Phosphatidylinositol-binding clathrin assembly protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• 1-phosphatidylinositol binding Source: UniProtKB
• clathrin binding Source: UniProtKB
• clathrin heavy chain binding Source: MGI
• identical protein binding Source: MGI
• low-density lipoprotein particle receptor binding Source: MGI
• phosphatidylinositol-4,5-bisphosphate binding Source: MGI
• Rab GTPase binding Source: MGI
• SH3 domain binding Source: MGI
• SNARE binding Source: MGI
• tau protein binding Source: MGI

GO - Biological processⁱ

• axonogenesis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 18842885
• cargo loading into vesicle Source: Alzheimers_University_of_TorontoInferred from mutant phenotypeⁱ
  • 22539346
• cell proliferation Source: Alzheimers_University_of_Toronto
• clathrin coat assembly Source: MGI
• clathrin-dependent endocytosis Source: Alzheimers_University_of_TorontoInferred from mutant phenotypeⁱ
  • 22539346
• dendrite morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 18842885
• endosomal transport Source: MGI
• hemopoiesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • 12832620
• iron ion homeostasis Source: Alzheimers_University_of_Toronto
• iron ion import across plasma membrane Source: Alzheimers_University_of_Toronto
• learning or memory Source: ARUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 26005850
• membrane bending Source: MGI
• modulation of age-related behavioral decline Source: ARUK-UCLInferred from genetic interactionⁱ
  • 26005850
• negative regulation of gene expression Source: Alzheimers_University_of_Toronto
• negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process Source: Alzheimers_University_of_TorontoInferred from mutant phenotypeⁱ
  • 22539346
• negative regulation of protein localization to cell surface Source: MGI
• negative regulation of protein localization to plasma membrane Source: MGI
• negative regulation of receptor-mediated endocytosis Source: MGI
• positive regulation of amyloid-beta clearance Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • 26005850
• positive regulation of amyloid-beta formation Source: Alzheimers_University_of_TorontoInferred from mutant phenotypeⁱ
  • 22539346
  • 24577224
• positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: Alzheimers_University_of_TorontoInferred from mutant phenotypeⁱ
  • 22539346
• positive regulation of axonogenesis Source: MGI
• positive regulation of dendrite extension Source: MGI
• positive regulation of GTPase activity Source: MGI
• positive regulation of neuron death Source: Alzheimers_University_of_Toronto
• positive regulation of synaptic vesicle clustering Source: MGI
• positive regulation of synaptic vesicle endocytosis Source: MGI
• positive regulation of transcription, DNA-templated Source: MGI
• receptor internalization Source: MGI
• receptor-mediated endocytosis Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 12832620
• regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: Alzheimers_University_of_Toronto
• regulation of endocytosis Source: MGI
• regulation of protein localization Source: MGI
• regulation of protein transport Source: MGI
• regulation of synaptic vesicle endocytosis Source: MGI
• regulation of synaptic vesicle transport Source: MGI
• regulation of terminal button organization Source: MGI
• regulation of vesicle size Source: MGI
• synaptic vesicle endocytosis Source: MGI
• synaptic vesicle maturation Source: Alzheimers_University_of_TorontoInferred from mutant phenotypeⁱ
  • 22851330
• transcytosis Source: MGI
• vesicle budding from membrane Source: MGI
• vesicle-mediated transport Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• clathrin binding Source: UniProtKB
• clathrin heavy chain binding Source: MGI
• identical protein binding Source: MGI
• low-density lipoprotein particle receptor binding Source: MGI
• Rab GTPase binding Source: MGI
• SH3 domain binding Source: MGI
• SNARE binding Source: MGI
• tau protein binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN 
        60         70         80         90        100
EMNVNIPQLA DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR 
       110        120        130        140        150
NTLFNLSNFL DKSGLQGYDM STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR 
       160        170        180        190        200
GADGVMRTMN TEKLLKTVPI IQNQMDALLD FNVNSNELTN GVINAAFMLL 
       210        220        230        240        250
FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF LTRMTRISEF 
       260        270        280        290        300
LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT 
       310        320        330        340        350
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP 
       360        370        380        390        400
HTSLTTAASP VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT 
       410        420        430        440        450
FHPSVHAMSA APQGASTWGD PFSATLDAVE DAIPSLNPFL TKSSGDVHLP 
       460        470        480        490        500
IASDVSTFTT RTPTHEMFVG FSPSPVAQPH SSAGLNVDFE SVFGNKSTNV 
       510        520        530        540        550
AVDSGGFDEL GGLLKPTVAS QNQSLPVAKL PPNKLVSDDL DSSLANLVGN 
       560        570        580        590        600
LGIGNGTTKN DVSWSQPGEK KLTGGSNWQP KVAPTTAWSA ATMNGMHFPQ 
       610        620        630        640        650
YAPPVMAYPA TTPTGMIGYG IPPQMGSVPV MTQPTLIYSQ PVMRPPNPFG 
       660
PVSGAQIQFM                                             

        10         20         30         40         50
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN 
        60         70         80         90        100
EMNVNIPQLA DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR 
       110        120        130        140        150
NTLFNLSNFL DKSGLQGYDM STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR 
       160        170        180        190        200
GADGVMRTMN TEKLLKTVPI IQNQMDALLD FNVNSNELTN GVINAAFMLL 
       210        220        230        240        250
FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF LTRMTRISEF 
       260        270        280        290        300
LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT 
       310        320        330        340        350
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP 
       360        370        380        390        400
HTSLTTAASP VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT 
       410        420        430        440        450
FHPSVHAMSA APQGASTWGG FSPSPVAQPH SSAGLNVDFE SVFGNKSTNV 
       460        470        480        490        500
AVDSGGGLLK PTVASQNQSL PVAKLPPNKL VSDDLDSSLA NLVGNLGIGN 
       510        520        530        540        550
GTTKNDVSWS QPGEKKLTGG SNWQPKVAPT TAWSAATMAP PVMAYPATTP 
       560        570        580        590 
TGMIGYGIPP QMGSVPVMTQ PTLIYSQPVM RPPNPFGPVS GAQIQFM    

        10         20         30         40         50
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN 
        60         70         80         90        100
EMNVNIPQLA DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR 
       110        120        130        140        150
NTLFNLSNFL DKSGLQGYDM STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR 
       160        170        180        190        200
GADGVMRTMN TEKLLKTVPI IQNQMDALLD FNVNSNELTN GVINAAFMLL 
       210        220        230        240        250
FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF LTRMTRISEF 
       260        270        280        290        300
LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT 
       310        320        330        340        350
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP 
       360        370        380        390        400
HTSLTTAASP VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT 
       410        420        430        440        450
FHPSVHAMSA APQGASTWGG FSPSPVAQPH SSAGLNVDFE SVFGNKSTNV 
       460        470        480        490        500
AVDSGGGLLK PTVASQNQSL PVAKLPPNKL VSDDLDSSLA NLVGNLGIGN 
       510        520        530        540        550
GTTKNDVSWS QPGEKKLTGG SNWQPKVAPT TAWSAATMNG MHFPQYAPPV 
       560        570        580        590        600
MAYPATTPTG MIGYGIPPQM GSVPVMTQPT LIYSQPVMRP PNPFGPVSGA 

QIQFM                                                  

        10         20         30         40         50
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN 
        60         70         80         90        100
EMNVNIPQLA DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR 
       110        120        130        140        150
NTLFNLSNFL DKSGLQGYDM STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR 
       160        170        180        190        200
GADGVMRTMN TEKLLKTVPI IQNQMDALLD FNVNSNELTN GVINAAFMLL 
       210        220        230        240        250
FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF LTRMTRISEF 
       260        270        280        290        300
LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT 
       310        320        330        340        350
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP 
       360        370        380        390        400
HTSLTTAASP VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT 
       410        420        430        440        450
FHPSVHAMSA APQGASTWGG FSPSPVAQPH SSAGLNVDFE SVFGNKSTNV 
       460        470        480        490        500
AVDSGGFDEL GGLLKPTVAS QNQSLPVAKL PPNKLVSDDL DSSLANLVGN 
       510        520        530        540        550
LGIGNGTTKN DVSWSQPGEK KLTGGSNWQP KVAPTTAWSA ATMNGMHFPQ 
       560        570        580        590        600
YAPPVMAYPA TTPTGMIGYG IPPQMGSVPV MTQPTLIYSQ PVMRPPNPFG 
       610
PVSGAQIQFM                                             

        10         20         30         40         50
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN 
        60         70         80         90        100
EMNVNIPQLA DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR 
       110        120        130        140        150
NTLFNLSNFL DKSGLQGYDM STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR 
       160        170        180        190        200
GADGVMRTMN TEKLLKTVPI IQNQMDALLD FNVNSNELTN GVINAAFMLL 
       210        220        230        240        250
FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF LTRMTRISEF 
       260        270        280        290        300
LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT 
       310        320        330        340        350
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP 
       360        370        380        390        400
HTSLTTAASP VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT 
       410        420        430        440        450
FHPSVHAMSA APQGASTWGD PFSATLDAVE DAIPSLNPFL TKSSGDVHLP 
       460        470        480        490        500
IASDVSTFTT RTPTHEMFVG FSPSPVAQPH SSAGLNVDFE SVFGNKSTNV 
       510        520        530        540        550
AVDSGGGLLK PTVASQNQSL PVAKLPPNKL VSDDLDSSLA NLVGNLGIGN 
       560        570        580        590        600
GTTKNDVSWS QPGEKKLTGG SNWQPKVAPT TAWSAATMNG MHFPQYAPPV 
       610        620        630        640        650
MAYPATTPTG MIGYGIPPQM GSVPVMTQPT LIYSQPVMRP PNPFGPVSGA 

QIQFM                                                  

        10         20         30         40         50
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN 
        60         70         80         90        100
EMNVNIPQLA DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR 
       110        120        130        140        150
NTLFNLSNFL DKSGLQGYDM STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR 
       160        170        180        190        200
GADGVMRTMN TEKLLKTVPI IQNQMDALLD FNVNSNELTN GVINAAFMLL 
       210        220        230        240        250
FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF LTRMTRISEF 
       260        270        280        290        300
LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT 
       310        320        330        340        350
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP 
       360        370        380        390        400
HTSLTTAASP VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT 
       410        420        430        440        450
FHPSVHAMSA APQGASTWGD PFSATLDAVE DAIPSLNPFL TKSSGDVHLP 
       460        470        480        490        500
IASDVSTFTT RTPTHEMFVG FSPSPVAQPH SSAGLNVDFE SVFGNKSTNV 
       510        520        530        540        550
AVDSGGFDEL GGLLKPTVAS QNQSLPVAKL PPNKLVSDDL DSSLANLVGN 
       560        570        580        590        600
LGIGNGTTKN DVSWSQPGEK KLTGGSNWQP KVAPTTAWSA ATMAPPVMAY 
       610        620        630        640        650
PATTPTGMIG YGIPPQMGSV PVMTQPTLIY SQPVMRPPNP FGPVSGAQIQ 

FM                                                     

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot