Apolipoprotein E

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• amyloid-beta binding Source: Ensembl
• antioxidant activity Source: Ensembl
• cholesterol transfer activity Source: Ensembl
• heparan sulfate proteoglycan binding Source: UniProtKB
• heparin binding Source: UniProtKB
• identical protein binding Source: UniProtKB
• lipoprotein particle binding Source: Ensembl
• low-density lipoprotein particle receptor binding Source: UniProtKB
• metal chelating activity Source: Ensembl
• phosphatidylcholine-sterol O-acyltransferase activator activity Source: Ensembl
• phospholipid binding Source: Ensembl
• protein homodimerization activity Source: Ensembl
• tau protein binding Source: Ensembl
• very-low-density lipoprotein particle receptor binding Source: Ensembl

GO - Biological processⁱ

• AMPA glutamate receptor clustering Source: Ensembl
• amyloid precursor protein metabolic process Source: Ensembl
• artery morphogenesis Source: Ensembl
• cellular calcium ion homeostasis Source: Ensembl
• cGMP-mediated signaling Source: Ensembl
• cholesterol catabolic process Source: Ensembl
• cholesterol efflux Source: UniProtKB
• cholesterol homeostasis Source: Ensembl
• chylomicron remnant clearance Source: UniProtKB
• fatty acid homeostasis Source: Ensembl
• gene expression Source: Ensembl
• G protein-coupled receptor signaling pathway Source: Ensembl
• high-density lipoprotein particle assembly Source: UniProtKB
• high-density lipoprotein particle clearance Source: Ensembl
• high-density lipoprotein particle remodeling Source: Ensembl
• intermediate-density lipoprotein particle clearance Source: UniProtKB
• lipid transport involved in lipid storage Source: Ensembl
• lipoprotein biosynthetic process Source: UniProtKB
• lipoprotein catabolic process Source: Ensembl
• locomotory exploration behavior Source: Ensembl
• long-chain fatty acid transport Source: Ensembl
• long-term memory Source: Ensembl
• low-density lipoprotein particle remodeling Source: Ensembl
• maintenance of location in cell Source: Ensembl
• negative regulation of amyloid-beta formation Source: Ensembl
• negative regulation of amyloid fibril formation Source: UniProtKB
• negative regulation of blood vessel endothelial cell migration Source: Ensembl
• negative regulation of canonical Wnt signaling pathway Source: Ensembl
• negative regulation of cholesterol biosynthetic process Source: Ensembl
• negative regulation of endothelial cell proliferation Source: Ensembl
• negative regulation of gene expression Source: Ensembl
• negative regulation of inflammatory response Source: Ensembl
• negative regulation of long-term synaptic potentiation Source: Ensembl
• negative regulation of MAP kinase activity Source: Ensembl
• negative regulation of neuron projection development Source: Ensembl
• negative regulation of platelet activation Source: Ensembl
• negative regulation of protein secretion Source: Ensembl
• negative regulation of smooth muscle cell proliferation Source: Ensembl
• negative regulation of triglyceride metabolic process Source: Ensembl
• neuron projection development Source: Ensembl
• nitric oxide mediated signal transduction Source: Ensembl
• NMDA glutamate receptor clustering Source: Ensembl
• phospholipid efflux Source: Ensembl
• positive regulation by host of viral process Source: Ensembl
• positive regulation of amyloid-beta clearance Source: UniProtKB
• positive regulation of cholesterol efflux Source: Ensembl
• positive regulation of cholesterol esterification Source: Ensembl
• positive regulation of dendritic spine development Source: Ensembl
• positive regulation of dendritic spine maintenance Source: Ensembl
• positive regulation of endocytosis Source: Ensembl
• positive regulation of ERK1 and ERK2 cascade Source: Ensembl
• positive regulation of heparan sulfate binding Source: Ensembl
• positive regulation of heparan sulfate proteoglycan binding Source: Ensembl
• positive regulation of lipid biosynthetic process Source: Ensembl
• positive regulation of lipid transport across blood-brain barrier Source: Ensembl
• positive regulation of low-density lipoprotein particle receptor catabolic process Source: Ensembl
• positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
• positive regulation of neuron projection development Source: Ensembl
• positive regulation of nitric-oxide synthase activity Source: Ensembl
• positive regulation of phospholipid efflux Source: Ensembl
• positive regulation of transcription, DNA-templated Source: Ensembl
• protein import Source: Ensembl
• receptor-mediated endocytosis Source: Ensembl
• regulation of apoptotic process Source: Ensembl
• regulation of behavioral fear response Source: Ensembl
• regulation of Cdc42 protein signal transduction Source: Ensembl
• regulation of cellular response to very-low-density lipoprotein particle stimulus Source: Ensembl
• regulation of innate immune response Source: Ensembl
• regulation of proteasomal protein catabolic process Source: Ensembl
• regulation of protein-containing complex assembly Source: Ensembl
• response to caloric restriction Source: Ensembl
• response to dietary excess Source: Ensembl
• response to oxidative stress Source: Ensembl
• reverse cholesterol transport Source: Ensembl
• triglyceride homeostasis Source: Ensembl
• triglyceride metabolic process Source: Ensembl
• triglyceride-rich lipoprotein particle clearance Source: UniProtKB
• vasodilation Source: Ensembl
• very-low-density lipoprotein particle clearance Source: UniProtKB
• very-low-density lipoprotein particle remodeling Source: Ensembl
• virion assembly Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• heparan sulfate proteoglycan binding Source: UniProtKB
• identical protein binding Source: UniProtKB
• low-density lipoprotein particle receptor binding Source: UniProtKB
• protein homodimerization activity Source: Ensembl
• tau protein binding Source: Ensembl
• very-low-density lipoprotein particle receptor binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MKVLWVALVV ALLAGCQADM EGELGSEEPL PPEQPRGQDS QPWEQVLGRL 
        60         70         80         90        100
WDYLRWVQTL SDQVQEELLN TQVIQELTVL MEETMKEVKA YREELEGQLA 
       110        120        130        140        150
PMAQETQARV SKELQAAQAR LGSDMEDLRN RLAQYRSEVQ AMLGQSTEEL 
       160        170        180        190        200
RARMASHLRK LRKRLLRDAD DLKKRLAVYQ AGASEGAERS VSAIRERLRP 
       210        220        230        240        250
LVEQSQSRAA TLSTQVGQPL LDRAEAWRQK LHGRLEEVGV RAQDRLDKMR 
       260        270        280        290        300
QQLEEVRSKV EEQGSQIRLQ AEAFQARLRS WFEPLVEDMQ RQWAGLVEKV 
       310 
QLALHLSPTS PPSENH                                      

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families