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Protein

SH2 domain-containing adapter protein F

Gene

SHF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.1 Publication

Miscellaneous

The sequence described in PubMed:11095946 is over-extended by 57 aa at the N-terminus due to the presence of an uncorrected 5' mismatch compared to the reference genome sequence.

GO - Molecular functioni

  • phosphotyrosine residue binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

SignaLinkiQ7M4L6

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing adapter protein F
Gene namesi
Name:SHFImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000138606.19
HGNCiHGNC:25116 SHF
neXtProtiNX_Q7M4L6

Pathology & Biotechi

Organism-specific databases

DisGeNETi90525
OpenTargetsiENSG00000138606

Polymorphism and mutation databases

DMDMi308153498

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003225581 – 423SH2 domain-containing adapter protein FAdd BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei201PhosphotyrosineBy similarity1

Post-translational modificationi

May become phosphorylated upon binding to PDGFRA.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7M4L6
PeptideAtlasiQ7M4L6
PRIDEiQ7M4L6
ProteomicsDBi68869
68870 [Q7M4L6-2]

PTM databases

iPTMnetiQ7M4L6
PhosphoSitePlusiQ7M4L6

Expressioni

Tissue specificityi

Expressed in skeletal muscle, brain, liver, prostate, testis, ovary, small intestine and colon.1 Publication

Gene expression databases

BgeeiENSG00000138606 Expressed in 131 organ(s), highest expression level in cerebellum
CleanExiHS_SHF
ExpressionAtlasiQ7M4L6 baseline and differential
GenevisibleiQ7M4L6 HS

Organism-specific databases

HPAiHPA057381

Interactioni

Subunit structurei

Interacts with phosphorylated 'Tyr-720' of PDGFRA via its SH2 domain.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124730, 1 interactor
STRINGi9606.ENSP00000290894

Structurei

3D structure databases

ProteinModelPortaliQ7M4L6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini323 – 418SH2PROSITE-ProRule annotationAdd BLAST96

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IGWI Eukaryota
ENOG410XQJ2 LUCA
GeneTreeiENSGT00390000015203
HOGENOMiHOG000038038
HOVERGENiHBG066172
InParanoidiQ7M4L6
OrthoDBiEOG091G0I06
PhylomeDBiQ7M4L6
TreeFamiTF325799

Family and domain databases

CDDicd10392 SH2_SHF, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR035043 SHF
IPR035044 SHF_SH2
PANTHERiPTHR15127:SF28 PTHR15127:SF28, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q7M4L6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQQEGGPVRS APCRTGTLEG SRQGSPGHRK RASPKGSLSS AQPHSWMLTP
60 70 80 90 100
SPLNSHCAHR EPISSSPQPV ANGPKQKKKS NWRSTTRLRI IRLRDRLEPR
110 120 130 140 150
PLAILEDYAD PFDVQETGEG SAGASGAPEK VPENDGYMEP YEAQKMMAEI
160 170 180 190 200
RGSKETATQP LPLYDTPYEP EEDGATAEGE GAPWPRESRL PEDDERPPEE
210 220 230 240 250
YDQPWEWKKE RISKAFAVDI KVIKDLPWPP PVGQLDSSPS LPDGDRDISG
260 270 280 290 300
PASPLPEPSL EDSSAQFEGP EKSCLSPGRE EKGRLPPRLS AGNPKSAKPL
310 320 330 340 350
SMEPSSPLGE WTDPALPLEN QVWYHGAISR TDAENLLRLC KEASYLVRNS
360 370 380 390 400
ETSKNDFSLS LKSSQGFMHM KLSRTKEHKY VLGQNSPPFS SVPEIVHHYA
410 420
SRKLPIKGAE HMSLLYPVAI RTL
Length:423
Mass (Da):46,768
Last modified:October 5, 2010 - v2
Checksum:iB63C06255825CC6C
GO
Isoform 21 Publication (identifier: Q7M4L6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     218-264: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:376
Mass (Da):41,865
Checksum:i288181FDF18CAD0E
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W6V4F8W6V4_HUMAN
SH2 domain-containing adapter prote...
SHF
239Annotation score:
H0YLM1H0YLM1_HUMAN
SH2 domain-containing adapter prote...
SHF
414Annotation score:
H0YNJ2H0YNJ2_HUMAN
SH2 domain-containing adapter prote...
SHF
163Annotation score:
H0YKA8H0YKA8_HUMAN
SH2 domain-containing adapter prote...
SHF
199Annotation score:
H0YMN4H0YMN4_HUMAN
SH2 domain-containing adapter prote...
SHF
161Annotation score:
H0YLD8H0YLD8_HUMAN
SH2 domain-containing adapter prote...
SHF
290Annotation score:
H0YN16H0YN16_HUMAN
SH2 domain-containing adapter prote...
SHF
146Annotation score:
H0YLW6H0YLW6_HUMAN
SH2 domain-containing adapter prote...
SHF
367Annotation score:
H0YNF2H0YNF2_HUMAN
SH2 domain-containing adapter prote...
SHF
26Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177A → P in AAH07586 (PubMed:15489334).Curated1
Sequence conflicti377 – 378EH → NN no nucleotide entry (PubMed:11095946).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052699218 – 264Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC051619 Genomic DNA No translation available.
BC007586 mRNA Translation: AAH07586.1
CCDSiCCDS10120.2 [Q7M4L6-1]
PIRiJC7552
UniGeneiHs.310399

Genome annotation databases

EnsembliENST00000290894; ENSP00000290894; ENSG00000138606 [Q7M4L6-1]
UCSCiuc001zuy.3 human [Q7M4L6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC051619 Genomic DNA No translation available.
BC007586 mRNA Translation: AAH07586.1
CCDSiCCDS10120.2 [Q7M4L6-1]
PIRiJC7552
UniGeneiHs.310399

3D structure databases

ProteinModelPortaliQ7M4L6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124730, 1 interactor
STRINGi9606.ENSP00000290894

PTM databases

iPTMnetiQ7M4L6
PhosphoSitePlusiQ7M4L6

Polymorphism and mutation databases

DMDMi308153498

Proteomic databases

PaxDbiQ7M4L6
PeptideAtlasiQ7M4L6
PRIDEiQ7M4L6
ProteomicsDBi68869
68870 [Q7M4L6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290894; ENSP00000290894; ENSG00000138606 [Q7M4L6-1]
UCSCiuc001zuy.3 human [Q7M4L6-1]

Organism-specific databases

DisGeNETi90525
EuPathDBiHostDB:ENSG00000138606.19
GeneCardsiSHF
HGNCiHGNC:25116 SHF
HPAiHPA057381
neXtProtiNX_Q7M4L6
OpenTargetsiENSG00000138606
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGWI Eukaryota
ENOG410XQJ2 LUCA
GeneTreeiENSGT00390000015203
HOGENOMiHOG000038038
HOVERGENiHBG066172
InParanoidiQ7M4L6
OrthoDBiEOG091G0I06
PhylomeDBiQ7M4L6
TreeFamiTF325799

Enzyme and pathway databases

SignaLinkiQ7M4L6

Miscellaneous databases

PROiPR:Q7M4L6

Gene expression databases

BgeeiENSG00000138606 Expressed in 131 organ(s), highest expression level in cerebellum
CleanExiHS_SHF
ExpressionAtlasiQ7M4L6 baseline and differential
GenevisibleiQ7M4L6 HS

Family and domain databases

CDDicd10392 SH2_SHF, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR035043 SHF
IPR035044 SHF_SH2
PANTHERiPTHR15127:SF28 PTHR15127:SF28, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSHF_HUMAN
AccessioniPrimary (citable) accession number: Q7M4L6
Secondary accession number(s): Q96IE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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