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UniProtKB - Q7M733 (HPS6_RAT)

Entry version 84 (02 Dec 2020)
Sequence version 1 (15 Dec 2003)
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Protein

Hermansky-Pudlak syndrome 6 protein homolog

Gene

Hps6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hermansky-Pudlak syndrome 6 protein homolog
Alternative name(s):
Ruby-eye protein homolog
Ruby-eye-like protein
Short name:
Ru
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hps6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...RGDi		631341, Hps6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Endosome, Lysosome, Membrane, Microsome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000840581 – 809Hermansky-Pudlak syndrome 6 protein homologAdd BLAST809

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7M733

PRoteomics IDEntifications database

More...PRIDEi		Q7M733

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7M733

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000018433, Expressed in skeletal muscle tissue and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7M733, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.

Interacts with HPS5 and HPS3.

Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1) (By similarity).

Interacts with AP-3 complex (PubMed:19010779).

Interacts with DCTN1 and dynein intermediate chain (By similarity).

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000024898

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7M733

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSBH, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001546

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019081_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7M733

Identification of Orthologs from Complete Genome Data

More...OMAi		APPDVWK

Database of Orthologous Groups

More...OrthoDBi		287250at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7M733

TreeFam database of animal gene trees

More...TreeFami		TF331635

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017218, BLOC-2_complex_Hps6_subunit

The PANTHER Classification System

More...PANTHERi		PTHR14696, PTHR14696, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15702, HPS6, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037476, BLOC-2_complex_Hps6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7M733-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRAGTLRLL SDLSNFTGAA RLRELLAGDP AILVRCSPDG RHLLLLRPPG 
        60         70         80         90        100
SPAPQLLVAV RGPGLPLERA WSEGDPSPLD VFFVPWLARP ALILVWESGL 
       110        120        130        140        150
TEVWGVGMEP GWKLLQSTEL CPDGGARVMA VAATRGRLVW CEERQPGVED 
       160        170        180        190        200
QPGQLSMAFN HCVCVKTLDT SGEAGTKLGC THILLHHCPS FGLIASRKEL 
       210        220        230        240        250
FLVPTSTTWP GVAHVLLIWS PSKGKVIVAA PSLGLSHSKS LNPKQGDTWD 
       260        270        280        290        300
FRTLLRGLPG FLSPREPLAV HTWAPSSQGL LLLDLKGKVS LVQCHGGTRT 
       310        320        330        340        350
VGLLQEAPVG LQGSAALGTF HGTLACVLGS TLELLDMSSG RLLERKVLST 
       360        370        380        390        400
DRVHLLEPPA PGVKNEEDLE TRGALRLLSA LGLFCVCWEA PQGLEVPSDK 
       410        420        430        440        450
DLVFEEACGY YQRRSLRGTQ LTPEELRHNS MFRAPQALAS ILQGHLPPSA 
       460        470        480        490        500
LLTTLRAELR DYRSIEQLKA QLVAGDDEET GWTELAEHEV ARLLRTHLTG 
       510        520        530        540        550
DQLAQFNTIF QALPTAAWSA TLQALQLQPD RSGRLRSQAP PDVWKKVLRA 
       560        570        580        590        600
PTAGKEHPNG ILPPFELLCQ CLGQLEPQWL PPFVELAQQQ GGPGWGAEGP 
       610        620        630        640        650
SLPLYRRALS VLGEEGKRPE ALELELLLGS GRPKAVLQAV RQLIKKEQWE 
       660        670        680        690        700
RALEAGLTLD SSSPLLRSEI FNLLLAEFAQ HRRLDTHLPL LCRLCPPEVA 
       710        720        730        740        750
PDELLLLLRT HLPDDAGATP FPEPGAEPGA EPPLTVGLVR ALLEQTGAQG 
       760        770        780        790        800
RSSGPVQSTF EDILWDSGTP PPTPPRGPMT TLQASDHPGQ EAWGPSGQGL 

GAADVGVHS
Length:809
Mass (Da):87,463
Last modified:December 15, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3D6A10D877C1DBA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC093941 Genomic DNA No translation available.
BK000658 Genomic DNA Translation: DAA00971.1
BC086975 mRNA Translation: AAH86975.1

NCBI Reference Sequences

More...RefSeqi		NP_852097.1, NM_181432.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000024898; ENSRNOP00000024898; ENSRNOG00000018433

Database of genes from NCBI RefSeq genomes

More...GeneIDi		309446

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:309446

UCSC genome browser

More...UCSCi		RGD:631341, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093941 Genomic DNA No translation available.
BK000658 Genomic DNA Translation: DAA00971.1
BC086975 mRNA Translation: AAH86975.1
RefSeqiNP_852097.1, NM_181432.2

3D structure databases

SMRiQ7M733
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024898

PTM databases

PhosphoSitePlusiQ7M733

Proteomic databases

PaxDbiQ7M733
PRIDEiQ7M733

Genome annotation databases

EnsembliENSRNOT00000024898; ENSRNOP00000024898; ENSRNOG00000018433
GeneIDi309446
KEGGirno:309446
UCSCiRGD:631341, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79803
RGDi631341, Hps6

Phylogenomic databases

eggNOGiENOG502QSBH, Eukaryota
GeneTreeiENSGT00390000001546
HOGENOMiCLU_019081_0_0_1
InParanoidiQ7M733
OMAiAPPDVWK
OrthoDBi287250at2759
PhylomeDBiQ7M733
TreeFamiTF331635

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q7M733

Gene expression databases

BgeeiENSRNOG00000018433, Expressed in skeletal muscle tissue and 21 other tissues
GenevisibleiQ7M733, RN

Family and domain databases

InterProiView protein in InterPro
IPR017218, BLOC-2_complex_Hps6_subunit
PANTHERiPTHR14696, PTHR14696, 1 hit
PfamiView protein in Pfam
PF15702, HPS6, 1 hit
PIRSFiPIRSF037476, BLOC-2_complex_Hps6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHPS6_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7M733
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 15, 2003
Last modified: December 2, 2020
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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