UniProtKB - Q7M6Y2 (SOX11_MOUSE)
Protein
Transcription factor SOX-11
Gene
Sox11
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor that acts as a transcriptional activator (PubMed:18505825, PubMed:18403418). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (PubMed:18505825, PubMed:18403418). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (PubMed:20596238). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (PubMed:20596238).3 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 49 – 117 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- cardiac ventricle formation Source: UniProtKB
- cell differentiation Source: GO_Central
- closure of optic fissure Source: UniProtKB
- cornea development in camera-type eye Source: UniProtKB
- embryonic digestive tract morphogenesis Source: UniProtKB
- embryonic skeletal system morphogenesis Source: UniProtKB
- eyelid development in camera-type eye Source: UniProtKB
- glial cell development Source: UniProtKB
- glial cell proliferation Source: UniProtKB
- hard palate development Source: UniProtKB
- kidney development Source: Ensembl
- lens morphogenesis in camera-type eye Source: UniProtKB
- limb bud formation Source: UniProtKB
- lung morphogenesis Source: UniProtKB
- negative regulation of cell death Source: UniProtKB
- negative regulation of gene expression Source: UniProtKB
- negative regulation of glial cell proliferation Source: UniProtKB
- negative regulation of lymphocyte proliferation Source: MGI
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- negative regulation of transcription regulatory region DNA binding Source: UniProtKB
- neural crest cell development Source: UniProtKB
- neural tube formation Source: UniProtKB
- neuroepithelial cell differentiation Source: UniProtKB
- neuron differentiation Source: GO_Central
- noradrenergic neuron differentiation Source: UniProtKB
- oligodendrocyte development Source: Ensembl
- outflow tract morphogenesis Source: UniProtKB
- positive regulation of BMP signaling pathway Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of hippo signaling Source: UniProtKB
- positive regulation of hormone secretion Source: UniProtKB
- positive regulation of lens epithelial cell proliferation Source: UniProtKB
- positive regulation of neurogenesis Source: UniProtKB
- positive regulation of neuron differentiation Source: UniProtKB
- positive regulation of ossification Source: UniProtKB
- positive regulation of osteoblast differentiation Source: UniProtKB
- positive regulation of stem cell proliferation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
- regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- signal transduction involved in cell cycle checkpoint Source: Ensembl
- skeletal muscle cell differentiation Source: MGI
- skeletal system development Source: UniProtKB
- soft palate development Source: UniProtKB
- somite development Source: UniProtKB
- spinal cord development Source: UniProtKB
- sympathetic nervous system development Source: UniProtKB
- ventricular septum morphogenesis Source: UniProtKB
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor SOX-11 |
Gene namesi | Name:Sox11 Synonyms:Sox-11 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98359, Sox11 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nuclear chromatin Source: GO_Central
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Mice die at birth with numerous morphological abnormalities (PubMed:20596238). Incomplete separation of the heart ventricles with fused aorta and pulmonary arteries (PubMed:20596238). Skeletal malformations including hypoplastic sternebrae, unfused vertebral bodies and hypomineralized skull (PubMed:20596238). All mice have microphthalmia and open eyelids, with 50% of mice exhibiting omphalocele, and 40% exhibiting cleft palate, cleft lips and a tail kink (PubMed:20596238). Sox11 and Sox4 double knockout mice die in utero at 10.5 dpc (PubMed:20596238). Embryos are small and unturned with developmental defects such as failure of heart primordia fusion, a thin and undulated neural tube, failure of limb budding and somite formation, suggesting developmental arrest at 8.5 dpc (PubMed:20596238). Embryos showed reduced cell proliferation and increased cell death in the neural tube, branchial arches, somites and reduced expression of Tead2 at 9.5 dpc (PubMed:20596238). Sox4, Sox11, and Sox12 triple knockout mice show severe thinning and undulation of the neural tube (PubMed:20596238).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048751 | 1 – 395 | Transcription factor SOX-11Add BLAST | 395 |
Proteomic databases
MaxQBi | Q7M6Y2 |
PaxDbi | Q7M6Y2 |
PRIDEi | Q7M6Y2 |
PTM databases
iPTMneti | Q7M6Y2 |
PhosphoSitePlusi | Q7M6Y2 |
Expressioni
Tissue specificityi
Expression prominent in the periventricular cells of the central nervous system, also observed in a wide range of tissues involved in epithelial-mesenchymal interactions.
Developmental stagei
Expression detected from 8.5 dpc through to 13.5 dpc, with a considerable increase in expression apparent at 13.5 dpc (PubMed:9337129, PubMed:18505825, PubMed:20596238). Expressed throughout the central and peripheral nervous system, as well as the mesenchyme of many developing organs between 12.5 dpc and 14.5 dpc (PubMed:18403418). Abundantly expressed in the developing cerebral cortex, thalamus, hippocampus, cerebellar cortex, and ganglia in the brain at 14.5 dpc and 16.5 dpc with low expression at 18.5 dpc (PubMed:18505825). Abundantly expressed in the gut epithelium at 14.5 dpc (PubMed:18505825). Abundantly expressed in the olfactory epithelium with low expression in skin, spinal cord, kidney, heart, muscle, cartilage from 14.5 dpc to 18.5 dpc (PubMed:18505825). Very low expression in intestine and lung, with no expression detectable at 18.5 dpc (PubMed:18505825). Abundantly expressed in the subventricular zone of the brain at 18.5 dpc (PubMed:18505825). Expressed in the brain at postnatal day 2 (PubMed:18403418).4 Publications
Gene expression databases
Bgeei | ENSMUSG00000063632, Expressed in rostral migratory stream and 300 other tissues |
Genevisiblei | Q7M6Y2, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 203398, 1 interactor |
STRINGi | 10090.ENSMUSP00000078070 |
Miscellaneous databases
RNActi | Q7M6Y2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 363 – 395 | Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F21 PublicationAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 188 – 214 | Asp/Glu-rich (highly acidic)Add BLAST | 27 | |
Compositional biasi | 297 – 308 | Poly-SerAdd BLAST | 12 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000161652 |
HOGENOMi | CLU_043342_0_0_1 |
InParanoidi | Q7M6Y2 |
OMAi | VKCVFMD |
OrthoDBi | 1186233at2759 |
PhylomeDBi | Q7M6Y2 |
TreeFami | TF351735 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR029551, SOX-11 IPR017386, SOX-12/11/4 |
PANTHERi | PTHR10270:SF113, PTHR10270:SF113, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
PIRSFi | PIRSF038098, SOX-12/11/4a, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7M6Y2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVQQAESSEA ESNLPRDALD TEEGEFMACS PVALDESDPD WCKTASGHIK
60 70 80 90 100
RPMNAFMVWS KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR
110 120 130 140 150
EAERLRLKHM ADYPDYKYRP RKKPKTDPAA KPSAGQSPDK SAAGAKAAKG
160 170 180 190 200
PGKKCAKLKA PAGKAGAGKA AQPGDCAAGK AAKCVFLDDD DEDDDEDDEL
210 220 230 240 250
QLRPKPDADD DDDEPAHSHL LPPPTQQQPP QLLRRYSVAK VPASPTLSSA
260 270 280 290 300
AESPEGASLY DEVRAGGRLY YSFKNITKQQ PPPAPPALSP ASSRCVSTSS
310 320 330 340 350
SSGSSSGSGA EDADDLMFDL SLNFSQGAHS ACEQPLGAGA AGNLSLSLVD
360 370 380 390
KDLDSFSEGS LGSHFEFPDY CTPELSEMIA GDWLEANFSD LVFTY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 103 | E → G in AAB82425 (PubMed:9337129).Curated | 1 | |
Sequence conflicti | 147 | A → T in AAB82425 (PubMed:9337129).Curated | 1 | |
Sequence conflicti | 171 | A → V in AAB82425 (PubMed:9337129).Curated | 1 | |
Sequence conflicti | 177 | A → G (PubMed:9337129).Curated | 1 | |
Sequence conflicti | 177 | A → G (PubMed:15456859).Curated | 1 | |
Sequence conflicti | 192 – 196 | EDDDE → DEEDD in AAB82425 (PubMed:9337129).Curated | 5 | |
Sequence conflicti | 225 | T → A in AAB82425 (PubMed:9337129).Curated | 1 | |
Sequence conflicti | 280 – 281 | QP → EA in AAB82425 (PubMed:9337129).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF009414 mRNA Translation: AAB82425.1 AB108675 mRNA Translation: BAC75670.1 BK001484 mRNA Translation: DAA01568.1 AK165693 mRNA Translation: BAE38341.1 AK146514 mRNA Translation: BAE27226.1 BC062095 mRNA Translation: AAH62095.1 Z18960 mRNA Translation: CAA79485.1 |
CCDSi | CCDS25849.1 |
RefSeqi | NP_033260.4, NM_009234.6 |
Genome annotation databases
Ensembli | ENSMUST00000079063; ENSMUSP00000078070; ENSMUSG00000063632 |
GeneIDi | 20666 |
KEGGi | mmu:20666 |
UCSCi | uc007nfn.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF009414 mRNA Translation: AAB82425.1 AB108675 mRNA Translation: BAC75670.1 BK001484 mRNA Translation: DAA01568.1 AK165693 mRNA Translation: BAE38341.1 AK146514 mRNA Translation: BAE27226.1 BC062095 mRNA Translation: AAH62095.1 Z18960 mRNA Translation: CAA79485.1 |
CCDSi | CCDS25849.1 |
RefSeqi | NP_033260.4, NM_009234.6 |
3D structure databases
SMRi | Q7M6Y2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203398, 1 interactor |
STRINGi | 10090.ENSMUSP00000078070 |
PTM databases
iPTMneti | Q7M6Y2 |
PhosphoSitePlusi | Q7M6Y2 |
Proteomic databases
MaxQBi | Q7M6Y2 |
PaxDbi | Q7M6Y2 |
PRIDEi | Q7M6Y2 |
Protocols and materials databases
Antibodypediai | 625, 323 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000079063; ENSMUSP00000078070; ENSMUSG00000063632 |
GeneIDi | 20666 |
KEGGi | mmu:20666 |
UCSCi | uc007nfn.2, mouse |
Organism-specific databases
CTDi | 6664 |
MGIi | MGI:98359, Sox11 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000161652 |
HOGENOMi | CLU_043342_0_0_1 |
InParanoidi | Q7M6Y2 |
OMAi | VKCVFMD |
OrthoDBi | 1186233at2759 |
PhylomeDBi | Q7M6Y2 |
TreeFami | TF351735 |
Miscellaneous databases
BioGRID-ORCSi | 20666, 2 hits in 18 CRISPR screens |
ChiTaRSi | Sox11, mouse |
PROi | PR:Q7M6Y2 |
RNActi | Q7M6Y2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000063632, Expressed in rostral migratory stream and 300 other tissues |
Genevisiblei | Q7M6Y2, MM |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR029551, SOX-11 IPR017386, SOX-12/11/4 |
PANTHERi | PTHR10270:SF113, PTHR10270:SF113, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
PIRSFi | PIRSF038098, SOX-12/11/4a, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SOX11_MOUSE | |
Accessioni | Q7M6Y2Primary (citable) accession number: Q7M6Y2 Secondary accession number(s): O35178 Q80XF0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | December 15, 2003 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot