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Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit hisF1 (hisF1), Putative imidazole glycerol phosphate synthase subunit hisF2 (hisF2), Putative imidazole glycerol phosphate synthase subunit hisF3 (hisF3), Imidazole glycerol phosphate synthase subunit HisH 2 (hisH2), Imidazole glycerol phosphate synthase subunit HisH 3 (hisH3), Imidazole glycerol phosphate synthase subunit HisH 1 (hisH1)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferaseUniRule annotation (EC:2.6.1.9UniRule annotation)
Alternative name(s):
Imidazole acetol-phosphate transaminaseUniRule annotation
Gene namesi
Name:hisCUniRule annotation
Ordered Locus Names:VV1352
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002675 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001534781 – 346Histidinol-phosphate aminotransferaseAdd BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei209N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ7MLS5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7MLS5
SMRiQ7MLS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000288512
KOiK00817
OMAiTYGMYKV
OrthoDBiPOG091H05S1

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7MLS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKLARKSVQ KLTPYLSARR IGGTGDVWLN ANESPFDNEY RTNFARLNRY
60 70 80 90 100
SDCQPKALIA AYAAYAGVKP EQTLTSRGAD EGIELLIRAF CEPNEDAILY
110 120 130 140 150
CPPTYGMYSV SAETIGVERK TVPLTEDWQL DLSGIEANLD KVKLVFVCSP
160 170 180 190 200
NNPTGNLVKR EDIIALLEMT KDRAIVVMDE AYIDFCPEAS TVDLLAQYSN
210 220 230 240 250
LAILRTLSKA FALAGLRCGF TLANEELINV LLKVIAPYPV PVPVAEIATQ
260 270 280 290 300
ALSEAGLARA KFQVLDLNAN RAYLQVGLSM IAGLEVFEGW GNYLLVKFPN
310 320 330 340
GDELFKAAWE SGIILRNSPI KDCVRISVGS RDECEKTLGF IRNYYS
Length:346
Mass (Da):38,257
Last modified:December 15, 2003 - v1
Checksum:i1145388B8B687294
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA Translation: BAC94116.1
RefSeqiWP_011150021.1, NC_005139.1

Genome annotation databases

EnsemblBacteriaiBAC94116; BAC94116; BAC94116
GeneIDi2624156
KEGGivvy:VV1352

Similar proteinsi

Entry informationi

Entry nameiHIS8_VIBVY
AccessioniPrimary (citable) accession number: Q7MLS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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