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Protein

Transcription factor SOX-11

Gene

Sox11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi49 – 117HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-11
Gene namesi
Name:Sox11
Synonyms:Sox-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:98359 Sox11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487511 – 395Transcription factor SOX-11Add BLAST395

Proteomic databases

MaxQBiQ7M6Y2
PaxDbiQ7M6Y2
PRIDEiQ7M6Y2

PTM databases

iPTMnetiQ7M6Y2
PhosphoSitePlusiQ7M6Y2

Expressioni

Tissue specificityi

Expression prominent in the periventricular cells of the central nervous system, also observed in a wide range of tissues involved in epithelial-mesenchymal interactions.

Developmental stagei

Expression detected from 8.5 dpc through to 13.5 dpc, with a considerable increase in expression apparent at 13.5 dpc.

Gene expression databases

BgeeiENSMUSG00000063632 Expressed in 288 organ(s), highest expression level in rostral migratory stream
CleanExiMM_SOX11
GenevisibleiQ7M6Y2 MM

Interactioni

Protein-protein interaction databases

BioGridi203398, 1 interactor
STRINGi10090.ENSMUSP00000078070

Structurei

3D structure databases

ProteinModelPortaliQ7M6Y2
SMRiQ7M6Y2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi188 – 214Asp/Glu-rich (highly acidic)Add BLAST27
Compositional biasi297 – 308Poly-SerAdd BLAST12

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG410XT0K LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231874
HOVERGENiHBG005040
InParanoidiQ7M6Y2
KOiK09268
OMAiVKCVFMD
OrthoDBiEOG091G0F15
PhylomeDBiQ7M6Y2
TreeFamiTF351735

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR029551 SOX-11
IPR017386 SOX-11/4
PANTHERiPTHR10270:SF113 PTHR10270:SF113, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PIRSFiPIRSF038098 SOX-12/11/4a, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7M6Y2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQQAESSEA ESNLPRDALD TEEGEFMACS PVALDESDPD WCKTASGHIK
60 70 80 90 100
RPMNAFMVWS KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR
110 120 130 140 150
EAERLRLKHM ADYPDYKYRP RKKPKTDPAA KPSAGQSPDK SAAGAKAAKG
160 170 180 190 200
PGKKCAKLKA PAGKAGAGKA AQPGDCAAGK AAKCVFLDDD DEDDDEDDEL
210 220 230 240 250
QLRPKPDADD DDDEPAHSHL LPPPTQQQPP QLLRRYSVAK VPASPTLSSA
260 270 280 290 300
AESPEGASLY DEVRAGGRLY YSFKNITKQQ PPPAPPALSP ASSRCVSTSS
310 320 330 340 350
SSGSSSGSGA EDADDLMFDL SLNFSQGAHS ACEQPLGAGA AGNLSLSLVD
360 370 380 390
KDLDSFSEGS LGSHFEFPDY CTPELSEMIA GDWLEANFSD LVFTY
Length:395
Mass (Da):42,629
Last modified:December 15, 2003 - v1
Checksum:iAFA34270A054C6C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103E → G in AAB82425 (PubMed:9337129).Curated1
Sequence conflicti147A → T in AAB82425 (PubMed:9337129).Curated1
Sequence conflicti171A → V in AAB82425 (PubMed:9337129).Curated1
Sequence conflicti177A → G (PubMed:9337129).Curated1
Sequence conflicti177A → G (PubMed:15456859).Curated1
Sequence conflicti192 – 196EDDDE → DEEDD in AAB82425 (PubMed:9337129).Curated5
Sequence conflicti225T → A in AAB82425 (PubMed:9337129).Curated1
Sequence conflicti280 – 281QP → EA in AAB82425 (PubMed:9337129).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009414 mRNA Translation: AAB82425.1
AB108675 mRNA Translation: BAC75670.1
BK001484 mRNA Translation: DAA01568.1
AK165693 mRNA Translation: BAE38341.1
AK146514 mRNA Translation: BAE27226.1
BC062095 mRNA Translation: AAH62095.1
Z18960 mRNA Translation: CAA79485.1
CCDSiCCDS25849.1
RefSeqiNP_033260.4, NM_009234.6
UniGeneiMm.41702
Mm.466344

Genome annotation databases

EnsembliENSMUST00000079063; ENSMUSP00000078070; ENSMUSG00000063632
GeneIDi20666
KEGGimmu:20666
UCSCiuc007nfn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009414 mRNA Translation: AAB82425.1
AB108675 mRNA Translation: BAC75670.1
BK001484 mRNA Translation: DAA01568.1
AK165693 mRNA Translation: BAE38341.1
AK146514 mRNA Translation: BAE27226.1
BC062095 mRNA Translation: AAH62095.1
Z18960 mRNA Translation: CAA79485.1
CCDSiCCDS25849.1
RefSeqiNP_033260.4, NM_009234.6
UniGeneiMm.41702
Mm.466344

3D structure databases

ProteinModelPortaliQ7M6Y2
SMRiQ7M6Y2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203398, 1 interactor
STRINGi10090.ENSMUSP00000078070

PTM databases

iPTMnetiQ7M6Y2
PhosphoSitePlusiQ7M6Y2

Proteomic databases

MaxQBiQ7M6Y2
PaxDbiQ7M6Y2
PRIDEiQ7M6Y2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079063; ENSMUSP00000078070; ENSMUSG00000063632
GeneIDi20666
KEGGimmu:20666
UCSCiuc007nfn.2 mouse

Organism-specific databases

CTDi6664
MGIiMGI:98359 Sox11

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG410XT0K LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231874
HOVERGENiHBG005040
InParanoidiQ7M6Y2
KOiK09268
OMAiVKCVFMD
OrthoDBiEOG091G0F15
PhylomeDBiQ7M6Y2
TreeFamiTF351735

Miscellaneous databases

ChiTaRSiSox11 mouse
PROiPR:Q7M6Y2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063632 Expressed in 288 organ(s), highest expression level in rostral migratory stream
CleanExiMM_SOX11
GenevisibleiQ7M6Y2 MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR029551 SOX-11
IPR017386 SOX-11/4
PANTHERiPTHR10270:SF113 PTHR10270:SF113, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PIRSFiPIRSF038098 SOX-12/11/4a, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX11_MOUSE
AccessioniPrimary (citable) accession number: Q7M6Y2
Secondary accession number(s): O35178
, O89036, Q04889, Q80XF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 15, 2003
Last modified: October 10, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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