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Entry version 135 (08 May 2019)
Sequence version 2 (25 Jul 2006)
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Protein

Inactive serine/threonine-protein kinase TEX14

Gene

Tex14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro.4 Publications

Miscellaneous

Used as a marker for intercellular bridges.1 Publication

Caution

Ser-370 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei267ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi205 – 213ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive serine/threonine-protein kinase TEX14
Alternative name(s):
Testis-expressed sequence 14
Testis-expressed sequence 14 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tex14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1933227 Tex14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Male mice are sterile, due to the absence of intercellular bridges. Intercellular bridges do not form during spermatogenesis, and male mice are sterile. In females, embryonic intercellular bridges are also absent, mice have fewer oocytes, but they are fertile.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi431S → A: Reduced phosphorylation by PLK1 and abolishes depletion from kinetochores and subsequent degradation by the APC/C complex. 1 Publication1
Mutagenesisi431S → D or E: Mimicks phosphorylation state; inducing early depletion from kinetochores and subsequent degradation by the APC/C complex. 1 Publication1
Mutagenesisi791G → A: Does not affect interaction with CEP55. 1 Publication1
Mutagenesisi792P → A: Abolishes interaction with CEP55. 1 Publication1
Mutagenesisi797Y → A: Abolishes interaction with CEP55. 1 Publication1
Mutagenesisi889 – 897Missing : Prevents degradation during metaphase. 1 Publication9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002469961 – 1450Inactive serine/threonine-protein kinase TEX14Add BLAST1450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei175PhosphoserineBy similarity1
Modified residuei186PhosphoserineCombined sources1
Modified residuei431Phosphoserine; by PLK11 Publication1
Modified residuei561PhosphoserineBy similarity1
Modified residuei662PhosphoserineBy similarity1
Modified residuei1060PhosphoserineCombined sources1
Modified residuei1221PhosphoserineCombined sources1
Modified residuei1357PhosphoserineCombined sources1
Modified residuei1358PhosphoserineCombined sources1
Modified residuei1412PhosphoserineCombined sources1
Modified residuei1449PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-431 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7M6U3

PeptideAtlas

More...
PeptideAtlasi
Q7M6U3

PRoteomics IDEntifications database

More...
PRIDEi
Q7M6U3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7M6U3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7M6U3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in testis and spermatogonia. Not detectable in the other tissues tested.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected at low levels in developing testis at 5 and 10 days after birth. Highly expressed in testis 15 and 20 days after birth. Highly expressed in pachytene, diplotene and meiotically dividing spermatocytes and in early round spermatids.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000010342 Expressed in 72 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7M6U3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7M6U3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KIF23 and RBM44.

Interacts with CEP55; inhibiting interaction between CEP55 and PDCD6IP/ALIX and TSG101.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Cep55Q8BT0711EBI-6674575,EBI-2552328

GO - Molecular functioni

Protein-protein interaction databases

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q7M6U3

Protein interaction database and analysis system

More...
IntActi
Q7M6U3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000054444

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati27 – 54ANK 1Add BLAST28
Repeati55 – 84ANK 2Add BLAST30
Repeati88 – 117ANK 3Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini199 – 512Protein kinasePROSITE-ProRule annotationAdd BLAST314

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi791 – 797GPPX3Y7
Motifi889 – 897D-box9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase domain is predicted to be catalytically inactive.
The GPPX3Y motif mediates interaction with CEP55.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHZA Eukaryota
ENOG410XT67 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015123

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7M6U3

KEGG Orthology (KO)

More...
KOi
K17540

Identification of Orthologs from Complete Genome Data

More...
OMAi
LEYMMES

Database of Orthologous Groups

More...
OrthoDBi
92703at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7M6U3

TreeFam database of animal gene trees

More...
TreeFami
TF328704

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR039339 Tex14

The PANTHER Classification System

More...
PANTHERi
PTHR23060 PTHR23060, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF07714 Pkinase_Tyr, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7M6U3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRGAPFPVP CPVLLGTFTD DSLEAQLHEY AKQGNCVKLK KILKKGVCVD
60 70 80 90 100
AVNTQGQSAL FVAALLGHVK LVDVLVDYGS DPNHRCFDGS TPVHAAAFSG
110 120 130 140 150
NQWILSKLLT AGGDLRLHDE KGRNPQAWAL TAGKDRSTQM VEFMQRCTSH
160 170 180 190 200
MKAIIQGFSY DLLKKIDSPQ RLIGSPPWFG SLIQGSPNSS PNRQLKPGII
210 220 230 240 250
SAQNIYSFGF GKFYLTSGMQ LTYPGSLPVI GEKEVVQADD EPTFSFFSGP
260 270 280 290 300
YMVMTNLVWN RSRVTVKELN LPTRPHCSRL RLADLLIAEQ EHSSNLRHPN
310 320 330 340 350
LLQLMAVCLS RDLEKIRLVY ERITVGTLFS VLHERRSQFP VLHMEVIVHL
360 370 380 390 400
LLQVADALIY LHSRGFIHRS LSSYAVHIVS AGEARLTNLE YLTESQDSGA
410 420 430 440 450
HRNVTRMPLP TQLYNWAAPE VVLQKAATVK SDIYSFSVII QEILTDSIPW
460 470 480 490 500
NGLDGSLVKE TIALGNYLEA DVRLPEPYYD IVKSGIHAKQ KNRTMNLQDI
510 520 530 540 550
RYILKNDLKE FIGAQKTQPT ESPRGQSYEP HPDVNICLGL TSEYQKDPPD
560 570 580 590 600
LDIKELKEMG SQPHSPTDHS FLTVKPTLAP QTLDSSLSAQ KPDNANVPSP
610 620 630 640 650
PAACLAEEVR SPTASQDSLC SFEINEIYSG CLTLGTDKEE ECLGTAASPE
660 670 680 690 700
GDRPNQGDEL PSLEEELDKM ERELHCFCEE DKSISEVDTD LLFEDDDWQS
710 720 730 740 750
DSLGSLNLPE PTREAKGKTS SWSKTDEYVS KCVLNLKISQ VMMQQSAEWL
760 770 780 790 800
RKLEQEVEEL EWAQKELDSQ CSSLRDASLK FANAKFQPAV GPPSLAYLPP
810 820 830 840 850
VMQLPGLKQP ENGGTWLTLA RSPGNEREFQ EGHFSKKPEK LSACGWKPFT
860 870 880 890 900
QVSEESRGDC SELNNQLPTL RGPGKQSTGE QLPSTQEARE SLEKNTNQNS
910 920 930 940 950
RSMASVSSEI YATKSRNNED NGEAHLKWRL AVKEMAEKAV SGQLLLPPWN
960 970 980 990 1000
PQSSAPFESK VENESTPLPR PPIRGPESTE WQHILEYQRE NDEPKGNTKF
1010 1020 1030 1040 1050
GKMDNSDCDK NKHSRWTGLQ RFTGIRYPFF RNHEQPEQNE ASQASCDTSV
1060 1070 1080 1090 1100
GTEKFYSTSS PIGDDFERFQ DSFAQRQGYV EENFQIREIF EKNAEILTKP
1110 1120 1130 1140 1150
QFQAIQCAED KQDETLGETP KELKEKNTSL TDIQDLSSIT YDQDGYFKET
1160 1170 1180 1190 1200
SYKTPKLKHA PTSASTPLSP ESISSAASHY EDCLENTTFH VKRGSTFCWN
1210 1220 1230 1240 1250
GQEAMRTLSA KFTTVRERAK SLESLLASSK SLPAKLTDSK RLCMLSETGS
1260 1270 1280 1290 1300
SNVSAAFVTS THATKRKSLP RELAEATSQQ HLDELPPPAQ ELLDEIEQLK
1310 1320 1330 1340 1350
QQQVSSLASH ENTARDLSVT NKDKKHLEEQ ETNSSKDSSF LSSREIQDLE
1360 1370 1380 1390 1400
DTERAHSSLD EDLERFLQSP EENTALLDPT KGSTREKKNK DQDVVEQKRK
1410 1420 1430 1440 1450
KKESIKPERR ESDSSLGTLE EDELKPCFWK RLGWSEPSRI IVLDQSDLSD
Length:1,450
Mass (Da):162,541
Last modified:July 25, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0628605EBE0FF0A4
GO
Isoform 2 (identifier: Q7M6U3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-218: Missing.

Show »
Length:1,232
Mass (Da):138,851
Checksum:iA2CDBD69A483AF39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5ND21Q5ND21_MOUSE
Inactive serine/threonine-protein k...
Tex14
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2KGK9B2KGK9_MOUSE
Inactive serine/threonine-protein k...
Tex14
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5ND20Q5ND20_MOUSE
Inactive serine/threonine-protein k...
Tex14
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAI35965 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti324T → A in AAK31963 (PubMed:11279525).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0198701 – 218Missing in isoform 2. 1 PublicationAdd BLAST218

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF285584 mRNA Translation: AAK31963.1
AL596086, AL669902 Genomic DNA Translation: CAI35127.1
AL669902 Genomic DNA Translation: CAI35965.1 Different initiation.
AL669902, AL596086 Genomic DNA Translation: CAI35966.1
CU406969, CU406988 Genomic DNA Translation: CAQ52018.1
CU406988, CU406969 Genomic DNA Translation: CAQ52278.1
AY193717 mRNA Translation: AAN86761.1
AY193718 mRNA Translation: AAN86762.1
BK000966 mRNA Translation: DAA01357.1
BK000967 mRNA Translation: DAA01358.1
AK139808 mRNA Translation: BAE24144.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS48877.1 [Q7M6U3-1]

NCBI Reference Sequences

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RefSeqi
NP_001186222.1, NM_001199293.1
NP_113563.2, NM_031386.2 [Q7M6U3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000060835; ENSMUSP00000054444; ENSMUSG00000010342 [Q7M6U3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83560

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:83560

UCSC genome browser

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UCSCi
uc007ktr.2 mouse [Q7M6U3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285584 mRNA Translation: AAK31963.1
AL596086, AL669902 Genomic DNA Translation: CAI35127.1
AL669902 Genomic DNA Translation: CAI35965.1 Different initiation.
AL669902, AL596086 Genomic DNA Translation: CAI35966.1
CU406969, CU406988 Genomic DNA Translation: CAQ52018.1
CU406988, CU406969 Genomic DNA Translation: CAQ52278.1
AY193717 mRNA Translation: AAN86761.1
AY193718 mRNA Translation: AAN86762.1
BK000966 mRNA Translation: DAA01357.1
BK000967 mRNA Translation: DAA01358.1
AK139808 mRNA Translation: BAE24144.1
CCDSiCCDS48877.1 [Q7M6U3-1]
RefSeqiNP_001186222.1, NM_001199293.1
NP_113563.2, NM_031386.2 [Q7M6U3-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

ELMiQ7M6U3
IntActiQ7M6U3, 2 interactors
STRINGi10090.ENSMUSP00000054444

PTM databases

iPTMnetiQ7M6U3
PhosphoSitePlusiQ7M6U3

Proteomic databases

PaxDbiQ7M6U3
PeptideAtlasiQ7M6U3
PRIDEiQ7M6U3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060835; ENSMUSP00000054444; ENSMUSG00000010342 [Q7M6U3-1]
GeneIDi83560
KEGGimmu:83560
UCSCiuc007ktr.2 mouse [Q7M6U3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56155
MGIiMGI:1933227 Tex14

Phylogenomic databases

eggNOGiENOG410IHZA Eukaryota
ENOG410XT67 LUCA
GeneTreeiENSGT00390000015123
InParanoidiQ7M6U3
KOiK17540
OMAiLEYMMES
OrthoDBi92703at2759
PhylomeDBiQ7M6U3
TreeFamiTF328704

Miscellaneous databases

Protein Ontology

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PROi
PR:Q7M6U3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000010342 Expressed in 72 organ(s), highest expression level in testis
ExpressionAtlasiQ7M6U3 baseline and differential
GenevisibleiQ7M6U3 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR039339 Tex14
PANTHERiPTHR23060 PTHR23060, 3 hits
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF07714 Pkinase_Tyr, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEX14_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7M6U3
Secondary accession number(s): B2KGL0
, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: May 8, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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