Sox11

Functionⁱ

Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	49 – 117	HMG boxPROSITE-ProRule annotationAdd BLAST		69

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21527504
enhancer sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19808959
- 21527504
RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18505825
transcription coactivator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18505825
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Source: MGI
Inferred from sequence orthologyⁱ
- 9632656
transcription regulatory region sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18505825
translation factor activity, RNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiac ventricle formation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20596238
closure of optic fissure
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18423449
cornea development in camera-type eye
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18423449
embryonic digestive tract morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15254231
embryonic skeletal system morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15254231
eyelid development in camera-type eye
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15254231
glial cell development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20147379
- 20646169
glial cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20147379
hard palate development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15254231
kidney development Source: Ensembl
lens morphogenesis in camera-type eye
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18423449
limb bud formation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20596238
lung morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15254231
negative regulation of cell death
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20596238
- 20646169
negative regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19808959
negative regulation of glial cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19808959
negative regulation of lymphocyte proliferation Source: MGI
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 19808959
negative regulation of transcription regulatory region DNA binding Source: UniProtKB
neural crest cell development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20596238
neural tube formation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20596238
neuroepithelial cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20646169
noradrenergic neuron differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20147379
oligodendrocyte development Source: Ensembl
outflow tract morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15254231
positive regulation of BMP signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18423449
positive regulation of cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20596238
positive regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19808959
positive regulation of hippo signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20596238
positive regulation of hormone secretion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21527504
positive regulation of lens epithelial cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18423449
positive regulation of neurogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 19490090
positive regulation of neuron differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 19490090
positive regulation of ossification
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15254231
positive regulation of osteoblast differentiation Source: UniProtKB
positive regulation of stem cell proliferation Source: UniProtKB
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 21527504
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 18505825
regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
signal transduction involved in cell cycle checkpoint Source: Ensembl
skeletal muscle cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 20847309
skeletal system development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20596238
soft palate development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15254231
somite development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20596238
spinal cord development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20646169
sympathetic nervous system development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20147379
ventricular septum morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15254231

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor SOX-11
Gene namesⁱ	Name:Sox11 Synonyms:Sox-11
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:98359 Sox11

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048751	1 – 395	Transcription factor SOX-11Add BLAST		395

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7M6Y2
PaxDbⁱ	Q7M6Y2
PRIDEⁱ	Q7M6Y2

PTM databases

iPTMnetⁱ	Q7M6Y2
PhosphoSitePlusⁱ	Q7M6Y2

Expressionⁱ

Tissue specificityⁱ

Expression prominent in the periventricular cells of the central nervous system, also observed in a wide range of tissues involved in epithelial-mesenchymal interactions.

Developmental stageⁱ

Expression detected from 8.5 dpc through to 13.5 dpc, with a considerable increase in expression apparent at 13.5 dpc.

Gene expression databases

Bgeeⁱ	ENSMUSG00000063632 Expressed in 288 organ(s), highest expression level in rostral migratory stream
CleanExⁱ	MM_SOX11
Genevisibleⁱ	Q7M6Y2 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	203398, 1 interactor
STRINGⁱ	10090.ENSMUSP00000078070

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7M6Y2
SMRⁱ	Q7M6Y2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	188 – 214	Asp/Glu-rich (highly acidic)Add BLAST		27
Compositional biasⁱ	297 – 308	Poly-SerAdd BLAST		12

Phylogenomic databases

eggNOGⁱ	KOG0527 Eukaryota ENOG410XT0K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118988
HOGENOMⁱ	HOG000231874
HOVERGENⁱ	HBG005040
InParanoidⁱ	Q7M6Y2
KEGG Orthology (KO) More...KOⁱ	K09268
OMAⁱ	VKCVFMD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F15
PhylomeDBⁱ	Q7M6Y2
TreeFamⁱ	TF351735

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR029551 SOX-11 IPR017386 SOX-11/4
PANTHERⁱ	PTHR10270:SF113 PTHR10270:SF113, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit
PIRSFⁱ	PIRSF038098 SOX-12/11/4a, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q7M6Y2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVQQAESSEA ESNLPRDALD TEEGEFMACS PVALDESDPD WCKTASGHIK 
        60         70         80         90        100
RPMNAFMVWS KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR 
       110        120        130        140        150
EAERLRLKHM ADYPDYKYRP RKKPKTDPAA KPSAGQSPDK SAAGAKAAKG 
       160        170        180        190        200
PGKKCAKLKA PAGKAGAGKA AQPGDCAAGK AAKCVFLDDD DEDDDEDDEL 
       210        220        230        240        250
QLRPKPDADD DDDEPAHSHL LPPPTQQQPP QLLRRYSVAK VPASPTLSSA 
       260        270        280        290        300
AESPEGASLY DEVRAGGRLY YSFKNITKQQ PPPAPPALSP ASSRCVSTSS 
       310        320        330        340        350
SSGSSSGSGA EDADDLMFDL SLNFSQGAHS ACEQPLGAGA AGNLSLSLVD 
       360        370        380        390 
KDLDSFSEGS LGSHFEFPDY CTPELSEMIA GDWLEANFSD LVFTY

Length:395

Mass (Da):42,629

Last modified:December 15, 2003 - v1

Checksum:ⁱAFA34270A054C6C5

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	103	E → G in AAB82425 (PubMed:9337129).Curated	1
Sequence conflictⁱ	147	A → T in AAB82425 (PubMed:9337129).Curated	1
Sequence conflictⁱ	171	A → V in AAB82425 (PubMed:9337129).Curated	1
Sequence conflictⁱ	177	A → G (PubMed:9337129).Curated	1
Sequence conflictⁱ	177	A → G (PubMed:15456859).Curated	1
Sequence conflictⁱ	192 – 196	EDDDE → DEEDD in AAB82425 (PubMed:9337129).Curated	5
Sequence conflictⁱ	225	T → A in AAB82425 (PubMed:9337129).Curated	1
Sequence conflictⁱ	280 – 281	QP → EA in AAB82425 (PubMed:9337129).Curated	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF009414 mRNA Translation: AAB82425.1 AB108675 mRNA Translation: BAC75670.1 BK001484 mRNA Translation: DAA01568.1 AK165693 mRNA Translation: BAE38341.1 AK146514 mRNA Translation: BAE27226.1 BC062095 mRNA Translation: AAH62095.1 Z18960 mRNA Translation: CAA79485.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25849.1
NCBI Reference Sequences More...RefSeqⁱ	NP_033260.4, NM_009234.6
UniGeneⁱ	Mm.41702 Mm.466344

Genome annotation databases

Ensemblⁱ	ENSMUST00000079063; ENSMUSP00000078070; ENSMUSG00000063632
GeneIDⁱ	20666
KEGGⁱ	mmu:20666
UCSC genome browser More...UCSCⁱ	uc007nfn.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7M6Y2	Transcription factor SOX-11		RAT		395	UniRef90_Q7M6Y2
Transcription factor SOX		NEOLE		403
Transcription factor SOX		MESAU		395
Transcription factor SOX		MOUSE		393
UPI000B4F6664		MERUN		396
+4

Protein	Similar proteins		Species	Score	Length	Source
Q7M6Y2	Transcription factor SOX-11		RAT		395	UniRef50_Q7M6Y2
Transcription factor SOX		NEOLE		403
Transcription factor SOX		MESAU		395
Transcription factor SOX		MOUSE		393
Transcription factor SOX		TAEGU		396
+31

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF009414 mRNA Translation: AAB82425.1 AB108675 mRNA Translation: BAC75670.1 BK001484 mRNA Translation: DAA01568.1 AK165693 mRNA Translation: BAE38341.1 AK146514 mRNA Translation: BAE27226.1 BC062095 mRNA Translation: AAH62095.1 Z18960 mRNA Translation: CAA79485.1
CCDSⁱ	CCDS25849.1
RefSeqⁱ	NP_033260.4, NM_009234.6
UniGeneⁱ	Mm.41702 Mm.466344

3D structure databases

ProteinModelPortalⁱ	Q7M6Y2
SMRⁱ	Q7M6Y2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203398, 1 interactor
STRINGⁱ	10090.ENSMUSP00000078070

PTM databases

iPTMnetⁱ	Q7M6Y2
PhosphoSitePlusⁱ	Q7M6Y2

Proteomic databases

MaxQBⁱ	Q7M6Y2
PaxDbⁱ	Q7M6Y2
PRIDEⁱ	Q7M6Y2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000079063; ENSMUSP00000078070; ENSMUSG00000063632
GeneIDⁱ	20666
KEGGⁱ	mmu:20666
UCSCⁱ	uc007nfn.2 mouse

Organism-specific databases

CTDⁱ	6664
MGIⁱ	MGI:98359 Sox11

Phylogenomic databases

eggNOGⁱ	KOG0527 Eukaryota ENOG410XT0K LUCA
GeneTreeⁱ	ENSGT00760000118988
HOGENOMⁱ	HOG000231874
HOVERGENⁱ	HBG005040
InParanoidⁱ	Q7M6Y2
KOⁱ	K09268
OMAⁱ	VKCVFMD
OrthoDBⁱ	EOG091G0F15
PhylomeDBⁱ	Q7M6Y2
TreeFamⁱ	TF351735

Miscellaneous databases

ChiTaRSⁱ	Sox11 mouse
Protein Ontology More...PROⁱ	PR:Q7M6Y2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000063632 Expressed in 288 organ(s), highest expression level in rostral migratory stream
CleanExⁱ	MM_SOX11
Genevisibleⁱ	Q7M6Y2 MM

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR029551 SOX-11 IPR017386 SOX-11/4
PANTHERⁱ	PTHR10270:SF113 PTHR10270:SF113, 1 hit
Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit
PIRSFⁱ	PIRSF038098 SOX-12/11/4a, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOX11_MOUSE
Accessionⁱ	Q7M6Y2Primary (citable) accession number: Q7M6Y2 Secondary accession number(s): O35178 , O89036, Q04889, Q80XF0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	December 15, 2003
	Last modified:	October 10, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7M6Y2 (SOX11_MOUSE)

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Transcription factor SOX-11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ