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Entry version 43 (26 Feb 2020)
Sequence version 2 (07 Feb 2006)
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Protein

Transposable element P transposase

Gene

T

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

P-element transposase that specifically mediates transposition of P-elements. Mediates both; precise and imprecise excision.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1 – 77THAP-typePROSITE-ProRule annotationAdd BLAST77

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Transferase
Biological processDNA integration, DNA recombination
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transposable element P transposase (EC:2.7.7.-)
Short name:
P-element transposase
Alternative name(s):
THAP domain-containing protein
Short name:
DmTHAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0013311, P\T

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi18H → A: Impairs DNA-binding by a factor of 12. 1 Publication1
Mutagenesisi42Q → A: Impairs DNA-binding by a factor of 15. 1 Publication1
Mutagenesisi65R → A: Impairs DNA-binding by a factor of 21. 1 Publication1
Mutagenesisi66R → A: Abolishes DNA-binding. 1 Publication1
Mutagenesisi67R → A: Impairs DNA-binding by a factor of 17. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000686561 – 751Transposable element P transposaseAdd BLAST751

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q7M3K2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1751
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7M3K2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The THAP-type zinc finger mediates DNA-binding and specifically recognizes sequence elements in a bipartite manner using both the major and minor grooves of its target DNA site. Minor-groove recognition is achieved by a combination of direct base contacts and indirect sequence readout of DNA deformation through a variable, basic loop. By contrast, the adjacent major groove is sequence-specifically recognized by the central beta-sheet of the domain (PubMed:20010837).1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 77THAP-typePROSITE-ProRule annotationAdd BLAST77

Keywords - Domaini

Zinc-finger

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022242, 87kDa_transposase
IPR006612, THAP_Znf
IPR038441, THAP_Znf_sf
IPR021896, Transposase_37

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05485, THAP, 1 hit
PF12017, Tnp_P_element, 1 hit
PF12596, Tnp_P_element_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00692, DM3, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50950, ZF_THAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A1 Publication (identifier: Q7M3K2-1) [UniParc]FASTAAdd to basket
Also known as: 87000Da1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKYCKFCCKA VTGVKLIHVP KCAIKRKLWE QSLGCSLGEN SQICDTHFND
60 70 80 90 100
SQWKAAPAKG QTFKRRRLNA DAVPSKVIEP EPEKIKEGYT SGSTQTESCS
110 120 130 140 150
LFNENKSLRE KIRTLEYEMR RLEQQLRESQ QLEESLRKIF TDTQIRILKN
160 170 180 190 200
GGQRATFNSD DISTAICLHT AGPRAYNHLY KKGFPLPSRT TLYRWLSDVD
210 220 230 240 250
IKRGCLDVVI DLMDSDGVDD ADKLCVLAFD EMKVAAAFEY DSSADIVYEP
260 270 280 290 300
SDYVQLAIVR GLKKSWKQPV FFDFNTRMDP DTLNNILRKL HRKGYLVVAI
310 320 330 340 350
VSDLGTGNQK LWTELGISES KTWFSHPADD HLKIFVFSDT PHLIKLVRNH
360 370 380 390 400
YVDSGLTING KKLTKKTIQE ALHLCNKSDL SILFKINENH INVRSLAKQK
410 420 430 440 450
VKLATQLFSN TTASSIRRCY SLGYDIENAT ETADFFKLMN DWFDIFNSKL
460 470 480 490 500
STSNCIECSQ PYGKQLDIQN DILNRMSEIM RTGILDKPKR LPFQKGIIVN
510 520 530 540 550
NASLDGLYKY LQENFSMQYI LTSRLNQDIV EHFFGSMRSR GGQFDHPTPL
560 570 580 590 600
QFKYRLRKYI IGMTNLKECV NKNVIPDNSE SWLNLDFSSK ENENKSKDDE
610 620 630 640 650
PVDDEPVDEM LSNIDFTEMD ELTEDAMEYI AGYVIKKLRI SDKVKENLTF
660 670 680 690 700
TYVDEVSHGG LIKPSEKFQE KLKELECIFL HYTNNNNFEI TNNVKEKLIL
710 720 730 740 750
AARNVDVDKQ VKSFYFKIRI YFRIKYFNKK IEIKNQKQKL IGNSKLLKIK

L
Length:751
Mass (Da):86,770
Last modified:February 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D5662D3CDB79C77
GO
Isoform B1 Publication (identifier: Q7M3K2-2) [UniParc]FASTAAdd to basket
Also known as: 66000Da1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     562-576: GMTNLKECVNKNVIP → ARNTEMLRNSGNIEE
     577-751: Missing.

Show »
Length:576
Mass (Da):66,174
Checksum:i571E48C2DD0FC502
GO
Isoform C1 Publication (identifier: Q7M3K2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-319: Missing.

Show »
Length:747
Mass (Da):86,384
Checksum:iD5EA61C05224CC20
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051942316 – 319Missing in isoform C. 1 Publication4
Alternative sequenceiVSP_051943562 – 576GMTNL…KNVIP → ARNTEMLRNSGNIEE in isoform B. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_051944577 – 751Missing in isoform B. 1 PublicationAdd BLAST175

Sequence databases

Protein sequence database of the Protein Information Resource

More...
PIRi
A24786

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

PIRiA24786

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KDEX-ray1.74C1-77[»]
6P5Aelectron microscopy3.60A/G1-561[»]
B/H617-751[»]
6PE2electron microscopy4.00A/G1-561[»]
B/H617-751[»]
SMRiQ7M3K2
ModBaseiSearch...
PDBe-KBiSearch...

Proteomic databases

PRIDEiQ7M3K2

Organism-specific databases

FlyBaseiFBgn0013311, P\T

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q7M3K2

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR022242, 87kDa_transposase
IPR006612, THAP_Znf
IPR038441, THAP_Znf_sf
IPR021896, Transposase_37
PfamiView protein in Pfam
PF05485, THAP, 1 hit
PF12017, Tnp_P_element, 1 hit
PF12596, Tnp_P_element_C, 1 hit
SMARTiView protein in SMART
SM00692, DM3, 1 hit
PROSITEiView protein in PROSITE
PS50950, ZF_THAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPELET_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7M3K2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: February 26, 2020
This is version 43 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Transposable element

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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