Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-acetylated-alpha-linked acidic dipeptidase-like protein

Gene

Naaladl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has no NAAG hydrolyzing activity (By similarity). Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity).By similarity

Catalytic activityi

Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi373Zinc 1Sequence analysis1
Metal bindingi383Zinc 1By similarity1
Metal bindingi383Zinc 2By similarity1
Active sitei421Nucleophile; for NAALADase activityBy similarity1
Metal bindingi422Zinc 2By similarity1
Metal bindingi450Zinc 1By similarity1
Metal bindingi550Zinc 2By similarity1
Active sitei622Charge relay systemSequence analysis1
Active sitei662Charge relay systemSequence analysis1
Active sitei685Charge relay systemSequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidase, Dipeptidase, Hydrolase, Metalloprotease, Multifunctional enzyme, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM28.011

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylated-alpha-linked acidic dipeptidase-like protein (EC:3.4.17.21)
Short name:
NAALADase L
Gene namesi
Name:Naaladl1
Synonyms:Gm964, Naaladasel
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2685810 Naaladl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST22
Topological domaini29 – 745ExtracellularSequence analysisAdd BLAST717

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001741241 – 745N-acetylated-alpha-linked acidic dipeptidase-like proteinAdd BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi593N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi620N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ7M758
PaxDbiQ7M758
PeptideAtlasiQ7M758
PRIDEiQ7M758

PTM databases

iPTMnetiQ7M758
PhosphoSitePlusiQ7M758

Expressioni

Gene expression databases

BgeeiENSMUSG00000054999 Expressed in 48 organ(s), highest expression level in intestine
GenevisibleiQ7M758 MM

Interactioni

Protein-protein interaction databases

IntActiQ7M758, 1 interactor
STRINGi10090.ENSMUSP00000044231

Structurei

3D structure databases

ProteinModelPortaliQ7M758
SMRiQ7M758
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 584NAALADaseAdd BLAST317

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi635 – 639Poly-Ala5

Sequence similaritiesi

Belongs to the peptidase M28 family. M28B subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2195 Eukaryota
COG2234 LUCA
GeneTreeiENSGT00550000074421
HOGENOMiHOG000211921
HOVERGENiHBG051639
InParanoidiQ7M758
KOiK01301
OMAiGSYYEYF
OrthoDBiEOG091G02ZM
PhylomeDBiQ7M758
TreeFamiTF312981

Family and domain databases

Gene3Di1.20.930.40, 1 hit
InterProiView protein in InterPro
IPR003137 PA_domain
IPR007484 Peptidase_M28
IPR039373 Peptidase_M28B
IPR007365 TFR-like_dimer_dom
IPR036757 TFR-like_dimer_dom_sf
PANTHERiPTHR10404 PTHR10404, 1 hit
PfamiView protein in Pfam
PF02225 PA, 1 hit
PF04389 Peptidase_M28, 1 hit
PF04253 TFR_dimer, 1 hit
SUPFAMiSSF47672 SSF47672, 1 hit

Sequencei

Sequence statusi: Complete.

Q7M758-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHWVKILGVA LGAAALLGLG IILGHFAIPK ATSPLTSSTS DSQDLDLAIL
60 70 80 90 100
DSVMGQLDAS RIRENLRELS KEPHVATSPR DEALVQLLLG RWKDTATGLD
110 120 130 140 150
SAKTYEYRVL LSFPNAEQPN SVEVVGPNGT TFHSFQPFEK NLTGEQAGPN
160 170 180 190 200
VLQPYAAYAP PGTPKGLLVY ANQGSEEDFK ELETQGINLE GTIALTRYGG
210 220 230 240 250
VGRGAKAINA AKHGVVGVLV YTDPGDINDG KSLPNETFPN SWRLPPSGVE
260 270 280 290 300
RGSYYEYFGD PLTPYLPAHP SSFRLDPHNT SGFPPIPTQP IGFEDARDLL
310 320 330 340 350
CNLTGTSAPA FWQGALGCEY KLGPGFEPNG SFPAGSEVKV SVHNRLELRT
360 370 380 390 400
SSNVLGIIQG AVEPDRYVIY GNHRDSWVHG AVDPSSGTAV LLEISRVLGT
410 420 430 440 450
LLKKGTWRPR RSIIFASWGA EEFGLIGSTE FTEEFLSKLQ ERTVAYINVD
460 470 480 490 500
ISVFSNATLR AQGTPPVQSV IFSATKEISA PGSSGLSIYD NWIRYTNRTS
510 520 530 540 550
PVYGLVPSLG TLGAGSDYAA FVHFLGITSM DLAYTYDRSK TSARIYPTYH
560 570 580 590 600
TAFDTFDYVE KFLDPGFSSH QAVARTAGSV LLRLSDSLFL PLNVSDYSET
610 620 630 640 650
LQSFLQAAQE ALGTQLEKQN ISLGPLVTAV ANFKAAAASL GEHILTLQKS
660 670 680 690 700
SPDPLQVRMV NDQLMLLERA FLNPRAFPEE RHYSHVLWAP NTASVDTFPG
710 720 730 740
LANAYAKAQE INSGSEAWAE VQRQLSIVVT ALEGAAATLV PVADL
Length:745
Mass (Da):80,513
Last modified:December 15, 2003 - v1
Checksum:i5DC21DFEAD6D34CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131114 Genomic DNA No translation available.
BN000129 mRNA Translation: CAD67582.1
CCDSiCCDS29494.1
RefSeqiNP_001009546.1, NM_001009546.1
UniGeneiMm.359041

Genome annotation databases

EnsembliENSMUST00000044451; ENSMUSP00000044231; ENSMUSG00000054999
GeneIDi381204
KEGGimmu:381204
UCSCiuc008ghk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131114 Genomic DNA No translation available.
BN000129 mRNA Translation: CAD67582.1
CCDSiCCDS29494.1
RefSeqiNP_001009546.1, NM_001009546.1
UniGeneiMm.359041

3D structure databases

ProteinModelPortaliQ7M758
SMRiQ7M758
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7M758, 1 interactor
STRINGi10090.ENSMUSP00000044231

Protein family/group databases

MEROPSiM28.011

PTM databases

iPTMnetiQ7M758
PhosphoSitePlusiQ7M758

Proteomic databases

MaxQBiQ7M758
PaxDbiQ7M758
PeptideAtlasiQ7M758
PRIDEiQ7M758

Protocols and materials databases

DNASUi381204
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044451; ENSMUSP00000044231; ENSMUSG00000054999
GeneIDi381204
KEGGimmu:381204
UCSCiuc008ghk.1 mouse

Organism-specific databases

CTDi10004
MGIiMGI:2685810 Naaladl1

Phylogenomic databases

eggNOGiKOG2195 Eukaryota
COG2234 LUCA
GeneTreeiENSGT00550000074421
HOGENOMiHOG000211921
HOVERGENiHBG051639
InParanoidiQ7M758
KOiK01301
OMAiGSYYEYF
OrthoDBiEOG091G02ZM
PhylomeDBiQ7M758
TreeFamiTF312981

Miscellaneous databases

PROiPR:Q7M758
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054999 Expressed in 48 organ(s), highest expression level in intestine
GenevisibleiQ7M758 MM

Family and domain databases

Gene3Di1.20.930.40, 1 hit
InterProiView protein in InterPro
IPR003137 PA_domain
IPR007484 Peptidase_M28
IPR039373 Peptidase_M28B
IPR007365 TFR-like_dimer_dom
IPR036757 TFR-like_dimer_dom_sf
PANTHERiPTHR10404 PTHR10404, 1 hit
PfamiView protein in Pfam
PF02225 PA, 1 hit
PF04389 Peptidase_M28, 1 hit
PF04253 TFR_dimer, 1 hit
SUPFAMiSSF47672 SSF47672, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNALDL_MOUSE
AccessioniPrimary (citable) accession number: Q7M758
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 15, 2003
Last modified: September 12, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again