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UniProtKB - Q7M6Y3 (PICAL_MOUSE)

Entry version 148 (12 Aug 2020)
Sequence version 1 (15 Dec 2003)
Previous versions | rss
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Protein

Phosphatidylinositol-binding clathrin assembly protein

Gene

Picalm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processEndocytosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-432722, Golgi Associated Vesicle Biogenesis
R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828, Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol-binding clathrin assembly protein
Alternative name(s):
Clathrin assembly lymphoid myeloid leukemia
Short name:
CALM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Picalm
Synonyms:Calm, Fit1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2385902, Picalm

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

PICALM-deficient mice suffer from severe anemia due to ineffective erythropoiesis in the bone marrow. In addition, they exhibit impaired clathrin-mediated internalization of transferrin leading to iron metabolism abnormalities.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001870632 – 660Phosphatidylinositol-binding clathrin assembly proteinAdd BLAST659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei20PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki238Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei303PhosphoserineBy similarity1
Modified residuei315PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7M6Y3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7M6Y3

PeptideAtlas

More...PeptideAtlasi		Q7M6Y3

PRoteomics IDEntifications database

More...PRIDEi		Q7M6Y3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7M6Y3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7M6Y3

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q7M6Y3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Skins and livers of 1-week-old mice.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000039361, Expressed in humerus cartilage element and 286 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7M6Y3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol 4,5- bisphosphate.

Interacts with PIMREG; this interaction may change the subcellular location into the nucleus.

Interacts with AP2A1 (via its alpha-appendage domain).

Interacts (via N-terminus) with VAMP2; VAMP3; VAMP7 and VAMP8 (Via N-terminus).

Interacts with LC3/MAP1LC3A.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		231417, 9 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q7M6Y3

Protein interaction database and analysis system

More...IntActi		Q7M6Y3, 5 interactors

Molecular INTeraction database

More...MINTi		Q7M6Y3

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000051092

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7M6Y3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7M6Y3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 145ENTHPROSITE-ProRule annotationCuratedAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni221 – 294Interaction with PIMREGBy similarityAdd BLAST74

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PICALM/SNAP91 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0251, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183068

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014080_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7M6Y3

KEGG Orthology (KO)

More...KOi		K20044

Identification of Orthologs from Complete Genome Data

More...OMAi		PPQMGNV

Database of Orthologous Groups

More...OrthoDBi		1592722at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7M6Y3

TreeFam database of animal gene trees

More...TreeFami		TF314861

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.150, 1 hit
1.25.40.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011417, ANTH_dom
IPR014712, Clathrin_AP_dom2
IPR013809, ENTH
IPR008942, ENTH_VHS
IPR030412, PICALM

The PANTHER Classification System

More...PANTHERi		PTHR22951:SF16, PTHR22951:SF16, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07651, ANTH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00273, ENTH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48464, SSF48464, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50942, ENTH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated (identifier: Q7M6Y3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN 
        60         70         80         90        100
EMNVNIPQLA DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR 
       110        120        130        140        150
NTLFNLSNFL DKSGLQGYDM STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR 
       160        170        180        190        200
GADGVMRTMN TEKLLKTVPI IQNQMDALLD FNVNSNELTN GVINAAFMLL 
       210        220        230        240        250
FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF LTRMTRISEF 
       260        270        280        290        300
LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT 
       310        320        330        340        350
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP 
       360        370        380        390        400
HTSLTTAASP VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT 
       410        420        430        440        450
FHPSVHAMSA APQGASTWGD PFSATLDAVE DAIPSLNPFL TKSSGDVHLP 
       460        470        480        490        500
IASDVSTFTT RTPTHEMFVG FSPSPVAQPH SSAGLNVDFE SVFGNKSTNV 
       510        520        530        540        550
AVDSGGFDEL GGLLKPTVAS QNQSLPVAKL PPNKLVSDDL DSSLANLVGN 
       560        570        580        590        600
LGIGNGTTKN DVSWSQPGEK KLTGGSNWQP KVAPTTAWSA ATMNGMHFPQ 
       610        620        630        640        650
YAPPVMAYPA TTPTGMIGYG IPPQMGSVPV MTQPTLIYSQ PVMRPPNPFG 
       660
PVSGAQIQFM
Length:660
Mass (Da):71,543
Last modified:December 15, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FB206508281BCDF
GO
Isoform 2Curated (identifier: Q7M6Y3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-469: Missing.
     506-510: Missing.
     594-601: Missing.

Show »
Length:597
Mass (Da):64,648
Checksum:i825D7F7B7154DD8A
GO
Isoform 3Curated (identifier: Q7M6Y3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-469: Missing.
     506-510: Missing.

Show »
Length:605
Mass (Da):65,623
Checksum:iC365144C975C2B50
GO
Isoform 4Curated (identifier: Q7M6Y3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-469: Missing.

Show »
Length:610
Mass (Da):66,184
Checksum:i86E8189B6C05F005
GO
Isoform 5Curated (identifier: Q7M6Y3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-510: Missing.

Show »
Length:655
Mass (Da):70,982
Checksum:iF729CEF5D3D82781
GO
Isoform 6Curated (identifier: Q7M6Y3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     594-601: Missing.

Show »
Length:652
Mass (Da):70,568
Checksum:i0CEEEEA9225CC446
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LHQ8A0A140LHQ8_MOUSE
Phosphatidylinositol-binding clathr...
Picalm
531Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SUR7A0A1L1SUR7_MOUSE
Phosphatidylinositol-binding clathr...
Picalm
404Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LHG9A0A140LHG9_MOUSE
Phosphatidylinositol-binding clathr...
Picalm
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC39454 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti522N → S in AAH21491 (PubMed:15489334).Curated1
Sequence conflicti522N → S in AAH23843 (PubMed:15489334).Curated1
Sequence conflicti522N → S in AAH25566 (PubMed:15489334).Curated1
Sequence conflicti522N → S in AAH57683 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050684420 – 469Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST50
Alternative sequenceiVSP_050685506 – 510Missing in isoform 2, isoform 3 and isoform 5. 2 Publications5
Alternative sequenceiVSP_050686594 – 601Missing in isoform 2 and isoform 6. 2 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY206701 mRNA Translation: AAO17153.1
BK001028 mRNA Translation: DAA01470.1
BC011470 mRNA Translation: AAH11470.1
BC021491 mRNA Translation: AAH21491.1
BC023843 mRNA Translation: AAH23843.1
BC025566 mRNA Translation: AAH25566.1
BC027116 mRNA Translation: AAH27116.1
BC057683 mRNA Translation: AAH57683.1
AK085472 mRNA Translation: BAC39454.2 Different initiation.
AK162360 mRNA Translation: BAE36872.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS52307.1 [Q7M6Y3-1]
CCDS85334.1 [Q7M6Y3-6]
CCDS85335.1 [Q7M6Y3-5]
CCDS85336.1 [Q7M6Y3-4]
CCDS85337.1 [Q7M6Y3-3]
CCDS85338.1 [Q7M6Y3-2]

NCBI Reference Sequences

More...RefSeqi		NP_001239449.1, NM_001252520.1 [Q7M6Y3-5]
NP_001239450.1, NM_001252521.1 [Q7M6Y3-6]
NP_001239451.1, NM_001252522.1 [Q7M6Y3-4]
NP_001239452.1, NM_001252523.1 [Q7M6Y3-3]
NP_001239453.1, NM_001252524.1 [Q7M6Y3-2]
NP_666306.2, NM_146194.4 [Q7M6Y3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000049537; ENSMUSP00000051092; ENSMUSG00000039361 [Q7M6Y3-5]
ENSMUST00000207225; ENSMUSP00000146659; ENSMUSG00000039361 [Q7M6Y3-2]
ENSMUST00000207484; ENSMUSP00000146501; ENSMUSG00000039361 [Q7M6Y3-1]
ENSMUST00000208730; ENSMUSP00000146541; ENSMUSG00000039361 [Q7M6Y3-3]
ENSMUST00000208742; ENSMUSP00000147016; ENSMUSG00000039361 [Q7M6Y3-6]
ENSMUST00000209068; ENSMUSP00000146386; ENSMUSG00000039361 [Q7M6Y3-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		233489

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:233489

UCSC genome browser

More...UCSCi		uc009igq.2, mouse [Q7M6Y3-1]
uc009igr.2, mouse [Q7M6Y3-5]
uc009igs.2, mouse [Q7M6Y3-6]
uc009igt.2, mouse [Q7M6Y3-4]
uc009igu.2, mouse [Q7M6Y3-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY206701 mRNA Translation: AAO17153.1
BK001028 mRNA Translation: DAA01470.1
BC011470 mRNA Translation: AAH11470.1
BC021491 mRNA Translation: AAH21491.1
BC023843 mRNA Translation: AAH23843.1
BC025566 mRNA Translation: AAH25566.1
BC027116 mRNA Translation: AAH27116.1
BC057683 mRNA Translation: AAH57683.1
AK085472 mRNA Translation: BAC39454.2 Different initiation.
AK162360 mRNA Translation: BAE36872.1
CCDSiCCDS52307.1 [Q7M6Y3-1]
CCDS85334.1 [Q7M6Y3-6]
CCDS85335.1 [Q7M6Y3-5]
CCDS85336.1 [Q7M6Y3-4]
CCDS85337.1 [Q7M6Y3-3]
CCDS85338.1 [Q7M6Y3-2]
RefSeqiNP_001239449.1, NM_001252520.1 [Q7M6Y3-5]
NP_001239450.1, NM_001252521.1 [Q7M6Y3-6]
NP_001239451.1, NM_001252522.1 [Q7M6Y3-4]
NP_001239452.1, NM_001252523.1 [Q7M6Y3-3]
NP_001239453.1, NM_001252524.1 [Q7M6Y3-2]
NP_666306.2, NM_146194.4 [Q7M6Y3-1]

3D structure databases

SMRiQ7M6Y3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi231417, 9 interactors
ELMiQ7M6Y3
IntActiQ7M6Y3, 5 interactors
MINTiQ7M6Y3
STRINGi10090.ENSMUSP00000051092

PTM databases

iPTMnetiQ7M6Y3
PhosphoSitePlusiQ7M6Y3
SwissPalmiQ7M6Y3

Proteomic databases

jPOSTiQ7M6Y3
PaxDbiQ7M6Y3
PeptideAtlasiQ7M6Y3
PRIDEiQ7M6Y3

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17636, 194 antibodies

Genome annotation databases

EnsembliENSMUST00000049537; ENSMUSP00000051092; ENSMUSG00000039361 [Q7M6Y3-5]
ENSMUST00000207225; ENSMUSP00000146659; ENSMUSG00000039361 [Q7M6Y3-2]
ENSMUST00000207484; ENSMUSP00000146501; ENSMUSG00000039361 [Q7M6Y3-1]
ENSMUST00000208730; ENSMUSP00000146541; ENSMUSG00000039361 [Q7M6Y3-3]
ENSMUST00000208742; ENSMUSP00000147016; ENSMUSG00000039361 [Q7M6Y3-6]
ENSMUST00000209068; ENSMUSP00000146386; ENSMUSG00000039361 [Q7M6Y3-4]
GeneIDi233489
KEGGimmu:233489
UCSCiuc009igq.2, mouse [Q7M6Y3-1]
uc009igr.2, mouse [Q7M6Y3-5]
uc009igs.2, mouse [Q7M6Y3-6]
uc009igt.2, mouse [Q7M6Y3-4]
uc009igu.2, mouse [Q7M6Y3-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8301
MGIiMGI:2385902, Picalm

Phylogenomic databases

eggNOGiKOG0251, Eukaryota
GeneTreeiENSGT00950000183068
HOGENOMiCLU_014080_0_0_1
InParanoidiQ7M6Y3
KOiK20044
OMAiPPQMGNV
OrthoDBi1592722at2759
PhylomeDBiQ7M6Y3
TreeFamiTF314861

Enzyme and pathway databases

ReactomeiR-MMU-432722, Golgi Associated Vesicle Biogenesis
R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828, Clathrin-mediated endocytosis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		233489, 6 hits in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Picalm, mouse

Protein Ontology

More...PROi		PR:Q7M6Y3
RNActiQ7M6Y3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000039361, Expressed in humerus cartilage element and 286 other tissues
GenevisibleiQ7M6Y3, MM

Family and domain databases

Gene3Di1.20.58.150, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR011417, ANTH_dom
IPR014712, Clathrin_AP_dom2
IPR013809, ENTH
IPR008942, ENTH_VHS
IPR030412, PICALM
PANTHERiPTHR22951:SF16, PTHR22951:SF16, 1 hit
PfamiView protein in Pfam
PF07651, ANTH, 1 hit
SMARTiView protein in SMART
SM00273, ENTH, 1 hit
SUPFAMiSSF48464, SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50942, ENTH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPICAL_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7M6Y3
Secondary accession number(s): Q3TS04
, Q811P1, Q8BUF6, Q8CIH8, Q8R0A9, Q8R3E1, Q8VDN5, Q921L0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 15, 2003
Last modified: August 12, 2020
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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