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Protein

Ovochymase-2

Gene

Ovch2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92Charge relay systemBy similarity1
Metal bindingi119CalciumBy similarity1
Active sitei142Charge relay systemBy similarity1
Active sitei240Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
LigandCalcium, Metal-binding

Protein family/group databases

MEROPSiS01.320

Names & Taxonomyi

Protein namesi
Recommended name:
Ovochymase-2 (EC:3.4.21.-)
Alternative name(s):
Oviductin
Gene namesi
Name:Ovch2
Synonyms:Ovtn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3045251 Ovch2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000026118323 – 51Activation peptideBy similarityAdd BLAST29
ChainiPRO_000026118452 – 609Ovochymase-2Add BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi77 ↔ 93By similarity
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi176 ↔ 246By similarity
Disulfide bondi207 ↔ 225By similarity
Disulfide bondi236 ↔ 265By similarity
Disulfide bondi311 ↔ 341By similarity
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi365 ↔ 384By similarity
Glycosylationi415N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi431 ↔ 458By similarity
Disulfide bondi485 ↔ 506By similarity
Glycosylationi530N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi549N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ7M761
PRIDEiQ7M761

PTM databases

PhosphoSitePlusiQ7M761

Expressioni

Gene expression databases

BgeeiENSMUSG00000048236
CleanExiMM_OVCH2

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102366

Structurei

3D structure databases

ProteinModelPortaliQ7M761
SMRiQ7M761
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 299Peptidase S1PROSITE-ProRule annotationAdd BLAST248
Domaini311 – 421CUB 1PROSITE-ProRule annotationAdd BLAST111
Domaini431 – 543CUB 2PROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000115306
HOVERGENiHBG082094
InParanoidiQ7M761
KOiK01362
OMAiQSLHYPE
OrthoDBiEOG091G0DF7
PhylomeDBiQ7M761
TreeFamiTF326419

Family and domain databases

CDDicd00041 CUB, 2 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR035914 Sperma_CUB_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF49854 SSF49854, 2 hits
SSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7M761-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPISKDKLIL ILGMVCLEQG HSETLSSIRN PDCGQSLVKP QPQNYFSLFS
60 70 80 90 100
RIVGGSQVEK GSYPWQVSLK QKQKHICGGT IISSQWVITA AHCMANRNIA
110 120 130 140 150
LTLNVTAGEH DLSQAEPGEQ TLAIETIIIH PQFSTRKPMI YDIALLKMAG
160 170 180 190 200
TFQFGQFVRP VCLPEPGEHF NAGFICTTAG WGRLSEGGRL PQVLQQVNLP
210 220 230 240 250
ILTQEECEAV LLTLKNPITG KTFLCTGSPD GGRDACQGDS GGSLMCQNRK
260 270 280 290 300
GAWTLAGVTS WGLGCGRSWR NNARKKEQGS PGIFTDLRRV LPWILKHIQT
310 320 330 340 350
GHRRKSTKAL CSEPDGLISG SEGELHFPES LHLYYESKQL CVWTFLVPED
360 370 380 390 400
MHMLLNLSHL DIESCHHNYL AMYSLEDRLV GKFCGENLPS SILIGSSSIR
410 420 430 440 450
LRFISDATDY ATGFNLTYKA LKPRYHPDSG CRSLTILFEE GTIQSLHYPE
460 470 480 490 500
DYSNMASCTW IFQAPNYCLI KLSFQSLEIE ENGDCSSDYV TVHSDVEKEK
510 520 530 540 550
EIARFCDYVI PSPVLSSSSV MLISFQSDEN GTARGFQADI SFISRADLNI
560 570 580 590 600
SISEDESVPL ETWDLPPGAM EIFDAERDTH TKPPYEEDIG EMPAIDSGLL

KQGERRGKH
Length:609
Mass (Da):67,611
Last modified:December 15, 2003 - v1
Checksum:i4653B1DAC4A2E5FB
GO
Isoform 2 (identifier: Q7M761-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: Missing.

Show »
Length:516
Mass (Da):57,372
Checksum:iC10CA43AFD8EA69F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0216681 – 93Missing in isoform 2. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033776 mRNA Translation: BAC28471.1
BC125284 mRNA Translation: AAI25285.1
BC125288 mRNA Translation: AAI25289.1
BN000123 mRNA Translation: CAD67553.1
CCDSiCCDS21692.1 [Q7M761-1]
RefSeqiNP_766496.2, NM_172908.3 [Q7M761-1]
UniGeneiMm.99576

Genome annotation databases

EnsembliENSMUST00000106755; ENSMUSP00000102366; ENSMUSG00000048236 [Q7M761-1]
GeneIDi244199
KEGGimmu:244199
UCSCiuc009jbk.1 mouse [Q7M761-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiOVCH2_MOUSE
AccessioniPrimary (citable) accession number: Q7M761
Secondary accession number(s): Q8BZQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 15, 2003
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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