66425.1
RefSeqiWP_005873421.1, NC_002950.2

Genome annotation databases

EnsemblBacteriaiAAQ66425; AAQ66425; PG_1361
KEGGipgi:PG_1361

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015924 Genomic DNA Translation: AAQ66425.1
RefSeqiWP_005873421.1, NC_002950.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D5LX-ray2.10A39-732[»]
2DCMX-ray2.90A39-732[»]
2EEPX-ray2.20A39-732[»]
2Z3WX-ray2.00A39-732[»]
2Z3ZX-ray1.95A39-732[»]
ProteinModelPortaliQ7MUW6
SMRiQ7MUW6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi242619.PG1361

Chemistry databases

DrugBankiDB07813 GLYCYLALANYL-N-2-NAPHTHYL-L-PROLINEAMIDE

Protein family/group databases

ESTHERiporgi-q7muw6 DPP4N_Peptidase_S9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAQ66425; AAQ66425; PG_1361
KEGGipgi:PG_1361

Phylogenomic databases

eggNOGiENOG4105C5Z Bacteria
COG1506 LUCA
KOiK18574
OMAiMYGERYM

Enzyme and pathway databases

BRENDAi3.4.14.12 756

Miscellaneous databases

EvolutionaryTraceiQ7MUW6

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTP_PORGI
AccessioniPrimary (citable) accession number: Q7MUW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: December 15, 2003
Last modified: November 7, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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