Ubiquitin carboxyl-terminal hydrolase 17-like protein E

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cysteine-type endopeptidase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• thiol-dependent ubiquitin-specific protease activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes."
    Zhu Y., Lambert K., Corless C., Copeland N.G., Gilbert D.J., Jenkins N.A., D'Andrea A.D.
    J. Biol. Chem. 272:51-57(1997) [PubMed] [Europe PMC] [Abstract]
• thiol-dependent ubiquitinyl hydrolase activity Source: UniProtKB

GO - Biological processⁱ

• apoptotic process Source: UniProtKB-KW
• CAAX-box protein processing Source: UniProtKB
• mitotic cell cycle checkpoint Source: UniProtKB
• negative regulation of GTPase activity Source: UniProtKB
• negative regulation of histone deacetylation Source: UniProtKB
• negative regulation of protein processing Source: UniProtKB
• negative regulation of protein targeting to membrane Source: UniProtKB
• positive regulation of GTPase activity Source: UniProtKB
• positive regulation of MDA-5 signaling pathway Source: UniProtKB
• positive regulation of RIG-I signaling pathway Source: UniProtKB
• protein deubiquitination Source: MGIInferred from direct assayⁱ
  • "DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes."
    Zhu Y., Lambert K., Corless C., Copeland N.G., Gilbert D.J., Jenkins N.A., D'Andrea A.D.
    J. Biol. Chem. 272:51-57(1997) [PubMed] [Europe PMC] [Abstract]
• protein K48-linked deubiquitination Source: UniProtKB
• protein K63-linked deubiquitination Source: UniProtKB
• regulation of apoptotic process Source: UniProtKB
• regulation of cell migration Source: UniProtKB
• regulation of cell population proliferation Source: UniProtKB
• regulation of defense response to virus by host Source: UniProtKB
• regulation of ruffle assembly Source: UniProtKB
• ubiquitin-dependent protein catabolic process Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MVVSLSFPEE TGGENLPSAP LEDSSKFFEE VFGDMVFARS FPEADPALSS 
        60         70         80         90        100
PDAPELHQDE AQVVEELTTN GKHSLSWESP QGPGCGLQNT GNSCYLNAAL 
       110        120        130        140        150
QCLTHTPPLA DYMLSQEHSQ TCCSPEGCKM CAMEAHVTQS LLHSHSGDVM 
       160        170        180        190        200
KPSQILTSAF HKHQQEDAHE FLMFTLETMH ESCLQVHRQS DPTPQDTSPI 
       210        220        230        240        250
HDIFGGWWRS QIKCLHCQGT SHTFDPFLDV PLDISSAQSV NQALWDTGKS 
       260        270        280        290        300
EELLGENAYY CGRCRQKMPA SKTLHVHIAP KVLLLVLKRF SAFTGNKLDR 
       310        320        330        340        350
KVSYPEFLDL KPYLSEPTGG PLPYALYAVL VHDGATSNSG HYFCCVKAGH 
       360        370        380        390        400
GKWYKMDDTK VTRCDVTSVL NENAYVLFYV QQTDLKQVSI DMPEGRVHEV 
       410        420        430        440        450
LDPKYQLKKS RRKKRKKQCH CTDDAGEACE NREKRAKKET SLGEGKVPQE 
       460        470        480        490        500
VNHEKAGQKH GNTKLVPQEQ NHQRAGQNLR NTEVELDLPV DAIVIHQPRS 
       510        520        530        540
TANWGTDAPD KENQPWHNGD RLLTSQGLMS PGQLCSQGGR            

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. Peptidase families
   Classification of peptidase families and list of entries