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Entry version 128 (02 Jun 2021)
Sequence version 1 (15 Dec 2003)
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Protein

Polyphosphate kinase

Gene

ppk

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei46ATPUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi377MagnesiumUniRule annotation1
Metal bindingi407MagnesiumUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei437Phosphohistidine intermediateUniRule annotation1
Binding sitei472ATPUniRule annotation1
Binding sitei568ATPUniRule annotation1
Binding sitei595ATPUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseUniRule annotationARBA annotation, Transferase
LigandATP-bindingUniRule annotationARBA annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyphosphate kinaseUniRule annotationARBA annotation (EC:2.7.4.1UniRule annotationARBA annotation)
Alternative name(s):
ATP-polyphosphate phosphotransferaseUniRule annotation
Polyphosphoric acid kinaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ppkUniRule annotationImported
Ordered Locus Names:PG_1885Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri242619 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000588 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
242619.PG_1885

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7MTR1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7MTR1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 115PP_kinase_NInterPro annotationAdd BLAST108
Domaini125 – 317PP_kinaseInterPro annotationAdd BLAST193
Domaini334 – 498PP_kinase_C_1InterPro annotationAdd BLAST165
Domaini507 – 677PP_kinase_CInterPro annotationAdd BLAST171

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polyphosphate kinase 1 (PPK1) family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0855, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009678_5_0_10

Identification of Orthologs from Complete Genome Data

More...
OMAi
AHPFPQV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1840.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00347, Polyphosphate_kinase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003414, PP_kinase
IPR041108, PP_kinase_C_1
IPR024953, PP_kinase_middle
IPR036830, PP_kinase_middle_dom_sf
IPR025200, PPK_C_dom2
IPR025198, PPK_N_dom
IPR036832, PPK_N_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR30218, PTHR30218, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02503, PP_kinase, 1 hit
PF13090, PP_kinase_C, 1 hit
PF17941, PP_kinase_C_1, 1 hit
PF13089, PP_kinase_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF015589, PP_kinase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140356, SSF140356, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03705, poly_P_kin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7MTR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVSAYPFFR RDMSWLSFNE RVLMEAADRT LPVYDRIKFL SIFSSNLEEF
60 70 80 90 100
YTVRVAYHQA VLQKRRDRSE AEEDSDADAH ILQAIRETVI RQDELYYRIF
110 120 130 140 150
YDQILPTLEE HGIRLRTHAP THPDHKAYLR RFFHEEIFPL LYPMLLLPSK
160 170 180 190 200
VRTFIRSGRV YLAVRLKEKE TDEAYSYALL NVPTDGLPRF VELPRLQTDT
210 220 230 240 250
FYYYSFLEDI IKEHLDVVFP GYEVMDSYSI KVSRDADLLL DAQRPEDLPG
260 270 280 290 300
EIRKKVKTRK LGAPTRFMYD GRMPDEVLRY ICSSCDIDPE EAIRSGNYVN
310 320 330 340 350
LQDLAMLPNP FAPRLETLTP EPLLSKHLEQ APSLMEGIRR KDYLIHVPYY
360 370 380 390 400
TYDYVVRLLM EAAISPDVSE IRLTQYRVAE NSSIISALEA AAQSGKKVSV
410 420 430 440 450
FVELKARFDE ENNLRLSERM RRSGIRIVYS MPGLKVHAKT ALILYHTPAG
460 470 480 490 500
ERPQGIALLS TGNFNETTAR IYSDTTLMTA NTDIVHDVYR LFRILDGDPE
510 520 530 540 550
PARFSRLLVA RYNMGEAITN LIEREIENVK RGKRGYMLLK MNGLQDKNVI
560 570 580 590 600
TQLYRASEAG VEIDLIVRGI CCLVPDMPQS RNIRVTRLVD MYLEHSRIWC
610 620 630 640 650
FHNGGKEEVF ISSADWMKRN LYNRIETACP VLDPALRREI IDILEIQLRD
660 670 680 690
NIKACRIDSS LNNIYKHNSD EKPVRAQAAI YRYLKGKEEA TPAAK
Length:695
Mass (Da):80,688
Last modified:December 15, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i907DEA69B893F91C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE015924 Genomic DNA Translation: AAQ66869.1

NCBI Reference Sequences

More...
RefSeqi
WP_005873993.1, NC_002950.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAQ66869; AAQ66869; PG_1885

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pgi:PG_1885

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015924 Genomic DNA Translation: AAQ66869.1
RefSeqiWP_005873993.1, NC_002950.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O8RX-ray2.70A/B1-695[»]
SMRiQ7MTR1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi242619.PG_1885

Genome annotation databases

EnsemblBacteriaiAAQ66869; AAQ66869; PG_1885
KEGGipgi:PG_1885

Phylogenomic databases

eggNOGiCOG0855, Bacteria
HOGENOMiCLU_009678_5_0_10
OMAiAHPFPQV

Miscellaneous databases

EvolutionaryTraceiQ7MTR1

Family and domain databases

Gene3Di3.30.1840.10, 1 hit
HAMAPiMF_00347, Polyphosphate_kinase, 1 hit
InterProiView protein in InterPro
IPR003414, PP_kinase
IPR041108, PP_kinase_C_1
IPR024953, PP_kinase_middle
IPR036830, PP_kinase_middle_dom_sf
IPR025200, PPK_C_dom2
IPR025198, PPK_N_dom
IPR036832, PPK_N_dom_sf
PANTHERiPTHR30218, PTHR30218, 1 hit
PfamiView protein in Pfam
PF02503, PP_kinase, 1 hit
PF13090, PP_kinase_C, 1 hit
PF17941, PP_kinase_C_1, 1 hit
PF13089, PP_kinase_N, 1 hit
PIRSFiPIRSF015589, PP_kinase, 1 hit
SUPFAMiSSF140356, SSF140356, 1 hit
TIGRFAMsiTIGR03705, poly_P_kin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7MTR1_PORGI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7MTR1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: June 2, 2021
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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