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Protein

Taste receptor type 2 member 109

Gene

Tas2r109

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Putative taste receptor which may play a role in the perception of bitterness.Curated

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.Curated

GO - Molecular functioni

  • bitter taste receptor activity Source: GO_Central
  • G protein-coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events
R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 109
Short name:
T2R109
Short name:
mT2R62
Gene namesi
Name:Tas2r109Imported
Synonyms:T2r621 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2681214 Tas2r109

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14ExtracellularSequence analysisAdd BLAST14
Transmembranei15 – 35Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini36 – 62CytoplasmicSequence analysisAdd BLAST27
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini84 – 94ExtracellularSequence analysisAdd BLAST11
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 135CytoplasmicSequence analysisAdd BLAST20
Transmembranei136 – 156Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini157 – 191ExtracellularSequence analysisAdd BLAST35
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 241CytoplasmicSequence analysisAdd BLAST29
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 270ExtracellularSequence analysis8
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 316CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002482541 – 316Taste receptor type 2 member 109Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7M707
PRIDEiQ7M707

Expressioni

Gene expression databases

BgeeiENSMUSG00000062528 Expressed in 2 organ(s), highest expression level in thymus
CleanExiMM_TAS2R109

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069300

Structurei

3D structure databases

ProteinModelPortaliQ7M707
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor T2R family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9F7 Eukaryota
ENOG4111BEG LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG060698
InParanoidiQ7M707
KOiK08474
OMAiEYHQINI
OrthoDBiEOG09070AVQ
PhylomeDBiQ7M707
TreeFamiTF335891

Family and domain databases

InterProiView protein in InterPro
IPR017452 GPCR_Rhodpsn_7TM
IPR007960 T2R
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7M707-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHLLKRTFD ITENILLIIL FIELIIGLIG NGFTALVHCM DWVKRKKMSL
60 70 80 90 100
VNKILTALAT SRIFLLWFML VGFPISSLYP YLVTTRLMIQ FTSTLWTIAN
110 120 130 140 150
HISVWFATCL SVFYFLKIAN FSNSPFLYLK RRVEKVVSVT LLVSLVLLFL
160 170 180 190 200
NILLLNLEIN MCINEYHQIN ISYIFISYYH LSCQIQVLGS HIIFLSVPVV
210 220 230 240 250
LSLSTFLLLI FSLWTLHKRM QQHVQGGRDA RTTAHFKALQ AVIAFLLLYS
260 270 280 290 300
IFILSLLLQF WIHGLRKKPP FIAFCQVVDT AFPSFHSYVL ILRDRKLRHA
310
SLSVLSWLKC RPNYVK
Length:316
Mass (Da):36,750
Last modified:December 15, 2003 - v1
Checksum:i4DCC3244FA827A28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151055 Genomic DNA No translation available.
BK001090 Genomic DNA Translation: DAA01229.1
CCDSiCCDS20631.1
RefSeqiNP_996900.1, NM_207017.1
UniGeneiMm.377905

Genome annotation databases

EnsembliENSMUST00000067539; ENSMUSP00000069300; ENSMUSG00000062528
GeneIDi387343
KEGGimmu:387343
UCSCiuc009ejx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151055 Genomic DNA No translation available.
BK001090 Genomic DNA Translation: DAA01229.1
CCDSiCCDS20631.1
RefSeqiNP_996900.1, NM_207017.1
UniGeneiMm.377905

3D structure databases

ProteinModelPortaliQ7M707
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069300

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ7M707
PRIDEiQ7M707

Protocols and materials databases

DNASUi387343
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067539; ENSMUSP00000069300; ENSMUSG00000062528
GeneIDi387343
KEGGimmu:387343
UCSCiuc009ejx.1 mouse

Organism-specific databases

CTDi387343
MGIiMGI:2681214 Tas2r109

Phylogenomic databases

eggNOGiENOG410J9F7 Eukaryota
ENOG4111BEG LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG060698
InParanoidiQ7M707
KOiK08474
OMAiEYHQINI
OrthoDBiEOG09070AVQ
PhylomeDBiQ7M707
TreeFamiTF335891

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events
R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

PROiPR:Q7M707
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062528 Expressed in 2 organ(s), highest expression level in thymus
CleanExiMM_TAS2R109

Family and domain databases

InterProiView protein in InterPro
IPR017452 GPCR_Rhodpsn_7TM
IPR007960 T2R
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTR109_MOUSE
AccessioniPrimary (citable) accession number: Q7M707
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 15, 2003
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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