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UniProtKB - Q7M764 (U17PE_MOUSE)
Protein
Ubiquitin carboxyl-terminal hydrolase 17-like protein E
Gene
Usp17le
Organism
Mus musculus (Mouse)
Status
Functioni
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
1 PublicationCatalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 94 | NucleophilePROSITE-ProRule annotation | 1 | |
Active sitei | 341 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: GO_Central
- thiol-dependent deubiquitinase Source: MGI
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- CAAX-box protein processing Source: UniProtKB
- cell cycle Source: UniProtKB-KW
- negative regulation of GTPase activity Source: UniProtKB
- negative regulation of histone deacetylation Source: UniProtKB
- negative regulation of protein processing Source: UniProtKB
- negative regulation of protein targeting to membrane Source: UniProtKB
- positive regulation of GTPase activity Source: UniProtKB
- positive regulation of MDA-5 signaling pathway Source: UniProtKB
- positive regulation of RIG-I signaling pathway Source: UniProtKB
- protein deubiquitination Source: MGI
- protein K48-linked deubiquitination Source: UniProtKB
- protein K63-linked deubiquitination Source: UniProtKB
- regulation of apoptotic process Source: UniProtKB
- regulation of cell migration Source: UniProtKB
- regulation of cell population proliferation Source: UniProtKB
- regulation of defense response to virus by host Source: UniProtKB
- regulation of G2/MI transition of meiotic cell cycle Source: UniProtKB
- regulation of ruffle assembly Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Apoptosis, Cell cycle, Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-MMU-5689880, Ub-specific processing proteases R-MMU-9648002, RAS processing |
Protein family/group databases
MEROPSi | C19.082 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin carboxyl-terminal hydrolase 17-like protein E (EC:3.4.19.12)Short name: USP17-E Alternative name(s): Deubiquitinating enzyme 17-like protein 2 Deubiquitinating protein 3 Short name: DUB-3 Deubiquitinating protein 6 Ubiquitin carboxyl-terminal hydrolase 17-like protein 2 Ubiquitin thioesterase 17-like protein 2 Ubiquitin-specific-processing protease 17-like protein 2 |
Gene namesi | Name:Usp17le Synonyms:Dub3, Dub6, Usp17, Usp17l2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107697, Usp17le |
Subcellular locationi
Nucleus
- Nucleus By similarity
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Cytosol
- cytosol Source: GO_Central
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
Endoplasmic reticulum, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_5000095963 | 1 – 540 | Ubiquitin carboxyl-terminal hydrolase 17-like protein EAdd BLAST | 540 |
Proteomic databases
PaxDbi | Q7M764 |
PRIDEi | Q7M764 |
Interactioni
Subunit structurei
Interacts with SUDS3; the interaction is direct.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000051716 |
Miscellaneous databases
RNActi | Q7M764, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 85 – 382 | USPAdd BLAST | 298 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 431 – 461 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 499 – 540 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 431 – 460 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 518 – 540 | Polar residuesSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1865, Eukaryota |
InParanoidi | Q7M764 |
PhylomeDBi | Q7M764 |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF00443, UCH, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q7M764-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVVSLSFPEE TGGENLPSAP LEDSSKFFEE VFGDMVFARS FPEADPALSS
60 70 80 90 100
PDAPELHQDE AQVVEELTTN GKHSLSWESP QGPGCGLQNT GNSCYLNAAL
110 120 130 140 150
QCLTHTPPLA DYMLSQEHSQ TCCSPEGCKM CAMEAHVTQS LLHSHSGDVM
160 170 180 190 200
KPSQILTSAF HKHQQEDAHE FLMFTLETMH ESCLQVHRQS DPTPQDTSPI
210 220 230 240 250
HDIFGGWWRS QIKCLHCQGT SHTFDPFLDV PLDISSAQSV NQALWDTGKS
260 270 280 290 300
EELLGENAYY CGRCRQKMPA SKTLHVHIAP KVLLLVLKRF SAFTGNKLDR
310 320 330 340 350
KVSYPEFLDL KPYLSEPTGG PLPYALYAVL VHDGATSNSG HYFCCVKAGH
360 370 380 390 400
GKWYKMDDTK VTRCDVTSVL NENAYVLFYV QQTDLKQVSI DMPEGRVHEV
410 420 430 440 450
LDPKYQLKKS RRKKRKKQCH CTDDAGEACE NREKRAKKET SLGEGKVPQE
460 470 480 490 500
VNHEKAGQKH GNTKLVPQEQ NHQRAGQNLR NTEVELDLPV DAIVIHQPRS
510 520 530 540
TANWGTDAPD KENQPWHNGD RLLTSQGLMS PGQLCSQGGR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GS33 | A0A1B0GS33_MOUSE | Ubiquitin carboxyl-terminal hydrola... | Usp17le | 540 | Annotation score: | ||
A0A140T8J5 | A0A140T8J5_MOUSE | Ubiquitin carboxyl-terminal hydrola... | Usp17le | 542 | Annotation score: |
Sequence cautioni
The sequence CAD66057 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC110621 Genomic DNA No translation available. BN000117 Genomic DNA Translation: CAD66057.1 Sequence problems. |
CCDSi | CCDS85368.1 |
Genome annotation databases
UCSCi | uc029wnn.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC110621 Genomic DNA No translation available. BN000117 Genomic DNA Translation: CAD66057.1 Sequence problems. |
CCDSi | CCDS85368.1 |
3D structure databases
AlphaFoldDBi | Q7M764 |
SMRi | Q7M764 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000051716 |
Protein family/group databases
MEROPSi | C19.082 |
Proteomic databases
PaxDbi | Q7M764 |
PRIDEi | Q7M764 |
Genome annotation databases
UCSCi | uc029wnn.1, mouse |
Organism-specific databases
MGIi | MGI:107697, Usp17le |
Phylogenomic databases
eggNOGi | KOG1865, Eukaryota |
InParanoidi | Q7M764 |
PhylomeDBi | Q7M764 |
Enzyme and pathway databases
Reactomei | R-MMU-5689880, Ub-specific processing proteases R-MMU-9648002, RAS processing |
Miscellaneous databases
PROi | PR:Q7M764 |
RNActi | Q7M764, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF00443, UCH, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | U17PE_MOUSE | |
Accessioni | Q7M764Primary (citable) accession number: Q7M764 Secondary accession number(s): D3YU85 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | May 25, 2022 | |
This is version 94 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families