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Protein

Probable tRNA pseudouridine synthase B

Gene

truB

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei82NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase BUniRule annotation (EC:5.4.99.25UniRule annotation)
Alternative name(s):
tRNA pseudouridine(55) synthaseUniRule annotation
Short name:
Psi55 synthaseUniRule annotation
tRNA pseudouridylate synthaseUniRule annotation
tRNA-uridine isomeraseUniRule annotation
Gene namesi
Name:truBUniRule annotation
Ordered Locus Names:PF1785
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001219681 – 340Probable tRNA pseudouridine synthase BAdd BLAST340

Proteomic databases

PRIDEiQ7LWY0

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
nop10Q8U1R46EBI-9025178,EBI-9025188

Protein-protein interaction databases

DIPiDIP-48526N
IntActiQ7LWY0, 1 interactor
STRINGi186497.PF1785

Structurei

Secondary structure

1340
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ7LWY0
SMRiQ7LWY0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7LWY0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 325PUAUniRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00987 Archaea
COG0130 LUCA
HOGENOMiHOG000231224
KOiK11131
OMAiIYQRPPL
OrthoDBiPOG093Z08NS

Family and domain databases

HAMAPiMF_01081 TruB_arch, 1 hit
InterProiView protein in InterPro
IPR012960 Dyskerin-like
IPR020103 PsdUridine_synth_cat_dom_sf
IPR002501 PsdUridine_synth_N
IPR002478 PUA
IPR015947 PUA-like_sf
IPR004802 tRNA_PsdUridine_synth_B_fam
IPR026326 TruB_arch
IPR032819 TruB_C
IPR004521 Uncharacterised_CHP00451
PANTHERiPTHR23127 PTHR23127, 1 hit
PfamiView protein in Pfam
PF08068 DKCLD, 1 hit
PF01472 PUA, 1 hit
PF16198 TruB_C_2, 1 hit
PF01509 TruB_N, 2 hits
SMARTiView protein in SMART
SM01136 DKCLD, 1 hit
SM00359 PUA, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00425 CBF5, 1 hit
TIGR00451 unchar_dom_2, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit

Sequencei

Sequence statusi: Complete.

Q7LWY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARDEVRRIL PADIKREVLI KDENAETNPD WGFPPEKRPI EMHIQFGVIN
60 70 80 90 100
LDKPPGPTSH EVVAWIKKIL NLEKAGHGGT LDPKVSGVLP VALEKATRVV
110 120 130 140 150
QALLPAGKEY VALMHLHGDV PEDKIIQVMK EFEGEIIQRP PLRSAVKRRL
160 170 180 190 200
RTRKVYYIEV LEIEGRDVLF RVGVEAGTYI RSLIHHIGLA LGVGAHMSEL
210 220 230 240 250
RRTRSGPFKE DETLITLHDL VDYYYFWKED GIEEYFRKAI QPMEKAVEHL
260 270 280 290 300
PKVWIKDSAV AAVTHGADLA VPGIAKLHAG IKRGDLVAIM TLKDELVALG
310 320 330 340
KAMMTSQEML EKTKGIAVDV EKVFMPRDWY PKLWEKRDRS
Length:340
Mass (Da):38,561
Last modified:July 5, 2004 - v1
Checksum:i76CFE5095C5562FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL81909.1
RefSeqiWP_011012926.1, NC_003413.1

Genome annotation databases

EnsemblBacteriaiAAL81909; AAL81909; PF1785
GeneIDi1469664
KEGGipfu:PF1785
PATRICifig|186497.12.peg.1856

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL81909.1
RefSeqiWP_011012926.1, NC_003413.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EY4X-ray2.11A/B1-333[»]
2HVYX-ray2.30A1-340[»]
2RFKX-ray2.87A5-338[»]
3HAXX-ray2.11A1-340[»]
3HAYX-ray4.99A1-340[»]
3HJWX-ray2.35A8-334[»]
3HJYX-ray3.65A8-334[»]
3LWOX-ray2.86A1-340[»]
3LWPX-ray2.50A1-340[»]
3LWQX-ray2.68A1-340[»]
3LWRX-ray2.20A1-340[»]
3LWVX-ray2.50A1-340[»]
3MQKX-ray2.80A8-335[»]
ProteinModelPortaliQ7LWY0
SMRiQ7LWY0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48526N
IntActiQ7LWY0, 1 interactor
STRINGi186497.PF1785

Proteomic databases

PRIDEiQ7LWY0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81909; AAL81909; PF1785
GeneIDi1469664
KEGGipfu:PF1785
PATRICifig|186497.12.peg.1856

Phylogenomic databases

eggNOGiarCOG00987 Archaea
COG0130 LUCA
HOGENOMiHOG000231224
KOiK11131
OMAiIYQRPPL
OrthoDBiPOG093Z08NS

Miscellaneous databases

EvolutionaryTraceiQ7LWY0

Family and domain databases

HAMAPiMF_01081 TruB_arch, 1 hit
InterProiView protein in InterPro
IPR012960 Dyskerin-like
IPR020103 PsdUridine_synth_cat_dom_sf
IPR002501 PsdUridine_synth_N
IPR002478 PUA
IPR015947 PUA-like_sf
IPR004802 tRNA_PsdUridine_synth_B_fam
IPR026326 TruB_arch
IPR032819 TruB_C
IPR004521 Uncharacterised_CHP00451
PANTHERiPTHR23127 PTHR23127, 1 hit
PfamiView protein in Pfam
PF08068 DKCLD, 1 hit
PF01472 PUA, 1 hit
PF16198 TruB_C_2, 1 hit
PF01509 TruB_N, 2 hits
SMARTiView protein in SMART
SM01136 DKCLD, 1 hit
SM00359 PUA, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00425 CBF5, 1 hit
TIGR00451 unchar_dom_2, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRUB_PYRFU
AccessioniPrimary (citable) accession number: Q7LWY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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